Patterns of plasma glucagon dynamics do not match metabolic phenotypes in young women
Open accessAbstract
Context: The role of hyperglucagonemia in type 2 diabetes is still debated. Objective: We analyzed glucagon dynamics during oral glucose tolerance tests (oGTTs) in young women with one out of three metabolic phenotypes: healthy control (normoglycemic after a normoglycemic pregnancy), normoglycemic high-risk (normoglycemic after a pregnancy complicated by gestational diabetes), and prediabetes/screening-diagnosed type 2 diabetes. We asked if glucagon patterns were homogeneous within the metabolic phenotypes. Design and Setting: Five-point oGTT, sandwich enzyme-linked immunosorbent assay for glucagon, and functional data analysis with unsupervised clustering. Participants: Cross-sectional analysis of 285 women from the monocenter observational study Prediction, Prevention, and Subclassification of gestational and type 2 Diabetes, recruited between November 2011 and May 2016. Results: We found four patterns of glucagon dynamics that did not match the metabolic phenotypes. Elevated fasting glucagon and delayed glucagon suppression was overrepresented with prediabetes/diabetes, but this was only detected in 21% of this group. It also occurred in 8% of the control group. Conclusions: We conclude that hyperglucagonemia may contribute to type 2 diabetes in a subgroup of affected individuals but that it is not a sine qua non for the disease. This should be considered in future pathophysiological studies and when testing pharmacotherapies addressing glucagon signaling.
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“(38), as representative of the four clusters identified in glucagon curve shapes of individuals with different metabolic phenotypes (i.”
BackgroundMethodInfluential
- Authors
- Gar, C., Rottenkolber, M., Sacco, V., Moschko, S., Banning, F., Hesse, N., Popp, D., Hübener, C., Seissler, J., & Lechner, A.
- Affiliations
- Helmholtz Munich (DE)
- Ludwig-Maximilians-Universität München (DE)
- Corresponding author
- Lechner, Andreas
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2017-12-13
- Volume
- 103
- Issue
- 3
- Pages
- 972-982
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2775507935
- Cited by
- 18
- References
- 46
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 4 · 2018: 1
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Site cant be reached (submittedVersion, other-oa)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Funders
- Helmholtz Zentrum München
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- hyperglucagonemia, type 2 diabetes, prediabetes, oral glucose tolerance test, gestational diabetes mellitus, young women, glucagon suppression, metabolic phenotypes, glucagon signaling
- MeSH terms
- Adult, Blood Glucose, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Glucagon, Glucose Tolerance Test, Humans, Phenotype, Prediabetic State, Pregnancy, Case-Control Studies, Diabetes, Gestational
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