The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
The Importance of Phosphate in Regulating Plasma 1,25-(OH)2-Vitamin D Levels in Humans: Studies in Healthy Subjects, in Calcium-Stone Formers and in Patients with Primary Hyperparathyroidism*
Abstract
We observed that plasma 1,25-(OH)2-D concentrations average 87 +/- 30 SD pmol/l in 48 healthy adults without a personal or family history of kidney stones. Plasma 1,25-(OH)2-D concentrations were significantly elevated among 26 patients with recurrent calcium-containing renal stones and hypophosphatemia: 150 +/- 74 pmol/l; P less than 0.001, and among 9 patients with proven parathyroid adenoma and hypophosphatemia: 200 +/- 54 pmol/l; P less than 0.001. Plasma 1,25-(OH)2-D levels in these 3 groups were inversely correlated with serum phosphate concentration: plasma 1,25-(OH)2-D, pmol/l = 282 - 141 X serum PO4, mmol/l; r = 0.51; P less than 0.001. During dietary PO4 deprivation lasting 11 to 16 days in 10 healthy women, serum PO4 fell and plasma 1,25-(OH)2-D concentrations rose whereas in 8 healthy men neither serum PO4 nor 1,25-(OH)2-D concentrations changed. The change from control in plasma 1,25-(OH)2-D levels were correlated with the change from control in serum PO4 concentrations: delta1,25-(OH)2-D, pmol/l = 1 - 82 X delta serum PO4 mmol/l; r = 0.59; P less than 0.01. We conclude that reductions in serum PO4 concentrations, either directly or indirectly, stimulate renal synthesis of 1,25-(OH)2-D in humans.
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Citations
Cites
COMPETITIVE PROTEIN-BINDING RADIOASSAY FOR 25-HYDROXYCHOLECALCIFEROL1
Haddad, J. G., & Chyu, K. J. (1971) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-33-6-992 · Cited by 905
The control of 25-hydroxyvitamin D metabolism by inorganic phosphorus
Tanaka, Y., & Deluca, H. F. (1973) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(73)90010-6 · Cited by 780
1,25-Dihydroxycholecalciferol: A Potent Stimulator of Bone Resorption in Tissue Culture
Raisz, L. G., Trummel, C. L., Holick, M. F., & Deluca, H. F. (1972) · Science · doi:10.1126/science.175.4023.768 · Cited by 628
Regulation of 25-Hydroxycholecalciferol-1-Hydroxylase Activity in Kidney by Parathyroid Hormone
FRASER, D. R., & KODICEK, E. (1973) · Nature New Biology · doi:10.1038/newbio241163a0 · Cited by 527
On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dog
Slatopolsky, E., Caglar, S., Pennell, J. P., Taggart, D. D., Canterbury, J. M., Reiss, E., & Bricker, N. S. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106517 · Cited by 481
Rasmussen, H., Wong, M., Bikle, D., & Goodman, D. B. P. (1972) · Journal of Clinical Investigation · doi:10.1172/jci107065 · Cited by 331
The role of phosphate in the secretion of parathyroid hormone in man
Reiss, E., Canterbury, J. M., Bercovitz, M. A., & Kaplan, E. L. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106432 · Cited by 288
The effects of diet and stool composition on the net external acid balance of normal subjects.
Lennon, E. J., Lemann, J., & Litzow, J. R. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105466 · Cited by 210
Self-citationDOMINGUEZ, J. H., GRAY, R. W., & LEMANN, J. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-43-5-1056 · Cited by 191
Self-citationBrumbaugh, P. F., Haussler, D. H., Bursac, K. M., & Haussler, M. R. (1974) · Biochemistry · doi:10.1021/bi00717a005 · Cited by 176
Cited by
REINHARDT, T. A., HORST, R. L., ORF, J. W., & HOLLIS, B. W. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-58-1-91 · Cited by 801
The Pathogenesis and Treatment of Kidney Stones
Coe, F. L., Parks, J. H., & Asplin, J. R. (1992) · New England Journal of Medicine · doi:10.1056/nejm199210153271607 · Cited by 696
Influence of the Vitamin D-binding Protein on the Serum Concentration of 1,25-Dihydroxyvitamin D3
Bouillon, R., Van Assche, F. A., Van Baelen, H., Heyns, W., & De Moor, P. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110072 · Cited by 507
Perwad, F., Azam, N., Zhang, M. Y. H., Yamashita, T., Tenenhouse, H. S., & Portale, A. A. (2005) · Endocrinology · doi:10.1210/en.2005-0777 · Cited by 425
Chines, A., & Pacifici, R. (1990) · Calcified Tissue International · doi:10.1007/bf02555911 · Cited by 44
Metadata
- Authors
- GRAY, R. W., WILZ, D. R., CALDAS, A. E., & LEMANN, J.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1977-08
- Volume
- 45
- Issue
- 2
- Pages
- 299-306
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1992214240
- Cited by
- 318
- References
- 12
- FWCI
- 20.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Importance of Phosphate in Regulating Plasma 1,25-(OH)2-Vitamin D Levels in Humans: Studies in Healthy Subjects, in Calcium-Stone Formers and in Patients with Primary Hyperparathyroidism*. https://app.cochat.ai/papers/10.1210/jcem-45-2-299
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- GRAY, R. W., WILZ, D. R., CALDAS, A. E., & LEMANN, J. (1977). The Importance of Phosphate in Regulating Plasma 1,25-(OH)2-Vitamin D Levels in Humans: Studies in Healthy Subjects, in Calcium-Stone Formers and in Patients with Primary Hyperparathyroidism*. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-45-2-299
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
