Perspectives on polycystic ovary syndrome: Is polycystic ovary syndrome research underfunded?
Open accessAbstract
Context: Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic abnormality with a worldwide prevalence of 4% to 21%, depending on diagnostic criteria. The National Institutes of Health (NIH) is the largest single funding agency in the world; it invests nearly $30.0 billion annually in biomedical research. Evidence Acquisition: Using the NIH Research Portfolio Online Reporting tool, we searched for all grants awarded by the NIH for PCOS and three other disorders with similar degrees of morbidity and similar or lower mortality and prevalence [rheumatoid arthritis (RA), tuberculosis (TB), and systemic lupus erythematosus (SLE)]. Evidence Synthesis: We compared funding by the NIH for PCOS, RA, TB, and SLE research for the years 2006 to 2015, inclusive. Conclusion: PCOS, compared with RA, TB, and SLE, was relatively less funded (total mean 10-year funding was $215.12 million vs $454.39 million, $773.77 million, and $609.52 million, respectively). Funding for PCOS was largely provided by one NIH Institute/Center (ICs) vs at least two ICs for SLE and RA; more individual Research Project Grants were awarded for RA, SLE, and TB than for PCOS, whereas PCOS funding was more likely to be through General Clinical Research Centers Program or Specialized Centers Program awards. Our data suggest that PCOS research may be underfunded considering its prevalence, economic burden, metabolic morbidity, and negative impact on quality of life. Greater education of NIH leaders, including those at the National Heart, Lung, and Blood Institute and National Institutes of Diabetes and Digestive and Kidney Diseases; other federal and state agency leads; elected leaders; and the general public by professional societies, the scientific community, and patient advocates regarding this disorder is needed.
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Cites
Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Futterweit, W., Janssen, O. E., Legro, R. S., Norman, R. J., Taylor, A. E., et al. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.06.035 · Cited by 2,132 · see citing works
Self-citationDiamanti-Kandarakis, E., & Dunaif, A. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1034 · Cited by 1,947 · see citing works
Cervera, R., Khamashta, M. A., Font, J., Sebastiani, G. D., Gil, A., Lavilla, P., Mejía, J. C., Aydintug, A. O., Chwalinska-Sadowska, H., de Ramón, E., et al. (2003) · Medicine · doi:10.1097/01.md.0000091181.93122.55 · Cited by 1,377 · see citing works
Criteria, Prevalence, and Phenotypes of Polycystic Ovary Syndrome
Lizneva, D., Suturina, L., Walker, W., Brakta, S., Gavrilova-Jordan, L., & Azziz, R. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.05.003 · Cited by 1,358 · see citing works
Self-citationMortality in systemic lupus erythematosus
Bernatsky, S., Boivin, J. ‐., Joseph, L., et al. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21955 · Cited by 1,198 · see citing works
Wild, S., Pierpoint, T., McKeigue, P., & Jacobs, H. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.01000.x · Cited by 970 · see citing works
Pregnancy complications in women with polycystic ovary syndrome
Palomba, S., de Wilde, M. A., Falbo, A., Koster, M. P. H., La Sala, G. B., & Fauser, B. C. J. M. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv029 · Cited by 691 · see citing works
Azziz, R., Marin, C., Hoq, L., Badamgarav, E., & Song, P. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0628 · Cited by 537 · see citing works
Self-citationMortality of Women with Polycystic Ovary Syndrome at Long-term Follow-up
Pierpoint, T., McKeigue, P. M., Isaacs, A. J., Wild, S. H., & Jacobs, H. S. (1998) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(98)00035-3 · Cited by 504 · see citing works
Gibson-Helm, M., Teede, H., Dunaif, A., & Dokras, A. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2963 · Cited by 428 · see citing works
Influence of Macrosocial Policies on Women's Health and Gender Inequalities in Health
Borrell, C., Palencia, L., Muntaner, C., Urquia, M. L., Malmusi, D., & O'Campo, P. J. (2013) · Epidemiologic Reviews · doi:10.1093/epirev/mxt002 · Cited by 222 · see citing works
Dokras, A., Saini, S., Gibson-Helm, M., Schulkin, J., Cooney, L., & Teede, H. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.04.011 · Cited by 218 · see citing works
Death rates and causes of death in patients with rheumatoid arthritis: a population‐based study
Sihvonen, S., Korpela, M., Laippala, P., et al. (2004) · Scandinavian Journal of Rheumatology · doi:10.1080/03009740410005845 · Cited by 174 · see citing works
Trends in Tuberculosis — United States, 2012
Miramontes, R., Pratt, R. H., Price, S. F., et al. (2013) · PubMed Central · Cited by 115 · see citing works
Trends in Tuberculosis--United States, 2005
Alami, N. N., Yuen, C. M., Miramontes, R., et al. (2006) · PsycEXTRA Dataset · doi:10.1037/e566482006-003 · Cited by 103 · see citing works
Danthi, N. S., Wu, C. O., Shi, P., & Lauer, M. S. (2014) · Circulation Research · doi:10.1161/circresaha.114.302656 · Cited by 82 · see citing works
Long term complications of polycystic ovary syndrome (PCOS)
Peigné, M., & Dewailly, D. (2014) · Annales d Endocrinologie · doi:10.1016/j.ando.2014.07.111 · Cited by 81 · see citing works
Factors associated with mortality in tuberculosis patients.
Alavi-Naini, R., Moghtaderi, A., Metanat, M., Mohammadi, M., & Zabetian, M. (2013) · Europe PMC (PubMed Central) · Cited by 67 · see citing works
Eblen, M., Wagner, R. M., Roychowdhury, D., Patel, K. C., & Pearson, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155060 · Cited by 42 · see citing works
Head, M., Fitchett, J. R. A., Nageshwaran, V., Kumari, N., Hayward, A. C., & Atun, R. A. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.12.016 · Cited by 41 · see citing works
Jung, R. S., Bennion, J. R., Sorvillo, F. J., et al. (2010) · Public Health Reports · doi:10.1177/003335491012500307 · Cited by 32 · see citing works
Martin, M. R., Kopstein, A., & Janice, J. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013526 · Cited by 31 · see citing works
Lindner, M. D., Vancea, A., Chen, M., & Chacko, G. W. (2015) · American Journal of Evaluation · doi:10.1177/1098214015582049 · Cited by 21 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Danthi N, Wu CO, Shi P, Lauer M. Percentile ranking and citation impact of a large cohort of NHLBI-funded cardiovascular R01 grants. Circ Res. 2014;114(4):600-606.
Cited by
Sorted by citations
Polycystic Ovary Syndrome: Definition, Aetiology, Diagnosis and Treatment
Escobar-Morreale, H. F. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2018.24 · Cited by 2,083 · see citing works
Riestenberg, C., Jagasia, A., Markovic, D., Buyalos, R. P., & Azziz, R. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab613 · Cited by 210 · see citing works
Self-citationTeede, H. J., Misso, M. L., Boyle, J. A., Garad, R. M., McAllister, V., Downes, L., Gibson‐Helm, M., Hart, R. J., Rombauts, L., Moran, L., et al. (2018) · Medical Journal of Australia · doi:10.5694/mja18.00656 · Cited by 115 · see citing works
Yadav, S., Delau, O., Bonner, A. J., Markovic, D., Patterson, W., Ottey, S., Buyalos, R. P., & Azziz, R. (2023) · eLife · doi:10.7554/elife.85338 · Cited by 85 · see citing works
Self-citationComplex diseases and co-morbidities: polycystic ovary syndrome and type 2 diabetes mellitus
Rodgers, R. J., Avery, J. C., Moore, V. M., Davies, M. J., Azziz, R., Stener-Victorin, E., Moran, L. J., Robertson, S. A., Stepto, N. K., Norman, R. J., et al. (2019) · Endocrine Connections · doi:10.1530/ec-18-0502 · Cited by 60 · see citing works
Self-citationHoyos, L. R., Putra, M., Armstrong, A. A., Cheng, C. Y., Riestenberg, C. K., Schooler, T. A., & Dumesic, D. A. (2020) · Journal of Medical Internet Research · doi:10.2196/16541 · Cited by 53 · see citing works
Vine, D., Ghosh, M., Wang, T., & Bakal, J. (2024) · CJC Open · doi:10.1016/j.cjco.2023.12.010 · Cited by 53 · see citing works
Wright, P. J., Dawson, R. M., & Corbett, C. F. (2020) · Journal of Advanced Nursing · doi:10.1111/jan.14371 · Cited by 53 · see citing works
Ismayilova, M., & Yaya, S. (2022) · BMC Women's Health · doi:10.1186/s12905-022-01734-w · Cited by 40 · see citing works
- Authors
- Brakta, S., Lizneva, D., Mykhalchenko, K., Imam, A., Walker, W., Diamond, M. P., & Azziz, R.
- Affiliations
- Augusta University (US)
- Bronx-Lebanon Hospital Center (US)
- HCA Florida Orange Park Hospital (US)
- State University of New York (US)
- Corresponding author
- Azziz, Ricardo
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2017-09-19
- Volume
- 102
- Issue
- 12
- Pages
- 4421-4427
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2754372557
- Cited by
- 76
- References
- 23
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 10 · 2023: 13 · 2022: 9 · 2021: 11 · 2020: 6 · 2019: 6 · 2018: 4
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- State University of New York
- Augusta University
- National Institutes of Health
- National Institute of Child Health and Human Development
- NIH Clinical Center
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health and Medical Research Impacts
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › scientometrics and bibliometrics research
- Keywords
- polycystic ovary syndrome, research funding, NIH grants, rheumatoid arthritis, tuberculosis, systemic lupus erythematosus, research funding disparities, research project grants, patient advocacy
- MeSH terms
- Female, Humans, National Institutes of Health (U.S.), Polycystic Ovary Syndrome, Quality of Life, Research, Research Support as Topic, United States, Prevalence
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