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Cited by 215Thyroid Disorders and TreatmentsBlood Pressure and Hypertension StudiesHormonal Regulation and Hypertension

The DOI matches its Crossref record; 27 of the 29 references it cites were found in a registry or an index.

Association between Blood Pressure and Serum Thyroid-Stimulating Hormone Concentration within the Reference Range: A Population-Based Study

Åsvold, Bjørn O., Bjøro, Trine, Nilsen, Tom I. L., Vatten, Lars J.·2007·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2006-2208
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Abstract

CONTEXT: The association between thyroid function and blood pressure is insufficiently studied. OBJECTIVE: The objective of the investigation was to study the association between TSH within the reference range and blood pressure. DESIGN AND SETTING: This was a cross-sectional, population-based study. SUBJECTS: A total of 30,728 individuals without previously known thyroid disease were studied. MAIN OUTCOME MEASURES: The main outcome measures were mean systolic and diastolic blood pressure and pulse pressure and odds ratio for hypertension (>140/90 mm Hg or current or previous use of antihypertensive medication), according to categories of TSH. RESULTS: Within the reference range of TSH (0.50-3.5 mU/liter), there was a linear increase in blood pressure with increasing TSH. The average increase in systolic blood pressure was 2.0 mm Hg [95% confidence interval (CI) 1.4-2.6 mm Hg] per milliunit per liter increase in TSH among men, and 1.8 mm Hg (95% CI 1.4-2.3 mm Hg) in women. The corresponding increase in diastolic blood pressure was 1.6 mm Hg (95% CI 1.2-2.0 mm Hg) in men and 1.1 mm Hg (95% CI 0.8-1.3 mm Hg) in women. Comparing TSH of 3.0-3.5 mU/liter (upper part of the reference) with TSH of 0.50-0.99 mU/liter (lower part of the reference), the odds ratio for hypertension was 1.98 (95% CI 1.56-2.53) in men and 1.23 (95% CI 1.04-1.46) in women. CONCLUSION: Within the reference range of TSH, we found a linear positive association between TSH and systolic and diastolic blood pressure that may have long-term implications for cardiovascular health.

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Metadata

Authors
Åsvold, B. O., Bjøro, T., Nilsen, T. I. L., & Vatten, L. J.
Affiliations
  • Department of Public Health (B.O. Å., T.I.L.N., L.J.V.), Faculty of Medicine, Norwegian University of Science and Technology, N-7489 Trondheim, Norway
  • Oslo University Hospital (NO)
  • Norwegian University of Science and Technology (NO)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2007-03-01
Volume
92
Issue
3
Pages
841-845
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2006-2208
OpenAlex
W2079601862
Cited by
215
References
29
Citations by year
2026: 3 · 2025: 9 · 2024: 8 · 2023: 7 · 2022: 13 · 2021: 9 · 2020: 15 · 2019: 15 · 2018: 17 · 2017: 8 · 2016: 13 · 2015: 12 · 2014: 15 · 2013: 11 · 2012: 18
FWCI
7.31
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
Norwegian Institute of Public Health
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords
thyroid-stimulating hormone, blood pressure, hypertension, thyroid function, reference values, systolic blood pressure, diastolic blood pressure, pulse pressure, cardiovascular health
MeSH terms
Adult, Aged, Aged, 80 and over, Blood Pressure, Cross-Sectional Studies, Female, Health Surveys, Humans, Hypertension, Male, Middle Aged, Norway, Reference Values, Thyrotropin

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