Acylated ghrelin inhibits spontaneous luteinizing hormone pulsatility and responsiveness to naloxone but not that to gonadotropin-releasing hormone in young men: evidence for a central inhibitory action of ghrelin on the gonadal axis
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CONTEXT: Recent evidence suggests that ghrelin exerts a negative modulation on the gonadal axis. Ghrelin was reported to suppress LH secretion in both animal and human models. Moreover, acylated ghrelin (AG) also decreases the LH responsiveness to GnRH in vitro. OBJECTIVE: The objective of the study was to evaluate the effects of AG infusion on spontaneous and stimulated gonadotropin secretion. DESIGN, PARTICIPANTS, AND INTERVENTION: In seven young healthy male volunteers (age mean +/- sem 26.4 +/- 2.6 yr), we evaluated LH and FSH levels every 15 min during: 1) iv isotonic saline infusion; 2) iv saline followed by AG; LH and FSH response to GnRH (100 microg iv as a bolus), 3) alone and 4) during AG infusion; LH and FSH response to naloxone (0.1 mg/kg iv as a slow bolus), 5) alone and 6) during AG infusion. RESULTS: Significant LH but not FSH pulses were recorded in all subjects under saline infusion. AG infusion inhibited LH levels [area under the curve((240-480)): 415.8 +/- 69.7 mIU/ml.min during AG vs. 744.6 +/- 120.0 mIU/ml.min during saline, P < 0.02] and abolished LH pulsatility. No change in FSH secretion was recorded. The LH and FSH responses to GnRH during saline were not affected by AG administration. However, AG inhibited the LH response to naloxone [area under the curve ((120-210)): 229.9 +/- 39.3 mIU/ml.min during AG vs. 401.1 +/- 44.6 mIU/ml.min during saline, P < 0.01]. FSH levels were not modified by naloxone alone or in combination with AG. CONCLUSIONS: AG inhibits both spontaneous LH pulsatility and the LH response to naloxone. Because AG does not affect the LH response to GnRH, these findings indicate that the ghrelin system mediates central inhibition of the gonadal axis.
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Ghrelin has direct actions on the brain and the pituitary, where it has an inhibitory effect on gonadotropin pulsatility and decreases LH responsiveness to GnRH, as well as a stimulatory effect on prolactin secretion, probably involving direct action on somatomammotroph cells.
“Ghrelin has direct actions on the brain and the pituitary, where it has an inhibitory effect on gonadotropin pulsatility and decreases LH responsiveness to GnRH, as well as a stimulatory effect on prolactin secretion, probably involving direct action on somatomammotroph cells.111”
From Pubertal development and regulation (2016) · cites this paper as [111]
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Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479 · see citing works
Ghrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949 · see citing works
Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679 · see citing works
The Novel Hypothalamic Peptide Ghrelin Stimulates Food Intake and Growth Hormone Secretion
Wren, A. M., Small, C. J., Ward, H. L., Murphy, K. G., Dakin, C. L., Taheri, S., Kennedy, A. R., Roberts, G. H., Morgan, D. G. A., Ghatei, M. A., et al. (2000) · Endocrinology · doi:10.1210/endo.141.11.7873 · Cited by 1,593 · see citing works
Biological, Physiological, Pathophysiological, and Pharmacological Aspects of Ghrelin
van der Lely, A. J., Tschöp, M., Heiman, M. L., & Ghigo, E. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0029 · Cited by 1,187 · see citing works
Self-citationGuan, X.-M., Yu, H., Palyha, O., McKee, K., Feighner, S., Sirinathsinghji, D., Smith, R. G., van der Ploeg, L., & Howard, A. (1997) · Brain Research. Molecular Brain Research · doi:10.1016/s0169-328x(97)00071-5 · Cited by 1,185 · see citing works
Ghrelin Strongly Stimulates Growth Hormone Release in Humans
Takaya, K., Ariyasu, H., Kanamoto, N., Iwakura, H., Yoshimoto, A., Harada, M., Mori, K., Komatsu, Y., Usui, T., Shimatsu, A., et al. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7167 · Cited by 864 · cited 1× · see citing works
“showing that acute boluses of AG, even at high doses, did not modify gonadotropin secretion in either rodents or humans (1, 29, 30) are likely to reflect the very limited time of observation and the acute administration.”
BackgroundLoucks, A. B., & Thuma, J. R. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020369 · Cited by 760 · see citing works
Deletion of Ghrelin Impairs neither Growth nor Appetite
Sun, Y., Ahmed, S., & Smith, R. G. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.7973-7981.2003 · Cited by 644 · see citing works
Hemodynamic and hormonal effects of human ghrelin in healthy volunteers.
Nagaya, N., Kojima, M., Uematsu, M., Yamagishi, M., Hosoda, H., Oya, H., Hayashi, Y., & Kangawa, K. (2001) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.5.r1483 · Cited by 629 · see citing works
Toshinai, K., Mondal, M. S., Nakazato, M., Date, Y., Murakami, N., Kojima, M., Kangawa, K., & Matsukura, S. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4518 · Cited by 626 · see citing works
Ghrelin?a hormone with multiple functions
Korbonits, M. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.03.002 · Cited by 593 · see citing works
Bruni, J. F., Vugt, D. V., Marshall, S., & Meites, J. (1977) · Life Sciences · doi:10.1016/0024-3205(77)90528-8 · Cited by 578 · see citing works
Veldhuis, J. D., Carlson, M. L., & Johnson, M. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7686 · Cited by 556 · see citing works
Peptidomimetic Regulation of Growth Hormone Secretion
Smith, R. G., der Ploeg, L. H. T. V., Howard, A. D., Feighner, S. D., Cheng, K., Hickey, G. J., Wyvratt, M. J., Fisher, M. H., Nargund, R. P., & Patchett, A. A. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.5.0316 · Cited by 527 · see citing works
Endocrine consequences of long-term intrathecal administration of opioids
Abs, R., Verhelst, J., Maeyaert, J., Van Buyten, J.-P., Opsomer, F., Adriaensen, H., Verlooy, J., Van Havenbergh, T., Smet, M., & Van Acker, K. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.6.6615 · Cited by 491 · see citing works
Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity
Muccioli, G., Tschöp, M. H., Papotti, M., Deghenghi, R., Heiman, M. L., & Ghigo, E. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01432-2 · Cited by 386 · see citing works
Self-citationNovel Expression and Functional Role of Ghrelin in Rat Testis
Tena‐Sempere, M., Barreiro, M. L., Gonzalez, L., Gaytán, F., Zhang, F., Caminos, J. E., Pinilla, L., Casanueva, F. F., Diéguez, C., & Aguilar, E. (2002) · Endocrinology · doi:10.1210/endo.143.2.8646 · Cited by 344 · see citing works
Endocrine Effects of Naloxone-Induced Opiate Receptor Blockade *
Morley, J. E., Baranetsky, N. G., Wingert, T. D., Carlson, H. E., Hershman, J. M., Melmed, S. K., Levin, S. R., Jamison, K. R., Weitzman, R. E., Chang, R., et al. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-50-2-251 · Cited by 299 · see citing works
Increased plasma ghrelin level in lung cancer cachexia.
Shimizu, Y., Nagaya, N., Isobe, T., Imazu, M., Okumura, H., Hosoda, H., Kojima, M., Kangawa, K., & Kohno, N. (2003) · PubMed · Cited by 284 · see citing works
Tannenbaum, G. S., Epelbaum, J., & Bowers, C. Y. (2003) · Endocrinology · doi:10.1210/en.2002-220852 · Cited by 243 · see citing works
Furuta, M., Funabashi, T., & Kimura, F. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5854 · Cited by 235 · see citing works
Esler, W., Rudolph, J., Claus, T., Tang, W.-F., Barucci, N., Brown, S.-E., Bullock, W., Daly, M., Decarr, L., Li, Y., et al. (2007) · Endocrinology · doi:10.1210/en.2007-0239 · Cited by 232 · see citing works
Fernández-Fernández, R., Tena‐Sempere, M., Navarro, V. M., Barreiro, M. L., Castellano, J. M., Aguilar, E., & Pinilla, L. (2005) · Neuroendocrinology · doi:10.1159/000092753 · Cited by 215 · see citing works
Biological, Physiological, and Pharmacological Aspects of Ghrelin
Hosoda, H., Kojima, M., & Kangawa, K. (2006) · Journal of Pharmacological Sciences · doi:10.1254/jphs.crj06002x · Cited by 202 · see citing works
Effects of Undernutrition on Reproductive Function in the Human*
Warren, M. P. (1983) · Endocrine Reviews · doi:10.1210/edrv-4-4-363 · Cited by 186 · see citing works
Ghrelin effects on gonadotropin secretion in male and female rats
Fernández-Fernández, R., Tena‐Sempere, M., Aguilar, E., & Pinilla, L. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.03.003 · Cited by 173 · see citing works
Vulliémoz, N. R., Xiao, E., Xia‐Zhang, L., Germond, M., Rivier, J., & Ferin, M. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1244 · Cited by 164 · see citing works
THE OPIOID CONTROL OF LH AND FSH RELEASE: EFFECTS OF A MET‐ENKEPHALIN ANALOGUE AND NALOXONE
Grossman, A. B., MOULT, P. J. A., Gaillard, R.-C., Delitala, G., Toff, W. D., REES, L. H., & BESSER, G. M. (1981) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1981.tb00363.x · Cited by 163 · see citing works
Ghrelin and reproduction: a novel signal linking energy status and fertility?
Barreiro, M. L., & Tena‐Sempere, M. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.07.015 · Cited by 163 · see citing works
Ghrelin Inhibits the Development of Mouse Preimplantation Embryos in Vitro
Kawamura, K., Sato, N., Fukuda, J., Kodama, H., Kumagai, J., Tanikawa, H., Nakamura, A., Honda, Y., Sato, T., & Tanaka, T. (2003) · Endocrinology · doi:10.1210/en.2003-0033 · Cited by 160 · see citing works
Iqbal, J., Kurose, Y., Canny, B. J., & Clarke, I. J. (2005) · Endocrinology · doi:10.1210/en.2005-1048 · Cited by 155 · see citing works
Tamura, T., Irahara, M., Tezuka, M., Kiyokawa, M., & Aono, T. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1573 · Cited by 152 · see citing works
Effects of Chronic Hyperghrelinemia on Puberty Onset and Pregnancy Outcome in the Rat
Fernández-Fernández, R., Navarro, V. M., Barreiro, M. L., Vigo, E., Tovar, S. A., Sirotkin, A. V., Casanueva, F. F., Aguilar, E., Diéguez, C., Pinilla, L., et al. (2005) · Endocrinology · doi:10.1210/en.2004-1622 · Cited by 147 · see citing works
Endocrine aspects of acute and prolonged critical illness
Vanhorebeek, I., Langouche, L., & Van den Berghe, G. (2006) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0071 · Cited by 141 · see citing works
Ghrelin Suppresses Secretion of Luteinizing Hormone in Humans
Kluge, M., SCHÜSSLER, P., Uhr, M., Yassouridis, A., & Steiger, A. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0593 · Cited by 139 · see citing works
Open-label pilot study of testosterone patch therapy in men with opioid-induced androgen deficiency
Daniell, H. W., Lentz, R., & Mazer, N. A. (2006) · The Journal of Pain · doi:10.1016/j.jpain.2005.10.009 · Cited by 135 · see citing works
Broglio, F., Gianotti, L., Destefanis, S., Fassino, S., Daga, G. A., Mondelli, V., Lanfranco, F., Gottero, C., Gauna, C., Hofland, L. J., et al. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02011.x · Cited by 128 · see citing works
Self-citationKaynard, A. H., Pau, K. ‐. F., Hess, D. L., & Spies, H. G. (1990) · Endocrinology · doi:10.1210/endo-127-5-2437 · Cited by 123 · see citing works
I’Anson, H., Foster, D. L., Foxcroft, G. R., & Booth, P. J. (1991) · PubMed · Cited by 116 · see citing works
Heterogeneity of Ghrelin/Growth Hormone Secretagogue Receptors
Muccioli, G., Baragli, A., Granata, R., Papotti, M., & Ghigo, E. (2007) · Neuroendocrinology · doi:10.1159/000105141 · Cited by 104 · see citing works
Self-citationCentral and Peripheral Roles of Ghrelin on Glucose Homeostasis
Sun, Y., Asnicar, M., & Smith, R. G. (2007) · Neuroendocrinology · doi:10.1159/000109094 · Cited by 102 · see citing works
Opiate receptors and anterior pituitary hormone secretion in man. Effect of naloxone infusion
Delitala, G., Devilla, L., & Arata, L. (1981) · European Journal of Endocrinology · doi:10.1530/acta.0.0970150 · Cited by 92 · see citing works
Vulliémoz, N. R., Xiao, E., Xia‐Zhang, L., Wardlaw, S. L., & Ferin, M. (2004) · Endocrinology · doi:10.1210/en.2004-1093 · Cited by 80 · see citing works
Exploring the role of ghrelin as novel regulator of gonadal function
Tena‐Sempere, M. (2005) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2005.02.001 · Cited by 69 · see citing works
Vulliémoz, N. R., Xiao, E., Xia‐Zhang, L., Rivier, J., & Ferin, M. (2007) · Endocrinology · doi:10.1210/en.2007-1350 · Cited by 67 · see citing works
Two Subgroups of Gonadotropin Releasing Hormone Neurons Control Gonadotropin Secretion in Rats
Kimura, F., & Funabashi, T. (1998) · Physiology · doi:10.1152/physiologyonline.1998.13.5.225 · Cited by 52 · see citing works
Energy availability and infertility
Loucks, A. (2007) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e3282f1cb6a · Cited by 38 · see citing works
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Müller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.03.005 · Cited by 1,034 · see citing works
Self-citationPubertal development and regulation
Abreu, A. P., & Kaiser, U. B. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00418-0 · Cited by 611 · see citing works
The relationship between gut and adipose hormones, and reproduction
Comninos, A. N., Jayasena, C. N., & Dhillo, W. S. (2013) · Human Reproduction Update · doi:10.1093/humupd/dmt033 · Cited by 167 · see citing works
Forbes, S. C., Li, X. F., Kinsey‐Jones, J. S., & O’Byrne, K. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.05.060 · Cited by 150 · see citing works
Avendaño, M. S., Vazquez, M. J., & Tena‐Sempere, M. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmx025 · Cited by 139 · see citing works
Connecting metabolism and reproduction: roles of central energy sensors and key molecular mediators
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Metabolic signals in human puberty: Effects of over and undernutrition
Martos‐Moreno, G. Á., Chowen, J. A., & Argente, J. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.12.017 · Cited by 126 · see citing works
The Human Experience With Ghrelin Administration
Garin, M. C., Burns, C. M., Kaul, S., & Cappola, A. R. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-4247 · Cited by 107 · see citing works
Ackerman, K. E., Slusarz, K., Guereca, G., Pierce, L., Slattery, M. J., Mendes, N., Herzog, D. B., & Misra, M. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00598.2011 · Cited by 106 · see citing works
Ghrelin as a pleotrophic modulator of gonadal function and reproduction
Tena‐Sempere, M. (2008) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet1003 · Cited by 101 · see citing works
Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight
Gahete, M. D., Pacheco, D. R. F., Villa-Osaba, A., Hormaechea‐Agulla, D., Ibáñez‐Costa, A., Martínez‐Fuentes, A. J., Gracia‐Navarro, F., Castano, J. P., & Luque, R. M. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0391 · Cited by 90 · see citing works
Kluge, M., SCHÜSSLER, P., Schmidt, D., Uhr, M., & Steiger, A. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2607 · Cited by 90 · see citing works
Allaway, H. C. M., Southmayd, E. A., & De Souza, M. J. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0053 · Cited by 89 · see citing works
Linking Stress and Infertility: A Novel Role for Ghrelin
Sominsky, L., Hodgson, D. M., McLaughlin, E. A., Smith, R., Wall, H. M., & Spencer, S. J. (2017) · Endocrine Reviews · doi:10.1210/er.2016-1133 · Cited by 77 · see citing works
Maïmoun, L., Georgopoulos, N., & Sultan, C. (2014) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2013-3030 · Cited by 69 · see citing works
Ghrelin: a metabolic signal affecting the reproductive system
Lorenzi, T., Meli, R., Marzioni, D., Morroni, M., Baragli, A., Castellucci, M., Gualillo, O., & Muccioli, G. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.02.003 · Cited by 69 · see citing works
Beyond the metabolic role of ghrelin: A new player in the regulation of reproductive function
Muccioli, G., Lorenzi, T., Lorenzi, M., Ghé, C., Arnoletti, E., Raso, G. M., Castellucci, M., Gualillo, O., & Meli, R. (2011) · Peptides · doi:10.1016/j.peptides.2011.10.020 · Cited by 65 · see citing works
Farkas, I., Vastagh, C., Sárvári, M., & Liposits, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078178 · Cited by 63 · see citing works
Alves, M. G., Jesus, T. T., Sousa, M., Goldberg, E., Silva, B. M., & Oliveira, P. F. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666151209151550 · Cited by 58 · see citing works
Scheid, J. L., & Souza, M. J. D. (2010) · Medicine and sport science/Medicine and sport · doi:10.1159/000321974 · Cited by 55 · see citing works
Hypogonadism in male cancer patients
Burney, B. O., & Garcia, J. M. (2012) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-012-0065-7 · Cited by 54 · see citing works
Ghrelin in Female and Male Reproduction
Dupont, J., Maillard, V., Coyral-Castel, S., Ramé, C., & Froment, P. (2010) · International Journal of Peptides · doi:10.1155/2010/158102 · Cited by 51 · see citing works
Hatef, A., & Unniappan, S. (2017) · Biology of Reproduction · doi:10.1095/biolreprod.116.146621 · Cited by 44 · see citing works
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Ghrelin and reproductive disorders
Repaci, A., Gambineri, A., Pagotto, U., & Pasquali, R. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.02.022 · Cited by 43 · see citing works
Feng, D. D., Yang, S.-K., Loudes, C., Simon, A., Al-Sarraf, T., Culler, M., Alvear-Perez, R., Llorens-Cortes, C., Chen, C., Epelbaum, J., et al. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07787.x · Cited by 41 · see citing works
Hypothalamic neuropeptides and neurocircuitries in Prader Willi syndrome
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Endocannabinoid Regulation of Neuroendocrine Systems
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Endogenous opiates and behavior: 2008
Bodnar, R. J. (2009) · Peptides · doi:10.1016/j.peptides.2009.09.027 · Cited by 39 · see citing works
Al-Hashem, F. H., Alkhateeb, M. A., Alshahrani, M., El-Refaey, H., Alsunaidi, M., Alessa, R., Sakr, H. F., Sarhan, M., Eleawa, S. M., & Khalil, M. A. (2014) · Europe PMC (PubMed Central) · doi:10.17877/de290r-289 · Cited by 39 · see citing works
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Witchel, S. F., & Topaloglu, A. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00017-2 · Cited by 40 · see citing works
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Kluge, M., Schmidt, D., Uhr, M., & Steiger, A. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.05.010 · Cited by 28 · see citing works
Reproductive health in women with type 2 diabetes mellitus
Creţu, D., Cernea, S., Onea, C. R., & Pop, R.-M. (2020) · HORMONES · doi:10.1007/s42000-020-00225-7 · Cited by 25 · see citing works
Angelidis, G., Dafopoulos, K. C., Messini, C. I., Valotassiou, V. J., Georgoulias, P., & Messinis, I. E. (2012) · Reproductive Sciences · doi:10.1177/1933719112443880 · Cited by 25 · see citing works
Grey, C. L., Grayfer, L., Belosevic, M., & Chang, J. P. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.12.024 · Cited by 22 · see citing works
Hypothalamic neuroendocrine integration of reproduction and metabolism in mammals
Yang, F., Zhao, S., Wang, P., & Xiang, W. (2023) · Journal of Endocrinology · doi:10.1530/joe-23-0079 · Cited by 22 · see citing works
Scheid, J. L., Souza, M. J. D., Hill, B. R., Leidy, H. J., & Williams, N. I. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00360.2012 · Cited by 22 · see citing works
Dysregulation of the Hypothalamic-Pituitary-Testicular Axis due to Energy Deficit
Grossmann, M., & Wittert, G. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab517 · Cited by 22 · see citing works
Ghrelin suppresses the GnRH-induced preovulatory gonadotropin surge in dairy heifers
Chouzouris, T. M., Dovolou, E., Dafopoulos, K. C., Georgoulias, P., Vasileiou, N. G. C., Fthenakis, G. C., Anifandis, G., & Amiridis, G. S. (2016) · Theriogenology · doi:10.1016/j.theriogenology.2016.05.022 · Cited by 21 · see citing works
Current and potential roles of ghrelin in clinical practice
Angelidis, G., Valotassiou, V. J., & Georgoulias, P. (2010) · Journal of Endocrinological Investigation · doi:10.1007/bf03350350 · Cited by 20 · see citing works
Ghrelin action on GnRH neurons and pituitary gonadotropes might be mediated by GnIH-GPR147 system
Çelik, Ö., Çelik, N., Aydın, S., Aygün, B., Haberal, E. T., Kuloğlu, T., Ulaş, M., Aktün, L. H., Acet, M., & Çelik, S. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0050 · Cited by 20 · see citing works
Karl, J. P., Berryman, C. E., Harris, M. N., Lieberman, H. R., Gadde, K. M., Rood, J. C., & Pasiakos, S. M. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa024 · Cited by 18 · see citing works
Neuroendocrine and metabolic activities of ghrelin gene products
Baragli, A., Lanfranco, F., Allasia, S., Granata, R., & Ghigo, E. (2011) · Peptides · doi:10.1016/j.peptides.2011.10.024 · Cited by 18 · see citing works
Self-citation“Sibling” battle or harmony: Crosstalk between nesfatin-1 and ghrelin
Chen, X., Dong, J., Jiao, Q., Du, X., Bi, M., & Jiang, H. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04193-6 · Cited by 17 · see citing works
Grey, C. L., & Chang, J. P. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02221.x · Cited by 17 · see citing works
Grey, C. L., & Chang, J. P. (2013) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2013.02.037 · Cited by 16 · see citing works
Rak, A., Wróbel, A. M., & Gregoraszczuk, E. Ł. (2014) · Reproductive Sciences · doi:10.1177/1933719114549854 · Cited by 16 · see citing works
Low Testosterone in Male Cancer Patients and Survivors
Xu, P. J., Choi, E. J., White, K. M., & Yafi, F. A. (2020) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2020.03.004 · Cited by 14 · see citing works
Hormones and athletic performance
Lanfranco, F., Ghigo, E., & Strasburger, C. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00026-2 · Cited by 16 · see citing works
Self-citationFuoco, D., Kilgour, R. D., & Vigano, A. A. L. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.09.008 · Cited by 14 · see citing works
Paslakis, G., Buchmann, A. F., Westphal, S., Banaschewski, T., Hohm, E., Zimmermann, U. S., Laucht, M., & Deuschle, M. (2014) · Neuroendocrinology · doi:10.1159/000363325 · Cited by 13 · see citing works
Human ghrelin decreases pituitary response to GnRH in superovulated ewes
Dovolou, E., Chadio, S. E., Messinis, I. E., Rekkas, C. A., Deligiannis, C., Kalogiannis, D., & Amiridis, G. S. (2013) · Theriogenology · doi:10.1016/j.theriogenology.2013.04.005 · Cited by 13 · see citing works
Endocrine Rhythms, the Sleep-Wake Cycle, and Biological Clocks
Copinschi, G., Turek, F. W., & Cauter, E. V. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00011-3 · Cited by 14 · see citing works
Other than Growth Hormone Neuroendocrine Actions of Ghrelin
Benso, A. S., Calvi, E., Gramaglia, E., Olivetti, I., Tomelini, M., Ghigo, E., & Broglio, F. (2013) · Endocrine development · doi:10.1159/000346054 · Cited by 12 · see citing works
Self-citationGhrelin Actions on Somatotropic and Gonadotropic Function in Humans
Motta, G., Allasia, S., Ghigo, E., & Lanfranco, F. (2016) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.11.001 · Cited by 12 · see citing works
Self-citationInfluence of ghrelin on energy balance and endocrine physiology.
Komarowska, H., Jaskuła, M., Stangierski, A., Waśko, R., Sowiński, J., & Ruchała, M. (2012) · PubMed · Cited by 11 · see citing works
The Antidepressant-like Effects of Estrogen-mediated Ghrelin
Wang, P., Liu, C., Liu, L., Zhang, X., Ren, B., & Li, B. (2015) · Current Neuropharmacology · doi:10.2174/1570159x1304150831120650 · Cited by 11 · see citing works
Physiological Mechanisms for the Metabolic Control of Reproduction
Tena‐Sempere, M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00035-1 · Cited by 11 · see citing works
Wójcik-Gładysz, A., Wańkowska, M., Gajewska, A., Misztal, T., Zielińska-Górska, M. K., Szlis, M., & Polkowska, J. (2016) · Reproduction Fertility and Development · doi:10.1071/rd16028 · Cited by 10 · see citing works
Circadian Rhythms in Neuroendocrine Systems
Arble, D. M., Copinschi, G., Vitaterna, M. H., Cauter, E. V., & Turek, F. W. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-375097-6.10012-5 · Cited by 10 · see citing works
Iwasa, T., Noguchi, H., Aoki, H., Tamura, K., Maeda, T., Takeda, A., Uchishiba, M., Arakaki, R., Minato, S., Kamada, S., et al. (2022) · Endocrine Journal · doi:10.1507/endocrj.ej22-0426 · Cited by 8 · see citing works
Chouzouris, T. M., Dovolou, E., Georgoulias, P., Rekkas, A., Dafopoulos, K. C., Athanasiou, L. V., Fthenakis, G. C., & Amiridis, G. S. (2017) · Theriogenology · doi:10.1016/j.theriogenology.2017.10.011 · Cited by 8 · see citing works
Mechanisms linking energy balance and reproduction: impact of prenatal environment
Keen‐Rhinehart, E. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0004 · Cited by 7 · see citing works
N-octanoylated ghrelin peptide inhibits bovine oocyte meiotic resumption
Xu, X., Bai, J., Feng, T., Xiao, L., Song, Y., Xiao, Y. X., & Liu, Y. (2018) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2018.04.016 · Cited by 7 · see citing works
Mechanisms and predictors of menses resumption once normal weight is reached in anorexia nervosa
Galusca, B., Gay, A., Belleton, G., Eisinger, M., Massoubre, C., Lang, F., Grouselle, D., Estour, B., & Germain, N. (2023) · Journal of Eating Disorders · doi:10.1186/s40337-023-00893-x · Cited by 7 · see citing works
Khazali, H., Mahmoudi, F., & Janahmadi, M. (2018) · Europe PMC (PubMed Central) · doi:10.22074/ijfs.2018.5332 · Cited by 6 · see citing works
Kluge, M. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.07.003 · Cited by 6 · see citing works
Neuroendocrine mechanisms of reproductive dysfunctions in undernourished condition
Iwasa, T., Yamamoto, Y., Noguchi, H., Takeda, A., Minato, S., Kamada, S., Imaizumi, J., Kagawa, T., Yoshida, A., Kawakita, T., et al. (2022) · The journal of obstetrics and gynaecology research · doi:10.1111/jog.15144 · Cited by 6 · see citing works
Chouzouris, T. M., Dovolou, E., Rekkas, C. A., Georgoulias, P., Athanasiou, L. V., & Amiridis, G. S. (2018) · Reproduction in Domestic Animals · doi:10.1111/rda.13321 · Cited by 5 · see citing works
Messini, C. I., Malandri, M., Anifandis, G., Dafopoulos, K. C., Georgoulias, P., Sveronis, G., Garas, A., Daponte, A. I., & Messinis, I. E. (2017) · Clinical Endocrinology · doi:10.1111/cen.13349 · Cited by 4 · see citing works
The Male Reproductive System, Exercise, and Training: Endocrine Adaptations
Lanfranco, F., & Minetto, M. A. (2013) · Humana Press eBooks · doi:10.1007/978-1-62703-314-5_7 · Cited by 4 · see citing works
Self-citationGrigoryan, O. R., Okhotnikova, A. A., & Andreeva, E. N. (2009) · Diabetes Mellitus · doi:10.14341/2072-0351-5696 · Cited by 4 · see citing works
Zhang, W., Peng, J., Yang, S., Huang, Y., & Tong, D. (2022) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2022.106763 · Cited by 3 · see citing works
CHAPTER 26 – Hormones and Athletic Performance
Lanfranco, F., Ghigo, E., & Strasburger, C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00026-5
Self-citationThe Male Reproductive System, Exercise, and Training: Endocrine Adaptations
Lanfranco, F., & Minetto, M. A. (2020) · Contemporary Endocrinology · doi:10.1007/978-3-030-33376-8_7 · Cited by 3 · see citing works
Self-citationGhrelin Suppresses Secretion of Gonadotropins in Women
Kluge, M. (2012) · Reproductive Sciences · doi:10.1177/1933719112459242 · Cited by 3 · see citing works
Ghrelin in the Regulation of GH Secretion and Other Pituitary Hormones
Lanfranco, F., Baldi, M., Motta, G., Minetto, M. A., Marotta, F., Gasco, V., & Ghigo, E. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-317-6_2 · Cited by 2 · see citing works
Self-citationRole of Leptin in the Reproduction and Metabolism: Focus on Regulation by Seasonality in Animals
Szczęsna, M., & Dorota, A. (2011) · InTech eBooks · doi:10.5772/16575 · Cited by 2 · see citing works
Hormonal and Reproductive Changes Associated with Physical Activity and Exercise
Gibbs, J., Mallinson, R. J., & Souza, M. D. D. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3402-7_12 · Cited by 2 · see citing works
Metabolism, Obesity, Thinness, and Reproduction
Prati, A., Napolitano, A., Despini, G., Manzo, A., Caroli, M., & Genazzani, A. D. (2019) · ISGE series · doi:10.1007/978-3-030-14358-9_6 · Cited by 1 · see citing works
Siddique, L. (2014) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 1 · see citing works
Regulation of Growth Hormone and Action (Secretagogues)
Kopchick, J. J., Martos‐Moreno, G. Á., Korbonits, M., Gaylinn, B. D., Nass, R. M., & Thorner, M. O. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00023-x · Cited by 1 · see citing works
Wen, Z., Zeng, Q., Wen, S., Yonghong, W., & He, J. (2022) · Gynecological Endocrinology · doi:10.1080/09513590.2022.2045938 · Cited by 1 · see citing works
Khazali, H., & Mahmoud, F. (2022) · PubMed Central · doi:10.30466/vrf.2020.118362.2802 · Cited by 1 · see citing works
Kluge, M. (2015) · Peptides · doi:10.1016/j.peptides.2015.09.003 · Cited by 1 · see citing works
Çelik, Ö., Aydın, S., Çelik, N., & Yılmaz, M. (2015) · Peptides · doi:10.1016/j.peptides.2015.10.011 · Cited by 1 · see citing works
The role of AgRP neurons as a central link between leptin receptors and fertility
Egan, O. K. (2016) · Otago University Research Archive (University of Otago) · Cited by 1 · see citing works
del Villar, V., & Jesús, M. (2011) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Physiological Regulation of Short-term Food Intake in Children During Puberty
Patel, B. P. (2014) · TSpace (University of Toronto)
Mendes, N., Herzog, D. B., Misra, M., Ackerman, K. E., Slusarz, K., Guereca, G., & Pierce, L. (2016)
- Authors
- Lanfranco, F., Bonelli, L., Baldi, M., Me, E., Broglio, F., & Ghigo, E.
- Affiliations
- University of Turin (IT)
- Corresponding author
- Ghigo, Ezio
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2008-09-01
- Volume
- 93
- Issue
- 9
- Pages
- 3633-3639
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2070539070
- Cited by
- 112
- References
- 48
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 8 · 2016: 12 · 2015: 9 · 2014: 8 · 2013: 9 · 2012: 9
- FWCI
- 10.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Zenodo (CERN European Organization for Nuclear Research)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- acylated ghrelin, luteinizing hormone, LH pulsatility, gonadotropin-releasing hormone, naloxone, follicle-stimulating hormone, gonadal axis, young men
- MeSH terms
- Acylation, Adult, Algorithms, Follicle Stimulating Hormone, Gonads, Humans, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Male, Naloxone, Pulsatile Flow, Time Factors, Ghrelin
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