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Cited by 597

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Bone Mineral Density Changes during the Menopause Transition in a Multiethnic Cohort of Women

Open access
Finkelstein, Joel S., Brockwell, Sarah E., Mehta, Vinay, Greendale, Gail A., Sowers, MaryFran R., Ettinger, Bruce, Lo, Joan C., Johnston, Janet M., Cauley, Jane A., Danielson, Michelle E., Neer, Robert M.·2008·The Journal of Clinical Endocrinology & Metabolism

Abstract

Context: Rates of bone loss across the menopause transition and factors associated with variation in menopausal bone loss are poorly understood. Objective: Our objective was to assess rates of bone loss at each stage of the transition and examine major factors that modify those rates. Design, Setting, and Participants: We conducted a longitudinal cohort study of 1902 African-American, Caucasian, Chinese, or Japanese women participating in The Study of Women’s Health Across the Nation. Women were pre- or early perimenopausal at baseline. Outcome Measure: We assessed bone mineral density (BMD) of the lumbar spine and total hip across a maximum of six annual visits. Results: There was little change in BMD during the pre- or early perimenopause. BMD declined substantially in the late perimenopause, with an average loss of 0.018 and 0.010 g/cm2·yr from the spine and hip, respectively (P < 0.001 for both). In the postmenopause, rates of loss from the spine and hip were 0.022 and 0.013 g/cm2·yr, respectively (P < 0.001 for both). During the late peri- and postmenopause, bone loss was approximately 35–55% slower in women in the top vs. the bottom tertile of body weight. Apparent ethnic differences in rates of spine bone loss were largely explained by differences in body weight. Conclusions: Bone loss accelerates substantially in the late perimenopause and continues at a similar pace in the first postmenopausal years. Body weight is a major determinant of the rate of menopausal BMD loss, whereas ethnicity, per se, is not. Healthcare providers should consider this information when deciding when to screen women for osteoporosis.

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Crossref · 10.1210/jc.2007-1876

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Metadata

Authors
Finkelstein, J. S., Brockwell, S. E., Mehta, V., Greendale, G. A., Sowers, M. R., Ettinger, B., Lo, J. C., Johnston, J. M., Cauley, J. A., Danielson, M. E., & Neer, R. M.
Venue
The Journal of Clinical Endocrinology & Metabolism
Published
2008-03-01
Volume
93
Issue
3
Pages
861-868
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
OpenAlex
W2151771709
Cited by
597
References
2
FWCI
11.37
Type
journal article
Language
en
Open access
green

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