Cited by 113Diabetes Treatment and ManagementHeme Oxygenase-1 and Carbon MonoxideAdipokines, Inflammation, and Metabolic Diseases

Liraglutide Reduces Oxidative Stress and Restores Heme Oxygenase-1 and Ghrelin Levels in Patients with Type 2 Diabetes: A Prospective Pilot Study

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Rizzo, Manfredi, Abate, Nicola, Chandalia, Manisha, Rizvi, Ali A., Giglio, Rosaria V., Nikolic, Dragana, Marino Gammazza, Antonella, Barbagallo, Ignazio +4 more·2015·The Journal of Clinical Endocrinology & Metabolism

Abstract

CONTEXT: Liraglutide is a glucagon-like peptide-1 analog and glucose-lowering agent whose effects on cardiovascular risk markers have not been fully elucidated. OBJECTIVE: We evaluated the effect of liraglutide on markers of oxidative stress, heme oxygenase-1 (HO-1), and plasma ghrelin levels in patients with type-2 diabetes mellitus (T2DM). DESIGN AND SETTING: A prospective pilot study of 2 months' duration has been performed at the Unit of Diabetes and Cardiovascular Prevention at University of Palermo, Italy. Patients and Intervention(s): Twenty subjects with T2DM (10 men and 10 women; mean age: 57 ± 13 y) were treated with liraglutide sc (0.6 mg/d for 2 wk, followed by 1.2 mg/d) in addition to metformin (1500 mg/d orally) for 2 months. Patients with liver disorders or renal failure were excluded. MAIN OUTCOME MEASURE(S): Plasma ghrelin concentrations, oxidative stress markers, and heat-shock proteins, including HO-1 were assessed. RESULTS: The addition of liraglutide resulted in a significant decrease in glycated hemoglobin (HbA1c) (8.5 ± 0.4 vs 7.5 ± 0.4%, P < .0001). In addition, plasma ghrelin and glutathione concentrations increased (8.2 ± 4.1 vs 13.6 ± 7.3 pg/ml, P = .0007 and 0.36 ± 0.06 vs 0.44 ± 0.07 nmol/ml, P = .0002, respectively), whereas serum lipid hydroperoxides and HO-1 decreased (0.11 ± 0.05 vs 0.04 ± 0.07 pg/ml, P = .0487 and 7.7 ± 7.7 vs 3.6 ± 1.8 pg/ml, P = .0445, respectively). These changes were not correlated with changes in fasting glycemia or HbA1c. CONCLUSIONS: In a 2-months prospective pilot study, the addition of liraglutide to metformin resulted in improvement in oxidative stress as well as plasma ghrelin and HO-1 concentrations in patients with T2DM. These findings seemed to be independent of the known effects of liraglutide on glucose metabolism.

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Authors
Rizzo, M., Abate, N., Chandalia, M., Rizvi, A. A., Giglio, R. V., Nikolic, D., Marino Gammazza, A., Barbagallo, I., Isenovic, E. R., Banach, M., Montalto, G., & Volti, G. L.
Affiliations
  • University of South Carolina (US)
  • The University of Texas Medical Branch at Galveston (US)
  • University of Palermo (IT)
  • Biomedical Department of Internal Medicine and Medical Specialties (M.R., R.V.G., D.N., G.M.), University of Palermo, Palermo 90127, Italy
  • Euro-Mediterranean Institute of Science and Technology (M.R., A.M.G., I.B., G.L.V.), Palermo 90139, Italy
  • University of Catania (IT)
  • Laboratory for Molecular Genetics and Radiobiology (E.R.I.), Vinca Institute, University of Belgrade, Belgrade 11000, Serbia
  • Medical University of Lodz (PL)
Corresponding author
Rizvi, Ali A.
Venue
The Journal of Clinical Endocrinology & Metabolism
Published
2015-02-01
Volume
100
Issue
2
Pages
603-606
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
OpenAlex
W2132146653
Cited by
113
References
20
Citations by year
2026: 5 · 2025: 9 · 2024: 13 · 2023: 11 · 2022: 15 · 2021: 8 · 2020: 8 · 2019: 13 · 2018: 5 · 2017: 8 · 2016: 12 · 2015: 6
FWCI
6.97
Type
journal article
Language
en
Open access
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
  • CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
  • VinaR (Institute of Nuclear Sciences "Vinča") (submittedVersion, other-oa)
Funders
  • Bristol-Myers Squibb
  • University of South Carolina
  • National Institutes of Health (UL1TR000071)
  • School of Medicine, University of South Carolina
  • National Center for Advancing Translational Sciences
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
liraglutide, type 2 diabetes, oxidative stress, heme oxygenase-1, ghrelin, glucagon-like peptide-1 analogues, metformin, glutathione, lipid hydroperoxides, HbA1c, heat shock proteins, cardiovascular risk markers, glycemic control, insulin resistance, dyslipidemia
MeSH terms
Liraglutide, Adult, Aged, Diabetes Mellitus, Type 2, Drug Therapy, Combination, Female, Humans, Hypoglycemic Agents, Male, Metformin, Middle Aged, Pilot Projects, Prospective Studies, Oxidative Stress, Heme Oxygenase-1, Glucagon-Like Peptide 1, Ghrelin

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