Caloric restriction, SIRT1 and longevity

Cantó, Carles; Auwerx, Johan

doi:10.1016/j.tem.2009.03.008

Cited by 397Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Caloric restriction, SIRT1 and longevity

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Cantó, Carles, Auwerx, Johan·2009·Trends in Endocrinology & Metabolism

DOI 10.1016/j.tem.2009.03.008PMC PMC3627124

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Abstract

More than 70 years after its initial report, caloric restriction stands strong as the most consistent non-pharmacological intervention increasing lifespan and protecting against metabolic disease. Among the different mechanisms by which caloric restriction might act, Sir2/SIRT1 (Silent information regulator 2/Silent information regulator T1) has been the focus of much attention because of its ability to integrate sensing of the metabolic status with adaptive transcriptional outputs. This review focuses on gathered evidence suggesting that Sir2/SIRT1 is a key mediator of the beneficial effects of caloric restriction and addresses the main questions that still need to be answered to consolidate this hypothesis.

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SIRT-1 levels are higher in muscular tissue under caloric restriction (calorie intake lower by about 20-40%).
“The levels of SIRT-1 are higher in the muscular tissue in the presence of caloric restriction (calorie intake lower of about 20–40%) [15].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [15]
Direct activation of SIRT-1 by resveratrol is controversial because in-vitro experiments showed that interaction between resveratrol and the artificial fluorescent substrate used could generate artifacts.
“The direct activation of SIRT-1 by resveratrol is controversial since in-vitro experiments have shown that the interaction between resveratrol and the artificial fluorescent substrate used could generate artifacts [15].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [15]

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Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway
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The Effects of Lactobacillus casei on Glycemic Response, Serum Sirtuin1 and Fetuin-A Levels in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial
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The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle
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Authors: Cantó, C., & Auwerx, J.
Affiliations: École Polytechnique Fédérale de Lausanne (CH)
Corresponding author: Auwerx, Johan
ORCID: Cantó, Carles
Auwerx, Johan
Venue: Trends in Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2009-09
Volume: 20
Issue: 7
Pages: 325-331
ISSN: 1043-2760 (ISSN-L)
DOI: 10.1016/j.tem.2009.03.008
PMC: PMC3627124
OpenAlex: W2090225971
Cited by: 395
References: 111
Citations by year: 2026: 9 · 2025: 14 · 2024: 15 · 2023: 18 · 2022: 12 · 2021: 33 · 2020: 24 · 2019: 17 · 2018: 30 · 2017: 18 · 2016: 23 · 2015: 33 · 2014: 24 · 2013: 28 · 2012: 27
FWCI: 3.36
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Physiology › Dietary Effects on Health
Keywords: caloric restriction, SIRT1, Sir2, longevity, lifespan extension, metabolic disorders, metabolic sensing, transcriptional regulation, non-pharmacological treatment
MeSH terms: Adaptation, Physiological, Animals, Humans, Longevity, Caloric Restriction, Sirtuins, Sirtuin 1

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Caloric restriction, SIRT1 and longevity

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