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Long-Term Testosterone Gel (AndroGel) Treatment Maintains Beneficial Effects on Sexual Function and Mood, Lean and Fat Mass, and Bone Mineral Density in Hypogonadal Men
Abstract
Transdermal testosterone (T) delivery represents an effective alternative to injectable androgens. We studied 163 hypogonadal men who applied 5, 7.5, or 10 g AndroGel (T gel) 1% CIII per day for up to 42 months. Efficacy data were presented in 123 subjects considered evaluable. Continuous AndroGel treatment normalized mean serum T and free T levels. Mean serum 5alpha-dihydrotestosterone concentrations and 5alpha-dihydrotestosterone/T ratio slightly increased, mean serum estradiol/T ratio doubled, and mean serum FSH and LH levels were suppressed by T replacement. Sexual function and mood parameters improved rapidly and were maintained throughout T treatment. Lean body mass increased (P = 0.0001) and fat mass decreased (P = 0.0001), and these changes were maintained with treatment but were not accompanied by significant increases in muscle strength. Increases in serum bone markers suggestive of increased bone formation were followed by gradual and progressive increases in bone mineral density more in the spine (P = 0.0001) than the hip (P = 0.0004). Mild local skin irritation occurred in 12 subjects, resulting in discontinuation in only one subject. Except for the anticipated increase in hematocrit and hemoglobin, there were no clinically significant changes in blood counts or biochemistry. In three subjects with elevated serum prostate-specific antigen, prostate biopsies showed cancer. We conclude that continued application of AndroGel resulted in beneficial effects similar to those with injectables and other transdermal preparations. This study was neither placebo controlled nor powered to determine the effects of T treatment on prostate cancer risk. Thus, monitoring for prostatic disease and assessment for erythrocytosis are strongly advised to reduce the risk of adverse events with T treatment of hypogonadal men.
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“Treatment increases BMD (132-135) and improves trabecular structure (136) and bone mechanical properties (137).”
From Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [137]
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“Prostate-specific antigen and volume rise, marginally, plateauing at 12 months; further increase should be related to aging rather than therapy.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [87]
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“In a study of 123 subjects over 42 months of testosterone gel application, there was significant increase in serum PSA over the first 6 months and then no further significant increases with continued testosterone treatment was found (87).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [87]
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The Influence of Finasteride on the Development of Prostate Cancer
Thompson, I. M., Goodman, P. J., Tangen, C. M., Lucia, M. S., Miller, G. J., Ford, L. G., Lieber, M. M., Cespedes, R. D., Atkins, J. N., Lippman, S. M., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030660 · Cited by 2,588
Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man
Smith, E. P., Boyd, J., Frank, G. R., Takahashi, H., Cohen, R. M., Specker, B., Williams, T. C., Lubahn, D. B., & Korach, K. S. (1994) · New England Journal of Medicine · doi:10.1056/nejm199410203311604 · Cited by 2,471
The Influence of Finasteride on the Development of Prostate Cancer
Sathianathen, N. J. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780190655341.003.0002 · Cited by 2,082
Morishima, A., Grumbach, M. M., Simpson, E. R., Fisher, C., & Qin, K. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.12.8530621 · Cited by 1,416
Effect of testosterone and estradiol in a man with aromatase deficiency
Carani, C., Qin, K., Simoni, M., Faustini-Fustini, M., Serpente, S., Boyd, J., Korach, K. S., & Simpson, E. R. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707103370204 · Cited by 1,151
Testosterone dose-response relationships in healthy young men
Bhasin, S., Woodhouse, L., Casaburi, R., Singh, A. B., Bhasin, D., Berman, N., Chen, X., Yarasheski, K. E., Magliano, L., Dzekov, C., et al. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.6.e1172 · Cited by 967
Self-citationKatznelson, L., Finkelstein, J. S., Schoenfeld, D. A., Rosenthal, D. I., Anderson, E. J., & Klibanski, A. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.12.8954042 · Cited by 791
Effects of Testosterone Replacement in Hypogonadal Men1
Snyder, P. J., Peachey, H., Berlin, J. A., Hannoush, P., Haddad, G., Dlewati, A., Santanna, J., Loh, L., Lenrow, D. A., Holmes, J. H., et al. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.8.6731 · Cited by 610
Self-citationTestosterone Replacement Increases Fat-Free Mass and Muscle Size in Hypogonadal Men
Bhasin, S., Storer, T. W., Berman, N., Yarasheski, K. E., Clevenger, B., Phillips, J., Lee, W. P., Bunnell, T. J., & Casaburi, R. H. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.2.3733 · Cited by 596
Long-term effect of testosterone therapy on bone mineral density in hypogonadal men
Behre, H. M., Kliesch, S., Leifke, E., Link, T. M., & Nieschlag, E. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4163 · Cited by 559
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Low Testosterone in Men with Cardiovascular Disease or Risk Factors: To Treat or Not To Treat?
Cassimatis, D. C., Crim, M. T., & WENGER, N. K. (2016) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-016-0496-0 · Cited by 9
Dutasteride in men receiving testosterone therapy: a randomised, double-blind study
Kacker, R., Harisaran, V., Given, L., Miner, M. M., Rittmaster, R. S., & Morgentaler, A. (2014) · Andrologia · doi:10.1111/and.12237 · Cited by 9
Roth, M. Y. (2012) · The AMA Journal of Ethic · doi:10.1001/virtualmentor.2012.14.2.stas1-1202 · Cited by 9
Role of androgens in modulating male and female sexual function
Traish, A. M. (2010) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2010.052 · Cited by 9
Emerging drugs for hypogonadism
Edelstein, D. L., Dobs, A. S., & Basaria, S. S. (2006) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.11.4.685 · Cited by 9
Self-citationCurrent and emerging testosterone therapies for male hypogonadism
Kaminetsky, J. C., & Wynia, B. (2015) · Research and Reports in Endocrine Disorders · doi:10.2147/rred.s46193 · Cited by 9
Die Therapie des Hypogonadismus des Mannes
Zitzmann, M. (2008) · Der Internist · doi:10.1007/s00108-008-2108-x · Cited by 9
Efros, M. D., Carrara, D., & Neijber, A. (2015) · Andrologia · doi:10.1111/and.12493 · Cited by 9
Rambhatla, A., & Rajfer, J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65376-x · Cited by 9
Birzniece, V., & Ho, K. K. Y. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0426 · Cited by 8
Recurrence of prostate cancer in patients receiving testosterone supplementation for hypogonadism
Gray, H., Seltzer, J., & Talbert, R. L. (2015) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp140128 · Cited by 8
Update on the safety of testosterone therapy in cardiac disease
Aaronson, A. J., Morrissey, R. P., Nguyen, C. T., Willix, R., & Schwarz, E. R. (2011) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2011.566213 · Cited by 8
Mendes, L. D. O., Castilho, A. C. S., Pinho, C. F., Gonçalvez, B. F., Razza, E. M., Chuffa, L. G. D. A., Anselmo-Franci, J. A., Scarano, W. R., & Martinez, F. E. (2018) · Cell Biology International · doi:10.1002/cbin.10990 · Cited by 8
Plasma Metabonomics in Insulin-Resistant Hypogonadic Patients Induced by Testosterone Treatment
Zolla, L., Grande, G., & Milardi, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147754 · Cited by 8
Testosterone gel for the treatment of male hypogonadism
de Ronde, W. (2008) · Expert Opinion on Biological Therapy · doi:10.1517/14712590802653593 · Cited by 8
Late-onset male hypogonadism and testosterone replacement therapy in primary care.
Brunton, S., & D, R. S. M. (2010) · PubMed · Cited by 8
Testosterone in men's health: a new role for an old hormone
Feeley, R. J., Saad, F., Guay, A. T., & Traish, A. M. (2009) · Journal of Men s Health · doi:10.1016/j.jomh.2009.06.005 · Cited by 8
A rational approach to androgen therapy for hypogonadal men with prostate cancer
Kaufman, J. M. (2005) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901401 · Cited by 8
Development of a transdermal gel for reversible male contraception
Sitruk-Ware, R. L., Blithe, D., Page, S. T., & Wang, C. (2025) · Contraception · doi:10.1016/j.contraception.2025.110830 · Cited by 7
Self-citationKe, Y., Xu, J., Zhang, X., Guo, Q., & Zhu, Y. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.724649 · Cited by 7
Joshi, R., Yadav, P., Bagwe‐Parab, S., Tuli, H. S., Buttar, H. S., & Kaur, G. (2023) · Current Bioactive Compounds · doi:10.2174/1573407219666230210101925 · Cited by 6
Wotring, V. E. (2019) · Springer eBooks · doi:10.1007/978-1-4939-9889-0_27 · Cited by 7
A critical analysis of testosterone supplementation therapy and cardiovascular risk in elderly men
Scovell, J. M., Ramasamy, R., & Kovac, J. R. (2014) · Canadian Urological Association Journal · doi:10.5489/cuaj.1962 · Cited by 7
Absorption of Testosterone Gel 1% (Testim) from Three Different Application Sites
Guay, A. T., Smith, T. M., & Offutt, L. A. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01366.x · Cited by 7
Benefits and Consequences of Testosterone Replacement Therapy: A Review
Polackwich, A. S., Tadros, N. N., Ostrowski, K. A., Resident, U., & Resident, U. (2010) · touchREVIEWS in Endocrinology · doi:10.17925/ee.2013.09.01.59 · Cited by 7
Comparison of Testosterone Replacement Therapy Medications in the Treatment of Hypogonadism
Luthy, K. E., Williams, C., Freeborn, D., & Cook, A. (2017) · The Journal for Nurse Practitioners · doi:10.1016/j.nurpra.2016.11.016 · Cited by 7
Mok, S. F., Fennell, C., Savkovic, S., Turner, L., Jayadev, V., Conway, A. J., & Handelsman, D. J. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz195 · Cited by 7
Haider, K. S., Haider, A., Doros, G. D., & Saad, F. (2021) · Androgens Clinical Research and Therapeutics · doi:10.1089/andro.2020.0011 · Cited by 7
Yalamanchi, S., & Dobs, A. S. (2017) · Current Opinion in Urology · doi:10.1097/mou.0000000000000435 · Cited by 7
Self-citationTestosterone Therapy and Glucose Homeostasis in Men with Testosterone Deficiency (Hypogonadism)
Saad, F. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_23 · Cited by 6
Burns, P. R., Kim, E. D., Ruff, D. D., & Seftel, A. D. (2015) · American Journal of Men s Health · doi:10.1177/1557988315609684 · Cited by 7
Evolutionary biology as a foundation for studying aging and aging-related disease
Ackermann, M., & Pletcher, S. D. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0018 · Cited by 7
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Wang, C. (2007) · European Urology Supplements · doi:10.1016/j.eursup.2007.08.002 · Cited by 7
Self-citationAdam, J., Pastuszak, A. W., Christensen, M. B., Spencer, R., Sandberg, A., Hotaling, J. M., & Lipshultz, L. I. (2022) · International Journal of Impotence Research · doi:10.1038/s41443-022-00585-1 · Cited by 6
Blood lipids may have influence on the emotional well-being in young men
Kramek, E., Jastrzębska, S., Walczak-Jędrzejowska, R., Marchlewska, K., Oszukowska, E., Gumińska, A., Kula, K., & Słowikowska‐Hilczer, J. (2010) · Health · doi:10.4236/health.2010.25066 · Cited by 5
Ugo-Neff, G., & Rizzolo, D. (2022) · JAAPA · doi:10.1097/01.jaa.0000824956.78048.ff · Cited by 7
Jørgensen, P. L., Kreiberg, M., Jørgensen, N., Juul, A., Oturai, P., Dehlendorff, C., Lauritsen, J., Wagner, T., Rosenvilde, J. J., Daugaard, G., et al. (2023) · Acta Oncologica · doi:10.1080/0284186x.2023.2207218 · Cited by 7
Management of Hypogonadism in Cardiovascular Patients
Tanna, M. S., Schwartzbard, A. Z., Berger, J. S., Underberg, J. A., Gianos, E., & WEINTRAUB, H. S. (2016) · Urologic Clinics of North America · doi:10.1016/j.ucl.2016.01.011 · Cited by 6
Knutson, K. M., Gotts, S. J., Wassermann, E. M., & Lewis, J. D. (2020) · Military Medicine · doi:10.1093/milmed/usaa142 · Cited by 6
ORWOLL, E. S., Vanderschueren, D., & Boonen, S. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415853-5.00032-7 · Cited by 6
The relationship between testosterone deficiency and frailty in elderly men
Saad, F. (2010) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2010.060 · Cited by 6
The population structure of pathogenic bacteria
Dykhuizen, D. E., & Kalia, A. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0014 · Cited by 7
Tung, D. S., & Cunningham, G. R. (2007) · The Endocrinologist · doi:10.1097/01.ten.0000260860.68375.96 · Cited by 6
Self-citationThe good, the bad, and the unknown of late onset hypogonadism: the urological perspective
Jockenhövel, F., Kaufman, J. M., Mickisch, G., Morales, Á., & Wang, C. (2005) · The Journal of Men s Health and Gender · doi:10.1016/j.jmhg.2005.07.001 · Cited by 6
Self-citationAndrogen Replacement Therapy in Hypogonadal Men
Wang, C., & Swerdloff, R. S. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-727-7_18 · Cited by 6
Self-citationHormonal Implications in the Development and Treatment of Prostate Cancer
Ip, C. C. K., & Hall, S. J. (2007) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2007.03.009 · Cited by 6
Wiren, K. M., Hashimoto, J. G., & Zhang, X.-W. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23288 · Cited by 5
Testosterone replacement therapy in men on active surveillance for prostate cancer
Applewhite, J., McCarter, J. H., Saffati, G., Kronstedt, S., Hinojosa-Gonzalez, D. E., La, T. M., Diejomaoh, R. M., Lipshultz, L. I., & Khera, M. (2025) · The Journal of Sexual Medicine · doi:10.1093/jsxmed/qdaf003 · Cited by 5
Testosterone and male rejuvenation
Helo, S., Thomas, P., & Tadros, N. N. (2019) · Panminerva Medica · doi:10.23736/s0031-0808.18.03513-9 · Cited by 5
Cardiovascular disease and testosterone therapy in male hypogonadism
de Silva, N. L., Grant, B., Minhas, S., & Jayasena, C. N. (2024) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.15211 · Cited by 6
The role of accurate testosterone testing in the treatment and management of male hypogonadism
Dobs, A. S. (2008) · Steroids · doi:10.1016/j.steroids.2008.06.007 · Cited by 5
Self-citationKitamura, T., Ishihara, Y., Kusakabe, T., Tsuiki, M., Nanba, K., Hiroshima-Hamanaka, K., Nomura, T., Satoh‐Asahara, N., Yasoda, A., & Tagami, T. (2023) · Endocrine Journal · doi:10.1507/endocrj.ej22-0564 · Cited by 5
Zhang, X., Zhong, Y., Saad, F., Haider, K. S., Haider, A., & Xu, X. (2019) · World Journal of Urology · doi:10.1007/s00345-018-02621-6 · Cited by 5
Barsky, S. T., & Monks, D. A. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00471-x · Cited by 7
Comparison of oral versus transdermal testosterone supplementation in hypogonadal men
Raynaud, J., Colle, M., Pujos-Gautraud, M., Lemaire, A., Auzerie, J., & Gardette, J. (2010) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2010.034 · Cited by 5
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Maillefer, A., Sabé, M., Coste, C., Bartolomei, J., Jaafar, J., & Sentissi, O. (2019) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000000930 · Cited by 5
Bilateral metachronous testicular seminoma
Kaplan, M., & Klein, E. A. (2005) · Nature Clinical Practice Urology · doi:10.1038/ncpuro0295 · Cited by 5
Recognising late-onset hypogonadism: a difficult task for sexual health care
Corona, G., Ferruccio, N., Morittu, S., Forti, G., & Maggi, M. (2009) · Journal of Men s Health · doi:10.1016/j.jomh.2009.05.002 · Cited by 5
Coward, R. M., Simhan, J., & Carson, C. C. (2010) · International braz j urol · doi:10.1590/s1677-55382010000600008 · Cited by 5
Cancer: evolutionary origins of vulnerability
Greaves, M. F. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0021 · Cited by 5
The evolutionary context of human aging and degenerative disease
Austad, S. N., & Finch, C. E. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0023 · Cited by 6
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Morgentaler, A. (2007) · Future Oncology · doi:10.2217/14796694.3.2.123 · Cited by 5
Shortridge, E. F., Polzer, P. K., Donga, P. Z., & Wade, R. L. (2015) · International Journal of Clinical Practice · doi:10.1111/ijcp.12636 · Cited by 4
Obesity’s role in secondary male hypogonadism: a review of pathophysiology and management issues
Seyam, O., Gandhi, J., Joshi, G. S., Smith, N. L., & Khan, S. A. (2019) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-019-00056-7 · Cited by 5
Zamir, A., Ben‐Zeev, T., Levi, C., Einstein, O., Ratamess, N. A., van Praag, H., & Hoffman, J. R. (2023) · Hormones and Behavior · doi:10.1016/j.yhbeh.2023.105444 · Cited by 4
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Schubert, M., & Jockenhövel, F. (2010) · Der Urologe · doi:10.1007/s00120-009-2198-7 · Cited by 4
Testosterone Replacement Therapy and Prostate Health
Polackwich, A. S., Ostrowski, K. A., & Hedges, J. C. (2012) · Current Urology Reports · doi:10.1007/s11934-012-0275-8 · Cited by 4
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Tanna, M. S., Schwartzbard, A. Z., Berger, J. S., Alukal, J. P., & WEINTRAUB, H. S. (2015) · Current Atherosclerosis Reports · doi:10.1007/s11883-015-0490-0 · Cited by 4
Funaro, M. G., Bolyakov, A., Gímenez, E. D., Herman, M. P., & Paduch, D. A. (2013) · Advances in Sexual Medicine · doi:10.4236/asm.2013.33a003 · Cited by 4
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Radi, S., & Karaplis, A. C. (2017) · Case Reports in Endocrinology · doi:10.1155/2017/6328524 · Cited by 4
Sex Hormones and Immunosenescence
Gómez, C. R., Nomellini, V., & Kovacs, E. J. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_42 · Cited by 4
Morgentaler, A., McGettigan, J. W., Xiang, Q., Danoff, T. M., & Gould, E. M. (2014) · International Journal of Impotence Research · doi:10.1038/ijir.2014.28 · Cited by 4
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Soliman, A. T., & Sanctis, V. D. (2014) · Andrology-Open Access · doi:10.4172/2167-0250.1000124 · Cited by 5
Alidu, H. W., Amidu, N., Owiredu, W. K. B. A., Gyasi-Sarpong, C. K., Bawah, A. T., Dapare, P. P. M., & Prempeh, E. B. A. (2017) · Advances in Sexual Medicine · doi:10.4236/asm.2017.72008 · Cited by 4
Sexual motivation: problem solved and new problems introduced
Pfaff, D. W., & Saad, F. (2020) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2019-0055 · Cited by 4
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Lawrentschuk, N., & Fleshner, N. E. (2009) · The Scientific World JOURNAL · doi:10.1100/tsw.2009.45 · Cited by 4
Frailty and its relationship to late onset hypogonadism
Gooren, L. J. (2007) · The Journal of Men s Health and Gender · doi:10.1016/j.jmhg.2007.09.002 · Cited by 4
Androgens and Coronary Artery Disease
Wu, F. C. W., & von Eckardstein, A. (2003) · Humana Press eBooks · doi:10.1385/1-59259-388-7:191 · Cited by 13
Nieschlag, E., & Behre, H. M. (2010) · Springer eBooks · doi:10.1007/978-3-540-78355-8_21 · Cited by 4
Low Testosterone Level in Men and Quality of Life
Horie, S. (2009) · Springer eBooks · doi:10.1007/978-0-387-78665-0_152 · Cited by 4
Testosterone: The Male Sex Hormone
Obukohwo, O. M., Ben‐Azu, B., Ovuakporaye, S. I., Oghenetega, O. B., Emojevwe, V. O., Faith, F. Y., Okwute, P. G., Rotu, R. A., Godswill, O. O., & Kingsley, N. E. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.110657 · Cited by 4
Clinical Evaluation of Leydig Cell Function
Swerdloff, R. S., & Wang, C. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-453-7_30 · Cited by 4
Self-citationTestosterone Substitution and the Prostate
Crawford, E. D. (2005) · European Urology Supplements · doi:10.1016/j.eursup.2005.05.004 · Cited by 4
Morgentaler, A. (2008) · European Urology · doi:10.1016/j.eururo.2008.02.008 · Cited by 4
Effects of Spinal Cord Injury and Related Conditions
Yarrow, J. F., & Cardozo, C. P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11219-x · Cited by 5
de Silva, N. L., Hyams, E., Grant, B., Dixit, P., Bassi, R., Bassett, P., Comninos, A. N., & Jayasena, C. N. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf488 · Cited by 4
Santucci, J., Stapleton, P., Perera, M., Ischia, J. J., Murphy, D. G., Bolton, D. M., Lawrentschuk, N., Frydenberg, M., & Sathianathen, N. J. (2025) · British Journal of Urology · doi:10.1111/bju.16870 · Cited by 3
Sokol, R. Z. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511635656.013 · Cited by 3
Thauvin, M., Robin-Jagerschmidt, C., Nique, F., Mollat, P., Fleury, D., & Prangé, T. (2008) · Acta Crystallographica Section F Structural Biology and Crystallization Communications · doi:10.1107/s1744309108036683 · Cited by 3
Phase II drugs currently being investigated for the treatment of hypogonadism
Udedibia, E., & Kaminetsky, J. C. (2014) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2014.948151 · Cited by 3
Xiaowei, Z., Zhen-hua, L., Yeqing, Y., Wenjun, B., Xiao-feng, W., Huan, S., & Yongping, Z. (2013) · The Aging Male · doi:10.3109/13685538.2012.754007 · Cited by 3
RetractedČeponis, J., Wang, C., Swerdloff, R. S., & Liu, P. Y. (2017) · Endocrinology · doi:10.1007/978-3-319-29456-8_11-1 · Cited by 3
Self-citationTestosterone Therapy in Adult-Onset Testosterone Deficiency: Hematocrit and Hemoglobin Changes
Lorde, N., Maarouf, A., Strange, R. C., König, C. S., Hackett, G. I., Haider, A., Haider, K. S., Desnerck, P., Saad, F., & Ramachandran, S. (2021) · Androgens Clinical Research and Therapeutics · doi:10.1089/andro.2021.0013 · Cited by 3
Androgen Deficiency in the Aging Male
Morales, Á. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4160-6911-9.00029-3 · Cited by 3
Mancini, A., Raimondo, S., Segni, C. D., Gadotti, G., Giacchi, E., Zollino, M., Bonomi, M., Persani, L., & Pontecorvi, A. (2014) · Cited by 3
[Age-related androgen deficiency: diagnostic work-up].
Rossi, D., & Tostain, J.-B. (2004) · PubMed · Cited by 3
Perspectives on human health and disease from evolutionary and behavioral ecology
Strassmann, B. I., & Mace, R. H. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0009 · Cited by 3
Androgen deficiency in aging men
T'Sjoen, G. G., & Kaufman, J. (2006) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/01.med.0000224805.31695.6a · Cited by 3
Lietuvos sveikatos mokslų universitetas
Šeškevičius, A., Lesauskaitė, V., Blaževičienė, A., Kubilius, R., Samėnienė, J., Gudas, R., & Macijauskienė, J. (2018) · Lithuanian University of Health Sciences · Cited by 3
Čeponis, J., Wang, C., Swerdloff, R. S., & Liu, P. Y. (2017) · Endocrinology · doi:10.1007/978-3-319-44441-3_11 · Cited by 3
Self-citation
Metadata
- Authors
- Wang, C., Cunningham, G., Dobs, A., Iranmanesh, A., Matsumoto, A. M., Snyder, P. J., Weber, T., Berman, N., Hull, L., & Swerdloff, R. S.
- Affiliations
- University of California, Los Angeles (US)
- Baylor College of Medicine (US)
- Johns Hopkins University (US)
- Veterans Health Administration (US)
- University of Washington (US)
- University of Pennsylvania Health System (US)
- Duke Medical Center (US)
- Corresponding author
- Wang, Christina
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-05
- Volume
- 89
- Issue
- 5
- Pages
- 2085-2098
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2001118572
- Semantic Scholar
- 2114ced4c5aa202f6d1a0eee503c76ffef92a68a
- Cited by
- 656
- References
- 48
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 4 · 2023: 14 · 2022: 24 · 2021: 6 · 2020: 15 · 2019: 23 · 2018: 23 · 2017: 36 · 2016: 22 · 2015: 30 · 2014: 36 · 2013: 37 · 2012: 40
- FWCI
- 32.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- University of Pennsylvania
- Johns Hopkins University
- Deutsches Krebsforschungszentrum
- National Institutes of Health (RR00425)
- National Center for Research Resources (M01RR000030, M01RR000425)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- testosterone replacement therapy, transdermal testosterone, hypogonadism, sexual function, mood, lean body mass, fat mass, bone mineral density, dihydrotestosterone, estradiol, gonadotropin suppression, erythrocytosis, prostate-specific antigen, prostate cancer risk, long-term treatment
- MeSH terms
- Adolescent, Adult, Affect, Aged, Androgens, Body Composition, Dose-Response Relationship, Drug, Drug Administration Schedule, Estradiol, Follicle Stimulating Hormone, Gels, Hematocrit, Hemoglobins, Humans, Hypogonadism, Luteinizing Hormone, Male, Prostatic Hyperplasia, Sexual Behavior, Sex Hormone-Binding Globulin, Testosterone, Ultrasonography, Biomarkers, Bone Density, Bone Remodeling, Prostate-Specific Antigen
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