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Cited by 126Adrenal Hormones and DisordersStress Responses and CortisolDietary Effects on Health

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Fasting as a metabolic stress paradigm selectively amplifies cortisol secretory burst mass and delays the time of maximal nyctohemeral cortisol concentrations in healthy men

Bergendahl, M, Vance, M L, Iranmanesh, A, Thorner, M O, Veldhuis, J D·1996·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.81.2.8636290
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Abstract

Serum cortisol concentrations are increased in fasted or malnourished human subjects. The dynamic mechanisms underlying this adaptive response have been investigated in eight normal men by analyzing serum cortisol concentrations measured in blood obtained at 5-min intervals over 24 h on a control (fed) day and on the fifth day of a fast (water only) assigned in randomized order. A multiple parameter deconvolution method was used to simultaneously resolve endogenous cortisol secretion and half-life. Five days of fasting induced a 1.8-fold increase in the 24-h endogenous cortisol production rate (fed, 2504 +/- 308; fasted, 4528 +/- 488 nmol/L distribution volume; P < 0.006). This enhanced cortisol production rate was accounted for by a 1.6-fold increase in the mass of cortisol secreted per burst (fed, 115 +/- 12.1; fasted, 183 +/- 17.3 nmol/L; P < 0.02). Cortisol secretory event amplitudes (maximal rates of cortisol release attained within a burst) increased in seven of eight men, and mean secretory burst durations remained unchanged by fasting. Moreover, the number of computer-resolved cortisol secretory bursts per 24 h (fed, 22 +/- 1.4; fasted, 25 +/- 2.0; P = NS) and the interburst interval (fed, 65 +/- 4.0; fasted, 57 +/- 4.4 min) did not change significantly during a 5-day fast. The calculated half-life of endogenous cortisol was not significantly altered by fasting (fed, 108 +/- 9.7; fasted, 129 +/- 11 min). There was no significant change in the nyctohemeral pattern of v…

Overview

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Crossref · 10.1210/jcem.81.2.8636290

Cites

49 of 49 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Bergendahl, M., Vance, M. L., Iranmanesh, A., Thorner, M. O., & Veldhuis, J. D.
Affiliations
U.S. National Science Foundation (US)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1996-02
Volume
81
Issue
2
Pages
692-699
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.81.2.8636290
OpenAlex
W2031664768
Cited by
126
References
49
Citations by year
2026: 1 · 2025: 6 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 3
FWCI
4.18
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK032632, DK32632)
  • National Center for Research Resources (RR 00847, M01RR000847)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (1 KO4 HD-00634, K04HD000634)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Keywords
fasting, cortisol secretion, diurnal cortisol rhythm, nyctohemeral rhythm, metabolic stress, adrenocortical function, glucocorticoids, cosinor analysis, mesor, healthy men, interburst interval
MeSH terms
Adult, Circadian Rhythm, Dehydroepiandrosterone, Fasting, Follicle Stimulating Hormone, Humans, Hydrocortisone, Luteinizing Hormone, Male, Metabolic Clearance Rate, Prolactin, Growth Hormone, Testosterone, Thyrotropin, Dehydroepiandrosterone Sulfate

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.