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Cited by 25Diabetes Management and ResearchPancreatic function and diabetesDiabetes Treatment and Management

Prandial insulin requirements in insulin-dependent diabetics: effects of size, time of day, and sequence of meals

SERVICE, F. J., RIZZA, R. A., HALL, L. D., WESTLAND, R. E., O’BRIEN, P. C., CLEMENS, A. H., HAYMOND, M. W., GERICH, J. E.·1983·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-57-5-931
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Abstract

To assess the effects of size, time of day, and sequence of meals on insulin requirements determined by an artificial endocrine pancreas, eight insulin-dependent diabetics ate meals of 12.5%, 25%, and 50% of total calories (30 Kcal/kg) at 0800, 1300, and 1800 on each of 3 separate days in a randomized order in one of two sequences in a three by three Latin square design. Plasma glucose and free insulin concentrations and amounts of insulin infused by the artificial endocrine pancreas were associated with meal size (P less than 0.001) but not with time of day of meal ingestion (analysis of variance). The sequence of meal ingestion did not alter integrated plasma glucose responses, but did influence the meal-related amounts of insulin infused. Thus, consideration should be given to meal size and sequence of meal ingestion but not time of day of meal ingestion when determining prandial iv insulin requirements.

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Crossref · 10.1210/jcem-57-5-931

Cites

20 of 20 references verified0 citation errors · 0 not checkable

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  • Service et al. did not observe a definitive diurnal pattern of postprandial insulin requirements in type 1 diabetic subjects.

    “but Service et al. (21) did not observe a definitive diurnal pattern of postprandial insulin requirements in type 1 diabetic subjects.”

    From Diurnal Pattern of Insulin Action in Type 1 Diabetes (2013) · cites this paper as [21]

  • Multiple investigators have reported correlations among total carbohydrate ingested, postprandial glucose excursions, and insulin administered when using the Biostator.

    “However, multiple investigators have reported correlations among the total amount of carbohydrate ingested, postprandial glucose excursions, and insulin administered when using the Biostator (21–23).”

    From Diurnal Pattern of Insulin Action in Type 1 Diabetes (2013) · cites this paper as [21]

  • Some but not all studies that used the Biostator controlled for physical activity levels, meal sizes, composition, and calorie content varied from meal to meal in all but one.

    “Although some (20,24,27) but not all (21–23,26) studies that used the Biostator controlled for physical activity levels, meal sizes, composition, and calorie content varied from meal to meal in all but one (27).”

    From Diurnal Pattern of Insulin Action in Type 1 Diabetes (2013) · cites this paper as [21]

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Authors
SERVICE, F. J., RIZZA, R. A., HALL, L. D., WESTLAND, R. E., O’BRIEN, P. C., CLEMENS, A. H., HAYMOND, M. W., & GERICH, J. E.
Affiliations
Mayo Clinic (US)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1983-11
Volume
57
Issue
5
Pages
931-936
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-57-5-931
OpenAlex
W2080329339
Cited by
25
References
20
Citations by year
2022: 1 · 2021: 2 · 2019: 1 · 2016: 1 · 2015: 2 · 2013: 1 · 2012: 4
FWCI
0.37
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
type 1 diabetes, meal size, artificial pancreas, plasma glucose, free insulin, intravenous insulin infusion, glucose-insulin dynamics
MeSH terms
Adult, Blood Glucose, Energy Intake, Diabetes Mellitus, Type 1, Diet, Dose-Response Relationship, Drug, Female, Glucagon, Humans, Insulin, Male, Time Factors

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