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Cited by 248Hormonal and reproductive studiesClinical Laboratory Practices and Quality ControlScientific Measurement and Uncertainty Evaluation

Toward Excellence in Testosterone Testing: A Consensus Statement

Rosner, William, Vesper, Hubert·2010·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2010-1314
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Abstract

BACKGROUND: Testosterone assays are widely used. However, deficiencies in these assays limit their broad and effective implementation and threaten the health of those patients whose medical care relies upon its accurate measurement. Furthermore, the translation of research findings into information useful for patient care, such as new evidence-based clinical guidelines, is not possible unless both research and clinical assays are held to higher standards than are currently required. A group of concerned stakeholders was convened to address this problem. METHODS: Representatives of multiple professional societies, government, and industry, having a stake in ensuring that testosterone levels are measured accurately and reliably, met to identify goals, objectives, and actions necessary to bring about the standardization of assays for testosterone. RESULTS: To ensure highly accurate testosterone testing that will result in improved diagnosis, treatment, and prevention of disease through the use of standardized assays, a series of recommendations were agreed upon. The recommendations included the following: technical improvements for assay standardization; education of health care providers, patients, and all others concerned with testosterone testing; plans to encourage all concerned journals, government agencies, and health insurance companies to support this effort; and encouragement to manufacturers to develop better and more cost effective assays. CONCLUSION: A preliminary timeline was set out to implement the recommendations of the Group.

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Crossref · 10.1210/jc.2010-1314

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4 of 4 references verified0 citation errors · 0 not checkable

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  • Mass spectrometry methods exhibit higher accuracy and lower variability than immunoassays, especially at low analyte concentrations.

    “Mass spectrometry (MS) methods exhibit higher accuracy and lower variability than immunoassays, especially at low analyte concentrations.”

    From Clinical Usefulness of Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry Method for Low Serum Testosterone Measurement (2023) · cites this paper as [5]

  • Upper lip Ferriman-Gallwey scores of 3-4 occur in less than 3% of Black and White US adolescents, while scores of 1-2 increase from 7.3% at less than 2 years after menarche to 28.2% at more than 2 years after menarche.

    “Upper lip scores of 3-4 were found in <3% of Black and White US adolescents, though scores of 1-2 rose in prevalence from 7.3% at <2 years after menarche to 28.2% at >2 years after menarche [40,41]”

    From The Diagnosis of Polycystic Ovary Syndrome during Adolescence (2015) · cites this paper as [41]

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Authors
Rosner, W., & Vesper, H.
Affiliations
  • St. Luke's-Roosevelt Hospital Center (US)
  • Centers for Disease Control and Prevention (US)
Corresponding author
Rosner, William
ORCID
Vesper, Hubert
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2010-10
Volume
95
Issue
10
Pages
4542-4548
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2010-1314
OpenAlex
W2104748844
Cited by
248
References
4
Citations by year
2026: 6 · 2025: 7 · 2024: 7 · 2023: 10 · 2022: 17 · 2021: 14 · 2020: 11 · 2019: 13 · 2018: 19 · 2017: 22 · 2016: 20 · 2015: 16 · 2014: 25 · 2013: 18 · 2012: 24
FWCI
14.51
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Centers for Disease Control and Prevention Foundation
  • U.S. Food and Drug Administration
  • National Center for Chronic Disease Prevention and Health Promotion
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
  • Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Scientific Measurement and Uncertainty Evaluation
Keywords
testosterone testing, clinical laboratory testing, health policy recommendations, health care provider education, clinical guidelines implementation
MeSH terms
Cost-Benefit Analysis, Diagnostic Techniques, Endocrine, Financing, Government, Humans, Insurance, Health, Reimbursement, National Institutes of Health (U.S.), Quality Assurance, Health Care, Quality Control, Testosterone, United States, Consensus

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