Cited by 404Hormonal and reproductive studiesErythropoietin and Anemia TreatmentIron Metabolism and Disorders

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Effects of Graded Doses of Testosterone on Erythropoiesis in Healthy Young and Older Men

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Coviello, Andrea D., Kaplan, Beth, Lakshman, Kishore M., Chen, Tai, Singh, Atam B., Bhasin, Shalender·2008·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2007-1692PMC PMC2266950

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Abstract

CONTEXT: Erythrocytosis is a dose-limiting adverse effect of testosterone therapy, especially in older men. OBJECTIVE: Our objective was to compare the dose-related changes in hemoglobin and hematocrit in young and older men and determine whether age-related differences in erythropoietic response to testosterone can be explained by changes in erythropoietin and soluble transferrin receptor (sTfR) levels. DESIGN: We conducted a secondary analysis of data from a testosterone dose-response study in young and older men who received long-acting GnRH agonist monthly plus one of five weekly doses of testosterone enanthate (25, 50, 125, 300, or 600 mg im) for 20 wk. SETTING: The study took place at a General Clinical Research Center. PARTICIPANTS: Participants included 60 older men aged 60-75 yr and 61 young men aged 19-35 yr. OUTCOME MEASURES: Outcome measures included hematocrit and hemoglobin and serum erythropoietin and sTfR levels. RESULTS: Hemoglobin and hematocrit increased significantly in a linear, dose-dependent fashion in both young and older men in response to graded doses of testosterone (P<0.0001). The increases in hemoglobin and hematocrit were significantly greater in older than young men. There was no significant difference in percent change from baseline in erythropoietin or sTfR levels across groups in either young or older men. Changes in erythropoietin or sTfR levels were not significantly correlated with changes in total or free testosterone levels. CONCLUSIONS: Testosterone has a dose-dependent stimulatory effect on erythropoiesis in men that is more pronounced in older men. The testosterone-induced rise in hemoglobin and hematocrit and age-related differences in response to testosterone therapy may be mediated by factors other than erythropoietin and sTfR.

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Authors: Coviello, A. D., Kaplan, B., Lakshman, K. M., Chen, T., Singh, A. B., & Bhasin, S.
Affiliations: Boston University (US)
Charles R. Drew University of Medicine and Science (US)
Corresponding author: Coviello, Andrea D.
ORCID: Coviello, Andrea D.
Chen, Tai
Bhasin, Shalender
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2008-03-01
Volume: 93
Issue: 3
Pages: 914-919
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2007-1692
PMC: PMC2266950
OpenAlex: W2102205904
Cited by: 404
References: 38
Citations by year: 2026: 12 · 2025: 27 · 2024: 25 · 2023: 34 · 2022: 34 · 2021: 21 · 2020: 30 · 2019: 18 · 2018: 18 · 2017: 24 · 2016: 20 · 2015: 23 · 2014: 19 · 2013: 23 · 2012: 24
FWCI: 8.66
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: School of Medicine, Boston University
National Institutes of Health
National Institute on Aging (1R01 AG-14369-01, R01AG014369)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK049296, 2R01 DK49296-08, R01DK070534, R01DK059627)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12HD0434)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords: testosterone replacement therapy, erythropoiesis, erythrocytosis, testosterone enanthate, dose-response relationship, hemoglobin, hematocrit, erythropoietin, soluble transferrin receptor, age differences, older men, GnRH agonist
MeSH terms: Adolescent, Adult, Age Factors, Aged, Dose-Response Relationship, Drug, Erythropoiesis, Erythropoietin, Hematocrit, Hemoglobins, Humans, Male, Middle Aged, Receptors, Transferrin, Testosterone

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Effects of Graded Doses of Testosterone on Erythropoiesis in Healthy Young and Older Men

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