Cited by 104Adipokines, Inflammation, and Metabolic DiseasesNutritional Studies and DietDiet, Metabolism, and Disease

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Macronutrient-Mediated Inflammation and Oxidative Stress: Relevance to Insulin Resistance, Obesity, and Atherogenesis

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Biobaku, Fatimo, Ghanim, Husam, Batra, Manav, Dandona, Paresh·2019·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2018-01833

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Abstract

Context: The intake of macronutrients as components of a Western dietary pattern leads to oxidative stress and inflammation. Evidence Acquisition: Data were largely retrieved from our previous and most recent work. PubMed and Google Scholar were searched for recent articles on the effect of macronutrients/dietary intake on inflammation, insulin resistance, obesity, and atherogenesis. The most relevant, high-quality articles were included in our review. Evidence Synthesis: Our previous work has demonstrated the molecular mechanisms of macronutrient-mediated oxidative stress and inflammation. With the induction of inflammation, proinflammatory molecules potentially interfere with insulin signal transduction, thus causing insulin resistance. In addition, other molecules promote atherogenic inflammation. More recently, our work has also shown that certain foods are noninflammatory or anti-inflammatory and thus, do not interfere with insulin signaling. Finally, as obesity is induced by chronic excessive caloric intake, it is characterized by an increase in the expression of proinflammatory molecules, which are induced acutely by a Western diet. Caloric restriction, including fasting, is associated with a reduction in oxidative and inflammatory stress. Conclusions: This review summarizes and attempts to provide an up-to-date profile of the molecular mechanisms involved in macronutrient-mediated oxidative/inflammatory stress and its potential consequences. An understanding of these underlying mechanisms is crucial for making appropriate dietary choices.

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Authors: Biobaku, F., Ghanim, H., Batra, M., & Dandona, P.
Affiliations: University at Buffalo, State University of New York (US)
Corresponding author: Dandona, Paresh
ORCID: Ghanim, Husam
Batra, Manav
Dandona, Paresh
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2019-06-20
Volume: 104
Issue: 12
Pages: 6118-6128
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2018-01833
OpenAlex: W2951964451
Cited by: 104
References: 90
Citations by year: 2026: 7 · 2025: 17 · 2024: 10 · 2023: 21 · 2022: 25 · 2021: 12 · 2020: 12
FWCI: 1.79
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: American Diabetes Association
Eli Lilly and Company
GlaxoSmithKline
Sanofi
Novo Nordisk
National Institutes of Health
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: macronutrients, dietary inflammation, oxidative stress, insulin resistance, obesity, atherogenesis, Western diet, insulin signaling, caloric restriction, fasting, anti-inflammatory foods, proinflammatory molecules
MeSH terms: Nutrients, Animals, Diet, Humans, Inflammation, Insulin Resistance, Obesity, Risk Factors, Oxidative Stress, Inflammation Mediators, Atherosclerosis

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Macronutrient-Mediated Inflammation and Oxidative Stress: Relevance to Insulin Resistance, Obesity, and Atherogenesis

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