Cited by 104Adipokines, Inflammation, and Metabolic DiseasesNutritional Studies and DietDiet, Metabolism, and Disease

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Macronutrient-Mediated Inflammation and Oxidative Stress: Relevance to Insulin Resistance, Obesity, and Atherogenesis

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Biobaku, Fatimo, Ghanim, Husam, Batra, Manav, Dandona, Paresh·2019·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2018-01833

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Abstract

Context: The intake of macronutrients as components of a Western dietary pattern leads to oxidative stress and inflammation. Evidence Acquisition: Data were largely retrieved from our previous and most recent work. PubMed and Google Scholar were searched for recent articles on the effect of macronutrients/dietary intake on inflammation, insulin resistance, obesity, and atherogenesis. The most relevant, high-quality articles were included in our review. Evidence Synthesis: Our previous work has demonstrated the molecular mechanisms of macronutrient-mediated oxidative stress and inflammation. With the induction of inflammation, proinflammatory molecules potentially interfere with insulin signal transduction, thus causing insulin resistance. In addition, other molecules promote atherogenic inflammation. More recently, our work has also shown that certain foods are noninflammatory or anti-inflammatory and thus, do not interfere with insulin signaling. Finally, as obesity is induced by chronic excessive caloric intake, it is characterized by an increase in the expression of proinflammatory molecules, which are induced acutely by a Western diet. Caloric restriction, including fasting, is associated with a reduction in oxidative and inflammatory stress. Conclusions: This review summarizes and attempts to provide an up-to-date profile of the molecular mechanisms involved in macronutrient-mediated oxidative/inflammatory stress and its potential consequences. An understanding of these underlying mechanisms is crucial for making appropriate dietary choices.

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Dandona, P., Ghanim, H., Monte, S. V., Caruana, J. A., Green, K., Abuaysheh, S., Lohano, T., Schentag, J., Dhindsa, S., & Chaudhuri, A. (2014) · Obesity · doi:10.1002/oby.20524 · Cited by 54
Self-citation
Resveratrol inhibits neointimal formation after arterial injury through an endothelial nitric oxide synthase-dependent mechanism
Breen, D. M., Dolinsky, V. W., Zhang, H., Ghanim, H., Guo, J., Mroziewicz, M., Tsiani, E., Bendeck, M. P., Dandona, P., Dyck, J. R. B., et al. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.03.021 · Cited by 46
Self-citation
Antiinflammatory and ROS Suppressive Effects of the Addition of Fiber to a High-Fat High-Calorie Meal
Ghanim, H., Batra, M., Abuaysheh, S., Green, K., Makdissi, A., Kuhadiya, N. D., Chaudhuri, A., & Dandona, P. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2669 · Cited by 46
Self-citation
Premeal Low-Fat Yogurt Consumption Reduces Postprandial Inflammation and Markers of Endotoxin Exposure in Healthy Premenopausal Women in a Randomized Controlled Trial
Pei, R., DiMarco, D. M., Putt, K. K., Martin, D., Chitchumroonchokchai, C., Bruno, R. S., & Bolling, B. W. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy046 · Cited by 39
Decreases in neprilysin and vasoconstrictors and increases in vasodilators following bariatric surgery
Ghanim, H., Monte, S., Caruana, J., Green, K., Abuaysheh, S., & Dandona, P. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13320 · Cited by 36
Self-citation
Insulin-induced vasodilatation of internal carotid artery
Chaudhuri, A., Kanjwal, Y., Mohanty, P., Rao, S. G., Sung, B. H., Wilson, M. F., & Dandona, P. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90161-0 · Cited by 32
Self-citation
Antioxidant enzymes induced by repeated intake of excess energy in the form of high-fat, high-carbohydrate meals are not sufficient to block oxidative stress in healthy lean individuals
Lim, S., Won, H., Kim, Y., Jang, M., Jyothi, K. R., Kim, Y., Dandona, P., Ha, J., & Kim, S. S. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511002091 · Cited by 29
Self-citation
Ezetimibe and simvastatin combination inhibits and reverses the pro-inflammatory and pro-atherogenic effects of cream in obese patients
Ghanim, H., Green, K., Abuaysheh, S., Patel, R. M., Batra, M., Chaudhuri, A., Makdissi, A., Kuhadiya, N. D., & Dandona, P. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.06.010 · Cited by 22
Self-citation
A Mixed Anti-Inflammatory and Pro-Inflammatory Response Associated with a High Dose of Corticosteroids
Dandona, P., Ghanim, H., Sia, C. L., Green, K., Abuaysheh, S., Dhindsa, S., Chaudhuri, A., & Makdissi, A. (2014) · Current Molecular Medicine · doi:10.2174/1566524014666140724105557 · Cited by 22
Self-citation
Macronutrient Content of the Diet: What Do We Know About Energy Balance and Weight Maintenance?
Fleming, J. A., & Kris‐Etherton, P. M. (2016) · Current Obesity Reports · doi:10.1007/s13679-016-0209-8 · Cited by 14
Macronutrient intake, insulin secretion, oxidative stress & inflammation
Dandona, P., Ghanim, H., Chaudhuri, A., & Mohanty, P. (2016) · The Indian Journal of Medical Research · doi:10.4103/ijmr.ijmr_1807_16 · Cited by 5
Self-citation
Dietary restriction and Sirtuin 1 in metabolic health: connections and divergences
Cantó, C. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s0029665115003225 · Cited by 3

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4 of the 90 references couldn’t be matched to a known paper.

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Das, 2017, Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans, Am J Clin Nutr, 105, 913, 10.3945/ajcn.116.137232 · DOI · Paper page

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Anti-Inflammatory Nutrients and Obesity-Associated Metabolic-Inflammation: State of the Art and Future Direction
Grosso, G., Laudisio, D., Frias-Toral, E., Barrea, L., Muscogiuri, G., Savastano, S., & Colao, A. (2022) · Nutrients · doi:10.3390/nu14061137 · Cited by 255
Oxidative Stress, Diet and Prostate Cancer
Tan, B. L., & Norhaizan, M. E. (2020) · The World Journal of Men s Health · doi:10.5534/wjmh.200014 · Cited by 71
Stress adaptation is associated with insulin resistance in women with gestational diabetes mellitus
Feng, Y., Feng, Q., Qu, H., Song, X., Hu, J., Xu, X., Zhang, L., & Yin, S. (2020) · Nutrition and Diabetes · doi:10.1038/s41387-020-0107-8 · Cited by 65
The Role of Prunes in Modulating Inflammatory Pathways to Improve Bone Health in Postmenopausal Women
Damani, J. J., Souza, M. J. D., VanEvery, H., Strock, N. C. A., & Rogers, C. J. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab162 · Cited by 60
Obesity and COVID-19: Oro-Naso-Sensory Perception
Khan, A. S., Hichami, A., & Khan, N. A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072158 · Cited by 57

See all 104

Authors: Biobaku, F., Ghanim, H., Batra, M., & Dandona, P.
Affiliations: University at Buffalo, State University of New York (US)
Corresponding author: Dandona, Paresh
ORCID: Ghanim, Husam
Batra, Manav
Dandona, Paresh
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2019-06-20
Volume: 104
Issue: 12
Pages: 6118-6128
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2018-01833
OpenAlex: W2951964451
Cited by: 104
References: 90
Citations by year: 2026: 7 · 2025: 17 · 2024: 10 · 2023: 21 · 2022: 25 · 2021: 12 · 2020: 12
FWCI: 1.79
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: American Diabetes Association
Eli Lilly and Company
GlaxoSmithKline
Sanofi
Novo Nordisk
National Institutes of Health
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: macronutrients, dietary inflammation, oxidative stress, insulin resistance, obesity, atherogenesis, Western diet, insulin signaling, caloric restriction, fasting, anti-inflammatory foods, proinflammatory molecules
MeSH terms: Nutrients, Animals, Diet, Humans, Inflammation, Insulin Resistance, Obesity, Risk Factors, Oxidative Stress, Inflammation Mediators, Atherosclerosis

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Macronutrient-Mediated Inflammation and Oxidative Stress: Relevance to Insulin Resistance, Obesity, and Atherogenesis

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