Cited by 565Thyroid Cancer Diagnosis and TreatmentIdentification and Quantification in FoodCervical Cancer and HPV Research

The DOI matches its Crossref record; 84 of the 86 references it cites were found in a registry or an index.

Deoxyribonucleic Acid Profiling Analysis of 40 Human Thyroid Cancer Cell Lines Reveals Cross-Contamination Resulting in Cell Line Redundancy and Misidentification

Open access

Schweppe, Rebecca E., Klopper, Joshua P., Korch, Christopher, Pugazhenthi, Umarani, Benezra, Miriam, Knauf, Jeffrey A., Fagin, James A., Marlow, Laura A., Copland, John A., Smallridge, Robert C., Haugen, Bryan R.·2008·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2008-1102PMC PMC2582569

Open this paper in CoChat — free account Open PDF

Abstract

CONTEXT: Cell lines derived from human cancers provide critical tools to study disease mechanisms and develop novel therapies. Recent reports indicate that up to 36% of cell lines are cross- contaminated. OBJECTIVE: We evaluated 40 reported thyroid cancer-derived cell lines using short tandem repeat and single nucleotide polymorphism array analysis. RESULTS: Only 23 of 40 cell lines tested have unique genetic profiles. The following groups of cell lines are likely derivatives of the same cell line: BHP5-16, BHP17-10, BHP14-9, and NPA87; BHP2-7, BHP10-3, BHP7-13, and TPC1; KAT5, KAT10, KAT4, KAT7, KAT50, KAK1, ARO81-1, and MRO87-1; and K1 and K2. The unique cell lines include BCPAP, KTC1, TT2609-C02, FTC133, ML1, WRO82-1, 8505C, SW1736, Cal-62, T235, T238, Uhth-104, ACT-1, HTh74, KAT18, TTA1, FRO81-2, HTh7, C643, BHT101, and KTC-2. The misidentified cell lines included the DRO90-1, which matched the melanoma-derived cell line, A-375. The ARO81-1 and its derivatives matched the HT-29 colon cancer cell line, and the NPA87 and its derivatives matched the M14/MDA-MB-435S melanoma cell line. TTF-1 and Pax-8 mRNA levels were determined in the unique cell lines. CONCLUSIONS: Many of these human cell lines have been widely used in the thyroid cancer field for the past 20 yr and are not only redundant, but not of thyroid origin. These results emphasize the importance of cell line integrity, and provide the short tandem repeat profiles for a panel of thyroid cancer cell lines that can be used as a reference for comparison of cell lines from other laboratories.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1210/jc.2008-1102

Cites

84 of 84 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

2 retracted

The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells
Melillo, R. M., Castellone, M. D., Guarino, V., Falco, V. D., Cirafici, A. M., Salvatore, G., Caiazzo, F., Basolo, F., Giannini, R., Kruhøffer, M., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87345 · Cited by 305
Retracted
The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells
Melillo, R. M., Castellone, M. D., Guarino, V., Falco, V. D., Cirafici, A. M., Salvatore, G., Caiazzo, F., Basolo, F., Giannini, R., Kruhøffer, M., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22758 · Cited by 298
Retracted
Mutations of the BRAF gene in human cancer
Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., et al. (2002) · Nature · doi:10.1038/nature00766 · Cited by 10,674
In Vitro Cultivation of Human Tumors: Establishment of Cell Lines Derived From a Series of Solid Tumors2
Giard, D. J., Aaronson, S. A., Todaro, G. J., Arnstein, P., Kersey, J. H., Dosik, H., & Parks, W. P. (1973) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/51.5.1417 · Cited by 2,336
High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.
Kimura, E. T., Nikiforova, M. N., Zhu, Z., Knauf, J. A., Nikiforov, Y. E., & Fagin, J. A. (2003) · PubMed · Cited by 1,510
Self-citation
BRAF Mutations in Thyroid Tumors Are Restricted to Papillary Carcinomas and Anaplastic or Poorly Differentiated Carcinomas Arising from Papillary Carcinomas
Nikiforova, M. N., Kimura, E. T., Gandhi, M., Biddinger, P. W., Knauf, J. A., Basolo, F., Zhu, Z., Giannini, R., Salvatore, G., Fusco, A., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030838 · Cited by 1,036
Self-citation
New Human Tumor Cell Lines
Fogh, J., & Trempe, G. (1975) · Springer eBooks · doi:10.1007/978-1-4757-1647-4_5 · Cited by 1,034
Molecular characterization of human prostate carcinoma cell lines
van Bokhoven, A., Varella‐Garcia, M., Korch, C. T., Johannes, W. U., Smith, E. E., Miller, H. L., Nordeen, S. K., Miller, G. J., & Lucia, M. S. (2003) · The Prostate · doi:10.1002/pros.10290 · Cited by 635
Self-citation
Clinical Implication of Hot SpotBRAFMutation, V599E, in Papillary Thyroid Cancers
Namba, H., Nakashima, M., Hayashi, T., Hayashida, N., Maeda, S., Rogounovitch, T., Ohtsuru, A., Saenko, V., Kanematsu, T., & Yamashita, S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030305 · Cited by 532
Short tandem repeat profiling provides an international reference standard for human cell lines
Masters, J. R., Thomson, J. A., Daly-Burns, B., Reid, Y. A., Dirks, W. G., Packer, P., Toji, L. H., Ohno, T., Tanabe, H., Arlett, C. F., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121616198 · Cited by 478
The Costs of using Unauthenticated, Over-Passaged Cell Lines: How Much more Data do we Need?
Hughes, P., Marshall, D., Reid, Y., Parkes, H., & Gelber, C. (2007) · BioTechniques · doi:10.2144/000112598 · Cited by 434
High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines.
Xu, X., Quiros, R. M., Gattuso, P., Ain, K. B., & Prinz, R. A. (2003) · PubMed · Cited by 415
Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia.
Yuen, S. T., Davies, H. R., Chan, T. L., Ho, J. W. C., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Tsui, W. W., Chan, A. S. Y., et al. (2002) · PubMed · Cited by 404
MDA-MB-435 cells are derived from M14 Melanoma cells––a loss for breast cancer, but a boon for melanoma research
Rae, J. M., Creighton, C. J., Meck, J. M., Haddad, B. R., & Johnson, M. D. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-006-9392-8 · Cited by 374
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling
McDermott, U., Sharma, S. V., Dowell, L., Greninger, P., Montagut, C. O., Lamb, J. A., Archibald, H., Raudales, R., Tam, A., Lee, D. W., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707498104 · Cited by 352
Phosphatidylinositol-3-OH Kinase or RAS Pathway Mutations in Human Breast Cancer Cell Lines
Hollestelle, A., Elstrodt, F., Nagel, J. H. A., Kallemeijn, W. W., & Schutte, M. E. M. (2007) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-06-0263 · Cited by 325
The Influence of Culture Time and Passage Number on the Morphological and Physiological Development of Caco-2 Cells
Briske‐Anderson, M., Finley, J. W., & Newman, S. M. (1997) · Experimental Biology and Medicine · doi:10.3181/00379727-214-44093 · Cited by 317
Restoration of Iodide Uptake in Dedifferentiated Thyroid Carcinoma: Relationship to Human Na+/I- Symporter Gene Methylation Status
Venkataraman, G. M., Yatin, M., Marcinek, R., & Ain, K. B. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.7.5815 · Cited by 222
Suppression of BRAF/MEK/MAP Kinase Pathway Restores Expression of Iodide-Metabolizing Genes in Thyroid Cells Expressing the V600E BRAF Mutant
Liu, D., Hu, S., Hou, P., JIANG, D., Condouris, S., & Xing, M. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1753 · Cited by 202
In vitro irradiation is able to cause RET oncogene rearrangement.
Ito, T., Seyama, T., Iwamoto, K. S., Hayashi, T., Mizuno, T., Tsuyama, N., Dohi, K., Nakamura, N., & Akiyama, M. (1993) · PubMed · Cited by 163
Formation and growth of multicellular spheroids of human origin
Carlsson, J., Nilsson, K., Westermark, B., Pontén, J., Sundström, C., Larsson, E., Bergh, J. C. S., Påhlman, S., Busch, C., & Collins, V. P. (1983) · International Journal of Cancer · doi:10.1002/ijc.2910310502 · Cited by 159
Persistent use of “false” cell lines
Lacroix, M. (2008) · International Journal of Cancer · doi:10.1002/ijc.23233 · Cited by 151
p53 re-expression inhibits proliferation and restores differentiation of human thyroid anaplastic carcinoma cells
Moretti, F., Farsetti, A., Soddu, S., Misiti, S., Crescenzi, M., Filetti, S., Andreoli, M., Sacchi, A., & Pontecorvi, A. (1997) · Oncogene · doi:10.1038/sj.onc.1200887 · Cited by 150
Early Occurrence of RASSF1A Hypermethylation and Its Mutual Exclusion with BRAF Mutation in Thyroid Tumorigenesis
Xing, M., Cohen, Y., Mambo, E., Tallini, G., Udelsman, R., Ladenson, P. W., & Sidransky, D. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3242 · Cited by 143
Evidence for Diminished Functional Expression of Intestinal Transporters in Caco-2 Cell Monolayers at High Passages
Yu, H., Cook, T. J., & Sinko, P. J. (1997) · Pharmaceutical Research · doi:10.1023/a:1012150405949 · Cited by 133
Cancer cell line identification by short tandem repeat profiling: power and limitations
Parson, W., Kirchebner, R., Mühlmann, R., Renner, K., Kofler, A., Schmidt, S., & Kofler, R. (2005) · The FASEB Journal · doi:10.1096/fj.04-3062fje · Cited by 129
BRAFV600E Mutation Is Associated with Preferential Sensitivity to Mitogen-Activated Protein Kinase Kinase Inhibition in Thyroid Cancer Cell Lines
Leboeuf, R., Baumgartner, J. E., Benezra, M., Malaguarnera, R., Solit, D. B., Pratilas, C. A., Rosen, N. X., Knauf, J. A., & Fagin, J. A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2825 · Cited by 127
Self-citation
Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype
van Staveren, W. C. G., Solís, D. W., Delys, L., Duprez, L., Andry, G., Franc, B., Thomas, G., Libert, F., Dumont, J. E., Detours, V., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4026 · Cited by 123
Growth Regulation of Normal Thyroids and Thyroid Tumors in Man
Goretzki, P. E., Frilling, A., Simon, D., & Roeher, H. D. (1990) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-642-83816-3_6 · Cited by 123
Somatostatin Receptor Subtype Expression in Human Thyroid and Thyroid Carcinoma Cell Lines1
Ain, K. B., Taylor, K. D., Tofiq, S., & Venkataraman, G. M. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.6.4013 · Cited by 119
Restoration of Iodide Uptake in Dedifferentiated Thyroid Carcinoma: Relationship to Human Na+/I- Symporter Gene Methylation Status
Venkataraman, G. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.7.2449 · Cited by 119
Characterization of Tumor Necrosis Factor-α Receptors in Human and Rat Thyroid Cells and Regulation of the Receptors by Thyrotropin*
PANG, X.-P., HERSHMAN, J. M., CHUNG, M., & PEKARY, A. E. (1989) · Endocrinology · doi:10.1210/endo-125-4-1783 · Cited by 116
Cases of Mistaken Identity
Chatterjee, R. (2007) · Science · doi:10.1126/science.315.5814.928 · Cited by 115
WiDr is a derivative of another colon adenocarcinoma cell line, HT-29
Chen, T. R., Drabkowski, D., Hay, R. J., Macy, M. L., & Peterson, W. (1987) · Cancer Genetics and Cytogenetics · doi:10.1016/0165-4608(87)90267-6 · Cited by 115
Retinoic Acid and Retinoid X Receptors Are Differentially Expressed in Thyroid Cancer and Thyroid Carcinoma Cell Lines and Predict Response to Treatment with Retinoids
Haugen, B. R., Larson, L. L., Pugazhenthi, U., Hays, W. R., Klopper, J. P., Kramer, C. A., & Sharma, V. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030770 · Cited by 113
Self-citation
Characterization of a human follicular thyroid carcinoma cell line (UCLA RO 82 W-1)
Estour, B., Herle, A. J. V., Juillard, G. J. F., Totanes, T. L., Sparkes, R. S., Giuliano, A. E., & KLANDORF, H. (1989) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02899078 · Cited by 110
Selective Growth Inhibition in BRAF Mutant Thyroid Cancer by the Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor AZD6244
Ball, D. W., Jin, N. Y., Rosen, D. M., Dackiw, A. P. B., Sidransky, D., Xing, M., & Nelkin, B. D. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1184 · Cited by 109
All-Trans-Retinoic Acid Modulates Expression Levels of Thyroglobulin and Cytokines in a New Human Poorly Differentiated Papillary Thyroid Carcinoma Cell Line, KTC-11
Kurebayashi, J., Tanaka, K., Otsuki, T., Moriya, T., Kunisue, H., Uno, M., & Sonoo, H. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.8.6732 · Cited by 109
Untitled work
(2001) · PubMed · Cited by 106
Self-citation
Effect of passage number on cellular response to DNA-damaging agents: cell survival and gene expression
Chang‐Liu, C., & Woloschak, G. E. (1997) · Cancer Letters · doi:10.1016/s0304-3835(97)04599-0 · Cited by 102
Molecular and Genotypic Characterization of Human Thyroid Follicular Cell Carcinoma–Derived Cell Lines
Meireles, A. M., Preto, A., Rocha, A. S., Rebocho, A. P., Máximo, V., Pereira‐Castro, I., Moreira, S., Feijão, T., Botelho, T. O., Marques, R., et al. (2007) · Thyroid · doi:10.1089/thy.2007.0097 · Cited by 101
A highly discriminating octoplex short tandem repeat polymerase chain reaction system suitable for human individual identification
Oldroyd, N. J., Urquhart, A. J., Kimpton, C. P., Millican, E. S., Watson, S. K., Downes, T., & Gill, P. (1995) · Electrophoresis · doi:10.1002/elps.1150160155 · Cited by 100
Widely used prostate carcinoma cell lines share common origins
van Bokhoven, A., Varella‐Garcia, M., Korch, C., Hessels, D., & Miller, G. J. (2001) · The Prostate · doi:10.1002/pros.1045 · Cited by 90
Self-citation
Cases of Mistaken Identity
Bailey, B., Einarson, A., & Koren, G. (2018) · The Canadian Journal of Hospital Pharmacy · doi:10.4212/cjhp.v50i2.2026 · Cited by 89
Effects of Histone Acetylation on Sodium Iodide Symporter Promoter and Expression of Thyroid-Specific Transcription Factors
Puppin, C., D’Aurizio, F., D'Elia, A. V., Cesaratto, L., Tell, G., Russo, D., Filetti, S., Ferretti, E., Tosi, E., Mattei, T., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0128 · Cited by 88
Establishment and biological characterization of an in vitro human cytomegalovirus latency model
Tanaka, J., Ogura, T., Sato, H., & Hatano, M. (1987) · Virology · doi:10.1016/0042-6822(87)90171-1 · Cited by 80
Osteopontin Is Overexpressed in Human Papillary Thyroid Carcinomas and Enhances Thyroid Carcinoma Cell Invasiveness
Guarino, V., Faviana, P., Salvatore, G., Castellone, M. D., Cirafici, A. M., Falco, V. D., Celetti, A., Giannini, R., Basolo, F., Melillo, R. M., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0271 · Cited by 80
All-Trans-Retinoic Acid Modulates Expression Levels of Thyroglobulin and Cytokines in a New Human Poorly Differentiated Papillary Thyroid Carcinoma Cell Line, KTC-1
Kurebayashi, J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.8.2889 · Cited by 79
Common origins of MDA-MB-435 cells from various sources with those shown to have melonoma properties
Rae, J. M., Ramus, S. J., Waltham, M., Armes, J. E., Campbell, I. G., Clarke, R., Barndt, R. J., Johnson, M. D., & Thompson, E. W. (2004) · Clinical & Experimental Metastasis · doi:10.1007/s10585-004-3759-1 · Cited by 74
Untitled work
(1976) · PubMed · Cited by 73
A reversal in the long-term increase in deaths attributable to malignant melanoma
Roush, G. C., McKay, L. A., & Holford, T. R. (1992) · Cancer · doi:10.1002/1097-0142(19920401)69:7 · Cited by 71
Establishment and characterization of the follicular thyroid carcinoma cell line ML-1
Schönberger, J., Bauer, J. W., Spruß, T., Weber, G., Chahoud, I., Eilles, C., & Grimm, D. G. (2000) · Journal of Molecular Medicine · doi:10.1007/s001090000085 · Cited by 70
Inhibitory Effects of the Mitogen-Activated Protein Kinase Kinase Inhibitor CI-1040 on the Proliferation and Tumor Growth of Thyroid Cancer Cells withBRAForRASMutations
Liu, D., Liu, Z., JIANG, D., Dackiw, A. P. B., & Xing, M. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0097 · Cited by 67
Somatostatin analogs affect proliferation of human thyroid carcinoma cell lines in vitro.
Ain, K. B., & Taylor, K. D. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.5.7909817 · Cited by 64
Cloning of the Human Sodium-Iodide Symporter Promoter and Characterization in a Differentiated Human Thyroid Cell Line, KAT-50
Venkataraman, G. M., Yatin, M., & Ain, K. B. (1998) · Thyroid · doi:10.1089/thy.1998.8.63 · Cited by 62
Coexpression of Functionally Active Receptors for Thyrotropin and Platelet-Derived Growth Factor in Human Thyroid Carcinoma Cells*
Heldin, N., Cvejic, D. S., Smeds, S., & Westermark, B. (1991) · Endocrinology · doi:10.1210/endo-129-4-2187 · Cited by 61
Growth Inhibition of New Human Thyroid Carcinoma Cell Lines by Activation of Adenylate Cyclase through the β-Adrenergic Receptor1
Ohta, K., Pang, X.-P., Berg, L., & Hershman, J. M. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4136 · Cited by 60
Peroxisome Proliferator‐activated Receptor Gamma Activation Induces Cell Cycle Arrest via the p53‐independent Pathway in Human Anaplastic Thyroid Cancer Cells
Chung, S.-H., Onoda, N., Ishikawa, T., Ogisawa, K., Takenaka, C., Yano, Y., Hato, F., & Hirakawa, K. (2002) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2002.tb01245.x · Cited by 55
Retrovirus-Mediated Herpes Simplex Virus Thymidine Kinase Gene Transduction Renders Human Thyroid Carcinoma Cell Lines Sensitive to Ganciclovir and Radiation in Vitro and in Vivo
Nishihara, E., Nagayama, Y., Mawatari, F., Tanaka, K., Namba, H., Niwa, M., & Yamashita, S. (1997) · Endocrinology · doi:10.1210/endo.138.11.5509 · Cited by 53
Molecular Cytogenetic Profiles of Novel and Established Human Anaplastic Thyroid Carcinoma Models
Lee, J.-J., Foukakis, T., Hashemi, J., Grimelius, L., Heldin, N., Wallin, G., Rudduck, C., Lui, W., Höög, A., & Larsson, C. (2007) · Thyroid · doi:10.1089/thy.2006.0246 · Cited by 51
Growth factors rescue cutaneous melanoma cells from apoptosis induced by knockdown of mutated (V600E) B-RAF
Christensen, C., & Guldberg, P. (2005) · Oncogene · doi:10.1038/sj.onc.1208758 · Cited by 48
Antitumor actions of cytokines on new human papillary thyroid carcinoma cell lines
Ohta, K., Pang, X.-P., Berg, L., & Hershman, J. M. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.7.8675585 · Cited by 45
Poorly differentiated and anaplastic thyroid carcinomas: chromosomal and oligo-array profile of five new cell lines
Rodrigues, R., Roque, L., Krug, T., & Leite, V. A. P. H. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603578 · Cited by 45
Characterization and radiosensitivity at high or low dose rate of four cell lines derived from human thyroid tumors
Vathaire, C. C.-D., Branea, F., Schlumberger, M. J., Béron‐Gaillard, N., de Vathaire, F., Badie, C., Antonini, P., & Parmentier, C. (1997) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(96)00449-x · Cited by 36
Establishment, characterization and drug sensitivity of a new anaplastic thyroid carcinoma cell line (BHT-101)
Pályi, I., Péter, I., Daubner, D., Vincze, B., & Lõrincz, I. (1993) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02899271 · Cited by 33
[Characterization of a human cell line from an anaplastic carcinoma of the thyroid gland].
Gioanni, J., Zanghellini, E., Mazeau, C., Zhang, D., Courdi, A., Farges, M., Lambert, J. C., Duplay, H., & Schneider, M. (1991) · PubMed · Cited by 32
Low-Level Genomic Instability Is a Feature of Papillary Thyroid Carcinoma: An Array Comparative Genomic Hybridization Study of Laser Capture Microdissected Papillary Thyroid Carcinoma Tumors and Clonal Cell Lines
Finn, S. P., Smyth, P. C., O’Regan, E. M., Cahill, S., Toner, M. E., Timon, C. I., Flavin, R., O’Leary, J. J., & Sheils, O. M. (2007) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2007-131-65-lgiiaf · Cited by 31
Medroxyprogesterone Acetate Decreases Secretion of Interleukin-6 and Parathyroid Hormone-Related Protein in a New Anaplastic Thyroid Cancer Cell Line, KTC-2
Kurebayashi, J., Otsuki, T., Tanaka, K., Yamamoto, Y., Moriya, T., & Sonoo, H. (2003) · Thyroid · doi:10.1089/105072503321582042 · Cited by 30
Effects on proliferation and melanogenesis by inhibition of mutant BRAF and expression of wild‐type INK4A in melanoma cells
Rotolo, S., Diotti, R., Gordon, R. E., Qiao, R., Yao, Z., Phelps, R. G., & Dong, J. (2005) · International Journal of Cancer · doi:10.1002/ijc.20865 · Cited by 28
Overexpression of thyroid hormone receptor beta1 is associated with thyrotropin receptor gene expression and proliferation in a human thyroid carcinoma cell line
Chen, S.-T., Shieh, H.-T., Lin, J., Chang, K., & Lin, K. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1650379 · Cited by 26
Growth Regulation of Human Thyrocytes by Thyrotropin, Cyclic Adenosine Monophosphate, Epidermal Growth Factor and Insulin-Like Growth Factor
Goretzki, P. E., Frilling, A., Simon, D., Rastegar, M., & Ohmann, C. (2015) · Frontiers of hormone research · doi:10.1159/000417502 · Cited by 26
The distribution of cellular adhesion molecules in pigmented skin lesions
Duinen, C. M. V., den Broek, L. J. C. M. V., Vermeer, B. J., Fleuren, G. J., & Bruijn, J. A. (1994) · Cancer · doi:10.1002/1097-0142(19940415)73:8 · Cited by 24
Decreased growth rate and tumour formation of human anaplastic thyroid carcinoma cells transfected with a human thyrotropin receptor cDNA in NMRI nude mice treated with propylthiouracil
Gustavsson, B. G., Hermansson, A., Andersson, A., Grimelius, L., Bergh, J. C. S., Westermark, B., & Heldin, N. (1996) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(96)03859-2 · Cited by 22
Humoral immune response to intralymphatic immunotherapy for disseminated melanoma: correlation with clinical response.
Ahn, S. S., Irie, R. F., WEISENBURGER, T. H., Pc, J., Juillard, G. J. F., Roe, D., & Dl, M. (1982) · PubMed · Cited by 20
Growth suppression of thyroid cancer cells by adenylcyclase activator
Yano, Y., Kamma, H., Matsumoto, H., Fujiwara, M., Bando, H., Hara, H., Yashiro, T., Ueno, E., Ito, K., & Uchida, K. (2007) · Oncology Reports · doi:10.3892/or.18.2.441 · Cited by 18
LCC15-MB Cells are MDA-MB-435: A Review of Misidentified Breast and prostate cell lines
Thompson, E. W., Waltham, M. C., Ramus, S. J., Hutchins, A., Armes, J. E., Campbell, I., Williams, E. D., Thompson, P. R., Rae, J. M., Johnson, M. D., et al. (2004) · Clinical & Experimental Metastasis · doi:10.1007/s10585-004-4117-z · Cited by 17
Establishment and characterization of a human papillary thyroid carcinoma cell line with oxyphilic differentiation (ONCO-DG 1)
Grimm, D. G., Hofstädter, F., Bauer, J. W., Spruß, T., Steinbach, P., Bernhardt, G., & Menze, R. (1992) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02899670 · Cited by 16
Susceptibility of Thyroid Cancer Cells to 7-Hydroxystaurosporine–Induced Apoptosis Correlates with Bcl-2 Protein Level
Wang, S. H., Phelps, E., Utsugi, S., & Baker, J. R. (2001) · Thyroid · doi:10.1089/10507250152484556 · Cited by 16
Clonally Related But Phenotypically Divergent Human Cancer Cell Lines Derived from a Single Follicular Thyroid Cancer Recurrence (TT2609)
Geldof, A. A., Versteegh, R. T., van Mourik, J. C., Rooimans, M. A., Arwert, F., Hermsen, M. A. J. A., Eestermans, I. L., van Dongen, G. A. M. S., van der Valk, P., Clement, E. H. V. D. P., et al. (2001) · Thyroid · doi:10.1089/105072501753210966 · Cited by 15
Effects of tamoxifen and somatostatin analogue on growth of human medullary, follicular, and papillary thyroid carcinoma cell lines: tissue culture and nude mouse xenograft studies.
Cj, W., Marvin, M. R., Krekun, S., Koschitzky, T., Karp, F. S., Benson, M., & Feind, C. R. (1990) · PubMed · Cited by 12
When 60 Lines Don't Add Up
Chatterjee, R. (2007) · Science · doi:10.1126/science.315.5814.929 · Cited by 9
Mutated E-Cadherin: Genomic and Functional Characterization in Thyroid Cells from the KAT Family
Rocha, A. S., Wever, O. D., Moreira, S., Costa, M. J. D. C., Vandekerckhove, J. S., Mareel, M. M. K., & Soares, P. (2004) · Thyroid · doi:10.1089/thy.2004.14.902 · Cited by 8
Quantitative and qualitative differences in growth, invasion and lung colonization of an anaplastic and a papillary human thyroid cancer cell linein vitro andin vivo
Boghaert, E. R., Ain, K. B., Taylor, K. D., Greenberg, V. L., Fowler, C. L., & Zimmer, S. G. (1996) · Clinical & Experimental Metastasis · doi:10.1007/bf00128960 · Cited by 7
Untitled work
(1999) · doi:10.1002/(sici)1097-0215(19991112)83:4

Research works printed but not linked: 2

Hay, 1984, Banking and strain data of cell cultures., In vitro TCA Monograph, 5, 215
Ain, 1992, Characterization of an immortalized cell-line (KAK-1) from a benign human thyroid follicular adenoma, Thyroid, 2, S49

Sorted by citations

Mutational Profile of Advanced Primary and Metastatic Radioactive Iodine-Refractory Thyroid Cancers Reveals Distinct Pathogenetic Roles for BRAF, PIK3CA , and AKT1
Ricarte‐Filho, J. C., Ryder, M. M., Chitale, D. A., Rivera, M., Heguy, A., Ladanyi, M., Janakiraman, M., Solit, D. B., Knauf, J. A., Tuttle, R. M., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0727 · Cited by 532
Self-citation
Check your cultures! A list of cross‐contaminated or misidentified cell lines
Capes‐Davis, A., Theodosopoulos, G., Atkin, I., Drexler, H. G., Kohara, A., MacLeod, R. A. F., Masters, J. R., Nakamura, Y., Reid, Y. A., Reddel, R. R., et al. (2010) · International Journal of Cancer · doi:10.1002/ijc.25242 · Cited by 520
Anaplastic Thyroid Carcinoma: Pathogenesis and Emerging Therapies
Smallridge, R. C., & Copland, J. A. (2010) · Clinical Oncology · doi:10.1016/j.clon.2010.03.013 · Cited by 480
Self-citation
Anaplastic thyroid cancer: molecular pathogenesis and emerging therapies
Smallridge, R. C., Marlow, L. A., & Copland, J. A. (2008) · Endocrine Related Cancer · doi:10.1677/erc-08-0154 · Cited by 396
Self-citation
Relief of Feedback Inhibition of HER3 Transcription by RAF and MEK Inhibitors Attenuates Their Antitumor Effects in BRAF -Mutant Thyroid Carcinomas
Montero-Conde, C., Ruiz-Llorente, S., Dominguez, J. M., Knauf, J. A., Viale, A., Sherman, E. J., Ryder, M., Ghossein, R. A., Rosen, N., & Fagin, J. A. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0531 · Cited by 382
Self-citation

See all 565

Authors: Schweppe, R. E., Klopper, J. P., Korch, C., Pugazhenthi, U., Benezra, M., Knauf, J. A., Fagin, J. A., Marlow, L. A., Copland, J. A., Smallridge, R. C., & Haugen, B. R.
Affiliations: University of Colorado Cancer Center (US)
Memorial Sloan Kettering Cancer Center (US)
Mayo Clinic in Florida (US)
ORCID: Schweppe, Rebecca E.
Klopper, Joshua P.
Korch, Christopher
Pugazhenthi, Umarani
Benezra, Miriam
Knauf, Jeffrey A.
Fagin, James A.
Marlow, Laura A.
Copland, John A.
Haugen, Bryan R.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2008-11-01
Volume: 93
Issue: 11
Pages: 4331-4341
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2008-1102
PMC: PMC2582569
OpenAlex: W2027855079
Cited by: 563
References: 86
Citations by year: 2026: 3 · 2025: 7 · 2024: 11 · 2023: 28 · 2022: 9 · 2021: 21 · 2020: 22 · 2019: 27 · 2018: 33 · 2017: 33 · 2016: 38 · 2015: 40 · 2014: 29 · 2013: 47 · 2012: 54
FWCI: 38.71
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Florida Department of Health
Memorial Sloan-Kettering Cancer Center
National Institutes of Health (CA-04-6934, P 30CA046934)
University of Colorado Denver
Cancer Center, University of Colorado (P30 CA046934, CA046934)
National Cancer Institute (CA 046934, CA 50706, CA-72597, CA100560, R01CA100560, R01CA050706, R01CA072597, P30CA15083, P30CA015083, P30CA046934)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Identification and Quantification in Food
Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
Keywords: thyroid cancer cell lines, cell line contamination, cell line misidentification, short tandem repeat profiling, DNA fingerprinting, TTF-1, PAX8
MeSH terms: Colonic Neoplasms, DNA, Neoplasm, Female, Humans, Male, Melanoma, Mutation, Neoplasm Proteins, RNA, Messenger, Thyroid Neoplasms, Reproducibility of Results, Adenocarcinoma, Follicular, Cell Culture Techniques, Polymorphism, Single Nucleotide, Gene Expression Profiling, Cell Line, Tumor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Deoxyribonucleic Acid Profiling Analysis of 40 Human Thyroid Cancer Cell Lines Reveals Cross-Contamination Resulting in Cell Line Redundancy and Misidentification

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks