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An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol
Open accessAbstract
Background: Resveratrol have been shown to exert an antiinflammatory and antiaging effects in vitro and in animal models. Objective: The objective of the study was to investigate the effect of a Polygonum cuspidatum extract (PCE) containing resveratrol on oxidative and inflammatory stress in normal subjects. Research Design and Methods: Two groups (10 each) of normal-weight healthy subjects were randomized to placebo or PCE containing 40 mg resveratrol daily for 6 wk. Fasting blood samples were obtained prior to and after treatment at 1, 3, and 6 wk. Mononuclear cells were prepared for reactive oxygen species generation, RNA isolation, nuclear extract, and total cell homogenate preparation. Indices of oxidative and inflammatory stress, suppressor of cytokine signaling-3, phosphotyrosine phosphatase-1B, jun-N-terminal kinase-1, and inhibitor of κB-kinase-β were measured by RT-PCR and Western blotting. Results: The extract induced a significant reduction in reactive oxygen species generation, the expression of p47phox, intranuclear nuclear factor-κB binding, and the expression of jun-N-terminal kinase-1, inhibitor of κB-kinase-β, phosphotyrosine phosphatase-1B, and suppressor of cytokine signaling-3 in mononuclear cells when compared with the baseline and the placebo. PCE intake also suppressed plasma concentrations of TNF-α, IL-6, and C-reactive protein. There was no change in these indices in the control group given placebo. Conclusions: The PCE-containing resveratrol has a comprehensive suppressive effect on oxidative and inflammatory stress.
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Resveratrol and health—A comprehensive review of human clinical trials
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Health benefits of resveratrol: Evidence from clinical studies
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Obesity-Associated Oxidative Stress: Strategies Finalized to Improve Redox State
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Metadata
- Authors
- Ghanim, H., Sia, C. L., Abuaysheh, S., Korzeniewski, K., Patnaik, P., Marumganti, A., Chaudhuri, A., & Dandona, P.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2010-09-01
- Volume
- 95
- Issue
- 9
- Pages
- E1-E8
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2114968425
- Cited by
- 238
- References
- 12
- FWCI
- 7.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ghanim, H., Sia, C. L., Abuaysheh, S., Korzeniewski, K., Patnaik, P., Marumganti, A., Chaudhuri, A., & Dandona, P. (2010). An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2010-0482
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