Krebs Cycle Metabolite Profiling for Identification and Stratification of Pheochromocytomas/Paragangliomas due to Succinate Dehydrogenase Deficiency

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase

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Accumulation of Krebs cycle intermediates and over-expression of HIF1α in tumours which result from germline FH and SDH mutations

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2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas

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SDH mutations establish a hypermethylator phenotype in paraganglioma

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Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking <i>KIT</i> and <i>PDGFRA</i> mutations

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Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas.

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Plasma methoxytyramine: A novel biomarker of metastatic pheochromocytoma and paraganglioma in relation to established risk factors of tumour size, location and SDHB mutation status

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Germline SDHB Mutations and Familial Renal Cell Carcinoma

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An Update on the Genetics of Paraganglioma, Pheochromocytoma, and Associated Hereditary Syndromes

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The Mitochondrial Chaperone TRAP1 Promotes Neoplastic Growth by Inhibiting Succinate Dehydrogenase

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The Warburg effect is genetically determined in inherited pheochromocytomas

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Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia

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Identification of additional IDH mutations associated with oncometabolite R(−)-2-hydroxyglutarate production

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Succinate inhibition of α-ketoglutarate-dependent enzymes in a yeast model of paraganglioma

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Analysis of plasma 3-methoxytyramine, normetanephrine and metanephrine by ultraperformance liquid chromatographytandem mass spectrometry: utility for diagnosis of dopamine-producing metastatic phaeochromocytoma

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Diagnostic Tests and Biomarkers for Pheochromocytoma and Extra-adrenal Paraganglioma: From Routine Laboratory Methods to Disease Stratification

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Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism

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GENETICS IN ENDOCRINOLOGY: The genetics of phaeochromocytoma: using clinical features to guide genetic testing

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A Comprehensive Next Generation Sequencing–Based Genetic Testing Strategy To Improve Diagnosis of Inherited Pheochromocytoma and Paraganglioma

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Simultaneous liquid chromatography tandem mass spectrometric determination of urinary free metanephrines and catecholamines, with comparisons of free and deconjugated metabolites

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Large Germline Deletions of Mitochondrial Complex II Subunits SDHB and SDHD in Hereditary Paraganglioma

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The management of head-and-neck paragangliomas

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Succinate-to-Fumarate Ratio as a New Metabolic Marker to Detect the Presence of SDHB/D-related Paraganglioma: Initial Experimental and Ex Vivo Findings

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Metabolomic Profiling from Formalin-Fixed, Paraffin-Embedded Tumor Tissue Using Targeted LC/MS/MS: Application in Sarcoma

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Gross SDHB deletions in patients with paraganglioma detected by multiplex PCR: A possible hot spot?

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Puzzling Patterns of Predisposition

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Genotype-Specific Abnormalities in Mitochondrial Function Associate with Distinct Profiles of Energy Metabolism and Catecholamine Content in Pheochromocytoma and Paraganglioma

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Next-Generation Sequencing for Clinical Diagnostics

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Identification of a Signaling Axis HIF-1α/MicroRNA-210/ISCU Independent of SDH Mutation That Defines a Subgroup of Head and Neck Paragangliomas

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A New Specific Succinate-Glutamate Metabolomic Hallmark in Sdhx-Related Paragangliomas

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Accumulation of 2-hydroxyglutarate is not a biomarker for malignant progression in IDH-mutated low-grade gliomas

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Mitochondrial function and content in pheochromocytoma/paraganglioma of succinate dehydrogenase mutation carriers

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Pitfalls in Genetic Analysis of Pheochromocytomas/Paragangliomas—Case Report

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Where metabolism meets oncogenesis: another false lead?

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Glutamine reliance in cell metabolism

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SDHB/SDHA immunohistochemistry in pheochromocytomas and paragangliomas: a multicenter interobserver variation analysis using virtual microscopy: a Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T)

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Current Approaches and Recent Developments in the Management of Head and Neck Paragangliomas

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New treatment strategies for advanced-stage gastrointestinal stromal tumours

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SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery

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Biochemical Assessment of Pheochromocytoma and Paraganglioma

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Metabolome-guided genomics to identify pathogenic variants in isocitrate dehydrogenase, fumarate hydratase, and succinate dehydrogenase genes in pheochromocytoma and paraganglioma

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Development of a LC-MS/MS Method for the Simultaneous Detection of Tricarboxylic Acid Cycle Intermediates in a Range of Biological Matrices

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Oncometabolites: A New Paradigm for Oncology, Metabolism, and the Clinical Laboratory

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SDHi fungicides: An example of mitotoxic pesticides targeting the succinate dehydrogenase complex

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Targeted Exome Sequencing of Krebs Cycle Genes Reveals Candidate Cancer–Predisposing Mutations in Pheochromocytomas and Paragangliomas

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Metabologenomics of Phaeochromocytoma and Paraganglioma: An Integrated Approach for Personalised Biochemical and Genetic Testing.

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Succinate uptake by T cells suppresses their effector function via inhibition of mitochondrial glucose oxidation

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Clinical implications of the oncometabolite succinate in SDHx ‐mutation carriers

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Biomedical analysis of formalin-fixed, paraffin-embedded tissue samples: The Holy Grail for molecular diagnostics

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Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate

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In Vivo Detection of Succinate by Magnetic Resonance Spectroscopy as a Hallmark of SDH x Mutations in Paraganglioma

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Metabolome Profiling by HRMAS NMR Spectroscopy of Pheochromocytomas and Paragangliomas Detects SDH Deficiency: Clinical and Pathophysiological Implications

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Challenges in Paragangliomas and Pheochromocytomas: from Histology to Molecular Immunohistochemistry

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GEP- NETS UPDATE: Genetics of neuroendocrine tumors

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Metabolic implications of hypoxia and pseudohypoxia in pheochromocytoma and paraganglioma

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Pheochromocytoma: The First Metabolic Endocrine Cancer

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Pheochromocytoma/paraganglioma: recent updates in genetics, biochemistry, immunohistochemistry, metabolomics, imaging and therapeutic options

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A review of the tumour spectrum of germline succinate dehydrogenase gene mutations: Beyond phaeochromocytoma and paraganglioma

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Intricacies of the Molecular Machinery of Catecholamine Biosynthesis and Secretion by Chromaffin Cells of the Normal Adrenal Medulla and in Pheochromocytoma and Paraganglioma

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Pheochromocytoma: A Genetic And Diagnostic Update

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Precision medicine in pheochromocytoma and paraganglioma: current and future concepts

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Epigenetic Mutation of the Succinate Dehydrogenase C Promoter in a Patient With Two Paragangliomas

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HEREDITARY ENDOCRINE TUMOURS: CURRENT STATE-OF-THE-ART AND RESEARCH OPPORTUNITIES: Metastatic pheochromocytomas and paragangliomas: proceedings of the MEN2019 workshop

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Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad

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New Biology of Pheochromocytoma and Paraganglioma

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Impact of LC-MS/MS on the laboratory diagnosis of catecholamine-producing tumors

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The 3PAs: An Update on the Association of Pheochromocytomas, Paragangliomas, and Pituitary Tumors

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Metabolomics, machine learning and immunohistochemistry to predict succinate dehydrogenase mutational status in phaeochromocytomas and paragangliomas

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The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/Paraganglioma

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SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas

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An Optimized Method of Metabolite Extraction from Formalin-Fixed Paraffin-Embedded Tissue for GC/MS Analysis

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Succinate Mediates Tumorigenic Effects via Succinate Receptor 1: Potential for New Targeted Treatment Strategies in Succinate Dehydrogenase Deficient Paragangliomas

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Magnetic resonance spectroscopy of paragangliomas: new insights into in vivo metabolomics

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