Reciprocal regulation of bone and energy metabolism
Abstract
The finding that fat regulates bone metabolism was viewed as an indication that bone might regulate some aspects of energy metabolism in a feedback loop. The search that started nine years ago for a bone-derived hormone that regulates energy metabolism first took a convoluted path through the identification of a modifier gene. Once this hormone, osteocalcin, was identified, it became clear that bone exerts a profound and complex influence on glucose and fat metabolism. This review highlights the most important salient features of this novel regulation of energy metabolism.
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Osteocalcin supports insulin function and thus storage of energy-rich fuels in adipose tissue and muscle.
“Nevertheless, these studies indicate that osteocalcin supports insulin function and thus storage of energy-rich fuels in adipose tissue and muscle.”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [32]
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- Authors
- Lee, N. K., & Karsenty, G.
- Affiliations
- Columbia University (US)
- ORCID
- Lee, Na Kyung
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 19
- Issue
- 5
- Pages
- 161-166
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W2052383327
- Cited by
- 190
- References
- 43
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 7 · 2017: 14 · 2016: 8 · 2015: 18 · 2014: 17 · 2013: 17 · 2012: 16
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- osteocalcin, bone metabolism, energy metabolism, glucose metabolism, fat metabolism, genetic modifiers
- MeSH terms
- Animals, Bone and Bones, Energy Metabolism, Feedback, Mice, Mutant Strains, Osteoblasts, Osteoclasts, Osteocalcin, Bone Remodeling, Mice
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