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Cited by 62Thyroid Disorders and TreatmentsCardiac electrophysiology and arrhythmiasOphthalmology and Eye Disorders

HLA and Thyrotoxic Periodic Paralysis in Japanese Patients

TAMAI, HAJIME, TANAKA, KENJI, KOMAKI, GEN, MATSUBAYASHI, SUNAO, HIROTA, YOSHIHIKO, MORI, KENJI, KUMA, KANJI, KUMAGAI, LINDY F. +1 more·1987·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-64-5-1075
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Abstract

Periodic paralysis (PP) is a well recognized although rare and peculiar complication of thyrotoxicosis, especially among Chinese and Japanese patients. The susceptibility to autoimmune thyroid disease has recently been reported to be strongly linked to certain immunogenetic factors, and increased frequency of certain HLA antigens has been found in patients with Graves' disease. This study was, therefore, undertaken to determine HLA haplotypes in Japanese men with thyrotoxic periodic paralysis (TPP). HLA typing in 35 TPP patients and 263 normal men and women demonstrated highly significant increases (P less than 0.01) in HLA-A2, Cw3, and DRw8 in the TPP patients. In comparing TPP patients with thyrotoxic men who did not have PP, the frequency of DRw8 antigen was 2.5-fold greater in patients with PP than in those without it (62.8% vs. 28.6%). The data suggest that the HLA-DRw8 gene itself may play a significant role in the susceptibility to TPP among Japanese men.

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Crossref · 10.1210/jcem-64-5-1075

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  • In Japanese populations, HLA-DRw8 is specifically associated with increased susceptibility to THPP.

    “In Japanese populations, HLA-DRw8 has been specifically associated with increased susceptibility to THPP [15].”

    From Thyrotoxic Hypokalemic Periodic Paralysis: Pathophysiological Mechanisms (2025) · cites this paper as [15]

  • Genetic factors, particularly HLA haplotypes and mutations in ion channel genes, have been identified in THPP.

    “While many cases of THPP are sporadic, genetic factors have been identified, particularly involving specific human leukocyte antigen (HLA) haplotypes [15] and mutations in ion channel genes [14].”

    From Thyrotoxic Hypokalemic Periodic Paralysis: Pathophysiological Mechanisms (2025) · cites this paper as [15]

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Authors
TAMAI, H., TANAKA, K., KOMAKI, G., MATSUBAYASHI, S., HIROTA, Y., MORI, K., KUMA, K., KUMAGAI, L. F., & NAGATAKI, S.
Affiliations
Kyushu University (JP)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1987-05
Volume
64
Issue
5
Pages
1075-1078
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-64-5-1075
OpenAlex
W2161372206
Cited by
62
References
15
Citations by year
2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2020: 1 · 2018: 1 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 1
FWCI
1.14
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
Keywords
thyrotoxic periodic paralysis, HLA haplotypes, HLA-DRw8, HLA-A2, HLA-Cw3, thyrotoxicosis, genetic susceptibility, Japanese men, Graves' disease, autoimmune thyroid disease
MeSH terms
Adult, Graves Disease, Haplotypes, HLA Antigens, HLA-DR Antigens, Humans, Japan, Male, Middle Aged, Paralysis, Thyrotoxicosis, HLA-DR Serological Subtypes

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