Cited by 18Pancreatic function and diabetesGestational Diabetes Research and ManagementDiabetes Treatment and Management

Patterns of plasma glucagon dynamics do not match metabolic phenotypes in young women

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Gar, Christina, Rottenkolber, Marietta, Sacco, Vanessa, Moschko, Sarah, Banning, Friederike, Hesse, Nina, Popp, Daniel, Hübener, Christoph +2 more·2018·The Journal of Clinical Endocrinology & Metabolism

Abstract

Context: The role of hyperglucagonemia in type 2 diabetes is still debated. Objective: We analyzed glucagon dynamics during oral glucose tolerance tests (oGTTs) in young women with one out of three metabolic phenotypes: healthy control (normoglycemic after a normoglycemic pregnancy), normoglycemic high-risk (normoglycemic after a pregnancy complicated by gestational diabetes), and prediabetes/screening-diagnosed type 2 diabetes. We asked if glucagon patterns were homogeneous within the metabolic phenotypes. Design and Setting: Five-point oGTT, sandwich enzyme-linked immunosorbent assay for glucagon, and functional data analysis with unsupervised clustering. Participants: Cross-sectional analysis of 285 women from the monocenter observational study Prediction, Prevention, and Subclassification of gestational and type 2 Diabetes, recruited between November 2011 and May 2016. Results: We found four patterns of glucagon dynamics that did not match the metabolic phenotypes. Elevated fasting glucagon and delayed glucagon suppression was overrepresented with prediabetes/diabetes, but this was only detected in 21% of this group. It also occurred in 8% of the control group. Conclusions: We conclude that hyperglucagonemia may contribute to type 2 diabetes in a subgroup of affected individuals but that it is not a sine qua non for the disease. This should be considered in future pathophysiological studies and when testing pharmacotherapies addressing glucagon signaling.

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Crossref · 10.1210/jc.2017-02014

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Authors
Gar, C., Rottenkolber, M., Sacco, V., Moschko, S., Banning, F., Hesse, N., Popp, D., Hübener, C., Seissler, J., & Lechner, A.
Affiliations
  • Helmholtz Munich (DE)
  • Ludwig-Maximilians-Universität München (DE)
Corresponding author
Lechner, Andreas
Venue
The Journal of Clinical Endocrinology & Metabolism
Published
2017-12-13
Volume
103
Issue
3
Pages
972-982
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
OpenAlex
W2775507935
Cited by
18
References
46
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 4 · 2018: 1
FWCI
1.41
Type
journal article
Language
en
Licence
other-oa
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Site cant be reached (submittedVersion, other-oa)
  • PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
Funders
Helmholtz Zentrum München
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
hyperglucagonemia, type 2 diabetes, prediabetes, oral glucose tolerance test, gestational diabetes mellitus, young women, glucagon suppression, metabolic phenotypes, glucagon signaling
MeSH terms
Adult, Blood Glucose, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Glucagon, Glucose Tolerance Test, Humans, Phenotype, Prediabetic State, Pregnancy, Case-Control Studies, Diabetes, Gestational

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