The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Fasting as a metabolic stress paradigm selectively amplifies cortisol secretory burst mass and delays the time of maximal nyctohemeral cortisol concentrations in healthy men
Abstract
Serum cortisol concentrations are increased in fasted or malnourished human subjects. The dynamic mechanisms underlying this adaptive response have been investigated in eight normal men by analyzing serum cortisol concentrations measured in blood obtained at 5-min intervals over 24 h on a control (fed) day and on the fifth day of a fast (water only) assigned in randomized order. A multiple parameter deconvolution method was used to simultaneously resolve endogenous cortisol secretion and half-life. Five days of fasting induced a 1.8-fold increase in the 24-h endogenous cortisol production rate (fed, 2504 +/- 308; fasted, 4528 +/- 488 nmol/L distribution volume; P < 0.006). This enhanced cortisol production rate was accounted for by a 1.6-fold increase in the mass of cortisol secreted per burst (fed, 115 +/- 12.1; fasted, 183 +/- 17.3 nmol/L; P < 0.02). Cortisol secretory event amplitudes (maximal rates of cortisol release attained within a burst) increased in seven of eight men, and mean secretory burst durations remained unchanged by fasting. Moreover, the number of computer-resolved cortisol secretory bursts per 24 h (fed, 22 +/- 1.4; fasted, 25 +/- 2.0; P = NS) and the interburst interval (fed, 65 +/- 4.0; fasted, 57 +/- 4.4 min) did not change significantly during a 5-day fast. The calculated half-life of endogenous cortisol was not significantly altered by fasting (fed, 108 +/- 9.7; fasted, 129 +/- 11 min). There was no significant change in the nyctohemeral pattern of v…
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“During fasting, plasma glucose decreases in conjunction with various neuroendocrine changes (22), which may per se act on HPA activity (23), and thereby prevent a clear-cut interpretation of changes after insulin administration.”
From Supraphysiological Hyperinsulinemia Acutely Increases Hypothalamic-Pituitary-Adrenal Secretory Activity in Humans (1999) · cites this paper as [23]
In the citing paper
“However, more prolonged fasting for 5 days almost doubles cortisol production rates (46) and chronic energy deprivation (eg, anorexia nervosa is associated with an activation of the HPA axis from corticotrophin releasing hormone hypersecretion) (12,47).”
From Dysregulation of the Hypothalamic-Pituitary-Testicular Axis due to Energy Deficit (2021) · cites this paper as [46]
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Ho, K. Y., Veldhuis, J. D., Johnson, M. L., Furlanetto, R., Evans, W. S., Alberti, K. G., & Thorner, M. O. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113450 · Cited by 503
Self-citationAbnormal Hypothalamic–Pituitary–Adrenal Function in Anorexia Nervosa
Gold, P. W., Gwirtsman, H., Avgerinos, P. C., Nieman, L. K., Gallucci, W. T., Kaye, W., Jimerson, D., Ebert, M., Rittmaster, R., Loriaux, D. L., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198605223142102 · Cited by 454
(1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.74.4.757 · Cited by 296
Cortisol Secretion and Metabolism in Anorexia Nervosa
Boyar, R. M., Hellman, L. D., Roffwarg, H., Katz, J., Zumoff, B., O'Connor, J., Bradlow, H. L., & Fukushima, D. K. (1977) · New England Journal of Medicine · doi:10.1056/nejm197701272960403 · Cited by 285
[26] Deconvolution analysis of hormone data
.Veldhuis, J. D., & Johnson, M. L. (1992) · Methods in Enzymology · doi:10.1016/0076-6879(92)10028-c · Cited by 263
Self-citationHotta, M., Shibasaki, T., Masuda, A., Imaki, T., Demura, H., LING, N. C., & SHIZUME, K. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-62-2-319 · Cited by 241
Kaye, W. H., Gwirtsman, H. E., George, D. T., Ebert, M. H., Jimerson, D. C., Tomai, T. P., Chrousos, G. P., & Gold, P. W. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-2-203 · Cited by 230
Veldhuis, J. D., Iranmanesh, A., Lizarralde, G., & Johnson, M. L. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.257.1.e6 · Cited by 224
Self-citationDubey, A. K., & Plant, T. M. (1985) · Biology of Reproduction · doi:10.1095/biolreprod33.2.423 · Cited by 217
Veldhuis, J. D., Iranmanesh, A., Johnson, M. L., & LIZARRALDE, G. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-6-1616 · Cited by 193
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Metadata
- Authors
- Bergendahl, M., Vance, M. L., Iranmanesh, A., Thorner, M. O., & Veldhuis, J. D.
- Affiliations
- U.S. National Science Foundation (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1996-02
- Volume
- 81
- Issue
- 2
- Pages
- 692-699
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2031664768
- Cited by
- 126
- References
- 49
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK032632, DK32632)
- National Center for Research Resources (RR 00847, M01RR000847)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (1 KO4 HD-00634, K04HD000634)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- fasting, cortisol secretion, diurnal cortisol rhythm, nyctohemeral rhythm, metabolic stress, adrenocortical function, glucocorticoids, cosinor analysis, mesor, healthy men, interburst interval
- MeSH terms
- Adult, Circadian Rhythm, Dehydroepiandrosterone, Fasting, Follicle Stimulating Hormone, Humans, Hydrocortisone, Luteinizing Hormone, Male, Metabolic Clearance Rate, Prolactin, Growth Hormone, Testosterone, Thyrotropin, Dehydroepiandrosterone Sulfate
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- This page
- CoChat. (2026). Citation check: Fasting as a metabolic stress paradigm selectively amplifies cortisol secretory burst mass and delays the time of maximal nyctohemeral cortisol concentrations in healthy men. https://app.cochat.ai/papers/10.1210/jcem.81.2.8636290
- The paper
- Bergendahl, M., Vance, M. L., Iranmanesh, A., Thorner, M. O., & Veldhuis, J. D. (1996). Fasting as a metabolic stress paradigm selectively amplifies cortisol secretory burst mass and delays the time of maximal nyctohemeral cortisol concentrations in healthy men. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem.81.2.8636290
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
