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Cited by 114Sexual Differentiation and DisordersAdrenal Hormones and DisordersOvarian function and disorders

The DOI matches its Crossref record; 41 of the 44 references it cites were found in a registry or an index.

Testicular Adrenal Rest Tumors and Leydig and Sertoli Cell Function in Boys with Classical Congenital Adrenal Hyperplasia

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Martinez-Aguayo, A., Rocha, A., Rojas, N., García, C., Parra, R., Lagos, M., Valdivia, L., Poggi, H., Cattani, A.·2007·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2007-0383
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Abstract

Context: Infertility observed in adult males with congenital adrenal hyperplasia (CAH) has been associated with testicular adrenal rest tumors (TART) that may originate during childhood. Objective: Our objective was to describe the prevalence of TART and Sertoli and Leydig cell function in a group of boys aged 2–10 yr with CAH and to compare prevalence with that of a control group. Design: From August 2005 to January 2007, 19 patients with classical CAH (CAH group) were referred from seven endocrinology centers. Methods: We studied 19 subjects in the CAH group and, as a control group, 13 boys from the community that did not have testicular diseases. A complete physical exam was performed. High-resolution ultrasound was used to determine TART prevalence. Inhibin B and anti-Müllerian hormone were used as Sertoli cell markers. The ratio between basal testosterone levels and testosterone levels 72 h after β-human chorionic gonadotropin (5000 U/m2) treatment [(T72− T0)/T0] was used to evaluate Leydig cell response. Results: CAH and control groups were comparable in chronological age (5.9 vs. 5.6 yr; P = 0.67) and bone age/chronological age ratio (1.09 vs. 1.03; P = 0.09). TART prevalence was four of 19 (21%) in the CAH group. Lower values for inhibin B (49.2. vs. 65.2 pg/ml; P = 0.018), anti-Müllerian hormone (70.1 vs. 94.2 ng/ml; P = 0.002), and (T72− T0)/T0 (5.6 vs. 13.6; P < 0.01) were observed in the CAH group. Conclusion: TART in prepubertal males with classic CAH could be found during childhood. We also report differences in markers of gonadal function in a subgroup of patients, especially in those with inadequate control.

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Metadata

Authors
Martinez-Aguayo, A., Rocha, A., Rojas, N., García, C., Parra, R., Lagos, M., Valdivia, L., Poggi, H., & Cattani, A.
Affiliations
  • Endocrinology Unit, Department of Pediatrics (A.M.-A., A.R., A.C.)
  • Pontificia Universidad Católica de Chile (CL)
  • Department of Radiology and Pediatrics (C.G., R.P.)
  • Molecular Biology Laboratory (M.L., L.V., H.P.), Pontificia Universidad Católica de Chile, 833-0074, Santiago, Chile
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2007-12-01
Volume
92
Issue
12
Pages
4583-4589
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2007-0383
OpenAlex
W1972363573
Cited by
114
References
44
Citations by year
2026: 3 · 2025: 3 · 2024: 4 · 2023: 7 · 2022: 1 · 2021: 6 · 2020: 1 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 9 · 2015: 10 · 2014: 6 · 2013: 5 · 2012: 5
FWCI
3.58
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Universidad de Chile (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords
testicular adrenal rest tumor, congenital adrenal hyperplasia, Leydig cell function, Sertoli cell function, inhibin B, anti-Müllerian hormone, prepubertal boys, male infertility
MeSH terms
Adrenal Hyperplasia, Congenital, Adrenal Rest Tumor, Anthropometry, Child, Child, Preschool, DNA, Hormones, Humans, Inhibins, Leydig Cells, Male, Sertoli Cells, Testicular Neoplasms, Anti-Mullerian Hormone

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