The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Origin of Estrogen in Normal Men and in Women with Testicular Feminization*
Abstract
The purpose of this study was to quantify the various sources of estrone (E1) and 17 beta-estradiol (E2) production in normal men and in women with testicular feminization. The mean production rate of E1 in four young adult men was 58 micrograms/24 h, while that of E2 was 44 micrograms/24 h. In these men, E1 production could be accounted for totally by extraglandular formation through 1) aromatization of plasma androstenedione, 2) conversion of E2 which was formed from the aromatization of plasma testosterone, and 3) conversion of secreted E2. In these men, only 12 micrograms or less of E2 production could not be accounted for by extraglandular formation from plasma C19 precursors, and is presumed to have arisen by testicular secretion. In six women with testicular feminization, the mean production rate of E1 was 99 micrograms/24 h, while that of E2 was 77 micrograms/24 h. THe amount of E2 production that arose by glandular secretion could be computed in four of these women and was considerably greater than that found in the young adult men. In these women with testicular feminization, an average of 44 micrograms/24 h E2 could not be accounted for by extraglandular formation and is presumed to have arisen by testicular secretion. The mean plasma production rate of testosterone in the normal men was 5.7 mg/24 h, while that in the women with testicular feminization was 8.3 mg/24 h. However, the range of plasma production rates of testosterone in the women with testicular feminization was large (1.3--17.0 mg/24 h).
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Cites
Source of Estrogen Production in Postmenopausal Women1
GRODIN, J. M., SIITERI, P. K., & MACDONALD, P. C. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-36-2-207 · Cited by 959
Self-citationWalsh, P. C., Madden, J. D., Harrod, M. J., Goldstein, J. L., MacDonald, P. C., & Wilson, J. D. (1974) · New England Journal of Medicine · doi:10.1056/nejm197410312911806 · Cited by 631
Self-citationHEMSELL, D. L., GRODIN, J. M., BRENNER, P. F., SIITERI, P. K., & MACDONALD, P. C. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-38-3-476 · Cited by 444
Self-citationMacDonald, P. C., Edman, C. D., Hemsell, D. L., Porter, J. C., & Siiteri, P. K. (1978) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(78)90287-9 · Cited by 440
Self-citationHorton, R., & Tait, J. F. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105344 · Cited by 401
Conversion of blood androgens to estrogens in normal adult men and women
Longcope, C., Kato, T., & Horton, R. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106185 · Cited by 370
MACDONALD, P. C., ROMBAUT, R. P., & SIITERI, P. K. (1967) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-27-8-1103 · Cited by 256
Self-citationSiiteri, P. K., & MacDonald, P. C. (1963) · Steroids · doi:10.1016/0039-128x(63)90044-8 · Cited by 251
Self-citationGriffin, J. E., Punyashthiti, K., & Wilson, J. D. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108402 · Cited by 231
Self-citationKelch, R. P., Jenner, M. R., Weinstein, R., Kaplan, S. L., & Grumbach, M. M. (1972) · Journal of Clinical Investigation · doi:10.1172/jci106877 · Cited by 227
Cited by
Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man
Smith, E. P., Boyd, J., Frank, G. R., Takahashi, H., Cohen, R. M., Specker, B., Williams, T. C., Lubahn, D. B., & Korach, K. S. (1994) · New England Journal of Medicine · doi:10.1056/nejm199410203311604 · Cited by 2,471
Androgen Receptor Defects: Historical, Clinical, and Molecular Perspectives*
QUIGLEY, C. A., BELLIS, A. D., MARSCHKE, K. B., EL-AWADY, M. K., WILSON, E. M., & FRENCH, F. S. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-3-271 · Cited by 1,447
Estrogen production and action
Nelson, L. R., & Bulun, S. E. (2001) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2001.117432 · Cited by 834
Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men
Finkelstein, J. S., Lee, H., Burnett-Bowie, S.-A. M., Pallais, J. C., Yu, E. W., Borges, L. F., Jones, B. F., Barry, C. V., Wulczyn, K. E., Thomas, B. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1206168 · Cited by 782
Mechanistic Pathways of Sex Differences in Cardiovascular Disease
Regitz-Zagrosek, V., & Kararigas, G. (2017) · Physiological Reviews · doi:10.1152/physrev.00021.2015 · Cited by 732
Metadata
- Authors
- MACDONALD, P. C., MADDEN, J. D., BRENNER, P. F., WILSON, J. D., & SIITERI, P. K.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1979-12
- Volume
- 49
- Issue
- 6
- Pages
- 905-916
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2017521059
- Cited by
- 321
- References
- 23
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- MACDONALD, P. C., MADDEN, J. D., BRENNER, P. F., WILSON, J. D., & SIITERI, P. K. (1979). Origin of Estrogen in Normal Men and in Women with Testicular Feminization*. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-49-6-905
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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