The DOI matches its Crossref record; 86 of the 90 references it cites were found in a registry or an index.
Macronutrient-Mediated Inflammation and Oxidative Stress: Relevance to Insulin Resistance, Obesity, and Atherogenesis
Open accessAbstract
Context: The intake of macronutrients as components of a Western dietary pattern leads to oxidative stress and inflammation. Evidence Acquisition: Data were largely retrieved from our previous and most recent work. PubMed and Google Scholar were searched for recent articles on the effect of macronutrients/dietary intake on inflammation, insulin resistance, obesity, and atherogenesis. The most relevant, high-quality articles were included in our review. Evidence Synthesis: Our previous work has demonstrated the molecular mechanisms of macronutrient-mediated oxidative stress and inflammation. With the induction of inflammation, proinflammatory molecules potentially interfere with insulin signal transduction, thus causing insulin resistance. In addition, other molecules promote atherogenic inflammation. More recently, our work has also shown that certain foods are noninflammatory or anti-inflammatory and thus, do not interfere with insulin signaling. Finally, as obesity is induced by chronic excessive caloric intake, it is characterized by an increase in the expression of proinflammatory molecules, which are induced acutely by a Western diet. Caloric restriction, including fasting, is associated with a reduction in oxidative and inflammatory stress. Conclusions: This review summarizes and attempts to provide an up-to-date profile of the molecular mechanisms involved in macronutrient-mediated oxidative/inflammatory stress and its potential consequences. An understanding of these underlying mechanisms is crucial for making appropriate dietary choices.
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“High-protein and low-carbohydrate diets improve satiety, preserve muscle mass, and reduce insulin resistance and hyperandrogenism [15, 16].”
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4 of the 90 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Das, 2017, Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans, Am J Clin Nutr, 105, 913, 10.3945/ajcn.116.137232 · DOI · Paper page
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Items 101–104 of 104
Yuan, L.-Y., Yuan, Q., Guo, D.-W., Tan, H.-L., & Guan, X. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1821763
Tini, S., Celano, S., Pigni, S., Palma, E. D., Ozdemir, H. I., Raiteri, T., Antonioli, A., Baima, J., Antoniotti, V., Caputo, M., et al. (2026) · Antioxidants · doi:10.3390/antiox15070844
Tremblay, X., Piché, M., Brassard, P., Ferland, A., O’Connor, S., & Poirier, P. (2026) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2026.109367
Blood and lymphatic vascular remodeling in intervertebral disc degeneration
Huang, F., Lin, M., Zhang, Q., Yan, S., Li, R., Li, S., Jia, Y., Zhao, Q., Song, P., & 周海宇 (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1862921
Metadata
- Authors
- Biobaku, F., Ghanim, H., Batra, M., & Dandona, P.
- Affiliations
- University at Buffalo, State University of New York (US)
- Corresponding author
- Dandona, Paresh
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2019-06-20
- Volume
- 104
- Issue
- 12
- Pages
- 6118-6128
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2951964451
- Cited by
- 104
- References
- 90
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 10 · 2023: 21 · 2022: 25 · 2021: 12 · 2020: 12
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- Eli Lilly and Company
- GlaxoSmithKline
- Sanofi
- Novo Nordisk
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- macronutrients, dietary inflammation, oxidative stress, insulin resistance, obesity, atherogenesis, Western diet, insulin signaling, caloric restriction, fasting, anti-inflammatory foods, proinflammatory molecules
- MeSH terms
- Nutrients, Animals, Diet, Humans, Inflammation, Insulin Resistance, Obesity, Risk Factors, Oxidative Stress, Inflammation Mediators, Atherosclerosis
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