Bone density threshold and other predictors of vertebral fracture in patients receiving oral glucocorticoid therapy
Abstract
OBJECTIVE: To evaluate predictors of vertebral fractures, including a threshold for bone mineral density (BMD), in patients receiving oral glucocorticoids (GCs). METHODS: Data were obtained from 2 randomized clinical trials (prevention and treatment trials of risedronate) using similar methods, but different inclusion criteria were applied with regard to prior exposure to GCs. Predictors of vertebral fracture in the placebo group were identified using Cox regression with forward selection. The BMD threshold analysis involved a comparison of the 1-year fracture risk in postmenopausal women receiving placebo in the GC trials with that in postmenopausal women not taking GCs in 3 other trials. RESULTS: The study population comprised 306 patients with baseline and 1-year followup data on vertebral fractures (111 receiving placebo and 195 receiving risedronate). In the placebo group, the statistically significant predictors of incident fracture were the baseline lumbar spine BMD (for each 1-point decrease in T score, relative risk [RR] 1.85, 95% confidence interval [95% CI] 1.06-3.21) and the daily GC dose (for each 10-mg dose increase, RR 1.62, 95% CI 1.11-2.36). In the BMD threshold analysis, compared with nonusers of GCs, patients receiving GCs were younger, had a higher BMD at baseline, and had fewer prevalent fractures; nevertheless, the risk of fracture was higher in the GC users compared with nonusers (adjusted RR 5.67, 95% CI 2.57-12.54). The increased risk of fracture was observed in GC users regardless of whether osteoporosis was present. CONCLUSION: The daily, but not cumulative, GC dose was found to be a strong predictor of vertebral fracture in patients receiving GCs. At similar levels of BMD, postmenopausal women taking GCs, as compared with nonusers of GCs, had considerably higher risks of fracture.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Prolonged glucocorticoid treatments worsen bone quality.
“Prolonged GC treatments further worsen the bone quality [35, 55]”
From Prevention of glucocorticoid induced bone changes with beta-ecdysone (2015) · cites this paper as [55]
The effect of hPTH (1-34) on hip fracture reduction has not been shown in clinical studies in glucocorticoid-induced osteoporosis populations.
“The effect of hPTH (1-34) on hip fracture reduction has not been shown in clinical studies in GIOP populations. [55, 57].”
From Prevention of glucocorticoid induced bone changes with beta-ecdysone (2015) · cites this paper as [55]
Cites
Vertebral fracture assessment using a semiquantitative technique
Genant, H. K., Wu, C. Y., van Kuijk, C., & Nevitt, M. C. (1993) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650080915 · Cited by 3,691 · see citing works
Effect of Risedronate on the Risk of Hip Fracture in Elderly Women
McClung, M. R., Geusens, P., Miller, P. D., Zippel, H., Bensen, W. G., Roux, C., Adami, S., Fogelman, I., Diamond, T., Eastell, R., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102013440503 · Cited by 1,918 · see citing works
Weinstein, R. S., Jilka, R. L., Parfitt, A. M., & Manolagas, S. C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2799 · Cited by 1,753 · cited 3× · see citing works
“Osteocyte apoptosis is prevalent in GC-induced osteoporosis (24), and preliminary results of an animal study demonstrated that osteocyte viability was an important determinant of bone strength independent of BMD (25).”
BackgroundResultReginster, J.-Y., Minne, H. W., Sorensen, O. H., Hooper, M., Roux, C., Brandi, M. L., Lund, B., Ethgen, D., Pack, S., Roumagnac, I., et al. (2000) · Osteoporosis International · doi:10.1007/s001980050010 · Cited by 1,580 · see citing works
Use of Inhaled Corticosteroids and Risk of Fractures
van Staa, T. P., Leufkens, H. G. M., & Cooper, C. C. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.3.581 · Cited by 1,297 · see citing works
Self-citationThe epidemiology of corticosteroid-induced osteoporosis: a meta-analysis
Staa, T. P. V., Staa, T. P. V., Staa, T. P. V., Leufkens, H. G. M., & Cooper, C. (2002) · Osteoporosis International · doi:10.1007/s001980200108 · Cited by 1,294 · see citing works
Self-citationUse of oral corticosteroids and risk of fractures
Van Staa, T. P., Leufkens, H. G. M., Abenhaim, L., Zhang, B., & Cooper, C. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.6.993 · Cited by 1,263 · see citing works
Self-citationDose-Response and Trend Analysis in Epidemiology
Greenland, S. (1995) · Epidemiology · doi:10.1097/00001648-199507000-00005 · Cited by 1,086 · see citing works
Recommendations for the prevention and treatment of glucocorticoid‐induced osteoporosis
American College of Rheumatology task force on Osteoporosis guidelines (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780391104 · Cited by 848 · see citing works
Oral corticosteroids and fracture risk: relationship to daily and cumulative doses
van Staa, T. P., Leufkens, H. G. M., Abenhaim, L., Zhang, B., & Cooper, C. C. (2000) · Lara D. Veeken · doi:10.1093/rheumatology/39.12.1383 · Cited by 699 · see citing works
Self-citationEFFECT OF RISEDRONATE ON THE RISK OF HIP FRACTURE IN ELDERLY WOMEN
Lung, R. M. C. C., Eusens, P. I. G., Aul, P., Iller, D. M., Ippel, H. A. Z., Ensen, W. I. G. B., Oux, C. H. R., Dami, S. I. A., Ogelman, I. G. F., Astell, R. I. E., et al. (2001) · Cited by 682 · see citing works
Reid, D. M., Hughes, R., Laan, R., Sacco-Gibson, N., Wenderoth, D., Adami, S., Eusebio, R. A., & Devogelaer, J.-P. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.6.1006 · Cited by 588 · see citing works
Self-citationUse of oral corticosteroids in the United Kingdom
van Staa, T. P. (2000) · QJM · doi:10.1093/qjmed/93.2.105 · Cited by 529 · see citing works
Peel, N. F. A., Moore, D., Barrington, N. A., Bax, D. E., & Eastell, R. (1995) · Annals of the Rheumatic Diseases · doi:10.1136/ard.54.10.801 · Cited by 377 · see citing works
Rheumatoid arthritis, corticosteroid therapy and hip fracture.
Cooper, C. C., Coupland, C. A. C., & Mitchell, M. (1995) · Annals of the Rheumatic Diseases · doi:10.1136/ard.54.1.49 · Cited by 354 · see citing works
Self-citationFractures after rheumatoid arthritis a population‐based study
Hooyman, J. R., Melton, L. J., Nelson, A. M., O’Fallon, W. M., & Riggs, B. L. (1984) · Arthritis & Rheumatism · doi:10.1002/art.1780271205 · Cited by 283 · see citing works
Dykman, T. R., Gluck, O. S., Murphy, W. A., Hahn, T. J., & Hahn, B. H. (1985) · Arthritis & Rheumatism · doi:10.1002/art.1780280402 · Cited by 281 · see citing works
Adverse effects of oral corticosteroids in relation to dose in patients with lung disease
Walsh, L. J. (2001) · Thorax · doi:10.1136/thorax.56.4.279 · Cited by 251 · see citing works
Vertebral fractures in steroid dependent asthma and involutional osteoporosis: a comparative study.
Luengo, M., Picado, C., del Río, L., Guañabens, N., Montserrat, J. M., & Setoaín, J. (1991) · Thorax · doi:10.1136/thx.46.11.803 · Cited by 241 · see citing works
Biochemical Indices of Bone Turnover and the Assessment of Fracture Probability
Johnell, O., Odén, A., Laet, C. E. D. H. D., Garnero, P., Delmas, P. D., & Kanis, J. A. (2002) · Osteoporosis International · doi:10.1007/s001980200068 · Cited by 195 · see citing works
Vertebral Fracture Risk With Long-term Corticosteroid Therapy
Naganathan, V., Jones, G., Nash, P. T., Nicholson, G. C., Eisman, J. A., & Sambrook, P. N. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.19.2917 · Cited by 141 · see citing works
Corticosteroids and Fractures: A Close Encounter of the Third Cell Kind
Manolagas, S. C. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.6.1001 · Cited by 135 · see citing works
Grados, F., Roux, C., de Vernejoul, M. C., Utard, G., Jl, S., & Fardellone, P. (2001) · Osteoporosis International · doi:10.1007/s001980170046 · Cited by 110 · see citing works
Corticosteroids Do Not Alter the Threshold for Vertebral Fracture
Selby, P. L., Halsey, J. P., Adams, K., Klimiuk, P. S., Knight, S. M., Pal, B., Stewart, I. M. G., & Swinson, D. R. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.5.952 · Cited by 91 · see citing works
Ichikawa, K., Tsutsumi, A., Atsumi, T., Matsuura, E., Kobayashi, S., Hughes, G. R. V., Khamashta, M. A., & Koike, T. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199911)42:11 · Cited by 88 · see citing works
Self-citationGuidelines for prevention and treatment of glucocorticoid-induced osteoporosis
Compston, J. E. (2009) · Bone · doi:10.1016/j.bone.2009.07.039 · Cited by 39 · see citing works
Ettinger, B. B., Pressman, A. R., & Shah, H. A. (2001) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2001.7.3.228 · Cited by 12 · see citing works
Santiago (2001) · doi:10.1002/1529-0131(200107)44:7
Flagged first, then by citations
Cited by
Sorted by citations
Papaioannou, A., Morin, S. N., Cheung, A. M., Atkinson, S. A., Brown, J. P., Feldman, S., Hanley, D. A., Hodsman, A. B., Jamal, S. A., Kaiser, S., et al. (2010) · Canadian Medical Association Journal · doi:10.1503/cmaj.100771 · Cited by 1,742 · see citing works
Epidemiology, etiology, and diagnosis of osteoporosis
Lane, N. E. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.08.047 · Cited by 1,300 · see citing works
Manolagas, S. C. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0024 · Cited by 1,210 · see citing works
Glucocorticoid-induced osteoporosis: pathophysiology and therapy
CANALIS, E. M., Mazziotti, G., Giustina, A., & Bilezikian, J. P. (2007) · Osteoporosis International · doi:10.1007/s00198-007-0394-0 · Cited by 1,118 · see citing works
O’Brien, C. A., Jia, D., Plotkin, L. I., Bellido, T., Powers, C. C., Stewart, S. A., Manolagas, S. C., & Weinstein, R. S. (2003) · Endocrinology · doi:10.1210/en.2003-0990 · Cited by 771 · see citing works
Glucocorticoid-Induced Bone Disease
Weinstein, R. S. (2011) · New England Journal of Medicine · doi:10.1056/nejmcp1012926 · Cited by 698 · see citing works
Reid, D. M., Devogelaer, J.-P., Saag, K., Roux, C., Lau, C.-S., Reginster, J.-Y., Papanastasiou, P., Ferreira, A., Hartl, F., Fashola, T., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60250-6 · Cited by 527 · see citing works
Self-citationSaag, K. G., Zanchetta, J. R., Devogelaer, J., Adler, R. A., Eastell, R., See, K., Krege, J. H., Krohn, K., & Warner, M. R. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24879 · Cited by 493 · see citing works
Glucocorticoid-induced osteoporosis: an update
Compston, J. E. (2018) · Endocrine · doi:10.1007/s12020-018-1588-2 · Cited by 484 · see citing works
ACG clinical guideline: Preventive care in inflammatory bowel disease
Farraye, F. A., Melmed, G. Y., Lichtenstein, G. R., & Kane, S. V. (2017) · American Journal of Gastroenterology · doi:10.1038/ajg.2016.537 · Cited by 473 · see citing works
Epidemiology of Vertebral Fractures
Schousboe, J. T. (2015) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2015.08.004 · Cited by 452 · see citing works
Hoes, J. N., Jacobs, J. W. G., Boers, M., Boumpas, D., Buttgereit, F., Caeyers, N., Choy, E., Cutolo, M., da Silva, J. A. P., Esselens, G., et al. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.072157 · Cited by 410 · see citing works
The epidemiology of glucocorticoid-associated adverse events
McDonough, A. K., Curtis, J. R., & Saag, K. G. (2008) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e3282f51031 · Cited by 404 · see citing works
Management of osteoporosis in postmenopausal women
(2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181c617e6 · Cited by 382 · see citing works
Glucocorticoid-Induced Osteoporosis and Osteonecrosis
Weinstein, R. S. (2012) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2012.04.004 · Cited by 367 · see citing works
Glucocorticoid-induced osteoporosis: an update
Mazziotti, G., Angeli, A., Bilezikian, J. P., Canalis, E., & Giustina, A. (2006) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2006.03.009 · Cited by 362 · see citing works
Angeli, A., Guglielmi, G., Dovio, A., Capelli, G., de Feo, D., Giannini, S., Giorgino, R., Moro, L., & Giustina, A. (2006) · Bone · doi:10.1016/j.bone.2006.02.005 · Cited by 361 · see citing works
Lane, N. E., Yao, W., Balooch, M., Nalla, R. K., Balooch, G., Habelitz, S., Kinney, J. H., & Bonewald, L. F. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.051103 · Cited by 355 · see citing works
Ebeling, P. R., Nguyen, H. H., Aleksova, J., Vincent, A. J., Wong, P., & Milat, F. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab028 · Cited by 354 · see citing works
Strehl, C., Bijlsma, J. W. J., de Wit, M. P. T., Boers, M., Caeyers, N., Cutolo, M., Dasgupta, B., Dixon, W. G., Geenen, R., Huizinga, T. W. J., et al. (2016) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2015-208916 · Cited by 342 · see citing works
MANAGEMENT OF ENDOCRINE DISEASE: Secondary osteoporosis: pathophysiology and management
Mirza, F., & CANALIS, E. M. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0118 · Cited by 334 · see citing works
Glucocorticoid-induced osteoporosis
Briot, K., & Roux, C. (2015) · RMD Open · doi:10.1136/rmdopen-2014-000014 · Cited by 300 · see citing works
Fracture risk with intermittent high‐dose oral glucocorticoid therapy
de Vries, F., Bracke, M., Leufkens, H. G. M., Lammers, J. J., Cooper, C. C., & van Staa, T. P. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22294 · Cited by 297 · see citing works
Self-citationSuzuki, Y., Nawata, H., Soen, S., Fujiwara, S., Nakayama, H., Tanaka, I., Ozono, K., Sagawa, A., Takayanagi, R., Tanaka, H., et al. (2014) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-014-0586-6 · Cited by 281 · see citing works
Weinstein, R. S., Wan, C., Liu, Q., Wang, Y., Almeida, M., O’Brien, C. A., Thostenson, J., Roberson, P. K., Boskey, A. L., Clemens, T. L., et al. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00545.x · Cited by 276 · see citing works
Manson, S. C., Brown, R. E., Cerulli, A., & Vidaurre, C. F. (2009) · Respiratory Medicine · doi:10.1016/j.rmed.2009.01.003 · Cited by 275 · see citing works
Bone turnover markers: use in osteoporosis
Naylor, K. E., & Eastell, R. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2012.86 · Cited by 263 · see citing works
Drug-induced Osteoporosis: Mechanisms and Clinical Implications
Mazziotti, G., CANALIS, E. M., & Giustina, A. (2010) · The American Journal of Medicine · doi:10.1016/j.amjmed.2010.02.028 · Cited by 259 · see citing works
The Pathogenesis, Epidemiology and Management of Glucocorticoid-Induced Osteoporosis
van Staa, T. P. (2006) · Calcified Tissue International · doi:10.1007/s00223-006-0019-1 · Cited by 257 · see citing works
Corticosteroid-Induced Adverse Events in Adults
Fardet, L., Kassar, A., Cabané, J., & Flahault, A. (2007) · Drug Safety · doi:10.2165/00002018-200730100-00005 · Cited by 254 · see citing works
Yao, W., Cheng, Z., Busse, C., Pham, A., Nakamura, M. C., & Lane, N. E. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23454 · Cited by 241 · see citing works
Glucocorticoid-induced osteoporosis: mechanisms, management, and future perspectives
Seibel, M. J., Cooper, M. S., & Zhou, H. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70045-7 · Cited by 230 · see citing works
Vertebral Fracture Assessment: The 2007 ISCD Official Positions
Schousboe, J. T., Vokes, T., Broy, S. B., Ferrar, L., McKiernan, F., Roux, C., & Binkley, N. (2008) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2007.12.008 · Cited by 214 · see citing works
Medication-induced osteoporosis: screening and treatment strategies
Panday, K., Gona, A., & Humphrey, M. B. (2014) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x14546350 · Cited by 201 · see citing works
Effects of Collagen Crosslinking on Bone Material Properties in Health and Disease
Saito, M., & Marumo, K. (2015) · Calcified Tissue International · doi:10.1007/s00223-015-9985-5 · Cited by 200 · see citing works
Influence of drugs on vitamin D and calcium metabolism
Gröber, U., & Kisters, K. (2012) · Dermato-Endocrinology · doi:10.4161/derm.20731 · Cited by 199 · see citing works
Management of glucocorticoid-induced osteoporosis
Compston, J. E. (2010) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2009.259 · Cited by 191 · see citing works
Glucocorticoid-induced osteoporosis: 2019 concise clinical review
Adami, G., & Saag, K. G. (2019) · Osteoporosis International · doi:10.1007/s00198-019-04906-x · Cited by 187 · see citing works
Dole, N. S., Mazur, C. M., Acevedo, C., Lopez, J. P., Monteiro, D. A., Fowler, T. W., Gludovatz, B., Walsh, F., Regan, J. N., Messina, S., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.115 · Cited by 173 · see citing works
Glucocorticoid-Induced Osteoporosis: New Insights into the Pathophysiology and Treatments
Lane, N. E. (2019) · Current Osteoporosis Reports · doi:10.1007/s11914-019-00498-x · Cited by 173 · see citing works
Glüer, C.-C., Marin, F., Ringe, J. D., Hawkins, F., Möricke, R., Papaioannu, N., Farahmand, P., Minisola, S., Martínez, G., Nolla, J. M., et al. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1870 · Cited by 171 · see citing works
COPD and osteoporosis: links, risks, and treatment challenges
Inoue, D., Watanabe, R., & Okazaki, R. (2016) · International Journal of COPD · doi:10.2147/copd.s79638 · Cited by 171 · see citing works
Prevalence of Vertebral Fractures in Men with Acromegaly
Mazziotti, G., Bianchi, A., Bonadonna, S., Cimino, V., Patelli, I., Fusco, A., Pontecorvi, A., De Marinis, L., & Giustina, A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0791 · Cited by 169 · see citing works
Glucocorticoids and bone: Local effects and systemic implications
Henneicke, H., Gasparini, S. J., Brennan-Speranza, T. C., Zhou, H., & Seibel, M. J. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.12.006 · Cited by 168 · see citing works
Glucocorticoid-induced osteoporosis: who to treat with what agent?
Rizzoli, R., & Biver, E. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.188 · Cited by 166 · see citing works
Glucocorticoid-induced osteoporosis: An update on effects and management
Buehring, B., Viswanathan, R. K., Binkley, N., & Busse, W. W. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.08.040 · Cited by 163 · see citing works
Determinants of imminent fracture risk in postmenopausal women with osteoporosis
Barron, R., Oster, G., Grauer, A., Crittenden, D. B., & Weycker, D. A. (2020) · Osteoporosis International · doi:10.1007/s00198-020-05294-3 · Cited by 160 · see citing works
A simple score for estimating the long-term risk of fracture in patients using oral glucocorticoids
van Staa, T. P., Geusens, P., Pols, H. A. P., Laet, C. E. D. H. D., Leufkens, H. G. M., & Cooper, C. C. (2005) · QJM · doi:10.1093/qjmed/hci029 · Cited by 160 · see citing works
Self-citationSecondary Osteoporosis and Metabolic Bone Diseases
Sobh, M., Abdalbary, M., Elnagar, S., Nagy, E., Elshabrawy, N. A., Abdelsalam, M., Asadipooya, K., & El-Husseini, A. A. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11092382 · Cited by 159 · see citing works
Glucocorticoid dose determines osteocyte cell fate
Jia, J., Yao, W., Guan, M., Dai, W., Shahnazari, M., Kar, R., Bonewald, L., Jiang, J. X., & Lane, N. E. (2011) · The FASEB Journal · doi:10.1096/fj.11-182519 · Cited by 157 · see citing works
Advances in Glucocorticoid-Induced Osteoporosis
den Uyl, D., Bultink, I. E. M., & Lems, W. F. (2011) · Current Rheumatology Reports · doi:10.1007/s11926-011-0173-y · Cited by 152 · see citing works
Longitudinal patterns in the prevention of osteoporosis in glucocorticoid‐treated patients
Curtis, J. R., Westfall, A. O., Allison, J. J., Becker, A., Casebeer, L. L., Freeman, A. N., Spettell, C. M., Weissman, N., Wilke, S., & Saag, K. G. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21194 · Cited by 151 · see citing works
Vertebral Fracture Assessment: The 2005 ISCD Official Positions
Vokes, T., Bachman, D. M., Baim, S., Binkley, N., Broy, S. B., Ferrar, L., Lewiecki, E. M., Richmond, B. J., & Schousboe, J. T. (2006) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2006.05.006 · Cited by 150 · see citing works
Devogelaer, J., Goemaere, S., Boonen, S., Body, J., Kaufman, J., Reginster, J., Rozenberg, S., & Boutsen, Y. (2005) · Osteoporosis International · doi:10.1007/s00198-005-2032-z · Cited by 144 · see citing works
Saag, K. G., Pannacciulli, N., Geusens, P., Adachi, J. D., Messina, O. D., Morales‐Torres, J., Emkey, R. D., Butler, P. W., Yin, X., & Lems, W. F. (2019) · Arthritis & Rheumatology · doi:10.1002/art.40874 · Cited by 138 · see citing works
Glucocorticoids, osteocytes, and skeletal fragility: The role of bone vascularity
Weinstein, R. S. (2009) · Bone · doi:10.1016/j.bone.2009.06.030 · Cited by 135 · see citing works
Prevalence and predictors of fragility fractures in systemic lupus erythematosus
Yee, C., Crabtree, N. J., Skan, J., Amft, N., Bowman, S., Situnayake, D., & Gordon, C. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.018127 · Cited by 130 · see citing works
Briot, K., Cortet, B., Roux, C., Fardet, L., Abitbol, V., Bacchetta, J., Buchon, D., Debiais, F., Guggenbuhl, P., Laroche, M., et al. (2014) · Joint Bone Spine · doi:10.1016/j.jbspin.2014.10.001 · Cited by 129 · see citing works
Yao, W., Cheng, Z., Pham, A., Busse, C., Zimmermann, E. A., Ritchie, R. O., & Lane, N. E. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23954 · Cited by 128 · see citing works
Cosman, F., Krege, J. H., Looker, A. C., Schousboe, J. T., Fan, B., Sarafrazi, N., Shepherd, J., Krohn, K., Steiger, P., Wilson, K. E., et al. (2017) · Osteoporosis International · doi:10.1007/s00198-017-3948-9 · Cited by 128 · see citing works
Graeff, C., Marín, F., Petto, H., Kayser, O., Reisinger, A., Peña, J. A., Zysset, P. K., & Glüer, C. (2012) · Bone · doi:10.1016/j.bone.2012.10.036 · Cited by 125 · see citing works
Armamento‐Villareal, R., Napoli, N., Diemer, K., Watkins, M. P., Civitelli, R., Teitelbaum, S. L., & Novack, D. V. (2009) · Calcified Tissue International · doi:10.1007/s00223-009-9263-5 · Cited by 118 · see citing works
Yao, W., Dai, W., Jiang, L., Lay, E. Y.-A., Zhong, Z. A., Ritchie, R. O., Li, X., Ke, H. Z., & Lane, N. E. (2015) · Osteoporosis International · doi:10.1007/s00198-015-3308-6 · Cited by 116 · see citing works
Glucocorticoid-induced Osteoporosis
Whittier, X., & Saag, K. G. (2015) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2015.08.005 · Cited by 112 · see citing works
Mazziotti, G., Formenti, A. M., Adler, R. A., Bilezikian, J. P., Grossman, A. B., Sbardella, E., Minisola, S., & Giustina, A. (2016) · Endocrine · doi:10.1007/s12020-016-1146-8 · Cited by 112 · see citing works
Claessen, K. M. J. A., Kroon, H. M., Pereira, A. M., Appelman-Dijkstra, N. M., Verstegen, M. J., Kloppenburg, M., Hamdy, N. A. T., & Biermasz, N. R. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2695 · Cited by 111 · see citing works
Understanding Bone Strength Is Not Enough
Hernandez, C. J., & van der Meulen, M. C. H. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3078 · Cited by 110 · see citing works
Sfeir, J. G., Drake, M. T., Khosla, S., & Farr, J. N. (2022) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2022.03.011 · Cited by 109 · see citing works
Important Determinants of Bone Strength
Friedman, A. (2006) · JCR Journal of Clinical Rheumatology · doi:10.1097/01.rhu.0000208612.33819.8c · Cited by 109 · see citing works
Autoimmune Myopathies: Updates on Evaluation and Treatment
McGrath, E. R., Doughty, C. T., & Amato, A. A. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-00676-2 · Cited by 103 · see citing works
Khandelwal, S., & Lane, N. E. (2023) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2022.10.009 · Cited by 103 · see citing works
Teriparatide or Alendronate in Glucocorticoid-Induced Osteoporosis
Rossi, C. M., & Comite, G. D. (2008) · New England Journal of Medicine · doi:10.1056/nejmc073408 · Cited by 102 · see citing works
Glucocorticoid exposure and fracture risk in patients with new-onset rheumatoid arthritis
Balasubramanian, A., Wade, S. W., Adler, R. A., Lin, C. J. F., Maricic, M. J., O’Malley, C. D., Saag, K. G., & Curtis, J. R. (2016) · Osteoporosis International · doi:10.1007/s00198-016-3646-z · Cited by 101 · see citing works
STOCH, S. A., SAAG, K. G., GREENWALD, M., SEBBA, A. I., COHEN, S., VERBRUGGEN, N., GIEZEK, H., WEST, J., & SCHNITZER, T. J. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.081207 · Cited by 100 · see citing works
Self-citationGlucocorticoids: Complications to Anticipate and Prevent
Gensler, L. S. (2013) · The Neurohospitalist · doi:10.1177/1941874412458678 · Cited by 100 · see citing works
Osteoporosis Associated with Excess Glucocorticoids
Shaker, J. L., & Lukert, B. P. (2005) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2005.01.014 · Cited by 100 · see citing works
Leib, E. S., Saag, K. G., Adachi, J. D., Geusens, P., Binkley, N., McCloskey, E. V., & Hans, D. B. (2011) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2011.05.014 · Cited by 98 · see citing works
Osteoporosis Associated with Chronic Obstructive Pulmonary Disease
Okazaki, R., Watanabe, R., & Inoue, D. (2016) · Journal of Bone Metabolism · doi:10.11005/jbm.2016.23.3.111 · Cited by 94 · see citing works
Bad to the Bone: The Effects of Therapeutic Glucocorticoids on Osteoblasts and Osteocytes
Gado, M., Baschant, U., Hofbauer, L. C., & Henneicke, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.835720 · Cited by 93 · see citing works
Minireview: Live and Let Die: Molecular Effects of Glucocorticoids on Bone Cells
Hofbauer, L. C., & Rauner, M. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0069 · Cited by 91 · see citing works
Glucocorticoids, Inflammation and Bone
Güler-Yüksel, M., Hoes, J. N., Bultink, I. E. M., & Lems, W. F. (2018) · Calcified Tissue International · doi:10.1007/s00223-017-0335-7 · Cited by 91 · see citing works
Chakhtoura, Z., Bachelot, A., Samara-Boustani, D., Ruiz, J.-C., Donadille, B., Dulon, J., Christin-Maître, S., Bouvattier, C., Raux-Demay, M.-C., Bouchard, P., et al. (2008) · European Journal of Endocrinology · doi:10.1530/eje-07-0887 · Cited by 90 · see citing works
Saag, K. G., Agnusdei, D., Hans, D. B., Kohlmeier, L., Krohn, K., Leib, E. S., Maclaughlin, E. J., Alam, J., Simonelli, C., Taylor, K. A., et al. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39726 · Cited by 90 · see citing works
Fowler, T. W., Acevedo, C., Mazur, C. M., Hall‐Glenn, F., Fields, A. J., Bale, H., Ritchie, R. O., Lotz, J. C., Vail, T. P., & Alliston, T. N. (2017) · Scientific Reports · doi:10.1038/srep44618 · Cited by 90 · see citing works
Weinstein, R. S., Hogan, E. A., Borrelli, M. J., Liachenko, S. M., O’Brien, C. A., & Manolagas, S. C. (2017) · Endocrinology · doi:10.1210/en.2017-00662 · Cited by 88 · see citing works
Clinical reviews in allergy and immunology
Leung, D. Y. M., Ledford, D. K., Wechsler, M. E., Fulkerson, P. C., Bochner, B. S., Gauvreau, G. M., Gleich, G. J., Henkel, T., Kolbeck, R., Mathur, S. K., et al. (2012) · Cited by 87 · see citing works
Vinolas, H., Grouthier, V., Mehsen-Cêtre, N., Boisson, A., Winzenrieth, R., Schaeverbeke, T., Mesguich, C., Bordenave, L., & Tabarin, A. (2018) · Clinical Endocrinology · doi:10.1111/cen.13743 · Cited by 86 · see citing works
Hygum, K., Starup‐Linde, J., & Langdahl, B. L. (2019) · Osteoporosis and Sarcopenia · doi:10.1016/j.afos.2019.05.001 · Cited by 86 · see citing works
From bone biology to clinical outcome: state of the art and future perspectives
Schett, G., Saag, K., & Bijlsma, J. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.135061 · Cited by 88 · see citing works
Integrins, growth factors, and the osteoclast cytoskeleton
Zou, W., & Teitelbaum, S. L. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05245.x · Cited by 84 · see citing works
A systematic review and meta-analysis of glucocorticoid-induced osteoporosis in children
Hansen, K. E., Kleker, B., Safdar, N., & Bartels, C. M. (2014) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2014.02.002 · Cited by 84 · see citing works
Glucocorticoids and osteocyte autophagy
Yao, W., Dai, W., Jiang, J. X., & Lane, N. E. (2013) · Bone · doi:10.1016/j.bone.2013.01.034 · Cited by 82 · see citing works
Tanaka, Y., & Ohira, T. (2018) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2018.03.006 · Cited by 81 · see citing works
Osteoporosis in Chronic Obstructive Pulmonary Disease
Sarkar, M. S., Bhardwaj, R., Madabhavi, I., & Khatana, J. (2015) · Clinical Medicine Insights Circulatory Respiratory and Pulmonary Medicine · doi:10.4137/ccrpm.s22803 · Cited by 80 · see citing works
Diretrizes para prevenção e tratamento da osteoporose induzida por glicocorticoide
Pereira, R. M. R., de Carvalho, J. F., de Paula, A. P., Zerbini, C. A. F., Domiciano, D. S., Gonçalves, H., Danowski, J. S., Neto, J. F. M., de Mendonça, L. M. C., Bezerra, M. C., et al. (2012) · Revista Brasileira de Reumatologia · doi:10.1590/s0482-50042012000400009 · Cited by 80 · see citing works
Kochar, B. D., Cai, W., Cagan, A., & Ananthakrishnan, A. N. (2020) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15821 · Cited by 79 · see citing works
Biologic therapies and systemic bone loss in rheumatoid arthritis
Dimitroulas, T., Nikas, S. N., Trontzas, P., & Kitas, G. D. (2013) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.03.015 · Cited by 78 · see citing works
How to prevent steroid induced osteoporosis
Sambrook, P. N. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.018556 · Cited by 78 · see citing works
Management of Osteoporosis in Patients Living With HIV—A Systematic Review and Meta-analysis
Starup‐Linde, J., Rosendahl, S. B., Storgaard, M., & Langdahl, B. L. (2019) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000002207 · Cited by 77 · see citing works
Recomendaciones de la Sociedad Española de Reumatología sobre osteoporosis
Naranjo, A., Fontecha, P. D. D. C., Acín, M. P. A., Rodríguez, L. M. A., Casado, E., Castañeda, S., Aresté, J. F., Gifre, L., Vaquero, C. G., Candelas, G., et al. (2018) · Reumatología Clínica · doi:10.1016/j.reuma.2018.09.004 · Cited by 76 · see citing works
- Authors
- Van Staa, T. P., Laan, R. F., Barton, I. P., Cohen, S., Reid, D. M., & Cooper, C.
- Affiliations
- Procter & Gamble (United Kingdom) (GB)
- University of Aberdeen (GB)
- University of Southampton (GB)
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 2003-11
- Volume
- 48
- Issue
- 11
- Pages
- 3224-3229
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W1978136096
- Cited by
- 559
- References
- 29
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 11 · 2023: 13 · 2022: 21 · 2021: 27 · 2020: 28 · 2019: 30 · 2018: 36 · 2017: 30 · 2016: 28 · 2015: 36 · 2014: 29 · 2013: 29 · 2012: 23
- FWCI
- 21.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arthritis & Rheumatism (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Oncology › Bone health and treatments
- Keywords
- vertebral fractures, oral corticosteroids, bone mineral density, fracture risk prediction, risedronate, postmenopausal women, glucocorticoid dose, osteoporosis, lumbar spine bone mineral density, T-score thresholds
- MeSH terms
- Administration, Oral, Adolescent, Adult, Aged, Aged, 80 and over, Double-Blind Method, Female, Femur Neck, Glucocorticoids, Humans, Lumbar Vertebrae, Male, Middle Aged, Prednisone, Risk, Risk Factors, Absorptiometry, Photon, Bone Density, Osteoporosis, Postmenopausal, Spinal Fractures, Postmenopause
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review