Expression of Insulin-Like Growth Factor-II and Its Receptor in Pediatric and Adult Adrenocortical Tumors

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860

Changing patterns in the incidence of esophageal and gastric carcinoma in the United States

Devesa, S. S., Blot, W. J., & Fraumeni, J. F. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19981115)83:10 · Cited by 2,097

The Role of the IGF System in Cancer Growth and Metastasis: Overview and Recent Insights

Samani, A. A., Yakar, S., LeRoith, D., & Brodt, P. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0001 · Cited by 1,017

Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors

Weiss, L. M. (1984) · The American Journal of Surgical Pathology · doi:10.1097/00000478-198403000-00001 · Cited by 920 · cited 1×

Adrenocortical Carcinoma: Clinical Update

Allolio, B., & Fassnacht, M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2639 · Cited by 775

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors

Mitsiades, C. S., Mitsiades, N., McMullan, C. J., Poulaki, V., Shringarpure, R., Akiyama, M., Hideshima, T., Chauhan, D., Joseph, M. G., Libermann, T. A., et al. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00050-9 · Cited by 614

In vivo antitumor activity of NVP-AEW541—A novel, potent, and selective inhibitor of the IGF-IR kinase

Garcı́a-Echeverrı́a, C., Pearson, M. A., Marti, A., Meyer, T., Mestan, J., Zimmermann, J., Gao, J., Brueggen, J., Capraro, H., Cozens, R. M., et al. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00051-0 · Cited by 543

An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma

Ribeiro, R. C., Sandrini, F., Figueiredo, B., Zambetti, G. P., Michalkiewicz, E., Lafferty, A. R., DeLacerda, L., Rabin, M., Cadwell, C., Sampaio, G., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161479898 · Cited by 541

Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid biosynthesis.

Gazdar, A. F., Oie, H. K., Shackleton, C. H. L., Chen, T. R., Triche, T. J., Myers, C. E., Chrousos, G. P., Brennan, M. F., Stein, C. A., & Rocca, R. V. L. (1990) · PubMed · Cited by 446

Clinical and biological features in the prognosis of adrenocortical cancer: poor outcome of cortisol-secreting tumors in a series of 202 consecutive patients

Abiven, G., Coste, J., Groussin, L., Anract, P., Tissier, F., Legmann, P., Dousset, B., Bertagna, X., & Bertherat, J. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2730 · Cited by 435

European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors

Faßnacht, M., Dekkers, O. M., Else, T., Baudin, É., Berruti, A., de Krijger, R. R., Haak, H. R., Mihai, R., Assié, G., & Terzolo, M. (2018) · European Journal of Endocrinology · doi:10.1530/eje-18-0608 · Cited by 976

Adrenocortical carcinoma

Else, T., Kim, A. C., Sabolch, A., Raymond, V. M., Kandathil, A., Caoili, E. M., Jolly, S., Miller, B. S., Giordano, T. J., & Hammer, G. D. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1029 · Cited by 892

Clinical management of adrenocortical carcinoma

Fassnacht, M., & Allolio, B. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.10.008 · Cited by 349

Regulation of insulin-like growth factor-mammalian target of rapamycin signaling by microRNA in childhood adrenocortical tumors

Doghman, M., Wakil, A. E., Cardinaud, B., Thomas, E., Wang, J., Zhao, W., Peralta-Del Valle, M. H. C., Figueiredo, B. C., Zambetti, G. P., & Lalli, E. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3970 · Cited by 221

Preclinical targeting of the type I insulin-like growth factor receptor in adrenocortical carcinoma

Barlaskar, F. M., Spalding, A. C., Heaton, J. H., Kuick, R., Kim, A. C., Thomas, D. G., Giordano, T. J., Ben-Josef, E., & Hammer, G. D. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1456 · Cited by 189

Development of adrenal cortex zonation

Xing, Y., Lerario, A. M., Rainey, W., & Hammer, G. D. (2015) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2015.02.001 · Cited by 174

Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and β-catenin

Heaton, J. H., Wood, M. A., Kim, A. C., Lima, L. O., Barlaskar, F. M., Almeida, M. Q., Fragoso, M. C. B. V., Kuick, R., Lerario, A. M., Simon, D. P., et al. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.05.026 · Cited by 173

MicroRNA profiling of adrenocortical tumors reveals miR-483 as a marker of malignancy

Patterson, E. E., Holloway, A. K., Weng, J., Fojo, T., & Kebebew, E. (2011) · Cancer · doi:10.1002/cncr.25724 · Cited by 171

Human adrenocortical carcinoma cell lines

Wang, T., & Rainey, W. E. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.08.041 · Cited by 149

In Search of Adrenocortical Stem and Progenitor Cells

Kim, A. C., Barlaskar, F. M., Heaton, J. H., Else, T., Kelly, V. R., Krill, K. T., Scheys, J. O., Simon, D. P., Trovato, A., Yang, W., et al. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0039 · Cited by 136

Insulin growth factor receptor (IGF-1R) antibody cixutumumab combined with the mTOR inhibitor temsirolimus in patients with metastatic adrenocortical carcinoma

Naing, A., LoRusso, P. M., Fu, S., Hong, D. S., Chen, H. X., Doyle, L. A., Phan, A. T., Habra, M. A., & Kurzrock, R. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.46 · Cited by 134

Genetics and epigenetics of adrenocortical tumors

Lerário, A. M., Moraitis, A. G., & Hammer, G. D. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.10.028 · Cited by 116

The Combination of Insulin-Like Growth Factor Receptor 1 (IGF1R) Antibody Cixutumumab and Mitotane as a First-Line Therapy for Patients with Recurrent/Metastatic Adrenocortical Carcinoma: a Multi-institutional NCI-Sponsored Trial

Lerário, A. M., Worden, F. P., Ramm, C. A., Hasseltine, E. A., Stadler, W. M., Else, T., Shah, M. H., Agamah, E. S., Rao, K., & Hammer, G. D. (2014) · Hormones and Cancer · doi:10.1007/s12672-014-0182-1 · Cited by 108

New targets and therapeutic approaches for endocrine malignancies☆

Fassnacht, M., Kreissl, M. C., Weismann, D., & Allolio, B. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.03.013 · Cited by 104

Next-generation therapies for adrenocortical carcinoma

Altieri, B., Ronchi, C. L., Kroiß, M., & Faßnacht, M. (2020) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2020.101434 · Cited by 100

Combined expression of BUB1B, DLGAP5, and PINK1 as predictors of poor outcome in adrenocortical tumors: validation in a Brazilian cohort of adult and pediatric patients

Fragoso, M. C. B. V., Almeida, M. Q., Mazzuco, T. L., Mariani, B. M. P., Brito, L. P., Gonçalves, T. C., Alencar, G. A., Lima, L. D. O., Faria, A. M., Bourdeau, I., et al. (2012) · European Journal of Endocrinology · doi:10.1530/eje-11-0806 · Cited by 93

Kinases as targets in the treatment of solid tumors

Giamas, G., Man, Y. L., Hirner, H., Bischof, J., Kramer, K. M., Khan, K., Ahmed, S. S. L., Stebbing, J., & Knippschild, U. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.01.011 · Cited by 88

[131I]Iodometomidate for targeted radionuclide therapy of advanced adrenocortical carcinoma

Hahner, S., Kreissl, M. C., Fassnacht, M., Haenscheid, H., Knoedler, P., Lang, K., Buck, A. K., Reiners, C., Allolio, B., & Schirbel, A. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2765 · Cited by 87

Inhibition of Adrenocortical Carcinoma Cell Proliferation by Steroidogenic Factor-1 Inverse Agonists

Doghman, M., Cazareth, J., Douguet, D., Madoux, F., Hodder, P., & Lalli, E. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2163 · Cited by 85

Steroidogenic Factor 1 Overexpression and Gene Amplification Are More Frequent in Adrenocortical Tumors from Children than from Adults

Almeida, M. Q., Soares, I. C., Ribeiro, T. C., Fragoso, M. C. B. V., Marins, L. V., Wakamatsu, A., Réssio, R. A., Nishi, M. Y., Jorge, A. A. L., Lerário, A. M., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2040 · Cited by 82

Analysis of the Role of Igf2 in Adrenal Tumour Development in Transgenic Mouse Models

Drelon, C., Berthon, A. S., Ragazzon, B., Tissier, F., Bandiera, R., Sahut‐Barnola, I., de Joussineau, C., Batisse‐Lignier, M., Lefrançois‐Martinez, A., Bertherat, J. Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044171 · Cited by 81

Genetics of tumors of the adrenal cortex

Bonnet-Serrano, F., & Bertherat, J. (2018) · Endocrine Related Cancer · doi:10.1530/erc-17-0361 · Cited by 80

Differences in the molecular mechanisms of adrenocortical tumorigenesis between children and adults

Faria, A. M., & Almeida, M. Q. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.040 · Cited by 82

Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis

Leal, L. F., Bueno, A. C., Gomes, D. C., Abduch, R. H., de Castro, M., & Antonini, S. R. R. (2015) · Oncotarget · doi:10.18632/oncotarget.5513 · Cited by 72

Pediatric Adrenocortical Tumors: What They Can Tell Us on Adrenal Development and Comparison with Adult Adrenal Tumors

Lalli, E., & de Figueiredo, B. C. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00023 · Cited by 64

Adrenocortical stem and progenitor cells: Implications for adrenocortical carcinoma

Simon, D. P., & Hammer, G. D. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.12.006 · Cited by 62

Adrenal cortical carcinoma: pathology, genomics, prognosis, imaging features, and mimics with impact on management

Ahmed, A. A., Thomas, A. J., Ganeshan, D., Blair, K. J., Lall, C. G., Lee, J. T., Morshid, A. I., Habra, M. A., & Elsayes, K. M. (2020) · Abdominal Radiology · doi:10.1007/s00261-019-02371-y · Cited by 59

Wnt/β-catenin pathway deregulation in childhood adrenocortical tumors

Leal, L. F., Mermejo, L. M., Ramalho, L. Z., Martinelli, C. E., Yunes, J. A., Seidinger, A. L., Mastellaro, M. J., Cardinalli, I. A., Brandalise, S. R., Moreira, A. C., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0363 · Cited by 55

Everolimus therapy for progressive adrenocortical cancer

Fraenkel, M., Gueorguiev, M., Barak, D. F., Salmon, A. Y., Grossman, A. B., & Gross, D. J. (2013) · Endocrine · doi:10.1007/s12020-013-9878-1 · Cited by 53

Update on adrenocortical carcinoma management and future directions

Varghese, J. M., & Habra, M. A. (2017) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000332 · Cited by 53

Comparison of Aldosterone Production Among Human Adrenocortical Cell Lines

Wang, T., Rowland, J., Parmar, J., Nesterova, M., Seki, T., & Rainey, W. E. (2012) · Hormone and Metabolic Research · doi:10.1055/s-0031-1298019 · Cited by 53

IGF2 Promotes Growth of Adrenocortical Carcinoma Cells, but Its Overexpression Does Not Modify Phenotypic and Molecular Features of Adrenocortical Carcinoma

Guillaud-Bataille, M., Ragazzon, B., de Reyniès, A., Chevalier, C., Francillard, I., Barreau, O., Steunou, V., Guillemot, J., Tissier, F., Rizk‐Rabin, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103744 · Cited by 60

Insulin-like growth factor system on adrenocortical tumorigenesis

Ribeiro, T. C., & Latronico, A. C. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.042 · Cited by 51

The role of mTOR inhibitors in the inhibition of growth and cortisol secretion in human adrenocortical carcinoma cells

Martino, M. C. D., van Koetsveld, P. M., Feelders, R. A., Sprij-Mooij, D. M., Waaijers, M., Lamberts, S. W. J., de Herder, W. W., Colao, A., Pivonello, R., & Hofland, L. J. (2012) · Endocrine Related Cancer · doi:10.1530/erc-11-0270 · Cited by 48

Genetic aspects of adrenocortical tumours and hyperplasias

Mazzuco, T. L., Durand, J., Chapman, A., Crespigio, J., & Bourdeau, I. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04403.x · Cited by 47

Current and Emerging Therapies for Advanced Adrenocortical Carcinoma

Tacon, L. J., Prichard, R. S., Soon, P. S. H., Robinson, B. G., Clifton-Bligh, R. J., & Sidhu, S. B. (2011) · The Oncologist · doi:10.1634/theoncologist.2010-0270 · Cited by 42

Adrenocortical Carcinoma in Childhood: A Systematic Review

Riedmeier, M., Decarolis, B., Haubitz, I., Müller, S., Uttinger, K., Boerner, K., Reibetanz, J., Wiegering, A., Härtel, C., Schlegel, P., et al. (2021) · Cancers · doi:10.3390/cancers13215266 · Cited by 48

The pathophysiology, diagnosis and prognosis of adrenocortical tumors revisited by transcriptome analyses

Assié, G., Guillaud-Bataille, M., Ragazzon, B., BERTAGNA, X. Y., Bertherat, J. Y., & Clauser, É. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.12.009 · Cited by 48

The Genetics of Adrenocortical Tumors

Espiard, S., & Bertherat, J. Y. (2015) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2015.02.004 · Cited by 47

Gene expression profiling in adrenocortical neoplasia

Assié, G., Giordano, T. J., & Bertherat, J. Y. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.044 · Cited by 41

Single Nucleotide Polymorphism Microarray Analysis in Cortisol-Secreting Adrenocortical Adenomas Identifies New Candidate Genes and Pathways

Ronchi, C. L., Leich, E., Sbiera, S., Weismann, D., Rosenwald, A., Allolio, B., & Faßnacht, M. (2012) · Neoplasia · doi:10.1593/neo.111758 · Cited by 40

Sonic Hedgehog Signaling Is Active in Human Adrenal Cortex Development and Deregulated in Adrenocortical Tumors

Gomes, D. C., Leal, L. F., Mermejo, L. M., Scrideli, C. A., Martinelli, C. E., Fragoso, M. C. B. V., Latronico, A. C., Tone, L. G., Tucci, S., Yunes, J. A., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4098 · Cited by 40

Bitter Melon ( Momordica charantia ) Extract Suppresses Adrenocortical Cancer Cell Proliferation Through Modulation of the Apoptotic Pathway, Steroidogenesis, and Insulin-Like Growth Factor Type 1 Receptor/RAC-α Serine/Threonine-Protein Kinase Signaling

Brennan, V. C., Wang, C., & Yang, W. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2011.0158 · Cited by 39

Role of the mTOR Pathway in Normal and Tumoral Adrenal Cells

Martino, M. C. D., van Koetsveld, P. M., Pivonello, R., & Hofland, L. J. (2010) · Neuroendocrinology · doi:10.1159/000314280 · Cited by 39

Adrenocortical Cancer

Wandoloski, M., Bussey, K. J., & Demeure, M. J. (2009) · Surgical Clinics of North America · doi:10.1016/j.suc.2009.06.019 · Cited by 39

Adrenocortical tumors and insulin resistance: What is the first step?

Altieri, B., Tirabassi, G., Casa, S. D., Ronchi, C. L., Balercia, G., Orio, F., Pontecorvi, A., Colao, A., & Muscogiuri, G. (2015) · International Journal of Cancer · doi:10.1002/ijc.29950 · Cited by 39

IGF and mTOR pathway expression and in vitro effects of linsitinib and mTOR inhibitors in adrenocortical cancer

Martino, M. C. D., van Koetsveld, P. M., Feelders, R. A., de Herder, W. W., Dogan, F., Janssen, J. A. M. J. L., Bruinink, D. H. O., Pivonello, C., Waaijers, A. M., Colao, A., et al. (2019) · Endocrine · doi:10.1007/s12020-019-01869-1 · Cited by 39

Therapy of adrenocortical cancer: present and future.

Maluf, D. F., de Oliveira, B. H., & Lalli, E. (2011) · Europe PMC (PubMed Central) · Cited by 34

Dysregulation of microRNAs in adrenocortical tumors

Singh, P., Soon, P. S. H., Feige, J., Chabre, O., Zhao, J., Cherradi, N., Lalli, E., & Sidhu, S. B. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.041 · Cited by 35

Pediatric adrenocortical tumor – review and management update

Balderrama-Brondani, V., & Fragoso, M. C. B. V. (2020) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000540 · Cited by 35

Update on Biology and Genomics of Adrenocortical Carcinomas: Rationale for Emerging Therapies

Lerário, A. M., Mohan, D. R., & Hammer, G. D. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac012 · Cited by 36

The Insulin and IGF-I Pathway in Endocrine Glands Carcinogenesis

Malaguarnera, R., Morcavallo, A., & Belfiore, A. (2012) · Journal of Oncology · doi:10.1155/2012/635614 · Cited by 33

Familial predisposition to adrenocortical tumors: Clinical and biological features and management strategies

Ribeiro, R. C., Pinto, E. M., & Zambetti, G. P. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.03.002 · Cited by 32

miRNAs orchestration of adrenocortical carcinoma - Particular emphasis on diagnosis, progression and drug resistance

El‐Dakroury, W. A., Midan, H. M., Abulsoud, A. I., Elshaer, S. S., El-Husseiny, A. A., Fathi, D., Abdelmaksoud, N. M., Mageed, S. S. A., Elballal, M. S., Zaki, M. B., et al. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154665 · Cited by 31

A phase II study of the orally administered negative enantiomer of gossypol (AT-101), a BH3 mimetic, in patients with advanced adrenal cortical carcinoma

Xie, H., Yin, J., Shah, M. H., Menefee, M. E., Bible, K. C., Reidy‐Lagunes, D. L., Kane, M. A., Quinn, D. I., Gandara, D. R., Erlichman, C., et al. (2019) · Investigational New Drugs · doi:10.1007/s10637-019-00797-1 · Cited by 31

Methylation of IGF2 regulatory regions to diagnose adrenocortical carcinomas

Creemers, S. G., van Koetsveld, P. M., van Kemenade, F. J., Papathomas, T. G., Franssen, G. J. H., Dogan, F., Eekhoff, E. M. W., van der Valk, P., de Herder, W. W., Janssen, J. A. M. J. L., et al. (2016) · Endocrine Related Cancer · doi:10.1530/erc-16-0266 · Cited by 30

The human adrenal cortex: growth control and disorders

Lotfi, C. F. P., Kremer, J. L., Passaia, B. D. S., & Cavalcante, I. P. (2018) · Clinics · doi:10.6061/clinics/2018/e473s · Cited by 31

Melanocortin 2 Receptor-Associated Protein (MRAP) and MRAP2 in Human Adrenocortical Tissues: Regulation of Expression and Association with ACTH Responsiveness

Hofland, J., Delhanty, P. J. D., Steenbergen, J., Hofland, L. J., van Koetsveld, P. M., van Nederveen, F. H., de Herder, W. W., Feelders, R. A., & de Jong, F. H. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2328 · Cited by 30

Treatment of biliary tract cancer with NVP-AEW541: Mechanisms of action and resistance

Wolf, S. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i2.156 · Cited by 30

Expression of LIN 28 and its regulatory micro RNA s in adult adrenocortical cancer

Faria, A. M., Sbiera, S., Ribeiro, T. C., Soares, I. C., Mariani, B. M. P., Freire, D. S., de Sousa, G. R. V., Lerário, A. M., Ronchi, C. L., Deutschbein, T., et al. (2014) · Clinical Endocrinology · doi:10.1111/cen.12607 · Cited by 28

Characterization of the mTOR pathway in human normal adrenal and adrenocortical tumors

Martino, M. C. D., Feelders, R. A., de Herder, W. W., van Koetsveld, P. M., Dogan, F., Janssen, J. A. M. J. L., Waaijers, A. M., Pivonello, C., Lamberts, S. W. J., Colao, A., et al. (2014) · Endocrine Related Cancer · doi:10.1530/erc-13-0112 · Cited by 27

IGF2 and IGF1R in pediatric adrenocortical tumors: roles in metastasis and steroidogenesis

Lira, R. C. P., Fedatto, P. F., Antônio, D. S. M., Leal, L. F., Martinelli, C. E., de Castro, M., Tucci, S., Neder, L., Ramalho, L. N. Z., Seidinger, A. L., et al. (2016) · Endocrine Related Cancer · doi:10.1530/erc-15-0426 · Cited by 27

The role of insulin-like growth factor system in the adrenocortical tumors

Altieri, B., Colao, A., & Faggiano, A. (2018) · Minerva Endocrinology · doi:10.23736/s0391-1977.18.02882-1 · Cited by 27

Non-Coding RNAs in Adrenocortical Cancer: From Pathogenesis to Diagnosis

Decmann, Á., Perge, P., Turai, P. I., Patócs, A., & Igaz, P. (2020) · Cancers · doi:10.3390/cancers12020461 · Cited by 27

Elucidating the Role of the Maternal Embryonic Leucine Zipper Kinase in Adrenocortical Carcinoma

Kiseljak‐Vassiliades, K., Zhang, Y., Kar, A., Razzaghi, R., Xu, M., Gowan, K., Raeburn, C. D., Albuja-Cruz, M. B., Jones, K. L., Somerset, H., et al. (2018) · Endocrinology · doi:10.1210/en.2018-00310 · Cited by 25

Primary Cultures and Cell Lines for In Vitro Modeling of the Human Adrenal Cortex

Nanba, K., Blinder, A., & Rainey, W. E. (2021) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.253.217 · Cited by 25

Low DICER1 expression is associated with poor clinical outcome in adrenocortical carcinoma

de Sousa, G. R. V., Ribeiro, T. C., Faria, A. M., Mariani, B. M. P., Lerário, A. M., Zerbini, M. C. N., Soares, I. C., Wakamatsu, A., Alves, V. A. F., Mendonca, B. B., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4261 · Cited by 25

Withanolides are Potent Novel Targeted Therapeutic Agents Against Adrenocortical Carcinomas

Subramanian, C., Zhang, H., Gallagher, R. J., Hammer, G. D., Timmermann, B. N., & Cohen, M. S. (2014) · World Journal of Surgery · doi:10.1007/s00268-014-2532-0 · Cited by 25

Hypoglycemia from IGF2 Overexpression Associated with Activation of Fetal Promoters and Loss of Imprinting in a Metastatic Hemangiopericytoma

Lawson, E. A., Zhang, X., Crocker, J., Wang, W., & Klibanski, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0153 · Cited by 24

Pathophysiological Link between Insulin Resistance and Adrenal Incidentalomas

Higgs, J. A., Quinn, A. P., Seely, K. D., Richards, Z., Mortensen, S. P., Crandall, C. S., & Brooks, A. E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084340 · Cited by 26

Unraveling the expression of the oncogene YAP1, a Wnt/beta-catenin target, in adrenocortical tumors and its association with poor outcome in pediatric patients

Abduch, R. H., Bueno, A. C., Leal, L. F., Cavalcanti, M. M., Gomes, D. C., Brandalise, S. R., Masterallo, M. J., Yunes, J. A., Martinelli, C. E., Tone, L. G., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.12382 · Cited by 23

The role of epithelial growth factors and insulin growth factors in the adrenal neoplasms

Angelousi, A. G., Kyriakopoulos, G., Ansari, N. N., Karageorgou, M., & Kassi, E. N. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.05.52 · Cited by 25

Insulin resistance and adrenal incidentalomas: A bidirectional relationship

Sydney, G. I., Ioakim, K. J., & Paschou, S. Α. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.12.002 · Cited by 23

The role of fibroblast growth factor receptor 4 overexpression and gene amplification as prognostic markers in pediatric and adult adrenocortical tumors.

Brito, L., Ribeiro, T. C., Almeida, M., Jorge, A. A. D. L., Soares, I., Latronico, A., Mendonça, B., Fragoso, M., & Lerário, A. (2012) · Endocrine-Related Cancer · doi:10.1530/erc-11-0231 · Cited by 21

The challenge of developmental therapeutics for adrenocortical carcinoma

da Costa, R. B., Carneiro, B. A., Tavora, F., Pai, S. G., Kaplan, J. B., Chae, Y. K., Chandra, S., Kopp, P. A., & Giles, F. J. (2016) · Oncotarget · doi:10.18632/oncotarget.8774 · Cited by 21

Interferon-β is a potent inhibitor of cell growth and cortisol production in vitro and sensitizes human adrenocortical carcinoma cells to mitotane

van Koetsveld, P. M., Vitale, G., Feelders, R. A., Waaijers, M., Sprij-Mooij, D. M., de Krijger, R. R., Speel, E. M., Hofland, J., Lamberts, S. W. J., de Herder, W. W., et al. (2013) · Endocrine Related Cancer · doi:10.1530/erc-12-0217 · Cited by 20

Co-inhibition of EGFR and IGF1R synergistically impacts therapeutically on adrenocortical carcinoma

Xu, L., Qi, Y., Xu, Y., Lian, J., Wang, X., Ning, G., Wang, W., & Zhu, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.8827 · Cited by 20

Molecular markers of adrenocortical tumors

Jain, M., Rechache, N. S., & Kebebew, E. (2012) · Journal of Surgical Oncology · doi:10.1002/jso.23119 · Cited by 17

Rak kory nadnercza (ACC) — przegląd piśmiennictwa i doświadczenia własne

Dorota Dworakowska, B., Drabarek, A., Wenzel, I., Babińska, A., Świątkowska−Stodulska, R., & Sworczak, K. (2015) · Endokrynologia Polska · doi:10.5603/ep.2014.0069 · Cited by 19

Preclinical Models of Adrenocortical Cancer

Sedlack, A. J. H., Hatfield, S. J., Kumar, S., Arakawa, Y., Roper, N., Sun, N.-Y., Nilubol, N., Kiseljak‐Vassiliades, K., Hoang, C. D., Bergsland, E. K., et al. (2023) · Cancers · doi:10.3390/cancers15112873 · Cited by 17

Pediatric adrenal cortical carcinomas: Histopathological criteria and clinical trials. A systematic review

Xu, X., & Sergi, C. M. (2016) · Contemporary Clinical Trials · doi:10.1016/j.cct.2016.07.011 · Cited by 17

Tissue Expression and Pharmacological In Vitro Analyses of mTOR and SSTR Pathways in Adrenocortical Carcinoma

Germano, A., Rapa, I., Duregon, E., Votta, A., Giorcelli, J., Buttigliero, C., Scagliotti, G. V., Volante, M., Terzolo, M., & Papotti, M. (2017) · Endocrine Pathology · doi:10.1007/s12022-017-9473-8 · Cited by 17

The cytoskeleton actin binding protein filamin A impairs both IGF2 mitogenic effects and the efficacy of IGF1R inhibitors in adrenocortical cancer cells

Catalano, R., Giardino, E., Treppiedi, D., Mangili, F., Morelli, V., Elli, F. M., Serban, A. L., Luconi, M., Mannelli, M., Spada, A., et al. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.10.022 · Cited by 16

Clinical and molecular aspects of a pediatric metachronous adrenocortical tumor

Lima, L. D. O., Lerário, A. M., Alencar, G. A., Brito, L. P., Almeida, M. Q., Domenice, S., Latronico, A. C., Mendonca, B. B., & Fragoso, M. C. B. V. (2011) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302011000100010 · Cited by 16

Pediatric adrenocortical tumors: diagnosis, management and advancements in the understanding of the genetic basis and therapeutic implications

Antonini, S. R. R., Leal, L. F., & Cavalcanti, M. M. (2014) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2014.941813 · Cited by 16

Are we failing in treatment of adrenocortical carcinoma? Lights and shadows of molecular signatures

Grisanti, S., Cosentini, D., Laganà, M., Abate, A., Rossini, E., Sigala, S., & Berruti, A. (2019) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2019.07.007 · Cited by 15

MicroRNA dysregulation interplay with childhood abdominal tumors

Salomão, K. B., Pezuk, J. A., de Sousa, G. R., Chagas, P. S., Pereira, T. C., Valera, E. T., & Brassesco, M. S. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09829-x · Cited by 13

Assessment of prognostic factors in pediatric adrenocortical tumors: a systematic review and evaluation of a modified S-GRAS score

Riedmeier, M., Decarolis, B., Haubitz, I., Reibetanz, J., Wiegering, A., Härtel, C., Schlegel, P., Faßnacht, M., & Wiegering, V. A. (2022) · European Journal of Endocrinology · doi:10.1530/eje-22-0173 · Cited by 15

The tyrosine kinase inhibitor nilotinib is more efficient than mitotane in decreasing cell viability in spheroids prepared from adrenocortical carcinoma cells

Silveira, E. R., Cavalcante, I. P., Kremer, J. L., de Mendonça, P. O. R., & Lotfi, C. F. P. (2018) · Cancer Cell International · doi:10.1186/s12935-018-0527-x · Cited by 16

The role of mTOR pathway as target for treatment in adrenocortical cancer

Martino, M. C. D., Feelders, R. A., Pivonello, C., Simeoli, C., Papa, F., Colao, A., Pivonello, R., & Hofland, L. J. (2019) · Endocrine Connections · doi:10.1530/ec-19-0224 · Cited by 14

SIRT1 is involved in adrenocortical cancer growth and motility

Chimento, A., Luca, A. D., Nocito, M. C., Sculco, S., Avena, P., Padula, D. L., Zavaglia, L., Sirianni, R., Casaburi, I., & Pezzi, V. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16317 · Cited by 15

Role of filamin A in the pathogenesis of neuroendocrine tumors and adrenal cancer

Treppiedi, D., Catalano, R., Mangili, F., Mantovani, G., & Peverelli, E. (2022) · Endocrine Oncology · doi:10.1530/eo-22-0055 · Cited by 13

Molecular markers and targeted therapies for adrenocortical carcinoma

Xu, Y., Qi, Y., Zhu, Y., Ning, G., & Huang, Y. (2013) · Clinical Endocrinology · doi:10.1111/cen.12358 · Cited by 13

Potent inhibitory effect of the cyclolignan picropodophyllin (PPP) on human adrenocortical carcinoma cells proliferation.

Doghman, M., Axelson, M., & Lalli, E. (2011) · Europe PMC (PubMed Central) · Cited by 12

Amplification of theInsulin-Like Growth Factor 1 ReceptorGene Is a Rare Event in Adrenocortical Adenocarcinomas: Searching for Potential Mechanisms of Overexpression

Ribeiro, T. C., Jorge, A. A. L., Almeida, M. Q., Mariani, B. M. P., Nishi, M. Y., Mendonca, B. B., Fragoso, M. C. B. V., & Latronico, A. C. (2014) · BioMed Research International · doi:10.1155/2014/936031 · Cited by 12

High Prevalence of Alterations in DNA Mismatch Repair Genes of Lynch Syndrome in Pediatric Patients with Adrenocortical Tumors Carrying a Germline Mutation on TP53

Balderrama-Brondani, V., Montenegro, L. R., Lacombe, A. M. F., Magalhães, B. M., Nishi, M. Y., Funari, M. F. A., Narcizo, A. D. M., Cardoso, L. C., Siqueira, S. A. C., Zerbini, M. C. N., et al. (2020) · Cancers · doi:10.3390/cancers12030621 · Cited by 11

Analysis of IGF and IGFBP as Prognostic Serum Biomarkers for Adrenocortical Carcinoma

Patel, D., Ellis, R. J., Howard, B., Boufraqech, M., Gara, S. K., Zhang, L., Quezado, M., Nilubol, N., & Kebebew, E. (2014) · Annals of Surgical Oncology · doi:10.1245/s10434-014-3768-5 · Cited by 12

Stathmin 1 is highly expressed and associated with survival outcome in malignant adrenocortical tumours

Passaia, B. D. S., Lima, K., Kremer, J. L., da Conceição, B. B., Mariani, B. M. P., da Silva, J. C. L., Zerbini, M. C. N., Fragoso, M. C. B. V., Machado‐Neto, J. A., & Lotfi, C. F. P. (2019) · Investigational New Drugs · doi:10.1007/s10637-019-00846-9 · Cited by 11

Insulin‐Like Growth Factor—Phosphatidylinositol 3 Kinase Signaling in Canine Cortisol‐Secreting Adrenocortical Tumors

Kool, M., Galac, S., van der Helm, N., Corradini, S., Kooistra, H., & Mol, J. A. (2015) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.12528 · Cited by 8

Szlaki molekularne w raku kory nadnercza — od wiedzy o sygnalizacji komórkowej do metod diagnostyki i leczenia

Szyszka, P., Grossman, A. B., Díaz‐Cano, S. J., & Dorota Dworakowska, B. (2015) · Endokrynologia Polska · doi:10.5603/ep.a2016.0054 · Cited by 11

Expression of IGF-II, IGF-IR, SF-1 and DAX-1 genes in pediatric and adult adrenocortical tumors

Almeida, M. Q. D. (2008) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

IGF2 and IGF1R in pediatric adrenocortical tumors: roles in metastasis and steroidogenesis

Lira, R. C. P., Fedatto, P. F., Antônio, D. S. M., Leal, L. F., Martinelli, C. E., de Castro, M., Tucci, S., Neder, L., Ramalho, L. N. Z., Seidinger, A. L., et al. (2016) · Endocrine Related Cancer · doi:10.1530/erc-15-0426 · Cited by 27

P01-27 Expression of IGF2 and IGF1R in pediatric adrenocortical tumors (ACT): Overexpression of IGF1R is associated with unfavorable event and metastasis in adrenocortical carcinomas

Lira, R. C. P., Fedatto, P. F., Martinelli, C. E., Antonini, S. R. R., Castro, M., Tucci, S. T., Neder, L., Ramalho, L. N. Z., Seidinger, A. L., Cardinalli, I., et al. (2012) · Growth Hormone & IGF Research · doi:10.1016/s1096-6374(12)60107-5 · Cited by 1

Insulin-like growth factors (IGFs) and their receptors in adrenal tumors: high IGF-II expression in functional adrenocortical carcinomas

Ilvesmäki, V., Kahri, A. I., Miettinen, P. J., & Voutilainen, R. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.3.8370710 · Cited by 152

Emerging role of IGF1R and IR expression and localisation in adrenocortical carcinomas

Catalano, R., Nozza, E., Altieri, B., Esposito, E., Croci, G. A., Barbieri, A. M., Treppiedi, D., Bari, S. D., Kimpel, O., Detomas, M., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02115-0 · Cited by 4