Cited by 190Bone Metabolism and DiseasesBone health and osteoporosis researchAdipokines, Inflammation, and Metabolic Diseases

Reciprocal regulation of bone and energy metabolism

Lee, Na Kyung, Karsenty, Gerard·2008·Trends in Endocrinology & Metabolism

Abstract

The finding that fat regulates bone metabolism was viewed as an indication that bone might regulate some aspects of energy metabolism in a feedback loop. The search that started nine years ago for a bone-derived hormone that regulates energy metabolism first took a convoluted path through the identification of a modifier gene. Once this hormone, osteocalcin, was identified, it became clear that bone exerts a profound and complex influence on glucose and fat metabolism. This review highlights the most important salient features of this novel regulation of energy metabolism.

Integrity signals

Registry

Crossref · 10.1016/j.tem.2008.02.006

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Lee, N. K., & Karsenty, G.
Affiliations
Columbia University (US)
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2008-07
Volume
19
Issue
5
Pages
161-166
ISSN
1043-2760 (ISSN-L)
OpenAlex
W2052383327
Cited by
190
References
43
Citations by year
2026: 2 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 7 · 2017: 14 · 2016: 8 · 2015: 18 · 2014: 17 · 2013: 17 · 2012: 16
FWCI
1.67
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
osteocalcin, bone metabolism, energy metabolism, glucose metabolism, fat metabolism, genetic modifiers
MeSH terms
Animals, Bone and Bones, Energy Metabolism, Feedback, Mice, Mutant Strains, Osteoblasts, Osteoclasts, Osteocalcin, Bone Remodeling, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review