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Cited by 308Regulation of Appetite and ObesitySleep and Wakefulness ResearchGrowth Hormone and Insulin-like Growth Factors

Improving influence of insulin on cognitive functions in humans

Kern, Werner, Peters, Achim, Fruehwald-Schultes, Bernd, Deininger, Eva, Born, Jan, Fehm, Horst L.·2001·Neuroendocrinology
DOI 10.1159/000054694
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Abstract

Insulin receptors have been identified in limbic brain structures, but their functional relevance is still unclear. In order to characterize some of their effects, we evaluated auditory evoked brain potentials (AEP) in a vigilance task, behavioral measures of memory (recall of words) and selective attention (Stroop test) during infusion of insulin. The hormone was infused at two different rates (1.5 mU/kg x min, "low insulin", and 15 mU/kg x min, "high insulin"), inducing respectively serum levels of 543 +/- 34 and 24,029 +/- 1,595 pmol/l. This experimental design allowed to compare cognitive parameters under two conditions presenting markedly different insulin levels, but with minimal incidence on blood glucose concentrations since these were kept constant by glucose infusion. A "no insulin treatment" group was not included in order to avoid leaving patients infused with glucose without insulin treatment. Measures were taken during a baseline phase preceding insulin infusion and every 90 min during the 360 min of insulin infusion. Compared with "low insulin", "high insulin" induced a slow negative potential shift in the AEP over the frontal cortex (average amplitude, high insulin: 0.27 +/- 0.48 microV; low insulin: 1.87 +/- 0.48 microV, p < 0.005), which was paralleled by enhanced memory performance (words recalled, high insulin: 22.04 +/- 0.93; low insulin: 19.29 +/- 0.92, p < 0.05). Also, during "high insulin" subjects displayed enhanced performance on the Stroop test (p < 0.05) and expressed less difficulty in thinking than during "low insulin" (p < 0.03). Results indicate an improving effect of insulin on cognitive function, and may provide a frame for further investigations of neurobehavioral effects of insulin in patients with lowered or enhanced brain insulin, i.e., patients with Alzheimer's disease or diabetes mellitus.

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  • Neuronal insulin receptors are involved in diverse brain functions including synapse plasticity, learning and memory.

    “Neuronal IRs are involved in diverse brain functions including synapse plasticity, learning and memory (Chiu et al., 2008; Craft et al., 1996; Kern et al., 2001; Lee et al., 2005; Park et al., 2000).”

    From The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease (2011) · cites this paper as Kern et al., 2001

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Authors
Kern, W., Peters, A., Fruehwald-Schultes, B., Deininger, E., Born, J., & Fehm, H. L.
Affiliations
University of Lübeck (DE)
ORCID
Peters, Achim
Venue
Neuroendocrinology
Publisher
S. Karger AG
Published
2001
Volume
74
Issue
4
Pages
270-280
ISSN
  • 0028-3835 (ISSN-L)
  • 1423-0194
DOI
10.1159/000054694
OpenAlex
W2076725316
Cited by
308
References
69
Citations by year
2026: 2 · 2025: 3 · 2024: 7 · 2023: 13 · 2022: 9 · 2021: 11 · 2020: 16 · 2019: 21 · 2018: 9 · 2017: 9 · 2016: 9 · 2015: 23 · 2014: 13 · 2013: 17 · 2012: 19
FWCI
2.61
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords
insulin, cognitive function, insulin receptor, limbic system, auditory evoked potentials, frontal cortex, memory, selective attention, Stroop task, insulin infusion, serum insulin, Alzheimer's disease, diabetes mellitus
MeSH terms
Adult, Affect, Attention, Blood Glucose, Cognition, Color Perception, Humans, Injections, Intravenous, Insulin, Male, Memory, Evoked Potentials, Auditory, Brain Stem

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