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Prevalence of Vertebral Fractures in Men with Acromegaly
Abstract
Context Data on osteoporotic fractures in acromegaly are limited. An increased prevalence of radiological vertebral fractures was already observed in postmenopausal women with active acromegaly. It is unknown whether this observation may reflect a more general increased risk of fractures in acromegaly. Design This was a cross-sectional study. Setting The study was conducted at referral centers. Patients and control subjects Subjects included 40 males with acromegaly (25 patients with controlled disease and 15 patients with active disease) and 31 control males, with age and gonadal status comparable with the patients. Interventions Evaluation of vertebral fractures (quantitative morphometric analysis) and bone mineral density (BMD) at lumbar spine and total hip (dual energy X-ray absorptiometry) was done. Main outcome measure Vertebral fractures were assessed. Results Although BMD was not significantly different between acromegalic patients and control subjects, the prevalence of vertebral fractures was higher in acromegalic patients as compared with the control subjects (57.5 vs. 22.6%; chi(2): 8.7; P = 0.003). Fractured and nonfractured acromegalic patients showed no significant difference in age and BMD Z-score. However, acromegalic patients with fractures had serum IGF-I values significantly higher and duration of active disease significantly longer with respect to patients without fractures. Moreover, patients with fractures showed significantly longer untreated hypogonad…
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“Hypogonadal patients with acromegaly are at higher risk of osteoporosis, particularly at sites composed predominantly of trabecular bone, which has more intimate contact with the circulation and is influenced by sex steroids to a greater extent [34, 39, 40].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [39]
In the citing paper
“which makes BMD a poor fracture predictor [27, 30, 39, 42].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [39]
In the citing paper
“Patients with acromegaly have an increased risk of fractures, which might be correlated with insufficient quality of bone [26, 27, 39, 42].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [39]
In the citing paper
“Vertebral fractures may be present in patients with normal or slightly decreased BMD, which makes BMD a poor fracture predictor [27, 30, 39, 42].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [39]
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Self-citation
Metadata
- Authors
- Mazziotti, G., Bianchi, A., Bonadonna, S., Cimino, V., Patelli, I., Fusco, A., Pontecorvi, A., De Marinis, L., & Giustina, A.
- Affiliations
- University of Brescia (IT)
- Università Cattolica del Sacro Cuore (IT)
- Corresponding author
- Giustina, Andrea
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2008-12
- Volume
- 93
- Issue
- 12
- Pages
- 4649-4655
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1979553864
- Cited by
- 169
- References
- 48
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 10 · 2023: 9 · 2022: 11 · 2021: 10 · 2020: 12 · 2019: 11 · 2018: 12 · 2017: 8 · 2016: 12 · 2015: 12 · 2014: 13 · 2013: 6 · 2012: 8
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- acromegaly, vertebral fractures, osteoporosis, men, bone mineral density, insulin-like growth factor I, hypogonadism, disease duration, fracture risk factors
- MeSH terms
- Acromegaly, Adolescent, Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Hip, Humans, Hypogonadism, Male, Middle Aged, Osteoporosis, Pituitary Hormones, Spinal Injuries, Absorptiometry, Photon, Bone Density, Logistic Models, Odds Ratio, Young Adult
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