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Cited by 164Sexual Differentiation and DisordersAdrenal Hormones and DisordersOvarian function and disorders

Long-Term Somatic Follow-Up of Prenatally Treated Children with Congenital Adrenal Hyperplasia1

Lajic, Svetlana, Wedell, Anna, Bui, The-Hung, Ritzén, E. Martin, Holst, Mikael·1998·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.83.11.5233
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Abstract

Prenatal virilization of female fetuses is a serious symptom associated with severe congenital adrenal hyperplasia. In attempt to avoid sexual ambiguity, prenatal treatment of 21-hydroxylase deficiency was initiated in 1984, with the first Scandinavian case treated in 1985. Here we have studied the outcome of prenatal diagnosis and therapy of 44 at-risk pregnancies monitored during the years 1985-1995 in Scandinavia. Treated mothers and children were compared with matched controls. Compared to their elder affected sisters, all 5 girls with severe congenital adrenal hyperplasia who were treated until term showed little virilization. Only 1 required surgery for labial fusion. The majority of the 44 dexamethasone-treated fetuses demonstrated normal pre- and postnatal growth compared to matched controls. However, several adverse events such as failure to thrive and delayed psychomotor development, were reported among the treated infants. In addition, treated mothers reported more side-effects during pregnancy than did controls. A significant increase in weight gain was observed during early pregnancy when treatment was initiated, but this initial rapid weight gain declined during late pregnancy or when treatment was terminated. Thus, experience to date suggests that prenatal treatment of affected female fetuses is generally efficient in minimizing virilization of external genitalia. However, there is still a need to collect more data concerning possible rare unfavorable effects of this therapy on mother and child.

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Crossref · 10.1210/jcem.83.11.5233

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  • Among pregnancies at risk for CAH, prenatally Dex-treated newborns have lower, but nominally normal, birth weights compared to untreated controls; the decrease averages ~400 g.

    “Among pregnancies at risk for CAH, prenatally Dex-treated newborns have lower, but nominally normal, birth weights compared to untreated controls (470); the decrease averages ~400 g (471).”

    From Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management (2022) · cites this paper as [470]

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Authors
Lajic, S., Wedell, A., Bui, T.-H., Ritzén, E. M., & Holst, M.
Affiliations
Karolinska University Hospital (SE)
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1998-11
Volume
83
Issue
11
Pages
3872-3880
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.83.11.5233
OpenAlex
W2069402873
Cited by
164
References
5
Citations by year
2026: 1 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 7 · 2017: 2 · 2016: 7 · 2015: 8 · 2014: 3 · 2013: 9 · 2012: 8
FWCI
3.12
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords
congenital adrenal hyperplasia, 21-hydroxylase deficiency, fetal therapy, dexamethasone, external genitalia, labial fusion, fetal growth, psychomotor development, maternal side effects, gestational weight gain, long-term follow-up
MeSH terms
Adrenal Hyperplasia, Congenital, Child, Dexamethasone, Female, Embryonic and Fetal Development, Follow-Up Studies, Glucocorticoids, Humans, Infant, Infant, Newborn, Male, Pregnancy, Prenatal Care, Prenatal Diagnosis, Psychomotor Performance, Time Factors

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