The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Harmonized Reference Ranges for Circulating Testosterone Levels in Men of Four Cohort Studies in the United States and Europe
Open accessAbstract
Background: Reference ranges for testosterone are essential for making a diagnosis of hypogonadism in men. Objective: To establish harmonized reference ranges for total testosterone in men that can be applied across laboratories by cross-calibrating assays to a reference method and standard. Population: The 9054 community-dwelling men in cohort studies in the United States and Europe: Framingham Heart Study; European Male Aging Study; Osteoporotic Fractures in Men Study; and Male Sibling Study of Osteoporosis. Methods: Testosterone concentrations in 100 participants in each of the four cohorts were measured using a reference method at Centers for Disease Control and Prevention (CDC). Generalized additive models and Bland-Altman analyses supported the use of normalizing equations for transformation between cohort-specific and CDC values. Normalizing equations, generated using Passing-Bablok regression, were used to generate harmonized values, which were used to derive standardized, age-specific reference ranges. Results: Harmonization procedure reduced intercohort variation between testosterone measurements in men of similar ages. In healthy nonobese men, 19 to 39 years, harmonized 2.5th, 5th, 50th, 95th, and 97.5th percentile values were 264, 303, 531, 852, and 916 ng/dL, respectively. Age-specific harmonized testosterone concentrations in nonobese men were similar across cohorts and greater than in all men. Conclusion: Harmonized normal range in a healthy nonobese population of European and American men, 19 to 39 years, is 264 to 916 ng/dL. A substantial proportion of intercohort variation in testosterone levels is due to assay differences. These data demonstrate the feasibility of generating harmonized reference ranges for testosterone that can be applied to assays, which have been calibrated to a reference method and calibrator.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“In their effort to harmonize reference ranges, they established 264 to 916 ng/dL as a normal interval for total T in European and American non-obese men aging from 19 to 39 years.”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [178]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Identification of late-onset hypogonadism in middle-aged and elderly men
Wu, F. C. W., Tajar, A., Beynon, J. M., Pye, S. R., Silman, A. J., Finn, J. D., O'Neill, T. W., Bartfai, G., Casanueva, F. F., Forti, G., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0911101 · Cited by 1,544
Self-citationSample Quantiles in Statistical Packages
Hyndman, R. J., & Fan, Y. (1996) · The American Statistician · doi:10.1080/00031305.1996.10473566 · Cited by 1,042
Bhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2847 · Cited by 965
Self-citationWu, F. C. W., Tajar, A., Pye, S. R., Silman, A. J., Finn, J. D., O'Neill, T. W., Bartfai, G., Casanueva, F., Forti, G., Giwercman, A., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1972 · Cited by 939
Self-citationEffects of Testosterone Treatment in Older Men
Snyder, P. J., Bhasin, S., Cunningham, G. R., Matsumoto, A. M., Stephens-Shields, A. J., Cauley, J. A., Gill, T. M., Barrett-Connor, E., Swerdloff, R. S., Wang, C., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1506119 · Cited by 890
Self-citationSplansky, G. L., Corey, D., Yang, Q., Atwood, L. D., Cupples, L. A., Benjamin, E. J., D'Agostino, R. B., Fox, C. S., Larson, M. G., Murabito, J. M., et al. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm021 · Cited by 860
ORWOLL, E. S., Blank, J. B., Barrett-Connor, E. L., Cauley, J. A., Cummings, S. R., Ensrud, K. E., Lewis, C. E., Cawthon, P. M., Marcus, R., Marshall, L. M., et al. (2005) · Contemporary Clinical Trials · doi:10.1016/j.cct.2005.05.006 · Cited by 769
Self-citationOverview of recruitment for the osteoporotic fractures in men study (MrOS)
Blank, J. B., Cawthon, P. M., Carrion-Petersen, M. L., Harper, L., Johnson, J., Mitson, E., & Delay, R. R. (2005) · Contemporary Clinical Trials · doi:10.1016/j.cct.2005.05.005 · Cited by 576
Travison, T. G., Araujo, A. B., Kupelian, V., O’Donnell, A. B., & McKinlay, J. B. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1859 · Cited by 410
Self-citationMyers, G. L., Cooper, G. R., Winn, C., & Smith, S. J. (1989) · Clinics in Laboratory Medicine · doi:10.1016/s0272-2712(18)30645-0 · Cited by 404
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 325
Montagna, G., Balestra, S., D’Aurizio, F., Romanelli, F., Benagli, C., Tozzoli, R., Risch, L., Giovanella, L., & Imperiali, M. (2018) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-1201 · Cited by 17
Baseline Testosterone Predicts Body Composition and Metabolic Response to Testosterone Therapy
Deepika, F., Ballato, E., Colleluori, G., Aguirre, L. E., Chen, R., Qualls, C., Villareal, D. T., & Armamento‐Villareal, R. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.915309 · Cited by 19
Testosterone replacement therapy and spermatogenesis in reproductive age men
Naelitz, B. D., Momtazi-Mar, L., Vallabhaneni, S., Cannarella, R., Vij, S. C., Parekh, N. V., Bole, R., & Lundy, S. D. (2025) · Nature Reviews Urology · doi:10.1038/s41585-025-01032-8 · Cited by 22
Collet, S., Gieles, N. C., Wiepjes, C. M., Heijboer, A. C., Reyns, T., Fiers, T., Lapauw, B., den Heijer, M., & T'Sjoen, G. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac576 · Cited by 16
Self-citationClomiphene citrate improved testosterone and sperm concentration in hypogonadal males
Delu, A., Kiltz, R. J., Kuznetsov, V. A., & Trussell, J. C. (2020) · Systems Biology in Reproductive Medicine · doi:10.1080/19396368.2020.1822457 · Cited by 16
The Association between Serum Testosterone and Hyperuricemia in Males
Tsai, M.-K., Hung, K.-C., Liao, C., Pan, L.-F., Hung, C.-L., & Yang, D. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11102743 · Cited by 19
Sharma, A. R., Kapoor, E., Singh, R., Chang, A. Y., & Erickson, D. Z. (2018) · Clinical Chemistry · doi:10.1373/clinchem.2018.290825 · Cited by 15
Diagnosis of hypogonadism in ageing men
Kaufman, J. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09763-4 · Cited by 18
Self-citationJayasena, C. N., de Silva, N. L., O’Reilly, M., MacKenzie, F., Marrington, R., Jones, H. T., Livingston, M. A., Downie, P., Hackett, G. I., Ramachandran, S., et al. (2023) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/00045632231179022 · Cited by 15
Self-citationOptimizing Diagnostic Accuracy and Treatment Decisions in Men With Testosterone Deficiency
Bhasin, S., & Ozimek, N. (2021) · Endocrine Practice · doi:10.1016/j.eprac.2021.08.002 · Cited by 15
Self-citationBenefits and Risks of Testosterone Treatment of Older Men with Hypogonadism
Galbiati, F., Goldman, A. L., Gattu, A. K., Guzelce, E. C., & Bhasin, S. (2022) · Urologic Clinics of North America · doi:10.1016/j.ucl.2022.07.011 · Cited by 14
Self-citationAndrogen Excess and Deficiency: Analytical and Diagnostic Approaches
Heijboer, A. C., & Hannema, S. E. (2023) · Clinical Chemistry · doi:10.1093/clinchem/hvad146 · Cited by 14
Aging and sex hormones in males
Decaroli, M. C., Vincentis, S. D., & Rochira, V. (2021) · Vitamins and hormones · doi:10.1016/bs.vh.2020.12.014 · Cited by 14
Prognostic value of total testosterone levels in patients with acute coronary syndromes
Gencer, B., Vuilleumier, N., Nanchen, D., Collet, T., Klingenberg, R., Räber, L., Auer, R., Carballo, D., Carballo, S., Aghlmandi, S., et al. (2019) · European Journal of Preventive Cardiology · doi:10.1177/2047487319853343 · Cited by 13
Semen quality in patients with pituitary disease and adult-onset hypogonadotropic hypogonadism
Andreassen, M., Juul, A., Feldt‐Rasmussen, U., & Jørgensen, N. (2018) · Endocrine Connections · doi:10.1530/ec-18-0061 · Cited by 13
The effect of Eurycoma Longifolia on the regulation of reproductive hormones in young males
Chan, K. Q., Stewart, C., Chester, N., Hamzah, S. H., & Yusof, A. (2021) · Andrologia · doi:10.1111/and.14001 · Cited by 12
Banica, T., Verroken, C., T'Sjoen, G. G., Goemaere, S., Zmierczak, H., Fiers, T., Kaufman, J., & Lapauw, B. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4543 · Cited by 24
Self-citationFigueiredo, M. G., Gagliano‐Jucá, T., & Basaria, S. S. (2023) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2022.12.002 · Cited by 12
Plusquin, M., Wang, C., Cosemans, C., Roels, H. A., Vangeneugden, M., Lapauw, B., Fiers, T., T'Sjoen, G. G., & Nawrot, T. S. (2023) · Environmental Health · doi:10.1186/s12940-023-01010-w · Cited by 12
Self-citationBenefits of Testosterone Hormone in the Human Body: A Systematic Review
Rojas-Zambrano, J. G., Rojas-Zambrano, A. R., Rojas-Zambrano, A. F., & Barahona-Cueva, G. E. (2025) · Cureus · doi:10.7759/cureus.78785 · Cited by 14
Depression in Nonclassical Hypogonadism in Young Men
Korenman, S. G., Grotts, J. F., Bell, D. S., & Elashoff, D. A. (2018) · Journal of the Endocrine Society · doi:10.1210/js.2018-00137 · Cited by 12
Berryman, C. E., McClung, H. L., Sepowitz, J. J., Gaffney‐Stomberg, E., Ferrando, A. A., McClung, J. P., & Pasiakos, S. M. (2022) · Physiological Reports · doi:10.14814/phy2.15461 · Cited by 10
Abouelgreed, T. A., Elatreisy, A., El‐Sherbiny, A. F., Abdelaal, M. A., Saafan, T., Shalkamy, O., Farag, H. I., Ghoneimy, O. M., El-Dydamony, E. M., Ibrahim, E. H., et al. (2023) · Basic and Clinical Andrology · doi:10.1186/s12610-023-00191-1 · Cited by 11
Narinx, N., Nyamaah, J. A., David, K., Sommers, V., Walravens, J., Fiers, T., Lapauw, B., Decallonne, B., Claessens, F., Uytfanghe, K. V., et al. (2025) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2024-1237 · Cited by 10
Self-citationLuberti, F. R., Reside, T.-L., Bonin, P. L., & Carré, J. M. (2021) · Hormones and Behavior · doi:10.1016/j.yhbeh.2021.105046 · Cited by 11
Anawalt, B. D., O’Connor, K., & Grossmann, M. (2026) · JAMA · doi:10.1001/jama.2026.8526 · Cited by 11
Kosidou, K., Karlsson, H., Arver, S., Bhasin, S., Dalman, C., & Gardner, R. M. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.02.1014 · Cited by 12
Self-citationTestosterone Therapy in Older Men: Present and Future Considerations
Yeap, B. B., Tran, C., Douglass, C. M., & McNeil, J. J. (2025) · Drugs & Aging · doi:10.1007/s40266-025-01209-1 · Cited by 10
Integrity of hypothalamic–pituitary‐testicular axis in exceptional longevity
Aleksić, S., Desai, D., Ye, K. Q., Duran, S., Gao, T., Crandall, J. P., Atzmon, G., Barzilai, N., & Milman, S. (2022) · Aging Cell · doi:10.1111/acel.13656 · Cited by 9
Pruett, J. E., Romero, D. G., & Cardozo, L. L. Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.951099 · Cited by 10
Beta-estradiol and ethinylestradiol enhance RBC deformability dependent on their blood concentration
Farber, P. L., Freitas, T., Saldanha, C., & Silva-Herdade, A. S. (2018) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-180392 · Cited by 10
The effects of age and obesity on postprandial dynamics of serum testosterone levels in men
de Velde, F. V., Reyns, T., Toye, K. R. C., Fiers, T., Kaufman, J., T'Sjoen, G. G., & Lapauw, B. (2019) · Clinical Endocrinology · doi:10.1111/cen.14141 · Cited by 10
Self-citationMale reproductive hormones in patients treated with pretomanid
Boekelheide, K., Olugbosi, M., Nedelman, J. R., Everitt, D. E., Smith, E., Betteridge, M., Sun, E., & Spigelman, M. (2022) · The International Journal of Tuberculosis and Lung Disease · doi:10.5588/ijtld.21.0654 · Cited by 9
Schiappa, E. (2021) · Routledge eBooks · doi:10.4324/9781003250494 · Cited by 9
King, B., Natale, C., & Hellstrom, W. J. G. (2022) · Urologic Clinics of North America · doi:10.1016/j.ucl.2022.07.009 · Cited by 9
Serum Total Testosterone and Premature Mortality Among Men in the USA
Fantus, R. J., Chang, C., Platz, E. A., Bennett, N., Helfand, B. T., Brannigan, R. E., & Halpern, J. A. (2021) · European Urology Open Science · doi:10.1016/j.euros.2021.05.008 · Cited by 9
Diagnosis and Evaluation of Hypogonadism
Matsumoto, A. M. (2022) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2021.11.001 · Cited by 9
Self-citationConnolly, M. J., Kerse, N. M., WILKINSON, T. J., Menzies, O. H., Rolleston, A. K., Chong, Y. H., Broad, J., Moyes, S. A., Jatrana, S., & Teh, R. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-016572 · Cited by 8
The anabolic applications of androgens in older adults with functional limitations
Gattu, A. K., Goldman, A. L., Guzelce, E. C., Galbiati, F., & Bhasin, S. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09766-1 · Cited by 9
Self-citationJayasena, C. N., de Silva, N. L., O’Reilly, M., MacKenzie, F., Marrington, R., Jones, H. T., Livingston, M. A., Downie, P., Hackett, G. I., Ramachandran, S., et al. (2023) · Clinical Endocrinology · doi:10.1111/cen.14929 · Cited by 9
Self-citationMale and female atria exhibit distinct acute electrophysiological responses to sex steroids
Wells, S. P., O’Shea, C., Hayes, S., Weeks, K. L., Kirchhof, P. F., Delbridge, L. M. D., Pavlović, D., & Bell, J. R. (2024) · Journal of Molecular and Cellular Cardiology Plus · doi:10.1016/j.jmccpl.2024.100079 · Cited by 8
Tan, Z., Shen, J., Huang, Y., Li, J., Ding, M., Sun, A., Hong, J., Yang, Y., He, S., Zhu, X., et al. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1398600 · Cited by 8
Jasuja, R., Pencina, K. M., Lawney, B. P., Stephens‐Shields, A. J., Ellenberg, S. S., Snyder, P. J., & Bhasin, S. (2024) · Andrology · doi:10.1111/andr.13707 · Cited by 8
Self-citationStress Responses to One-Day Athletic Tournament in Sport Coaches: A Pilot Study
Obmiński, Z., Supiński, J., Rydzik, Ł., Cynarski, W. J., Ozimek, M., Borysiuk, Z., Błach, W., & Ambroży, T. (2022) · Biology · doi:10.3390/biology11060828 · Cited by 8
Grossmann, M., Fui, M. N. T., Hoermann, R., & Wittert, G. (2019) · Asian Journal of Andrology · doi:10.4103/aja.aja_96_19 · Cited by 8
Impact of Testosterone on Male Health: A Systematic Review
Rojas-Zambrano, J. G., Rojas-Zambrano, A. R., & Rojas-Zambrano, A. F. (2025) · Cureus · doi:10.7759/cureus.82917 · Cited by 10
Xie, Y., Pan, M., Zhang, Z., Zhang, L., Liu, H., Wang, X., Lu, W. W., Tang, P., & Ge, W. (2025) · Advanced Science · doi:10.1002/advs.202501518 · Cited by 7
Testosterone Treatment in Prostate Cancer Survivors With Hypogonadism
Bhasin, S., Burnett, A. L. “., Gagliano‐Jucá, T., Storer, T. W., Reid, K. F., Shang, Y. V., Privat, F., Chandra, M. S., Weiss, M., Beleva, Y. M., et al. (2026) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2026.1343 · Cited by 7
Self-citationMedical Treatment of Hypogonadism in Men
Mani, S. B., & Clavijo, R. I. (2022) · Urologic Clinics of North America · doi:10.1016/j.ucl.2021.12.008 · Cited by 7
Ascorbic acid is associated with favourable hormonal profiles among infertile males
Panah, M. R., Tahir, I., García‐Bailo, B., Lo, K. C., Jarvi, K. A., & El‐Sohemy, A. (2023) · Frontiers in Reproductive Health · doi:10.3389/frph.2023.1143579 · Cited by 7
Harmonization of Liquid Chromatography–Tandem Mass Spectrometry Protein Assays
Rockwood, A. L., Lowenthal, M. S., & Bystrom, C. E. (2018) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2018.05.004 · Cited by 7
Hadlow, N. C., Brown, S. J., Lim, E. M., Prentice, D. A., Pettigrew, S., Cronin, S. L., Prescott, S. L., Silva, D. T., & Yeap, B. B. (2022) · Clinical Endocrinology · doi:10.1111/cen.14725 · Cited by 7
Hypogonadism in Systemic Diseases
Rochira, V. (2017) · Endocrinology · doi:10.1007/978-3-319-29456-8_28-1 · Cited by 7
Tamura, N., Watanabe, E., Shirakawa, R., Nakatani, E., Yamada, K., Hatakeyama, H., Torii-Hanakita, M., Kyo, C., Kosugi, R., Ogawa, T., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0253807 · Cited by 7
Judge, C., Lightowler, D., Singh, A., Yeap, B. B., & Thin, L. W. Y. (2024) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izae177 · Cited by 5
Walravens, J., Snaterse, G., Narinx, N., Reyns, T., Uytfanghe, K. V., Vanderschueren, D., Wu, F. C. W., Kaufman, J., Antonio, L., Fiers, T., et al. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf507 · Cited by 5
Self-citationDietary patterns and testosterone balance: a review of clinical data and perspectives
Liu, X., Li, X., Cai, D., Sun, J., & Bai, W. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.11.016 · Cited by 6
Results of a 5-Year N-of-1 Growth Hormone Releasing Hormone Gene Therapy Experiment
Hanley, B. P., Brewer, K., & Church, G. M. (2021) · Rejuvenation Research · doi:10.1089/rej.2021.0036 · Cited by 6
Pavan, A., Cendron, L., Nisio, A. D., Pedrucci, F., Šabović, I., Scarso, A., Ferlin, A., Angelini, A., Foresta, C., & Toni, L. D. (2023) · Toxicology · doi:10.1016/j.tox.2023.153664 · Cited by 6
Braun, V., Ceglarek, U., Gaudl, A., Gawinecka, J., Müller, D., Rauh, M., Weber, M., & Seger, C. (2023) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2023-0847 · Cited by 6
Pharmacological targeting of age-related changes in skeletal muscle tissue
Leuchtmann, A. B., & Handschin, C. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.02.030 · Cited by 7
Low testosterone and cardiometabolic risks in a real-world study of US male firefighters
Ranadive, S. M., Lofrano‐Porto, A., Soares, E. D. M. K. V. K., Eagan, L. E., Porto, L. G. G., & Smith, D. L. (2021) · Scientific Reports · doi:10.1038/s41598-021-93603-z · Cited by 6
Carré, J. M., Hemsworth, C. T., & Alabi, I. A. (2023) · Adaptive Human Behavior and Physiology · doi:10.1007/s40750-023-00229-8 · Cited by 6
Agretti, P., Pelosini, C., Bianchi, L., Grosso, A. D., Saba, A., Canale, D., & Sessa, M. R. (2020) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01304-7 · Cited by 6
Smelser, W., Randall, J. H., Caldwell, J., Glavin, K., Lee, E. K., Nangia, A. K., & Holzbeierlein, J. M. (2021) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2020.12.013 · Cited by 6
An oral lipidic native testosterone formulation that is absorbed independent of food
Newell-Price, J. D. C., Huatan, H., Quirke, J., Porter, J. B., Daniel, E., Mumdzic, E., Voet, B., Keevil, B. G., Whitaker, M. J., & Ross, R. J. M. (2021) · European Journal of Endocrinology · doi:10.1530/eje-21-0606 · Cited by 6
Sexual Dysfunction in Chronic Kidney Disease
Johansen, K. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815876-0.00037-1 · Cited by 6
Cousins, H. C., & Altman, R. B. (2023) · medRxiv · doi:10.1101/2023.02.28.23286515 · Cited by 6
Detomas, M., Altieri, B., Nasi‐Kordhishti, I., Ryba, A. S., Haberbosch, L., Chierigo, F., Deutschbein, T., Faßnacht, M., Mortini, P., Flitsch, J., et al. (2025) · Journal of Endocrinological Investigation · doi:10.1007/s40618-025-02559-8 · Cited by 5
Shahid, W., & Noor, R. (2025) · Scientific Reports · doi:10.1038/s41598-025-00599-x · Cited by 5
Park, S., Song, S.-S., Jung, W., Yun, H., Lee, S., Kang, S., & Chae, J. (2025) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2025.05.036 · Cited by 6
Variability in SHBG assays and the effect thereof on calculated estimates of free testosterone
Walravens, J., Adaway, J., Reyns, T., Narinx, N., Nyamaah, J. A., Antonio, L., Jean-Marc, K., Keevil, B. G., Fiers, T., & Lapauw, B. (2025) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/00045632251350676 · Cited by 5
Self-citationChen, K. L., Kenney, H. M., Schwarz, E. M., & Rahimi, H. (2024) · Journal of the Endocrine Society · doi:10.1210/jendso/bvae169 · Cited by 5
The androgen clock is an epigenetic predictor of long-term male hormone exposure
Sugrue, V. J., Prescott, M., Glendining, K. A., Bond, D. M., Horvath, S., Anderson, G. M., Garratt, M., Campbell, R. E., & Hore, T. A. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2420087121 · Cited by 4
Delgouffe, E., Silva, S. M., Chalmel, F., Cools, W., Raets, C., Tilleman, K., T'Sjoen, G. G., Baert, Y., & Goossens, E. (2024) · eLife · doi:10.7554/elife.94825.3 · Cited by 5
Klokol, D., Nallenthiran, L., Wong, M. B., Chernykh, V., Yefimov, S., Nalapko, Y., & Nesamany, B. (2019) · Obstetrics & Gynecology International Journal · doi:10.15406/ogij.2019.10.00449 · Cited by 5
Exploring the concept of vigor and dys-vigor in men of 50-65 years: effects of Robuvit®
Ledda, A. G., Hosoi, M., Cesarone, M. R., Dugall, M., Hu, S., Belcaro, G. V., Maione, C., Cotellese, R., Feragalli, B., SCIPIONE, V., et al. (2020) · Panminerva Medica · doi:10.23736/s0031-0808.19.03795-9 · Cited by 5
Майданюк, Е. В., & Вдовенко, Н. В. (2021) · PROBLEMS OF ENDOCRINE PATHOLOGY · doi:10.21856/j-pep.2021.2.07 · Cited by 8
Hypogonadism in Systemic Diseases
Rochira, V. (2017) · Endocrinology · doi:10.1007/978-3-319-44441-3_28 · Cited by 5
The role of testosterone in men’s health: is it time for a new approach?
Diokno, A. C. (2022) · International Urology and Nephrology · doi:10.1007/s11255-022-03292-4 · Cited by 5
Ishay, A., Tzemah, S., Nitzan, R., Jehassi, A., & Cohen, M. (2019) · Sexual Medicine · doi:10.1016/j.esxm.2019.06.011 · Cited by 5
Handelsman, D. J., & Shankara‐Narayana, N. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa326 · Cited by 5
Non-human primates as a translational model for the study of male reproductive health
Edenfield, R. C., Bash, J. C., Shorey‐Kendrick, L. E., D'Mello, R. J., Rice-Stitt, T. L., Hagen, O. L., Graham, J. A., Orwig, K. E., Easley, C. A., Hedges, J. C., et al. (2025) · Nature Reviews Urology · doi:10.1038/s41585-025-01062-2 · Cited by 4
Testosterone Therapy in Adult Males with Hypogonadism
Boeri, L., Masterson, T., Antonio, L., Corona, G., Khera, M., Salonia, P. A., & Mulhall, J. P. (2025) · European Urology · doi:10.1016/j.eururo.2025.12.015 · Cited by 7
Testosterone and cancers: biological functions, molecular mechanisms and therapy
Zhou, Z., Huang, T., Li, J., Fu, L., Xu, L., Feng, X., Zhang, Z., Pan, H., Qin, K., Zhou, X., et al. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02676-9 · Cited by 4
Prostate Cancer: Epidemiology, Etiology, Pathogenesis, and Risk Factors
Pejcic, T. P. (2024) · Springer eBooks · doi:10.1007/978-3-031-51712-9_1 · Cited by 4
Rajmil, O., & Moreno-Sepulveda, J. A. (2023) · Actas Urológicas Españolas · doi:10.1016/j.acuro.2023.07.001 · Cited by 4
Rajmil, O., & Moreno-Sepulveda, J. A. (2023) · Actas Urológicas Españolas (English Edition) · doi:10.1016/j.acuroe.2023.07.007 · Cited by 6
Understanding One Half of the Sex Difference Equation
Visanji, M., Venegas-Pino, D. E., & Werstuck, G. H. (2023) · American Journal Of Pathology · doi:10.1016/j.ajpath.2023.11.009 · Cited by 4
Novel reference range values for serum testosterone: a cross-sectional study of 200,000 males
Fantus, R. J., Greenberg, D. R., Chang, C., Helfand, B. T., Xu, J., Wei, J., Shoag, J. E., Nangia, A. K., Brannigan, R. E., & Halpern, J. A. (2024) · Journal of Endocrinological Investigation · doi:10.1007/s40618-024-02319-0 · Cited by 4
Porto, L. G. G., Soares, E. D. M. K. V. K., Ranadive, S. M., Lofrano‐Porto, A., & Smith, D. L. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21030274 · Cited by 4
Deitrich, J. N., & Gorgey, A. S. (2024) · Spinal Cord · doi:10.1038/s41393-024-01022-4 · Cited by 6
Testosterone acts through the membrane protein GPRC6A to cause cardiac edema in zebrafish embryos
Zadmajid, V., Shahriar, S., & Gorelick, D. A. (2024) · Development · doi:10.1242/dev.204390 · Cited by 6
Rethinking Low Testosterone in Older Men: Association With Obesity Rather Than Aging
Tiraboschi, T. L. N., Miranda, E., Novaes, M. T., Silva, C. S., Contreras, J. C. Z., Filho, J. D. S. R., Reggio, E., Suartz, C. V., Gomes, C. M., & de Bessa, J. (2025) · Urology · doi:10.1016/j.urology.2024.12.036 · Cited by 4
A brief update on mass spectrometry applications to routine clinical endocrinology
Holmes, D. T. (2019) · Clinical mass spectrometry · doi:10.1016/j.clinms.2019.05.006 · Cited by 4
Loss of vision: How mathematics turned blind while it learned to see more clearly
Buldt, B., & Schlimm, D. (2010) · Cited by 4
Testosterone and Life Span or Why Women Live Longer than Men: A Hypothesis
Kulikov, A. V., & Архипова, Л. В. (2021) · Moscow University Biological Sciences Bulletin · doi:10.3103/s0096392521030093 · Cited by 4
Saleem, M., Khan, S., Khan, M., Suchal, Z. A., & Ram, N. (2023) · PubMed Central · doi:10.22074/ijfs.2022.540499.1201 · Cited by 4
Er-Lukowiak, M., Hansen, C. S., & Lotter, H. (2023) · Current topics in microbiology and immunology · doi:10.1007/978-3-031-35139-6_8 · Cited by 4
Adult Male Hypogonadism: A Laboratory Medicine Perspective on Its Diagnosis and Management
Livingston, M. A., & Heald, A. H. (2023) · Diagnostics · doi:10.3390/diagnostics13243650 · Cited by 6
Metadata
- Authors
- Travison, T. G., Vesper, H. W., Orwoll, E., Wu, F., Kaufman, J. M., Wang, Y., Lapauw, B., Fiers, T., Matsumoto, A. M., & Bhasin, S.
- Affiliations
- Hebrew SeniorLife (US)
- Centers for Disease Control and Prevention (US)
- Oregon Health & Science University (US)
- Manchester Academic Health Science Centre (GB)
- Ghent University Hospital (BE)
- University of Washington (US)
- Brigham and Women's Hospital (US)
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2017-01-10
- Volume
- 102
- Issue
- 4
- Pages
- 1161-1173
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC5460736
- OpenAlex
- W2604915862
- Cited by
- 326
- References
- 41
- Citations by year
- 2026: 26 · 2025: 41 · 2024: 42 · 2023: 41 · 2022: 45 · 2021: 28 · 2020: 34 · 2019: 27 · 2018: 28 · 2017: 11
- FWCI
- 21.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- National Institutes of Health (UL1TR000128, n01hc25195-41-0-1, 5p30ag031679-15)
- Centers for Disease Control and Prevention
- National Institute on Aging (U01AG042145, R01AG031206, U01AG042168, U01AG042143, U01AG027810, P30-AG031679, U01AG042139, U01AG042124, U01AG042140)
- National Heart, Lung, and Blood Institute (N01-HC-025195)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (U01AR066160)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- total testosterone, reference values, hypogonadism, assay harmonization, age-related reference values, men, Framingham Heart Study, Osteoporotic Fractures in Men Study
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Blood Chemical Analysis, Diagnostic Techniques, Endocrine, Europe, Feasibility Studies, Female, Humans, Hypogonadism, Male, Middle Aged, Reference Standards, Reference Values, Testosterone, United States, Cohort Studies, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review