The Warburg effect is genetically determined in inherited pheochromocytomas

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197 · see citing works

Bioconductor: open software development for computational biology and bioinformatics

Gentleman, R., Carey, V., Bates, D., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004) · Genome Biology · doi:10.1186/gb-2004-5-10-r80 · Cited by 13,133 · see citing works

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

Irizarry, R. A. (2003) · Biostatistics · doi:10.1093/biostatistics/4.2.249 · Cited by 10,603 · see citing works

Targeting HIF-1 for cancer therapy

Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717 · see citing works

On Respiratory Impairment in Cancer Cells

Warburg, O. H. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,472 · see citing works

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase

Selak, M. A., Armour, S. M., MacKenzie, E. D., Boulahbel, H., Watson, D. G., Mansfield, K. D., Pan, Y., Simon, M. C., Thompson, C. B., & Gottlieb, E. (2005) · Cancer Cell · doi:10.1016/j.ccr.2004.11.022 · Cited by 2,108 · see citing works

TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

Bensaad, K., Tsuruta, A., Selak, M. A., Vidal, M. N. C., Nakano, K., Bartrons, R., Gottlieb, E., & Vousden, K. H. (2006) · Cell · doi:10.1016/j.cell.2006.05.036 · Cited by 2,019 · see citing works

p53 Regulates Mitochondrial Respiration

Matoba, S., Kang, J.-G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P. J., Bunz, F., & Hwang, P. M. (2006) · Science · doi:10.1126/science.1126863 · Cited by 1,650 · see citing works

HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells

Fukuda, R., Zhang, H., Kim, J.-W., Shimoda, L., Dang, C. V., & Semenza, G. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.047 · Cited by 1,225 · see citing works

Role of VHL Gene Mutation in Human Cancer

Kim, W. Y., & Kaelin, W. G. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.05.061 · Cited by 940 · see citing works

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

Zhang, H., Gao, P., Fukuda, R., Kumar, G., Krishnamachary, B., Zeller, K. I., Dang, C. V., & Semenza, G. L. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.04.001 · Cited by 885 · see citing works

Genetic Testing in Pheochromocytoma or Functional Paraganglioma

Amar, L., Bertherat, J. Y., Baudin, É., Ajzenberg, C., Paillerets, B. B., Chabre, O., Chamontin, B., Delemer, B., Giraud, S., Murat, A., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.1484 · Cited by 683 · see citing works

Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer

King, A., Selak, M. A., & Gottlieb, E. (2006) · Oncogene · doi:10.1038/sj.onc.1209594 · Cited by 672 · see citing works

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

Kim, J.-W., Gao, P., Liu, Y.-C., Semenza, G. L., & Dang, C. V. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00440-07 · Cited by 658 · see citing works

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

Tian, H., Hammer, R. E., Matsumoto, A. M., Russell, D. W., & McKnight, S. L. (1998) · Genes & Development · doi:10.1101/gad.12.21.3320 · Cited by 647 · see citing works

Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation

Uldry, M., Yang, W., St‐Pierre, J., Lin, J. D., Seale, P., & Spiegelman, B. M. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.002 · Cited by 644 · see citing works

Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy

Mathupala, S. P., Ko, Y. H., & Pedersen, P. L. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.11.006 · Cited by 578 · see citing works

An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis

van Nederveen, F. H., Gaal, J., Favier, J., Korpershoek, E., Oldenburg, R. A., de Bruyn, E. M., Sleddens, H. F. B. M., Derkx, P., Rivière, J., Dannenberg, H., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70164-0 · Cited by 534 · see citing works

Roles of p53, MYC and HIF-1 in regulating glycolysis–the seventh hallmark of cancer

Yeung, S. J., Pan, J., & Lee, M.-H. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8224-x · Cited by 514 · see citing works

Succinate Dehydrogenase B Gene Mutations Predict Survival in Patients with Malignant Pheochromocytomas or Paragangliomas

Amar, L., Baudin, É., Burnichon, N., Peyrard, S., Silvera, S., Bertherat, J. Y., BERTAGNA, X. Y., Schlumberger, M. J., Jeunemaı̂tre, X., Gimenez‐Roqueplo, A., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0709 · Cited by 447 · see citing works

A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas

Dahia, P. L. M., Ross, K. N., Wright, M. E., Hayashida, C. Y., Santagata, S., Barontini, M., Kung, A. L., Sanso, G., Powers, J. F., Tischler, A. S., et al. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010008 · Cited by 443 · see citing works

Mitochondrial Uncoupling and the Warburg Effect: Molecular Basis for the Reprogramming of Cancer Cell Metabolism

Samudio, I. J., Fiegl, M., & Andreeff, M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3722 · Cited by 309 · see citing works

Differential Regulation of the Transcriptional Activities of Hypoxia-Inducible Factor 1 Alpha (HIF-1α) and HIF-2α in Stem Cells

Hu, C., Iyer, S. R., Sataur, A., Covello, K. L., Chodosh, L. A., & Simon, M. C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.9.3514-3526.2006 · Cited by 267 · see citing works

Proteomic changes in renal cancer and co‐ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect

Unwin, R. D., Craven, R. A., Harnden, P., Hanrahan, S. J., Totty, N., Knowles, M. A., Ian Eardley, C., Selby, P. J., & Banks, R. E. (2003) · PROTEOMICS · doi:10.1002/pmic.200300464 · Cited by 244 · see citing works

p53 Stabilization and Transactivation by a von Hippel-Lindau Protein

Roe, J., Kim, H., Lee, S.-M., Kim, S.-T., Cho, E., & Youn, H. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.04.006 · Cited by 240 · see citing works

Distinct gene expression profiles in norepinephrine- and epinephrine-producing hereditary and sporadic pheochromocytomas: activation of hypoxia-driven angiogenic pathways in von Hippel–Lindau syndrome

Eisenhofer, G., Huynh, T.-T., Pacak, K., Brouwers, F. M., Walther, M. M., Linehan, W. M., Munson, P. J., Mannelli, M., Goldstein, D. S., & Elkahloun, A. G. (2004) · Endocrine-Related Cancer · doi:10.1677/erc.1.00838 · Cited by 207 · see citing works

Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis

Lebedeva, M. A., Eaton, J. S., & Shadel, G. S. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.01.004 · Cited by 184 · see citing works

Mitochondrial succinate is instrumental for HIF1α nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions

Brière, J.-J., Favier, J., Bénit, P., Ghouzzi, V. E., Lorenzato, A., Rabier, D., Renzo, M. F. D., Gimenez‐Roqueplo, A., & Rustin, P. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi359 · Cited by 153 · see citing works

Expression of HIF-1α, HIF-2α (EPAS1), and Their Target Genes in Paraganglioma and Pheochromocytoma with VHL and SDH Mutations

Pollard, P. J., El-Bahrawy, M. A., Poulsom, R., Elia, G., Killick, P., Kelly, G. P., Hunt, T., Jeffery, R. E., Seedhar, P., Barwell, J., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0920 · Cited by 140 · see citing works

Three spectrophotometric assays for the measurement of the five respiratory chain complexes in minuscule biological samples

Bénit, P., Gonçalves, S., Dassa, E. P., Brière, J.-J., Martin, G. R., & Rustin, P. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2006.05.034 · Cited by 101 · see citing works

17q12-21 amplicon, a novel recurrent genetic change in intestinal type of gastric carcinoma: A comparative genomic hybridization study

Kokkola, A., Monni, O. M., Puolakkainen, P. A., Larramendy, M. L., Victorzon, M., Nordling, S., Haapiainen, R. K., Kivilaakso, E. O., & Knuutila, S. (1997) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199709)20:1 · Cited by 100 · see citing works

Hereditary Paraganglioma/Pheochromocytoma and Inherited Succinate Dehydrogenase Deficiency

Favier, J., Brière, J.-J., Strompf, L., Amar, L., Filali, M., Jeunemaı̂tre, X., Rustin, P., & Gimenez‐Roqueplo, A. (2005) · Hormone Research in Paediatrics · doi:10.1159/000084685 · Cited by 86 · see citing works

A new role for the von Hippel-Lindau tumor suppressor protein: stimulation of mitochondrial oxidative phosphorylation complex biogenesis

Hervouet, É. (2004) · Carcinogenesis · doi:10.1093/carcin/bgi001 · Cited by 82 · see citing works

Proteomic analysis of primary cell lines identifies protein changes present in renal cell carcinoma

Craven, R. A., Stanley, A. J., Hanrahan, S. J., Dods, J. S., Unwin, R. D., Totty, N., Harnden, P., Ian Eardley, C., Selby, P. J., & Banks, R. E. (2006) · PROTEOMICS · doi:10.1002/pmic.200500549 · Cited by 76 · see citing works

HIF-2α expression in human fetal paraganglia and neuroblastoma: relation to sympathetic differentiation, glucose deficiency, and hypoxia

Nilsson, H., Jögi, A., Beckman, S., Harris, A. L., Poellinger, L., & Påhlman, S. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.10.003 · Cited by 75 · see citing works

Role of positron emission tomography and bone scintigraphy in the evaluation of bone involvement in metastatic pheochromocytoma and paraganglioma: specific implications for succinate dehydrogenase enzyme subunit B gene mutations

Zelinka, T., Timmers, H. J. L. M., Kozupa, A., Chen, C. C., Carrasquillo, J. A., Reynolds, J. C., Ling, A. L., Eisenhofer, G., Lazúrová, I., Adams, K. T., et al. (2008) · Endocrine Related Cancer · doi:10.1677/erc-07-0217 · Cited by 67 · see citing works

Cloning and expression pattern of EPAS1 in the chicken embryo

Favier, J., Kempf, H., Corvol, P. L., & Gasc, J. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01476-3 · Cited by 51 · see citing works

Mitochondria and Cancer

Rustin, P., & Kroemer, G. (2008) · Ernst Schering Research Foundation workshop/Ernst Schering Foundation Symposium proceedings · doi:10.1007/2789_2008_086 · Cited by 45 · see citing works

The relatively high frequency of p53 gene mutations in multiple and malignant phaeochromocytomas

Yoshimoto, T., Naruse, M., Zeng, Z., Nishikawa, T., Kasajima, T., Toma, H., Yamamori, S., Matsumoto, H., Tanabe, A., Naruse, K., et al. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1590247 · Cited by 40 · see citing works

Frequent loss of 17p, but no p53 mutations or protein overexpression in benign and malignant pheochromocytomas

Petri, B., Speel, E. M., Korpershoek, E., Claessen, S. M. H., van Nederveen, F. H., Giesen, V., Dannenberg, H., van der Harst, E., Dinjens, W. N. M., & de Krijger, R. R. (2008) · Modern Pathology · doi:10.1038/modpathol.3801013 · Cited by 29 · see citing works

Transcriptional adaptation of neuroblastoma cells to hypoxia

Fredlund, E., Ovenberger, M., Borg, Å., & Påhlman, S. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.12.074 · Cited by 25 · see citing works

Mitochondria and Cancer

Owens, K. M., Modica-Napolitano, J. S., & Singh, K. K. (2008) · Springer eBooks · doi:10.1007/978-0-387-84835-8_1 · Cited by 21 · see citing works

SDH mutations establish a hypermethylator phenotype in paraganglioma

Letouzé, E., Martinelli, C., Loriot, C., Burnichon, N., Abermil, N., Ottolenghi, C., Janin, M., Menara, M., Nguyen, A. T., Benit, P., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.04.018 · Cited by 776 · see citing works

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

Wigerup, C., Påhlman, S., & Bexell, D. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.04.009 · Cited by 687 · see citing works

Cancer as a metabolic disease

Seyfried, T. N., & Shelton, L. M. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-7 · Cited by 656 · see citing works

SDHA is a tumor suppressor gene causing paraganglioma

Burnichon, N., Brière, J.-J., Libé, R., Vescovo, L., Rivière, J., Tissier, F., Jouanno, E., Jeunemaı̂tre, X., Bénit, P., Tzagoloff, A., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq206 · Cited by 645 · see citing works

Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma

Comino‐Méndez, I., Gracia-Aznárez, F. J., Schiavi, F., Landa, I., Leandro-Garcia, L. J., Letón, R., Honrado, E., Ramos‐Medina, R., Caronia, D., Pita, G., et al. (2011) · Nature Genetics · doi:10.1038/ng.861 · Cited by 528 · see citing works

Paraganglioma and phaeochromocytoma: from genetics to personalized medicine

Favier, J., Amar, L., & Gimenez‐Roqueplo, A. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.188 · Cited by 484 · see citing works

Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneity

Dahia, P. L. M. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3648 · Cited by 545 · see citing works

European Association of Nuclear Medicine Practice Guideline/Society of Nuclear Medicine and Molecular Imaging Procedure Standard 2019 for radionuclide imaging of phaeochromocytoma and paraganglioma

Taïeb, D., Hicks, R. J., Hindié, E., Guillet, B. A., Avram, A. M., Ghedini, P., Timmers, H. J. L. M., Scott, A. T., Elojeimy, S. N., Rubello, D., et al. (2019) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-019-04398-1 · Cited by 403 · see citing works

Somatic<i>HIF2A</i>Gain-of-Function Mutations in Paraganglioma with Polycythemia

Zhuang, Z., Yang, C., Lorenzo, F., Merino, M., Fojo, T., Kebebew, E., Popovic, V., Stratakis, C. A., Prchal, J. T., & Pacak, K. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1205119 · Cited by 397 · see citing works

SDH mutations in cancer

Bardella, C., Pollard, P. J., & Tomlinson, I. (2011) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2011.07.003 · Cited by 395 · see citing works

Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity

Tello, D., Balsa, E., Acosta‐Iborra, B., Fuertes-Yebra, E., Elorza, A., Ordóñez, Á., Corral-Escariz, M., Soro-Arnáiz, I., López-Bernardo, E., Perales‐Clemente, E., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.10.008 · Cited by 369 · see citing works

Genetics and clinical characteristics of hereditary pheochromocytomas and paragangliomas

Welander, J., Söderkvist, P., & Gimm, O. (2011) · Endocrine Related Cancer · doi:10.1530/erc-11-0170 · Cited by 356 · see citing works

MAX Mutations Cause Hereditary and Sporadic Pheochromocytoma and Paraganglioma

Burnichon, N., Cascón, A., Schiavi, F., Morales, N. P., Comino‐Méndez, I., Abermil, N., Inglada‐Pérez, L., de Cubas, A. A., Amar, L., Barontini, M., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0160 · Cited by 331 · see citing works

New Perspectives on Pheochromocytoma and Paraganglioma: Toward a Molecular Classification

Crona, J., Taïeb, D., & Pacák, K. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00062 · Cited by 322 · see citing works

Integrative genomic analysis reveals somatic mutations in pheochromocytoma and paraganglioma

Burnichon, N., Vescovo, L., Amar, L., Libé, R., de Reyniès, A., Vénisse, A., Jouanno, E., Laurendeau, I., Parfait, B., Bertherat, J. Y., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr324 · Cited by 304 · see citing works

The Redox Basis of Epigenetic Modifications: From Mechanisms to Functional Consequences

Cyr, A. R., & Domann, F. E. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3492 · Cited by 294 · see citing works

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis

Cardaci, S., Zheng, L., MacKay, G., van den Broek, N. J. F., MacKenzie, E. D., Nixon, C., Stevenson, D., Tumanov, S., Bulusu, V., Kamphorst, J. J., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3233 · Cited by 286 · see citing works

Staging and Functional Characterization of Pheochromocytoma and Paraganglioma by 18F-Fluorodeoxyglucose (18F-FDG) Positron Emission Tomography

Timmers, H. J. L. M., Chen, C. C., Carrasquillo, J. A., Whatley, M. A., Ling, A. L., Eisenhofer, G., King, K. S., Rao, J. U., WESLEY, R. A., Adams, K. T., et al. (2012) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djs188 · Cited by 278 · see citing works

EANM 2012 guidelines for radionuclide imaging of phaeochromocytoma and paraganglioma

Taïeb, D., Timmers, H. J. L. M., Hindié, E., Guillet, B. A., Neumann, H. P. H., Walz, M. K., Opocher, G., de Herder, W. W., Boedeker, C. C., de Krijger, R. R., et al. (2012) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-012-2215-8 · Cited by 253 · see citing works

Oxidative phosphorylation in cancer cells

Solaini, G., Sgarbi, G., & Baracca, A. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.09.003 · Cited by 231 · see citing works

Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism

Lussey-Lepoutre, C., Hollinshead, K. E. R., Ludwig, C., Menara, M., Morin, A., Castro-Vega, L.-J., Parker, S. J., Janin, M., Martinelli, C., Ottolenghi, C., et al. (2015) · Nature Communications · doi:10.1038/ncomms9784 · Cited by 227 · see citing works

Research Resource: Transcriptional Profiling Reveals Different Pseudohypoxic Signatures in SDHB and VHL-Related Pheochromocytomas

López-Jiménez, E. A., Goméz-López, G., Leandro-Garcia, L. J., Muñoz, I., Schiavi, F., Montero‐Conde, C., de Cubas, A. A., Fernández‐Ramires, R., Landa, I., Leskelä, S., et al. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0256 · Cited by 209 · see citing works

Catecholamine metabolomic and secretory phenotypes in phaeochromocytoma

Eisenhofer, G., Pacák, K., Huynh, T.-T., Qin, N., Bratslavsky, G., Linehan, W. M., Mannelli, M., Friberg, P., Grebe, S. K., Timmers, H. J. L. M., et al. (2010) · Endocrine Related Cancer · doi:10.1677/erc-10-0211 · Cited by 206 · see citing works

Pheochromocytoma and paraganglioma: Diagnosis, genetics, management, and treatment

Martucci, V. L., & Pacák, K. (2014) · Current Problems in Cancer · doi:10.1016/j.currproblcancer.2014.01.001 · Cited by 204 · see citing works

Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas

Castro‐Vega, L. J., Letouzé, É., Burnichon, N., Buffet, A., Disderot, P.-H., Khalifa, E., Loriot, C., Elarouci, N., Morin, A., Menara, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms7044 · Cited by 195 · see citing works

Metastatic Pheochromocytoma/Paraganglioma Related to Primary Tumor Development in Childhood or Adolescence: Significant Link to SDHB Mutations

King, K. S., Prodanov, T., Kantorovich, V., Fojo, T., Hewitt, J. K., Zacharin, M., WESLEY, R. A., Lodish, M. B., Raygada, M. J., Gimenez‐Roqueplo, A., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.34.6353 · Cited by 193 · see citing works

Current and Future Treatments for Malignant Pheochromocytoma and Sympathetic Paraganglioma

Jiménez, C., ROHREN, E. M., Habra, M. A., Rich, T. A., Jiménez, P., Ayala‐Ramirez, M., & Baudin, É. (2013) · Current Oncology Reports · doi:10.1007/s11912-013-0320-x · Cited by 179 · see citing works

Hypoxia-Inducible Factor Signaling in Pheochromocytoma: Turning the Rudder in the Right Direction

Jochmanová, I., Yang, C., Zhuang, Z., & Pacák, K. (2013) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt201 · Cited by 173 · see citing works

Current Approaches and Recent Developments in the Management of Head and Neck Paragangliomas

Taïeb, D., Kaliski, A., Boedeker, C. C., Martucci, V. L., Fojo, T., Adler, J. R., & Pacák, K. (2014) · Endocrine Reviews · doi:10.1210/er.2014-1026 · Cited by 169 · see citing works

Therapeutic targeting of the Warburg effect in pancreatic cancer relies on an absence of p53 function

Rajeshkumar, N. V., Dutta, P., Yabuuchi, S., de Wilde, R. F., Martinez, G. V., Le, A., Kamphorst, J. J., Rabinowitz, J. D., Jain, S. K., Hidalgo, M., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0108 · Cited by 158 · see citing works

Oncometabolites‐driven tumorigenesis: From genetics to targeted therapy

Morin, A., Letouzé, É., Gimenez‐Roqueplo, A., & Favier, J. (2014) · International Journal of Cancer · doi:10.1002/ijc.29080 · Cited by 150 · see citing works

Krebs Cycle Metabolite Profiling for Identification and Stratification of Pheochromocytomas/Paragangliomas due to Succinate Dehydrogenase Deficiency

Richter, S., Peitzsch, M., Rapizzi, E., Lenders, J. W., Qin, N., de Cubas, A. A., Schiavi, F., Rao, J. U., Beuschlein, F., Quinkler, M., et al. (2014) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2014-2151 · Cited by 135 · see citing works

The role of complex II in disease

Hoekstra, A. S., & Bayley, J. (2012) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.11.005 · Cited by 136 · see citing works

Updated and New Perspectives on Diagnosis, Prognosis, and Therapy of Malignant Pheochromocytoma/Paraganglioma

Parenti, G., Zampetti, B., Rapizzi, E., Ercolino, T., Giaché, V., & Mannelli, M. (2012) · Journal of Oncology · doi:10.1155/2012/872713 · Cited by 126 · see citing works

Isocitrate Dehydrogenase Mutations Are Rare in Pheochromocytomas and Paragangliomas

Gaal, J., Burnichon, N., Korpershoek, E., Roncelin, I., Bertherat, J. Y., Plouin, P., de Krijger, R. R., Gimenez‐Roqueplo, A., & Dinjens, W. N. M. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2170 · Cited by 126 · see citing works

Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer?

Lemarié, A., & Grimm, S. (2011) · Oncogene · doi:10.1038/onc.2011.167 · Cited by 123 · see citing works

Mechanistic Investigation into the Selective Anticancer Cytotoxicity and Immune System Response of Surface-Functionalized, Dichloroacetate-Loaded, UiO-66 Nanoparticles

Lázaro, I. A., Haddad, S., Rodrigo-Muñoz, J. M., Orellana‐Tavra, C., del Pozo, V., Fairen‐Jiménez, D., & Forgan, R. S. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b17756 · Cited by 120 · see citing works

Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree?

Bayley, J., & Devilee, P. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.02.008 · Cited by 117 · see citing works

Updates on the genetics and the clinical impacts on phaeochromocytoma and paraganglioma in the new era

Pillai, S., Gopalan, V., Smith, R. A., & Lam, A. K.-Y. (2016) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2016.01.022 · Cited by 113 · see citing works

Diagnostic Tests and Biomarkers for Pheochromocytoma and Extra-adrenal Paraganglioma: From Routine Laboratory Methods to Disease Stratification

Eisenhofer, G., Tischler, A. S., & de Krijger, R. R. (2011) · Endocrine Pathology · doi:10.1007/s12022-011-9188-1 · Cited by 111 · see citing works

Pheochromocytomas: The (pseudo)-hypoxia hypothesis

Favier, J., & Gimenez‐Roqueplo, A. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.10.004 · Cited by 110 · see citing works

Metastatic Paraganglioma

Fliedner, S. M. J., Lehnert, H., & Pacák, K. (2010) · Seminars in Oncology · doi:10.1053/j.seminoncol.2010.10.017 · Cited by 110 · see citing works

SDH-related pheochromocytoma and paraganglioma

Kantorovich, V., King, K. S., & Pacák, K. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.04.001 · Cited by 105 · see citing works

Mitochondrial complex II, a novel target for anti-cancer agents

Kluckova, K., Bezawork-Geleta, A., Rohlena, J., Dong, L., & Neuzil, J. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.10.015 · Cited by 104 · see citing works

TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition

Morin, A., Goncalves, J., Moog, S., Castro‐Vega, L. J., Job, S., Buffet, A., Fontenille, M., Woszczyk, J., Gimenez‐Roqueplo, A., Letouzé, É., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.022 · Cited by 105 · see citing works

Deregulation of glycolysis in cancer: glyceraldehyde-3-phosphate dehydrogenase as a therapeutic target

Krasnov, G. S., Dmitriev, A. A., Snezhkina, A. V., & Kudryavtseva, A. V. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.775253 · Cited by 98 · see citing works

NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma

Lai, R. K., Xu, M., Chiu, D. K., Tse, A. P., Wei, L. L., Law, C., Lee, D. P. H., Wong, C., Wong, M. P., Ng, I. O., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1987 · Cited by 91 · see citing works

Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors

Lorendeau, D., Rinaldi, G., Boon, R., Spincemaille, P., Metzger, K., Jäger, C., Christen, S., Dong, X., Kuenen, S., Voordeckers, K., et al. (2016) · Metabolic Engineering · doi:10.1016/j.ymben.2016.11.005 · Cited by 91 · see citing works

Rationale for Anti-angiogenic Therapy in Pheochromocytoma and Paraganglioma

Favier, J., Igaz, P., Burnichon, N., Amar, L., Libé, R., Badoual, C., Tissier, F., Bertherat, J. Y., Plouin, P., Jeunemaı̂tre, X., et al. (2011) · Endocrine Pathology · doi:10.1007/s12022-011-9189-0 · Cited by 86 · see citing works

Modern Nuclear Imaging for Paragangliomas: Beyond SPECT

Taïeb, D., Neumann, H. P. H., Rubello, D., AL-NAHHAS, A. M., Guillet, B. A., & Hindié, E. (2012) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.098152 · Cited by 85 · see citing works

Superiority of 68Ga-DOTATATE over 18F-FDG and anatomic imaging in the detection of succinate dehydrogenase mutation (SDHx )-related pheochromocytoma and paraganglioma in the pediatric population

Jha, A., Ling, A. L., Millo, C., Gupta, G., Viana, B., Lin, F. I., Herscovitch, P., Adams, K. T., Taïeb, D., Metwalli, A. R., et al. (2017) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-017-3896-9 · Cited by 87 · see citing works

Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel

Wojtovich, A. P., Smith, C. O., Haynes, C. M., Nehrke, K. W., & Brookes, P. S. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.12.007 · Cited by 83 · see citing works

Metabologenomics of Phaeochromocytoma and Paraganglioma: An Integrated Approach for Personalised Biochemical and Genetic Testing.

Eisenhofer, G., Klink, B., Richter, S., Lenders, J. W. M., & Robledo, M. (2017) · Europe PMC (PubMed Central) · Cited by 84 · see citing works

Targeted next-generation sequencing detects rare genetic events in pheochromocytoma and paraganglioma

Aim, L. B., Pigny, P., Castro‐Vega, L. J., Buffet, A., Amar, L., Bertherat, J. Y., Drui, D., Guilhem, I., Baudin, É., Lussey‐Lepoutre, C., et al. (2019) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2018-105714 · Cited by 83 · see citing works

Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC‐associated factor X

Qin, N., de Cubas, A. A., García-Martín, R., Richter, S., Peitzsch, M., Menschikowski, M., Lenders, J. W. M., Timmers, H. J. L. M., Mannelli, M., Opocher, G., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.28868 · Cited by 81 · see citing works

Frequent EPAS1/HIF2α exons 9 and 12 mutations in non-familial pheochromocytoma

Welander, J., Stenman, A., Brauckhoff, M., Bäckdahl, M., Larsson, C., Gimm, O., & Söderkvist, P. (2014) · Endocrine Related Cancer · doi:10.1530/erc-13-0384 · Cited by 79 · see citing works

Clinical implications of the oncometabolite succinate in SDHx ‐mutation carriers

Eijkelenkamp, K., Osinga, T. E., Links, T. P., & van der Horst‐Schrivers, A. N. A. (2019) · Clinical Genetics · doi:10.1111/cge.13553 · Cited by 77 · see citing works

Alterations of oxidative phosphorylation complexes in astrocytomas

Feichtinger, R. G., Weis, S., Mayr, J. A., Zimmermann, F., Geilberger, R., Sperl, W., & Kofler, B. (2014) · Glia · doi:10.1002/glia.22621 · Cited by 76 · see citing works

Correlation Between In Vivo 18F-FDG PET and Immunohistochemical Markers of Glucose Uptake and Metabolism in Pheochromocytoma and Paraganglioma

van Berkel, A., Rao, J. U., Küsters, B., Demir, T., Visser, E. P., Mensenkamp, A. R., van der Laak, J. A. W. M., Oosterwijk, E., Lenders, J. W. M., Sweep, F. C. G. J., et al. (2014) · Journal of Nuclear Medicine · doi:10.2967/jnumed.114.137034 · Cited by 76 · see citing works

Pheochromocytoma and Paraganglioma

Kantorovich, V., & Pacák, K. (2010) · Progress in brain research · doi:10.1016/s0079-6123(10)82015-1 · Cited by 75 · see citing works

Targeting NAD+/PARP DNA Repair Pathway as a Novel Therapeutic Approach to SDHB -Mutated Cluster I Pheochromocytoma and Paraganglioma

Pang, Y. K., Lu, Y., Caisová, V., Liu, Y., Bullova, P., Huynh, T., Zhou, Y., Yu, D., Fryšák, Z., Hartmann, I., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-3406 · Cited by 74 · see citing works

Phaeochromocytoma: a catecholamine and oxidative stress disorder

Pacák, K. (2011) · Endocrine Regulations · doi:10.4149/endo_2011_02_65 · Cited by 73 · see citing works

Pheochromocytoma and Paraganglioma

Pacák, K., & Wimalawansa, S. J. (2015) · Endocrine Practice · doi:10.4158/ep14481.ra · Cited by 70 · see citing works

Mutation of SDHB is a Cause of Hypoxia-Related High-Altitude Paraganglioma

Cerecer-Gil, N. Y., Figuera, L. E., Llamas, F. J., Lara, M., Escamilla, J. N., Ramos, R., Estrada, G., Hussain, A. K., Gaal, J., Korpershoek, E., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0637 · Cited by 70 · see citing works

Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate

Goncalves, J., Moog, S., Morin, A., Gentric, G., Müller, S., Morrell, A. P., Kľučková, K., Stewart, T. J., Andoniadou, C. L., Lussey‐Lepoutre, C., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-2936 · Cited by 72 · see citing works

SDHB loss predicts malignancy in pheochromocytomas/sympathethic paragangliomas, but not through hypoxia signalling

Blank, A., Schmitt, A. M., Korpershoek, E., van Nederveen, F. H., Rudolph, T. J., Weber, N., Strebel, R. T., de Krijger, R. R., Komminoth, P., & Perren, A. A. (2010) · Endocrine Related Cancer · doi:10.1677/erc-09-0316 · Cited by 66 · see citing works

Metabolic implications of hypoxia and pseudohypoxia in pheochromocytoma and paraganglioma

Kľučková, K., & Tennant, D. A. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2801-6 · Cited by 66 · see citing works

Pheochromocytoma: The First Metabolic Endocrine Cancer

Jochmanová, I., & Pacák, K. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0606 · Cited by 65 · see citing works

Intricacies of the Molecular Machinery of Catecholamine Biosynthesis and Secretion by Chromaffin Cells of the Normal Adrenal Medulla and in Pheochromocytoma and Paraganglioma

Berends, A. M. A., Eisenhofer, G., Fishbein, L. M., van der Horst‐Schrivers, A. N. A., Kema, I. P., Links, T. P., Lenders, J. W. M., & Kerstens, M. N. (2019) · Cancers · doi:10.3390/cancers11081121 · Cited by 63 · see citing works

Rethinking pheochromocytomas and paragangliomas from a genomic perspective

Castro‐Vega, L. J., Lussey‐Lepoutre, C., Gimenez‐Roqueplo, A., & Favier, J. (2015) · Oncogene · doi:10.1038/onc.2015.172 · Cited by 64 · see citing works

Simultaneous positron emission tomography and ultrafast ultrasound for hybrid molecular, anatomical and functional imaging

Provost, J., Garofalakis, A., Sourdon, J., Bouda, D., Berthon, B., Viel, T., Pérez-Liva, M., Lussey‐Lepoutre, C., Favier, J., Correia, M., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0188-z · Cited by 62 · see citing works

MANAGEMENT OF ENDOCRINE DISEASE: Clinical management of paragangliomas

Corssmit, E. P. M., & Romijn, J. A. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0396 · Cited by 61 · see citing works

Signaling Pathways in Pheochromocytomas and Paragangliomas: Prospects for Future Therapies

Nölting, S., & Grossman, A. B. (2012) · Endocrine Pathology · doi:10.1007/s12022-012-9199-6 · Cited by 61 · see citing works

15 YEARS OF PARAGANGLIOMA: Genetics and mechanism of pheochromocytoma–paraganglioma syndromes characterized by germline SDHB and SDHD mutations

Baysal, B. E., & Maher, E. R. (2015) · Endocrine Related Cancer · doi:10.1530/erc-15-0226 · Cited by 60 · see citing works

Genotype-Specific Abnormalities in Mitochondrial Function Associate with Distinct Profiles of Energy Metabolism and Catecholamine Content in Pheochromocytoma and Paraganglioma

Rao, J. U., Engelke, U. F. H., Rodenburg, R. J., Wevers, R. A., Pacák, K., Eisenhofer, G., Qin, N., Küsters, B., Goudswaard, A. G., Lenders, J. W. M., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3922 · Cited by 58 · see citing works

Metastatic Phaeochromocytoma: Spinning Towards More Promising Treatment Options

Nölting, S., Grossman, A. B., & Pacák, K. (2018) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-0715-1888 · Cited by 56 · see citing works

Integrative analysis of miRNA and mRNA expression profiles in pheochromocytoma and paraganglioma identifies genotype-specific markers and potentially regulated pathways

de Cubas, A. A., Leandro-Garcia, L. J., Schiavi, F., Mančíková, V., Comino‐Méndez, I., Inglada‐Pérez, L., Pérez‐Martínez, M., Ibarz, N., Ximénez‐Embún, P., López-Jiménez, E. A., et al. (2013) · Endocrine Related Cancer · doi:10.1530/erc-12-0183 · Cited by 57 · see citing works

Distinct deregulation of the hypoxia inducible factor by PHD2 mutants identified in germline DNA of patients with polycythemia

Ladroue, C., Hoogewijs, D., Gad, S., Carcenac, R., Storti, F., Barrois, M., Gimenez-Roqueplo, A.-P., Leporrier, M., Casadevall, N., Hermine, O., et al. (2012) · Haematologica · doi:10.3324/haematol.2011.044644 · Cited by 55 · see citing works

SDHD Immunohistochemistry: A New Tool to ValidateSDHxMutations in Pheochromocytoma/Paraganglioma

Menara, M., Oudijk, L., Badoual, C., Bertherat, J. Y., Lussey‐Lepoutre, C., Amar, L., Iturrioz, X., Sibony, M., Zinzindohoué, F., de Krijger, R. R., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1870 · Cited by 55 · see citing works

Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics

Her, Y. F., & Maher, L. J. (2015) · International Journal of Endocrinology · doi:10.1155/2015/296167 · Cited by 53 · see citing works

Identification of a Signaling Axis HIF-1α/MicroRNA-210/ISCU Independent of SDH Mutation That Defines a Subgroup of Head and Neck Paragangliomas

Merlo, A., Fernández, S. B. D. Q., Secades, P., Zambrano, I., Balbı́n, M., Astudillo, A., Scola, B., Arístegui, M., Suarez, C. M., & Chiara, M. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2410 · Cited by 51 · see citing works

Immunohistochemical markers of the hypoxic response can identify malignancy in phaeochromocytomas and paragangliomas and optimize the detection of tumours with VHL germline mutations

Pinato, D. J., Ramachandran, R., Toussi, S. T. K., Vergine, M., Ngo, N., Sharma, R., Lloyd, T., Meeran, K. M., Palazzo, F. F., Martin, N., et al. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.538 · Cited by 52 · see citing works

From Nf1 to Sdhb knockout: Successes and failures in the quest for animal models of pheochromocytoma

Lussey‐Lepoutre, C., Thibault, C., Buffet, A., Morin, A., Badoual, C., Bénit, P., Rustin, P., Ottolenghi, C., Janin, M., Castro‐Vega, L. J., et al. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.06.027 · Cited by 48 · see citing works

Functional Imaging Signature of Patients Presenting with Polycythemia/Paraganglioma Syndromes

Janssen, I., Chen, C. C., Zhuang, Z., Millo, C., Wolf, K. I., Ling, A. L., Lin, F. I., Adams, K. T., Herscovitch, P., Feelders, R. A., et al. (2017) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.187690 · Cited by 47 · see citing works

Quantitative Analysis of Glucose Metabolic Cleavage in Glucose Transporters Overexpressed Cancer Cells by Target-Specific Fluorescent Gold Nanoclusters

Cheng, T.-M., Chu, H., Lee, Y.-C., Wang, D., Chang, C., Chung, K.-L., Yen, H., Hsiao, C.-W., Pan, X.-Y., Kuo, T., et al. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.7b04961 · Cited by 46 · see citing works

Combined Inhibition of mTORC1 and mTORC2 Signaling Pathways Is a Promising Therapeutic Option in Inhibiting Pheochromocytoma Tumor Growth: In Vitro and In Vivo Studies in Female Athymic Nude Mice

Giubellino, A., Bullova, P., Nölting, S., Turková, H., Powers, J. F., Liu, Q., Guichard, S. M., Tischler, A. S., Grossman, A. B., & Pacák, K. (2013) · Endocrinology · doi:10.1210/en.2012-1854 · Cited by 45 · see citing works

A novel TMEM127 mutation in a patient with familial bilateral pheochromocytoma

Burnichon, N., Lussey‐Lepoutre, C., Laffaire, J., Gadessaud, N., Molinié, V., Hernigou, A., Plouin, P., Jeunemaı̂tre, X., Favier, J., & Gimenez‐Roqueplo, A. (2010) · European Journal of Endocrinology · doi:10.1530/eje-10-0758 · Cited by 44 · see citing works

Impact of Extrinsic and Intrinsic Hypoxia on Catecholamine Biosynthesis in Absence or Presence of Hif2α in Pheochromocytoma Cells

Bechmann, N., Poser, I., Seifert, V., Greunke, C., Ullrich, M., Qin, N., Walch, A. K., Peitzsch, M., Robledo, M., Pacák, K., et al. (2019) · Cancers · doi:10.3390/cancers11050594 · Cited by 44 · see citing works

Therapeutic Targeting of SDHB -Mutated Pheochromocytoma/Paraganglioma with Pharmacologic Ascorbic Acid

Liu, Y., Pang, Y. K., Zhu, B., Uher, O., Caisová, V., Huynh, T., Taïeb, D., Vanova, K. H., Ghayee, H. K., Neužil, J., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-2335 · Cited by 46 · see citing works

A New Specific Succinate-Glutamate Metabolomic Hallmark in Sdhx-Related Paragangliomas

Impériale, A., Moussallieh, F., Sebag, F. A., Brunaud, L., Barlier, A., Elbayed, K., Bachellier, P., Goichot, B., Pacák, K., Namer, I. J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080539 · Cited by 43 · see citing works

Minireview: The Busy Road to Pheochromocytomas and Paragangliomas Has a New Member, TMEM127

Jiang, S., & Dahia, P. L. M. (2011) · Endocrinology · doi:10.1210/en.2011-0052 · Cited by 43 · see citing works

Molecular markers of paragangliomas/pheochromocytomas

Zhikrivetskaya, S. O., Snezhkina, A. V., Zaretsky, A. R., Alekseev, B. Y., Pokrovsky, A. V., Golovyuk, A. L., Melnikova, N. V., Stepanov, O. A., Kalinin, D. V., Moskalev, A., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15201 · Cited by 43 · see citing works

Theileria induces oxidative stress and HIF1α activation that are essential for host leukocyte transformation

Medjkane, S., Perichon, M., Marsolier, J., Dairou, J., & Weitzman, J. B. (2013) · Oncogene · doi:10.1038/onc.2013.134 · Cited by 42 · see citing works

The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/Paraganglioma

Song, P., Zhang, J., Tan, X., Huang, Y., Xu, J., Silk, N., Zhang, D., Liu, Q., & Jiang, J. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.586857 · Cited by 42 · see citing works

Role of Hypoxia and HIF2α in Development of the Sympathoadrenal Cell Lineage and Chromaffin Cell Tumors with Distinct Catecholamine Phenotypic Features

Richter, S., Qin, N., Pacak, K., & Eisenhofer, G. (2013) · Advances in Pharmacology · doi:10.1016/b978-0-12-411512-5.00014-2 · Cited by 42 · see citing works

Gerometabolites: The pseudohypoxic aging side of cancer oncometabolites

Menéndez, J. A., Alarcón, T., & Joven, J. (2014) · Cell Cycle · doi:10.4161/cc.28079 · Cited by 41 · see citing works

SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas

Armstrong, N., Storey, C. M., Noll, S. E., Margulis, K., Soe, M. H., Xu, H., Yeh, B. T., Fishbein, L. M., Kebebew, E., Howitt, B. E., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110453 · Cited by 41 · see citing works

Magnetic resonance spectroscopy of paragangliomas: new insights into in vivo metabolomics

Varoquaux, A. D., Fur, Y. L., Impériale, A., Reyre, A., Montava, M., Fakhry, N., Namer, I. J., Moulin, G., Pacák, K., Guye, M., et al. (2015) · Endocrine Related Cancer · doi:10.1530/erc-15-0246 · Cited by 39 · see citing works

Metabolic Subtyping of Pheochromocytoma and Paraganglioma by 18F-FDG Pharmacokinetics Using Dynamic PET/CT Scanning

van Berkel, A., Vriens, D., Visser, E. P., Janssen, M. J. R., Gotthardt, M., Hermus, A. R., de Geus‐Oei, L., & Timmers, H. J. L. M. (2018) · Journal of Nuclear Medicine · doi:10.2967/jnumed.118.216796 · Cited by 39 · see citing works

Genotype and Tumor Locus Determine Expression Profile of Pseudohypoxic Pheochromocytomas and Paragangliomas

Shankavaram, U. T., Fliedner, S. M. J., ELKAHLOUN, A. G., Barb, J. J., Munson, P. J., Huynh, T., Matro, J. C., Turková, H., Linehan, W. M., Timmers, H. J. L. M., et al. (2013) · Neoplasia · doi:10.1593/neo.122132 · Cited by 38 · see citing works

Warburg Effect’s Manifestation in Aggressive Pheochromocytomas and Paragangliomas: Insights from a Mouse Cell Model Applied to Human Tumor Tissue

Fliedner, S. M. J., Kaludercic, N., Jiang, X.-S., Hansíková, H., Hájková, Z., Sládková, J., Limpuangthip, A., Backlund, P. S., WESLEY, R. A., Martiniova, L., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040949 · Cited by 34 · see citing works

Metabolic implications of hypoxia and pseudohypoxia in pheochromocytoma and paraganglioma

Kľučková, K., & Tennant, D. A. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2801-6 · Cited by 66 · see citing works

Pseudohypoxia, Mitochondrial Mutations, the Warburg Effect, and Cancer.

Sanders, E. (2012) · Cited by 4 · see citing works

Pheochromocytomas: The (pseudo)-hypoxia hypothesis

Favier, J., & Gimenez‐Roqueplo, A. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.10.004 · Cited by 110 · see citing works

Pheochromocytoma: Gasping for Air

Jochmanová, I., Zhuang, Z., & Pacák, K. (2015) · Hormones and Cancer · doi:10.1007/s12672-015-0231-4 · Cited by 29 · see citing works