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Cited by 221Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and TreatmentChemical Analysis and Environmental Impact

A Review: Radiographic Iodinated Contrast Media-Induced Thyroid Dysfunction

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Lee, Sun Y., Rhee, Connie M., Leung, Angela M., Braverman, Lewis E., Brent, Gregory A., Pearce, Elizabeth N.·2015·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2014-3292PMC PMC4318903
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Abstract

CONTEXT: Thyroid hormone production is dependent on adequate iodine intake. Excess iodine is generally well-tolerated, but thyroid dysfunction can occur in susceptible individuals after excess iodine exposure. Radiological iodinated contrast media represent an increasingly common source of excess iodine. OBJECTIVE: This review will discuss the thyroidal response after acute exposure to excess iodine; contrast iodine-induced thyroid dysfunction; risks of iodine-induced thyroid dysfunction in vulnerable populations, such as the fetus, neonate, and patients with impaired renal function; and recommendations for the assessment and treatment of contrast iodine-induced thyroid dysfunction. METHODS: Data for this review were identified by searching PubMed, Google Scholar, and references from relevant articles from 1948 to 2014. CONCLUSIONS: With the increase in the use of computed tomography scans in the United States, there is increasing risk of contrast-induced thyroid dysfunction. Patients at risk of developing iodine-induced thyroid dysfunction should be closely monitored after receiving iodinated contrast media and should be treated as needed.

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  • Elderly patients with autonomously functioning nodular goiters are the most susceptible to iodine-induced hyperthyroidism; less commonly, patients with occult GD or prior GD in remission after ATDs are susceptible.

    “Individuals who are the most susceptible are elderly patients with autonomously functioning nodular goiters (557) and, less commonly, patients with occult GD (558) or patients with a prior history of GD who are in remission after a course of ATDs (559).”

    From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [558]

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Research works printed but not linked: 6

  1. [13]13. Lee SY, Chang DLF, He X, Pearce EN, Braverman LE, Leung AM. Urinary iodine excretion and changes in thyroid hormone levels after computer tomography scan with iodinated contrast administration. Poster presented at: 84th Annual Meeting of American Thyroid Association; October 29–November 2, 2014; Coronado, CA. [Google Scholar]
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Authors
Lee, S. Y., Rhee, C. M., Leung, A. M., Braverman, L. E., Brent, G. A., & Pearce, E. N.
Affiliations
  • Boston University (US)
  • University of California, Irvine (US)
  • University of California, Los Angeles (US)
Corresponding author
  • Lee, Sun Y.
  • Rhee, Connie M.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2015-02
Volume
100
Issue
2
Pages
376-383
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2014-3292
PMC
PMC4318903
OpenAlex
W1996335887
Cited by
221
References
73
Citations by year
2026: 7 · 2025: 15 · 2024: 33 · 2023: 25 · 2022: 30 · 2021: 29 · 2020: 23 · 2019: 18 · 2018: 17 · 2017: 5 · 2016: 10 · 2015: 7 · 2014: 2
FWCI
6.43
Type
journal article
Language
en
Open access
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007201, K23DK102903)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (K23HD068552)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Chemical Analysis and Environmental Impact
Keywords
iodinated contrast media, thyroid hormone synthesis, iodine toxicity, computed tomography, renal dysfunction, thyroid function monitoring
MeSH terms
Contrast Media, Humans, Thyroid Diseases, Thyroid Function Tests

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