The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Low Population Selenium Status Is Associated With Increased Prevalence of Thyroid Disease
Open accessAbstract
CONTEXT: Epidemiological studies have supported the premise that an adequate selenium intake is essential for thyroid gland function. OBJECTIVE: The objective was to investigate whether the prevalence of thyroid disease differed in two areas that were similar, except for very different soil/crop selenium concentrations. DESIGN: Cross-sectional observational study. SETTING: The setting was two counties of Shaanxi Province, China, here defined as adequate- and low-selenium. PARTICIPANTS: A total of 6152 participants were selected by stratified cluster-sampling. MAIN OUTCOME MEASURES: Participants completed demographic and dietary questionnaires and underwent physical and thyroid ultrasound examinations. Serum samples were analyzed for thyroid function parameters and selenium concentration. Serum selenium was compared between different demographic, dietary, and lifestyle categories in the two counties. The relationship between selenium status, dietary factors, and pathological thyroid conditions was explored by logistic regression. RESULTS: Complete data sets were available from 3038 adequate-selenium participants and 3114 low-selenium participants in whom median (interquartile range) selenium concentrations differed almost 2-fold (103.6 [79.7, 135.9] vs 57.4 [39.4, 82.1] μg/L; P = .001). The prevalence of pathological thyroid conditions (hypothyroidism, subclinical hypothyroidism, autoimmune thyroiditis, and enlarged thyroid) was significantly lower in the adequate-selenium county than in the low-selenium county (18.0 vs 30.5%; P < .001). Higher serum selenium was associated with lower odds ratio (95% confidence interval) of autoimmune thyroiditis (0.47; 0.35, 0.65), subclinical hypothyroidism (0.68; 0.58, 0.93), hypothyroidism (0.75; 0.63, 0.90), and enlarged thyroid (0.75; 0.59, 0.97). CONCLUSIONS: Low selenium status is associated with increased risk of thyroid disease. Increased selenium intake may reduce the risk in areas of low selenium intake that exist not only in China but also in many other parts of the world.
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Citations
Cites
The importance of selenium to human health
Rayman, M. P. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02490-9 · Cited by 4,163
Self-citationRayman, M. P. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61452-9 · Cited by 3,563
Self-citationThe epidemiology of thyroid disease
Vanderpump, M. P. J. (2011) · British Medical Bulletin · doi:10.1093/bmb/ldr030 · Cited by 1,179
Effect of Iodine Intake on Thyroid Diseases in China
Teng, W., Shan, Z., Teng, X., Guan, H., Li, Y., Teng, D., Jin, Y., Yu, X., Fan, C., Chong, W., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054022 · Cited by 742
Selenium and the Course of Mild Graves' Orbitopathy
Marcocci, C., Kahaly, G. J., Krassas, G. E., Bartalena, L., Prummel, M., Stahl, M., Altea, M. A., Nardi, M., Pitz, S., Boboridis, K., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1012985 · Cited by 619
Selenium in soil and endemic diseases in China
Tan, J., Zhu, W., Wang, W., Li, R., Hou, S., Wang, D., & Yang, L. (2002) · Science of The Total Environment · doi:10.1016/s0048-9697(01)00889-0 · Cited by 438
Selenium, selenoproteins and the thyroid gland: interactions in health and disease
Schomburg, L. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.174 · Cited by 368
Self-citationNegro, R., Greco, G., Mangieri, T., Pezzarossa, A., Dazzi, D., & Hassan, H. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1821 · Cited by 368
MECHANISMS IN ENDOCRINOLOGY: Autoimmune thyroid disease: old and new players
Effraimidis, G., & Wiersinga, W. M. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0047 · Cited by 350
Reiners, C., Wegscheider, K., Schicha, H., Theissen, P., Vaupel, R., Wrbitzky, R., & Schumm-Draeger, P.-M. (2004) · Thyroid · doi:10.1089/thy.2004.14.926 · Cited by 348
Cited by
Chaker, L., Bianco, A. C., Jonklaas, J., & Peeters, R. P. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30703-1 · Cited by 1,159
Selenium and Selenoproteins: It’s Role in Regulation of Inflammation
Hariharan, S., & Dharmaraj, S. (2020) · Inflammopharmacology · doi:10.1007/s10787-020-00690-x · Cited by 659
Hypothyroidism in Context: Where We’ve Been and Where We’re Going
Chiovato, L., Magri, F., & Carlé, A. (2019) · Advances in Therapy · doi:10.1007/s12325-019-01080-8 · Cited by 459
Chaker, L., Razvi, S., Bensenor, I. M., Azizi, F., Pearce, E. N., & Peeters, R. P. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00357-7 · Cited by 330
Selenium in thyroid disorders—essential knowledge for clinicians
Winther, K. H., Rayman, M. P., Bonnema, S. J., & Hegedüs, L. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0311-6 · Cited by 288
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Metadata
- Authors
- Wu, Q., Rayman, M. P., Lv, H., Schomburg, L., Cui, B., Gao, C., Chen, P., Zhuang, G., Zhang, Z., Peng, X., Li, H., Zhao, Y., He, X., Zeng, G., Qin, F., Hou, P., & Shi, B.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2015-11
- Volume
- 100
- Issue
- 11
- Pages
- 4037-4047
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2144579285
- Cited by
- 265
- References
- 38
- FWCI
- 17.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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