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Cited by 69Pituitary Gland Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsBone health and osteoporosis research

Serum GH and IGF-I are significant determinants of bone turnover but not bone mineral density in active acromegaly: a prospective study of more than 70 consecutive patients

Ueland, T, Fougner, S L, Godang, K, Schreiner, T, Bollerslev, J·2006·European Journal of Endocrinology
DOI 10.1530/eje.1.02285
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Abstract

Objective: Acromegaly is characterized by a persistent hypersecretion of GH and provides information on long-term effects of GH on bone metabolism. The aim of this study was to examine the effect of gonadal status and disease activity on bone metabolism in active acromegaly. Methods: Seventy-three consecutive patients with active acromegaly: 40 women and 33 men (50 ± 13 (mean ± s.d.) and 49 ± 10 years respectively) were evaluated and compared with age-, sex-, and body mass index (BMI)-matched controls by X-ray absorptiometry and biochemical analysis (markers of disease activity and bone turnover). Results: We found that bone turnover, as evaluated by biochemical bone markers, is coupled and markedly increased in relation to disease activity in active acromegaly. Acromegalic women, but not men, were characterized by an increased bone area and slightly decreased bone mineral content resulting in significantly decreased bone mineral density (BMD) in the ultradistal radius, proximal radius, and total body. No differences in bone turnover or BMD were found between eu-and hypogonadal subjects. Multivariate analysis identified age, BMI, and gender as independent predictors of total BMD in acromegaly. Conclusion: Our study demonstrates a decreased total body BMD in women, not men, with active acromegaly, regardless of gonadal status or disease activity. Bone turnover is markedly increased in relation to disease activity, possibly counteracting the anabolic effects of excess GH/IGF-I in these subjects. We suggest more focus on biomechanical analyses when investigating endocrine disorders affecting bone size and distribution between compartments.

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  • Hypogonadal patients with acromegaly are at higher risk of osteoporosis, particularly at sites composed predominantly of trabecular bone.

    “Hypogonadal patients with acromegaly are at higher risk of osteoporosis, particularly at sites composed predominantly of trabecular bone, which has more intimate contact with the circulation and is influenced by sex steroids to a greater extent [34, 39, 40].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [40]

  • The axial skeleton is composed of 70% trabecular bone, while the appendicular skeleton is composed of 90% cortical bone.

    “Axial skeleton is composed of 70% trabecular bone, while appendicular skeleton of 90% cortical bone [40].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [40]

  • Indicators of bone resorption such as urinary hydroxyproline/creatinine, urinary type I collagen cross-linked N-telopeptide, and serum C-terminal collagen type I cross-links are in higher concentrations in acromegaly than in controls.

    “Indicators of bone resorption such as urinary hydroxyproline/creatinine, urinary type I collagen cross-linked N-telopeptide, and serum C-terminal collagen type I cross-links are in higher concentrations than in controls [28, 29, 35, 40, 43].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [40]

  • Osteocalcin, a specific marker of bone formation, is elevated in subjects with active acromegaly.

    “A specific marker of bone formation, osteocalcin, is elevated in subjects with active disease [28, 29, 35, 40, 43].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [40]

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Authors
Ueland, T., Fougner, S. L., Godang, K., Schreiner, T., & Bollerslev, J.
Affiliations
  • Oslo University Hospital (NO)
  • University of Oslo (NO)
Corresponding author
Ueland, T
ORCID
Venue
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Published
2006-11
Volume
155
Issue
5
Pages
709-715
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
DOI
10.1530/eje.1.02285
OpenAlex
W2121385580
Cited by
69
References
32
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 7 · 2017: 1 · 2016: 4 · 2015: 7 · 2014: 8 · 2013: 3 · 2012: 4
FWCI
1.81
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
acromegaly, growth hormone, insulin-like growth factor I, bone turnover, bone mineral density, bone metabolism, disease activity, gonadal status, sex differences, hypogonadism, bone area, body mass index
MeSH terms
Acromegaly, Adult, Bone Resorption, Female, Humans, Insulin-Like Growth Factor I, Male, Middle Aged, Osteogenesis, Prospective Studies, Bone Density, Osteocalcin, Multivariate Analysis, Human Growth Hormone, Collagen Type I

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