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Cited by 119Cardiovascular Health and Disease PreventionThyroid Disorders and TreatmentsCardiovascular Function and Risk Factors

Increased central arterial stiffness in hypothyroidism

Obuobie, K., Smith, J., Evans, L. M., John, R., Davies, J. S., Lazarus, J. H.·2002·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2002-020493
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Abstract

Hypothyroidism is associated with cardiovascular dysfunction. It is increasingly apparent that stiffening of central arteries may lead to increased afterload and cardiac dysfunction. We noninvasively studied the peripheral and central pressure waveforms in 12 untreated hypothyroid patients as well as in 12 age-, sex-, and body mass index-matched controls using the technique of pulse wave analysis from recordings at the radial artery. Indexes of arterial stiffness, augmentation index (AI) and augmentation of central arterial pressure (AG), were derived as well as time of travel of the reflected wave (TR), a direct estimate of aortic pulse wave velocity. At baseline, there were no significant differences between the 2 groups in brachial and aortic blood pressures. Hypothyroid patients had significantly higher AI than controls (mean +/- SEM[SCAP], 32.0 +/- 3.4% vs. 17.0 +/- 2.4%; P < 0.0005) even when corrected for heart rate (AI(C); 28.0 +/- 3.2% vs. 17.0 +/- 2.4%; P < 0.006) and AG (13.0 +/- 2.2 vs. 7.0 +/- 2.1 mm Hg; P < 0.03) together with a lower TR (132.0 +/- 4.1 vs. 142.0 +/- 1.5 msec; P < 0.03). After 6 months of therapy with T(4), all patients were euthyroid. AI(C) had decreased in the patient group (23.0 +/- 3.2% vs. 28.0 +/- 3.2%; P < 0.01) as had AG (9.0 +/- 1.5 vs. 13.0 +/- 2.2 mm Hg; P < 0.008), but TR was significantly higher (142.0 +/- 3.0 vs. 132.0 +/- 4.1 msec; P < 0.008). AI correlated with age in all groups (hypothyroid group: r = 0.937; P < 0.0005; control group: r = 0.804; P < 0.0005), but correlated with TSH level only among controls (r = 0.591; P < 0.05). This study confirms that hypothyroidism is associated with increased cardiovascular risk, as evidenced by increased augmentation of central aortic pressures and central arterial stiffness. Furthermore, these abnormalities are reversed after adequate T(4) replacement.

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  • Pulse wave velocity, a surrogate measure of arterial stiffness, improves with levothyroxine treatment in hypothyroid and subclinical hypothyroid patients.

    “as does pulse wave velocity, a surrogate measure of arterial stiffness (52,53).”

    From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [53]

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Authors
Obuobie, K., Smith, J., Evans, L. M., John, R., Davies, J. S., & Lazarus, J. H.
Affiliations
University of Wales (GB)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2002-10
Volume
87
Issue
10
Pages
4662-4666
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2002-020493
OpenAlex
W2020739261
Cited by
119
References
27
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 3 · 2016: 8 · 2015: 8 · 2014: 9 · 2013: 13 · 2012: 5
FWCI
2.62
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
hypothyroidism, central arterial stiffness, pulse wave analysis, augmentation index, aortic pulse wave velocity, thyroid hormone replacement, levothyroxine, cardiovascular dysfunction, afterload, thyroid-stimulating hormone, age-related stiffness, radial artery pressure waveform, euthyroid patients, cardiovascular risk factors
MeSH terms
Adult, Aged, Aging, Aorta, Arteries, Biomechanical Phenomena, Blood Pressure, Brachial Artery, Female, Heart Rate, Humans, Hypothyroidism, Male, Middle Aged, Regression Analysis, Thyroxine, Body Mass Index

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