The altered mononuclear cell-derived cytokine response to glucose ingestion is not regulated by excess adiposity in polycystic ovary syndrome

González, Frank; Sia, Chang Ling; Shepard, Marguerite K.; Rote, Neal S.; Minium, Judi

doi:10.1210/jc.2014-2046

Cited by 35Ovarian function and disordersAdipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and Lipoproteins

The altered mononuclear cell-derived cytokine response to glucose ingestion is not regulated by excess adiposity in polycystic ovary syndrome

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González, Frank, Sia, Chang Ling, Shepard, Marguerite K., Rote, Neal S., Minium, Judi·2014·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2014-2046PMC PMC4223432

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Abstract

CONTEXT: Excess adipose tissue is a source of inflammation. Polycystic ovary syndrome (PCOS) is a proinflammatory state and is often associated with excess abdominal adiposity (AA) alone and/or frank obesity. OBJECTIVE: To determine the effect of glucose ingestion on cytokine release from mononuclear cells (MNC) in women with PCOS with and without excess AA and/or obesity. DESIGN: A cross-sectional study. SETTING: Academic medical center. PATIENTS: Twenty-three women with PCOS (seven normal weight with normal AA, eight normal weight with excess AA, eight obese) and 24 ovulatory controls (eight normal weight with normal AA, eight normal weight with excess AA, eight obese). INTERVENTION: Three-hour 75-g oral glucose tolerance test (OGTT). MAIN OUTCOME MEASURES: Body composition was measured by dual energy x-ray absorptiometry. Insulin sensitivity was derived from the OGTT (ISOGTT). TNFα, IL-6, and IL-1β release was measured in supernatants of cultured MNC isolated from blood samples drawn while fasting and 2 hours after glucose ingestion. RESULTS: Insulin sensitivity was lower in obese subjects regardless of PCOS status and in normal-weight women with PCOS compared with normal-weight controls regardless of body composition status. In response to glucose ingestion, MNC-derived TNFα, IL-6, and IL-1β release decreased in both normal-weight control groups but failed to suppress in either normal-weight PCOS group and in obese women regardless of PCOS status. For the combined groups, the cytokine responses were negatively correlated with insulin sensitivity and positively correlated with abdominal fat and androgens. CONCLUSIONS: Women with PCOS fail to suppress MNC-derived cytokine release in response to glucose ingestion, and this response is independent of excess adiposity. Nevertheless, a similar response is also a feature of obesity per se. Circulating MNC and excess adipose tissue are separate and distinct sources of inflammation in this population.

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Specific nutrients, such as glucose, are able to stimulate the production of androgen by ovarian and directly promote inflammation in PCOS women.
“specific nutrients, such as glucose, are able to stimulate the production of androgen by ovarian and directly promote inflammation in PCOS women [65,68].”
From Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS) (2019) · cites this paper as [65]
This pro-inflammatory status might result in exacerbating IR, hyperandrogenism and inflammation in women with PCOS.
“This pro-inflammatory status might result in exacerbating IR, hyperandrogenism and inflammation in women with PCOS [65].”
From Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS) (2019) · cites this paper as [65]
Ovarian dysfunction in PCOS may be further enhanced by specific nutritional deficiencies and high dietary contents of sugar and fat.
“Besides a well-established role of weight gain in the pathophysiology of IR, there is evidence that ovarian dysfunction in PCOS may be further enhanced by specific nutritional deficiencies and high dietary contents of sugar and fat [126,127].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [127]

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Authors: González, F., Sia, C. L., Shepard, M. K., Rote, N. S., & Minium, J.
Affiliations: Indiana University Indianapolis (US)
Case Western Reserve University (US)
Corresponding author: González, Frank
ORCID: González, Frank
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2014-11-01
Volume: 99
Issue: 11
Pages: E2244-E2251
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2014-2046
PMC: PMC4223432
OpenAlex: W1976898950
Cited by: 35
References: 42
Citations by year: 2026: 1 · 2024: 4 · 2023: 2 · 2022: 6 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 3 · 2016: 4 · 2015: 4
FWCI: 3.23
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
IUScholarWorks (Indiana University) (submittedVersion)
Purdue University Indianapolis (Indiana University) (submittedVersion)
PMC
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-048535, R03HD048535)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: polycystic ovary syndrome, mononuclear cells, cytokine response, glucose ingestion, insulin sensitivity, abdominal fat, obesity, inflammation, TNF-α, interleukin-6, IL-1β, androgens, oral glucose tolerance test
MeSH terms: Adult, Body Composition, Cross-Sectional Studies, Female, Glucose, Glucose Tolerance Test, Humans, Leukocytes, Mononuclear, Polycystic Ovary Syndrome, Tumor Necrosis Factor-alpha, Interleukin-6, Adiposity, Interleukin-1beta, Young Adult

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The altered mononuclear cell-derived cytokine response to glucose ingestion is not regulated by excess adiposity in polycystic ovary syndrome

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