Combined expression of BUB1B, DLGAP5, and PINK1 as predictors of poor outcome in adrenocortical tumors: validation in a Brazilian cohort of adult and pediatric patients
Abstract
BACKGROUND: A recent microarray study identified a set of genes whose combined expression patterns were predictive of poor outcome in a cohort of adult adrenocortical tumors (ACTs). The difference between the expression values measured by qRT-PCR of DLGAP5 and PINK1 genes was the best molecular predictor of recurrence and malignancy. Among the adrenocortical carcinomas, the combined expression of BUB1B and PINK1 genes was the most reliable predictor of overall survival. The prognostic and molecular heterogeneity of ACTs raises the need to study the applicability of these molecular markers in other cohorts. OBJECTIVE: To validate the combined expression of BUB1B, DLGAP5, and PINK1 as outcome predictor in ACTs from a Brazilian cohort of adult and pediatric patients. PATIENTS AND METHODS: BUB1B, DLGAP5, and PINK1 expression was assessed by quantitative PCR in 53 ACTs from 52 patients - 24 pediatric and 28 adults (one pediatric patient presented a bilateral asynchronous ACT). RESULTS: DLGAP5-PINK1 and BUB1B-PINK1 were strong predictors of disease-free survival and overall survival, respectively, among adult patients with ACT. In the pediatric cohort, these molecular predictors were only marginally associated with disease-free survival but not with overall survival. CONCLUSION: This study confirms the prognostic value of the combined expression of BUB1B, DLGAP5, and PINK1 genes in a Brazilian group of adult ACTs. Among pediatric ACTs, other molecular predictors of outcome are required.
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These findings were later validated in a separate cohort of adult patients.
“These findings were later validated in a separate cohort of adult patients (193).”
From Adrenocortical carcinoma (2014) · cites this paper as [193]
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Diagnostic Role of Prostate-Specific Membrane Antigen in Adrenocortical Carcinoma
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- Authors
- Fragoso, M. C. B. V., Almeida, M. Q., Mazzuco, T. L., Mariani, B. M. P., Brito, L. P., Gonçalves, T. C., Alencar, G. A., Lima, L. D. O., Faria, A. M., Bourdeau, I., Lucon, A. M., Freire, D. S., Latronico, A. C., Mendonca, B. B., Lacroix, A., & Lerario, A. M.
- Affiliations
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Centre Hospitalier de l’Université de Montréal (CA)
- Corresponding author
- Fragoso, Maria Candida B V
- ORCID
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-01
- Volume
- 166
- Issue
- 1
- Pages
- 61-67
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2106037975
- Cited by
- 93
- References
- 21
- Citations by year
- 2026: 4 · 2024: 3 · 2023: 4 · 2022: 14 · 2021: 7 · 2020: 11 · 2019: 8 · 2018: 11 · 2017: 6 · 2016: 6 · 2015: 4 · 2014: 5 · 2013: 8 · 2012: 2
- FWCI
- 4.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Neurology › Neuroblastoma Research and Treatments
- Keywords
- adrenocortical tumors, adrenocortical carcinoma, BUB1B, DLGAP5, PINK1, gene expression signatures, prognostic factors, overall survival, disease-free survival, pediatric adrenocortical tumors, tumor recurrence, Brazilian cohort
- MeSH terms
- PTEN-Induced Putative Kinase, Adolescent, Adrenal Cortex Neoplasms, Brazil, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Neoplasm Proteins, Protein Kinases, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Protein Serine-Threonine Kinases, Disease-Free Survival
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