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Cited by 401Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsObesity, Physical Activity, Diet

The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.

Impact of Obesity on the Risk for Polycystic Ovary Syndrome

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Yildiz, Bulent O., Knochenhauer, Eric S., Azziz, Ricardo·2008·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2007-1834PMC PMC2190739
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Abstract

CONTEXT: Although it is well established that adiposity increases the severity of the clinical features of polycystic ovary syndrome (PCOS), the data regarding the prevalence of PCOS in obese women and the change in body weight women presented with PCOS over time are scarce. OBJECTIVE: The objective of the study was to determine whether obesity increases the risk of PCOS and whether the degree of obesity of PCOS patients has increased, paralleling the rise in obesity in the population. DESIGN: We analyzed data from two consecutive populational studies assessing the prevalence of PCOS and a database containing all untreated PCOS patients evaluated at a university clinic between 1987 and 2002. SETTING: The study was conducted at a tertiary care center. PATIENTS OR OTHER PARTICIPANTS: Participants included 675 women who participated in prevalence studies and 746 PCOS patients. MAIN OUTCOME MEASURES: Populational prevalence of PCOS according to body mass index (BMI) and change in BMI of PCOS patients over time were measured. RESULTS: The prevalence rates of PCOS in underweight, normal-weight, overweight, and obese women were 8.2, 9.8, 9.9, and 9.0%, respectively. Prevalence rates reached 12.4 and 11.5% in women with BMI 35-40 kg/m2 and greater than 40 kg/m2 (P = NS). The mean BMI of PCOS patients diagnosed between 1987 and 2002 rose, beginning in 1997 and reaching 37.3 +/- 9.9 kg/m2 in 2000-2002, paralleling the change in BMI of the surrounding population (10-14% obesity rate in 1987, 15-19% in 1997, and 25% or greater in 2002). CONCLUSION: Our results suggest that the risk of PCOS is only minimally increased with obesity, although the degree of obesity of PCOS patients has increased, similar to that observed in the general population. These data indicate that obesity in PCOS reflects environmental factors to a great extent.

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Crossref · 10.1210/jc.2007-1834

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Metadata

Authors
Yildiz, B. O., Knochenhauer, E. S., & Azziz, R.
Affiliations
  • Department of Internal Medicine, Endocrinology, and Metabolism Unit (B.O.Y.), Hacettepe University School of Medicine, Hacettepe, 06100 Ankara, Turkey
  • Staten Island University Hospital (US)
  • Cedars-Sinai Medical Center (US)
Corresponding author
Azziz, Ricardo
ORCID
Azziz, Ricardo
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2008-01-01
Volume
93
Issue
1
Pages
162-168
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2007-1834
PMC
PMC2190739
OpenAlex
W2101492737
Cited by
401
References
46
Citations by year
2026: 7 · 2025: 27 · 2024: 17 · 2023: 23 · 2022: 28 · 2021: 22 · 2020: 21 · 2019: 27 · 2018: 17 · 2017: 21 · 2016: 16 · 2015: 23 · 2014: 24 · 2013: 22 · 2012: 35
FWCI
20.63
Type
journal article
Language
en
Open access
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Hacettepe University Institutional Repository (hacettepe.edu.tr) (submittedVersion, other-oa)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (K24HD001346, R01HD029364, K24 HD 01346, R01-HD29364)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
polycystic ovary syndrome, obesity, body mass index, PCOS prevalence, overweight, environmental factors, adiposity
MeSH terms
Adolescent, Adult, Alabama, Androstenedione, Female, Humans, Male, Middle Aged, Obesity, Polycystic Ovary Syndrome, Progesterone, Prolactin, Sex Hormone-Binding Globulin, Testosterone, Thyrotropin, Body Mass Index, Prevalence, Dehydroepiandrosterone Sulfate, 17-alpha-Hydroxyprogesterone

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