The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Harmonized Reference Ranges for Circulating Testosterone Levels in Men of Four Cohort Studies in the United States and Europe
Open accessAbstract
Background: Reference ranges for testosterone are essential for making a diagnosis of hypogonadism in men. Objective: To establish harmonized reference ranges for total testosterone in men that can be applied across laboratories by cross-calibrating assays to a reference method and standard. Population: The 9054 community-dwelling men in cohort studies in the United States and Europe: Framingham Heart Study; European Male Aging Study; Osteoporotic Fractures in Men Study; and Male Sibling Study of Osteoporosis. Methods: Testosterone concentrations in 100 participants in each of the four cohorts were measured using a reference method at Centers for Disease Control and Prevention (CDC). Generalized additive models and Bland-Altman analyses supported the use of normalizing equations for transformation between cohort-specific and CDC values. Normalizing equations, generated using Passing-Bablok regression, were used to generate harmonized values, which were used to derive standardized, age-specific reference ranges. Results: Harmonization procedure reduced intercohort variation between testosterone measurements in men of similar ages. In healthy nonobese men, 19 to 39 years, harmonized 2.5th, 5th, 50th, 95th, and 97.5th percentile values were 264, 303, 531, 852, and 916 ng/dL, respectively. Age-specific harmonized testosterone concentrations in nonobese men were similar across cohorts and greater than in all men. Conclusion: Harmonized normal range in a healthy nonobese population of European and American men, 19 to 39 years, is 264 to 916 ng/dL. A substantial proportion of intercohort variation in testosterone levels is due to assay differences. These data demonstrate the feasibility of generating harmonized reference ranges for testosterone that can be applied to assays, which have been calibrated to a reference method and calibrator.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“In their effort to harmonize reference ranges, they established 264 to 916 ng/dL as a normal interval for total T in European and American non-obese men aging from 19 to 39 years.”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [178]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Identification of late-onset hypogonadism in middle-aged and elderly men
Wu, F. C. W., Tajar, A., Beynon, J. M., Pye, S. R., Silman, A. J., Finn, J. D., O'Neill, T. W., Bartfai, G., Casanueva, F. F., Forti, G., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0911101 · Cited by 1,544
Self-citationSample Quantiles in Statistical Packages
Hyndman, R. J., & Fan, Y. (1996) · The American Statistician · doi:10.1080/00031305.1996.10473566 · Cited by 1,042
Bhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2847 · Cited by 965
Self-citationWu, F. C. W., Tajar, A., Pye, S. R., Silman, A. J., Finn, J. D., O'Neill, T. W., Bartfai, G., Casanueva, F., Forti, G., Giwercman, A., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1972 · Cited by 939
Self-citationEffects of Testosterone Treatment in Older Men
Snyder, P. J., Bhasin, S., Cunningham, G. R., Matsumoto, A. M., Stephens-Shields, A. J., Cauley, J. A., Gill, T. M., Barrett-Connor, E., Swerdloff, R. S., Wang, C., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1506119 · Cited by 890
Self-citationSplansky, G. L., Corey, D., Yang, Q., Atwood, L. D., Cupples, L. A., Benjamin, E. J., D'Agostino, R. B., Fox, C. S., Larson, M. G., Murabito, J. M., et al. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm021 · Cited by 860
ORWOLL, E. S., Blank, J. B., Barrett-Connor, E. L., Cauley, J. A., Cummings, S. R., Ensrud, K. E., Lewis, C. E., Cawthon, P. M., Marcus, R., Marshall, L. M., et al. (2005) · Contemporary Clinical Trials · doi:10.1016/j.cct.2005.05.006 · Cited by 769
Self-citationOverview of recruitment for the osteoporotic fractures in men study (MrOS)
Blank, J. B., Cawthon, P. M., Carrion-Petersen, M. L., Harper, L., Johnson, J., Mitson, E., & Delay, R. R. (2005) · Contemporary Clinical Trials · doi:10.1016/j.cct.2005.05.005 · Cited by 576
Travison, T. G., Araujo, A. B., Kupelian, V., O’Donnell, A. B., & McKinlay, J. B. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1859 · Cited by 410
Self-citationMyers, G. L., Cooper, G. R., Winn, C., & Smith, S. J. (1989) · Clinics in Laboratory Medicine · doi:10.1016/s0272-2712(18)30645-0 · Cited by 404
Cited by
Sorted by citations
Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline.
Bhasin, S., Brito, J. P., Cunningham, G. R., Hayes, F. J., Hodis, H. N., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., Wu, F. C., & Yialamas, M. A. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-00229 · Cited by 1,736
Self-citationSalonia, A., Bettocchi, C., Boeri, L., Capogrosso, P., Carvalho, J., Çilesiz, N. C., Cocci, A., Corona, G., Dimitropoulos, K., Gül, M., et al. (2021) · European Urology · doi:10.1016/j.eururo.2021.06.007 · Cited by 858
Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance
Handelsman, D. J., Hirschberg, A. L., & Bermon, S. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00020 · Cited by 594
Corona, G., Goulis, D. G., Huhtaniemi, I., Zitzmann, M., Toppari, J., Forti, G., Vanderschueren, D., & Wu, F. C. (2020) · Andrology · doi:10.1111/andr.12770 · Cited by 431
Self-citationPaediatric and adult-onset male hypogonadism
Salonia, A., Rastrelli, G., Hackett, G., Seminara, S. B., Huhtaniemi, I. T., Rey, R. A., Hellstrom, W. J. G., Palmert, M. R., Corona, G., Dohle, G. R., et al. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0087-y · Cited by 286
Lessons From the Testosterone Trials
Snyder, P. J., Bhasin, S., Cunningham, G. R., Matsumoto, A. M., Stephens-Shields, A. J., Cauley, J. A., Gill, T. M., Barrett-Connor, E., Swerdloff, R. S., Wang, C., et al. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00234 · Cited by 280
Self-citationHUNTER, S. K., S. ANGADI, S., BHARGAVA, A., HARPER, J., HIRSCHBERG, A. L., D. LEVINE, B., L. MOREAU, K., J. NOKOFF, N., STACHENFELD, N. S., & BERMON, S. (2023) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003300 · Cited by 241
European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity
Pasquali, R., Casanueva, F., Haluzik, M., van Hulsteijn, L., Ledoux, S., Monteiro, M. P., Salvador, J., Santini, F., Toplak, H., & Dekkers, O. M. (2020) · European Journal of Endocrinology · doi:10.1530/eje-19-0893 · Cited by 188
Isidori, A. M., Aversa, A., Calogero, A. E., Ferlin, A., Francavilla, S., Lanfranco, F., Pivonello, R., Rochira, V., Corona, G., & Maggi, M. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-022-01859-7 · Cited by 163
Society for Endocrinology guidelines for testosterone replacement therapy in male hypogonadism
Jayasena, C. N., Anderson, R. A., Llahana, S., Barth, J. H., MacKenzie, F., Wilkes, S., Smith, N., Sooriakumaran, P., Minhas, S., Wu, F. C. W., et al. (2022) · Clinical Endocrinology · doi:10.1111/cen.14633 · Cited by 147
Self-citationAging and the Male Reproductive System
Kaufman, J., Lapauw, B., Mahmoud, A., T'Sjoen, G. G., & Huhtaniemi, I. T. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00178 · Cited by 150
Self-citationAging and sex hormones in males
Decaroli, M. C., & Rochira, V. (2016) · Virulence · doi:10.1080/21505594.2016.1259053 · Cited by 150
The Impact of Testicular Torsion on Testicular Function
Jacobsen, F. M., Rudlang, T. M., Fode, M. M., Østergren, P. B., Sønksen, J., Ohl, D. A., Jensen, C. F. S., & Collaborative, O. B. O. T. C. (2019) · The World Journal of Men s Health · doi:10.5534/wjmh.190037 · Cited by 130
Obesity and male hypogonadism: Tales of a vicious cycle
Carrageta, D. F., Oliveira, P. F., Alves, M. G., & Monteiro, M. P. (2019) · Obesity Reviews · doi:10.1111/obr.12863 · Cited by 130
Chen, J., Lin, P., Tsai, Y.-R., Yang, Y.-C., & Kang, H. (2019) · Cells · doi:10.3390/cells8111318 · Cited by 129
Hypogonadism in Exercising Males: Dysfunction or Adaptive-Regulatory Adjustment?
Hackney, A. C. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00011 · Cited by 134
Hudson, J., Cruickshank, M., Quinton, R., Aucott, L. S., Aceves‐Martins, M., Gillies, K., Bhasin, S., Snyder, P. J., Ellenberg, S. S., Grossmann, M., et al. (2022) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(22)00096-4 · Cited by 115
Self-citationAssessment of free testosterone concentration
Keevil, B. G., & Adaway, J. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.04.008 · Cited by 111
Clark, R. V., Wald, J. A., Swerdloff, R. S., Wang, C., Wu, F. C. W., Bowers, L. D., & Matsumoto, A. M. (2018) · Clinical Endocrinology · doi:10.1111/cen.13840 · Cited by 102
Self-citationNarinx, N., David, K., Walravens, J., Vermeersch, P., Claessens, F., Fiers, T., Lapauw, B., Antonio, L., & Vanderschueren, D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04562-1 · Cited by 96
Self-citationHormones and Aging: An Endocrine Society Scientific Statement
Cappola, A. R., Auchus, R. J., Fuleihan, G. E., Handelsman, D. J., Kalyani, R. R., McClung, M. R., Stuenkel, C. A., Thorner, M. O., & Verbalis, J. G. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad225 · Cited by 108
Male sex hormones, aging, and inflammation
Ketchem, J. M., Bowman, E. J., & Isales, C. M. (2023) · Biogerontology · doi:10.1007/s10522-022-10002-1 · Cited by 94
Becerra-Díaz, M., Song, M., & Heller, N. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01698 · Cited by 89
Beyond the X Factor: Relevance of Sex Hormones in NAFLD Pathophysiology
Torre, S. D. (2021) · Cells · doi:10.3390/cells10092502 · Cited by 91
Targeting chronic inflammation as a potential adjuvant therapy for osteoporosis
Livshits, G., & Kalinkovich, A. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120847 · Cited by 84
Gharahdaghi, N., Rudrappa, S. S., Brook, M. S., IDRIS, I. R., Crossland, H., Hamrock, C., Aziz, M. H. A., Kadi, F., Tarum, J., Greenhaff, P. L., et al. (2019) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12472 · Cited by 88
Measuring testosterone in women and men
Kanakis, G., Tsametis, C. P., & Goulis, D. G. (2019) · Maturitas · doi:10.1016/j.maturitas.2019.04.203 · Cited by 78
Free Testosterone: Pumping up the Tires or Ending the Free Ride?
Handelsman, D. J. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00171 · Cited by 78
Adler, R. A. (2018) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2018.05.007 · Cited by 77
Duong, P., Tenkorang, M. A. A., Trieu, J., McCuiston, C., Rybalchenko, N., & Cunningham, R. L. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-0283-1 · Cited by 76
Update on male reproductive endocrinology
Clavijo, R. I., & Hsiao, W. (2018) · Translational Andrology and Urology · doi:10.21037/tau.2018.03.25 · Cited by 75
Fiers, T., Wu, F., Moghetti, P., Vanderschueren, D., Lapauw, B., & Kaufman, J.-M. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02360 · Cited by 70
Self-citationCritical evaluation of different available guidelines for late‐onset hypogonadism
Giagulli, V., Castellana, M., Lisco, G., & Triggiani, V. (2020) · Andrology · doi:10.1111/andr.12850 · Cited by 54
Mazur, D. J., & Lipshultz, L. I. (2018) · Current Urology Reports · doi:10.1007/s11934-018-0802-3 · Cited by 65
Male hypogonadism: pathogenesis, diagnosis, and management
de Silva, N. L., Papanikolaou, N., Grossmann, M., Antonio, L., Quinton, R., Anawalt, B. D., & Jayasena, C. N. (2024) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(24)00199-2 · Cited by 68
Testosterone Deficiency: A Review and Comparison of Current Guidelines
Kwong, J. C. C., Krakowsky, Y., & Grober, E. D. (2019) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2019.03.262 · Cited by 58
Anabolic-Androgenic Steroid Use in Sports, Health, and Society
Bhasin, S., Hatfield, D. L., Hoffman, J. R., Kraemer, W. J., LaBotz, M., Phillips, S. M., & Ratamess, N. A. (2021) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002670 · Cited by 63
Self-citationThe Role of Sex in Acute and Chronic Liver Damage
Sayaf, K., Gabbia, D., Russo, F. P., & Martin, S. D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810654 · Cited by 59
Pedersen, T. L., Gray, I. J., & Newman, J. W. I. (2020) · Analytica Chimica Acta · doi:10.1016/j.aca.2020.11.019 · Cited by 53
Giagulli, V. A., Castellana, M., Carbone, M. D., Pelusi, C., Ramunni, M. I., Pergola, G. D., Guastamacchia, E., & Triggiani, V. (2020) · Andrology · doi:10.1111/andr.12754 · Cited by 54
Progress in nanoparticle-based electrochemical biosensors for hormone detection
Rossi, F., Trakoolwilaiwan, T., Gigli, V., Tortolini, C., Lenzi, A., Isidori, A. M., Thanh, N. T. K., & Antiochia, R. (2024) · Nanoscale · doi:10.1039/d4nr02075h · Cited by 51
Yeap, B. B., Manning, L. A., Chubb, S. A. P., Handelsman, D. J., Almeida, O. P., Hankey, G. J., & Flicker, L. A. (2017) · Clinical Endocrinology · doi:10.1111/cen.13484 · Cited by 45
Epidemiology of Male Hypogonadism
Thirumalai, A., & Anawalt, B. D. (2022) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2021.11.016 · Cited by 44
Sun, J., Pan, Y., Li, X., Wang, L., Liu, M., Tu, P., Wu, C., Xiao, J., Han, Q., Da, W., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.849544 · Cited by 47
Hunter, S. K., Angadi, S. S., Bhargava, A., Harper, J., Hirschberg, A. L., Levine, B. D., Moreau, K. L., Nokoff, N. J., Stachenfeld, N. S., & Bermon, S. (2023) · Translational Journal of the American College of Sports Medicine · doi:10.1249/tjx.0000000000000236 · Cited by 43
Esteves, S. C., Humaidan, P., Ubaldi, F. M., Alviggi, C., Antonio, L., Barratt, C. L. R., Behre, H. M., Jørgensen, N., Pacey, A. A., Simoni, M., et al. (2023) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2023.103647 · Cited by 45
Yeap, B. B., & Wu, F. C. W. (2018) · Clinical Endocrinology · doi:10.1111/cen.13888 · Cited by 45
Self-citationAl‐Sharefi, A., & Quinton, R. (2020) · Endocrinology and Metabolism · doi:10.3803/enm.2020.760 · Cited by 44
Belka, M., Konieczna, L., Okońska, M., Pyszka, M., Ulenberg, S., & Bączek, T. (2019) · Analytica Chimica Acta · doi:10.1016/j.aca.2019.05.078 · Cited by 42
Santos, H. O., & Teixeira, F. J. (2020) · The Aging Male · doi:10.1080/13685538.2019.1573220 · Cited by 41
Testosterone Replacement Therapy in Hypogonadal Men
Wang, C., & Swerdloff, R. S. (2022) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2021.11.005 · Cited by 48
Trussell, J. C., Coward, R. M., Santoro, N. F., Stetter, C., Kunselman, A. R., Diamond, M. P., Hansen, K. R., Krawetz, S. A., Legro, R. S., Heisenleder, D. J., et al. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.01.034 · Cited by 38
Physical activity as an adjunct treatment for erectile dysfunction
Allen, M. S. (2019) · Nature Reviews Urology · doi:10.1038/s41585-019-0210-6 · Cited by 38
Yeap, B. B., Marriott, R. J., Antonio, L., Bhasin, S., Dobs, A. S., Dwivedi, G., Flicker, L. A., Matsumoto, A. M., Ohlsson, C., ORWOLL, E. S., et al. (2020) · Clinical Endocrinology · doi:10.1111/cen.14342 · Cited by 35
Self-citationFalqueto, H., Júnior, J. L. R., Silvério, M. N. O., Farias, J. C. H., Schoenfeld, B. J., & Manfredi, L. H. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09634-4 · Cited by 40
Coward, R. M., Stetter, C., Kunselman, A. R., Trussell, J. C., Lindgren, M. C., Alvero, R. J., Casson, P. R., Christman, G. M., Coutifaris, C., Diamond, M. P., et al. (2019) · The Journal of Urology · doi:10.1097/ju.0000000000000205 · Cited by 38
Testosterone Deficiency, Weakness, and Multimorbidity in Men
Peterson, M. D., Belakovskiy, A., McGrath, R. P., & Yarrow, J. F. (2018) · Scientific Reports · doi:10.1038/s41598-018-24347-6 · Cited by 36
Allen, M. S., & Tostes, R. C. (2023) · Sexual Medicine Reviews · doi:10.1093/sxmrev/qeac007 · Cited by 34
Abilmona, S. M., Sumrell, R. M., Gill, R. S., Adler, R. A., & Gorgey, A. S. (2018) · Spinal Cord · doi:10.1038/s41393-018-0207-7 · Cited by 34
Irwig, M. S., Fleseriu, M., Jonklaas, J., Tritos, N. A., Yuen, K. C. J., Correa, R. R., Elhomsy, G. C., Garla, V. V., Jasim, S., Soe, K. K., et al. (2020) · Endocrine Practice · doi:10.4158/ps-2019-0540 · Cited by 35
Collet, T., Ewing, S. K., Ensrud, K. E., Laughlin, G. A., Hoffman, A. R., Varosy, P. D., Stefanick, M. L., Stone, K. L., ORWOLL, E. S., & Bauer, D. C. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa038 · Cited by 31
Self-citationLyle, A. N., Pokuah, F., Dietzen, D. J., Wong, E. C. C., Pyle‐Eilola, A. L., Fuqua, J. S., Woodworth, A. L., Jones, P. M., Akinbami, L. J., GARIBALDI, L. R., et al. (2022) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2022.0794 · Cited by 32
Self-citationFanelli, F., Baronio, F., Ortolano, R., Mezzullo, M., Cassio, A., Pagotto, U., & Balsamo, A. (2018) · Sexual Development · doi:10.1159/000486840 · Cited by 31
Banica, T., Verroken, C., Reyns, T., Mahmoud, A., T’Sjoen, G., Fiers, T., Kaufman, J.-M., & Lapauw, B. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa915 · Cited by 32
Self-citationKlein, L. D., Huang, J., Quinn, E., Martin, M. A., Breakey, A. A., Gurven, M., Kaplan, H. S., Valeggia, C. R., Jasieńska, G., Scelza, B. A., et al. (2018) · Evolution Medicine and Public Health · doi:10.1093/emph/eoy031 · Cited by 31
Testosterone administration in human social neuroendocrinology: Past, present, and future
Carré, J. M., & Robinson, B. A. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104754 · Cited by 35
EMAS position statement: Testosterone replacement therapy in older men
Kanakis, G., Pofi, R., Goulis, D. G., Isidori, A. M., Armeni, E., Erel, C. T., Fistonić, I., Hillard, T., Hirschberg, A. L., Męczekalski, B., et al. (2023) · Maturitas · doi:10.1016/j.maturitas.2023.107854 · Cited by 35
Ageing male (part I): Pathophysiology and diagnosis of functional hypogonadism
Huhtaniemi, I. T., & Wu, F. C. W. (2022) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2022.101622 · Cited by 31
Self-citationTheodorakis, N., Feretzakis, G., Vamvakou, G., Verykios, V. S., Polymeris, A., & Nikolaou, M. (2024) · Hormones · doi:10.1007/s42000-024-00587-2 · Cited by 28
Androgen-dependent immune modulation in parasitic infection
Sellau, J., Groneberg, M., & Lotter, H. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0722-9 · Cited by 28
Smith, J. B., Rosen, J. H., & Colbert, A. (2017) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2017.08.007 · Cited by 26
Accurate measurement of total and free testosterone levels for the diagnosis of androgen disorders
Guzelce, E. C., Galbiati, F., Goldman, A. L., Gattu, A. K., Basaria, S. S., & Bhasin, S. (2022) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2022.101683 · Cited by 27
Self-citationLivingston, M. A., Downie, P., Hackett, G. I., Marrington, R., Heald, A. H., & Ramachandran, S. (2020) · International Journal of Clinical Practice · doi:10.1111/ijcp.13607 · Cited by 25
Jasuja, R., Pencina, K. M., Spencer, D. J., Peng, L., Privat, F., Dhillo, W. S., Jayasena, C. N., Hayes, F. J., Yeap, B. B., Matsumoto, A. M., et al. (2022) · Andrology · doi:10.1111/andr.13310 · Cited by 25
Self-citationDietary trends and the decline in male reproductive health
Whittaker, J. (2023) · HORMONES · doi:10.1007/s42000-023-00431-z · Cited by 26
Corona, G., Rastrelli, G., Sparano, C., Carinci, V., Casella, G., Vignozzi, L., Sforza, A., & Maggi, M. (2024) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2024.2337741 · Cited by 26
GREEN, D. J., Chasland, L. C., Yeap, B. B., & Naylor, L. H. (2024) · Sports Medicine - Open · doi:10.1186/s40798-024-00703-x · Cited by 28
Santos, H. O., Cadegiani, F., & Forbes, S. C. (2022) · Clinical Therapeutics · doi:10.1016/j.clinthera.2022.06.006 · Cited by 24
Finkelstein, J. S., Lee, H., Burnett‐Bowie, S. M., Darakananda, K., Gentile, E. C., Goldstein, D. W., Prizand, S. H., Krivicich, L. M., Taylor, A. P., Wulczyn, K. E., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa318 · Cited by 23
Oladele, C. A., Akintayo, C. O., Badejogbin, O. C., Oniyide, A. A., Omoaghe, A. O., Agunbiade, T. B., & Olaniyi, K. S. (2021) · Andrologia · doi:10.1111/and.14242 · Cited by 22
New Biomarkers to Evaluate Hyperandrogenemic Women and Hypogonadal Men
Karakas, S. E., & Surampudi, P. N. (2018) · Advances in clinical chemistry · doi:10.1016/bs.acc.2018.06.001 · Cited by 23
The Effects of Androgens on Cardiometabolic Syndrome: Current Therapeutic Concepts
Kırlangıç, O. F., Yilmaz‐Oral, D., Kaya‐Sezginer, E., Toktanis, G., Tezgelen, A. S., Sen, E., Khanam, A., Öztekin, Ç. V., & Gür, S. (2020) · Sexual Medicine · doi:10.1016/j.esxm.2020.02.006 · Cited by 23
Santen, R. J., Pinkerton, J. V., LIU, J. H., Matsumoto, A. M., Lobo, R. A., Davis, S. R., & Simon, J. A. (2020) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001556 · Cited by 22
Self-citationPetrov, P., Fernández-Murga, M. L., Conde, I., Martínez-Sena, T., Guzmán, C., Castell, J. V., & Jover, R. (2020) · Archives of Toxicology · doi:10.1007/s00204-019-02643-y · Cited by 22
Sexually Dimorphic Neurosteroid Synthesis Regulates Neuronal Activity in the Murine Brain
Wartenberg, P., Farkas, I., Csillag, V., Colledge, W. H., Hrabovszky, E., & Boehm, U. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0885-21.2021 · Cited by 21
Ciardullo, S., Zerbini, F., Cannistraci, R., Muraca, E., Perra, S., Oltolini, A., & Perseghin, G. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12144783 · Cited by 24
Huang, G. T.-W., Bhasin, S., Pencina, K. M., Cheng, M., & Jasuja, R. (2022) · Fertility and Sterility · doi:10.1016/j.fertnstert.2022.09.011 · Cited by 20
Self-citationCruickshank, M., Hudson, J., Hernández, R. A., Aceves‐Martins, M., Quinton, R., Gillies, K., Aucott, L. S., Kennedy, C., Manson, P. D., Oliver, N. S., et al. (2024) · Health Technology Assessment · doi:10.3310/jryt3981 · Cited by 20
Self-citationYeap, B. B. (2018) · Asian Journal of Andrology · doi:10.4103/aja.aja_50_17 · Cited by 19
Yu, S., Qiu, L., Liu, M., Li, S., Tao, Z., Zhang, Q., Xia, L., Li, P., Hou, L., Qin, X., et al. (2018) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-0749 · Cited by 19
Marcelli, M., & Mediwala, S. N. (2020) · Journal of Investigative Medicine · doi:10.1136/jim-2019-001233 · Cited by 23
Impact of age, body weight and metabolic risk factors on steroid reference intervals in men
Mezzullo, M., Dalmazi, G. D., Fazzini, A., Baccini, M., Repaci, A., Gambineri, A., Vicennati, V., Pelusi, C., Pagotto, U., & Fanelli, F. (2020) · European Journal of Endocrinology · doi:10.1530/eje-19-0928 · Cited by 17
Management of male sexual dysfunction after cancer treatment
Kim, P., & Clavijo, R. I. (2020) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2020.08.006 · Cited by 22
Marriott, R. J., Murray, K., Hankey, G. J., Manning, L. A., Dwivedi, G., Wu, F. C. W., & Yeap, B. B. (2021) · Clinical Endocrinology · doi:10.1111/cen.14648 · Cited by 18
Self-citationAccurate Measurement and Harmonized Reference Ranges for Total and Free Testosterone Levels
Jasuja, R., Pencina, K. M., Peng, L., & Bhasin, S. (2022) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2021.11.002 · Cited by 19
Self-citationSexually Dimorphic Neurosteroid Synthesis Regulates Neuronal Activity in the Murine Brain.
Wartenberg, P., Farkas, I., Csillag, V., Colledge, W. H., Hrabovszky, E., & Boehm, U. (2021) · Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) · doi:10.17863/cam.76813 · Cited by 18
Obesity Surgery Improves Hypogonadism and Sexual Function in Men without Effects in Sperm Quality
Miñambres, I., Sardà, H., Urgell, E., Genua, I., Ramos, A., Fernández–Ananín, S., Balagué, C., Sánchez‐Quesada, J. L., Bassas, L., & Pérez, A. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11175126 · Cited by 20
Khera, M., Torres, L. O., Grober, E. D., Morgentaler, A., Miner, M. M., Jones, T. H., Mills, J. N., & Salonia, A. (2025) · Sexual Medicine Reviews · doi:10.1093/sxmrev/qeaf036 · Cited by 21
Detomas, M., Deutschbein, T., Tamburello, M., Chifu, I. O., Kimpel, O., Sbiera, S., Kroiß, M., Faßnacht, M., & Altieri, B. (2023) · Journal of Endocrinological Investigation · doi:10.1007/s40618-023-02128-x · Cited by 17
Energetic costs of testosterone in two subsistence populations
Trumble, B. C., Pontzer, H., Stieglitz, J., Cummings, D. K., Wood, B. M., Thompson, M. E., Raichlen, D. A., Beheim, B., Yetish, G. M., Kaplan, H. S., et al. (2023) · American Journal of Human Biology · doi:10.1002/ajhb.23949 · Cited by 18
Metadata
- Authors
- Travison, T. G., Vesper, H. W., Orwoll, E., Wu, F., Kaufman, J. M., Wang, Y., Lapauw, B., Fiers, T., Matsumoto, A. M., & Bhasin, S.
- Affiliations
- Hebrew SeniorLife (US)
- Centers for Disease Control and Prevention (US)
- Oregon Health & Science University (US)
- Manchester Academic Health Science Centre (GB)
- Ghent University Hospital (BE)
- University of Washington (US)
- Brigham and Women's Hospital (US)
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2017-01-10
- Volume
- 102
- Issue
- 4
- Pages
- 1161-1173
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC5460736
- OpenAlex
- W2604915862
- Cited by
- 326
- References
- 41
- Citations by year
- 2026: 26 · 2025: 41 · 2024: 42 · 2023: 41 · 2022: 45 · 2021: 28 · 2020: 34 · 2019: 27 · 2018: 28 · 2017: 11
- FWCI
- 21.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- National Institutes of Health (UL1TR000128, n01hc25195-41-0-1, 5p30ag031679-15)
- Centers for Disease Control and Prevention
- National Institute on Aging (U01AG042145, R01AG031206, U01AG042168, U01AG042143, U01AG027810, P30-AG031679, U01AG042139, U01AG042124, U01AG042140)
- National Heart, Lung, and Blood Institute (N01-HC-025195)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (U01AR066160)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- total testosterone, reference values, hypogonadism, assay harmonization, age-related reference values, men, Framingham Heart Study, Osteoporotic Fractures in Men Study
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Blood Chemical Analysis, Diagnostic Techniques, Endocrine, Europe, Feasibility Studies, Female, Humans, Hypogonadism, Male, Middle Aged, Reference Standards, Reference Values, Testosterone, United States, Cohort Studies, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
