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Heritability of cortisol responses to human corticotropin-releasing hormone, ergometry, and psychological stress in humans.
Abstract
The present study investigated cortisol responses to three different stimulation procedures, with a focus on the contribution of genetic factors. Thirteen monozygotic (MZ) twin pairs and 11 dizygotic (DZ) twin pairs performed bicycle ergometry until exhaustion and were exposed to the psychological stress of public speaking and mental arithmetic in front of an audience. Furthermore, 9 MZ pairs and 10 DZ pairs were injected with 100 micrograms synthetic human CRH (hCRH). The adrenocortical response to these challenges was monitored by determination of cortisol in saliva. Significant intraindividual stability of baseline cortisol levels was found in females, but was less in males. Maximum cortisol responses to all three stimulation procedures were significantly intercorrelated in males, but in females only the cortisol responses to hCRH and ergometer exercise showed a significant correlation. While a decided influence of genetic factors was observed for all three baseline cortisol levels as well as for the response to hCRH, heredity appeared to be play a minor role in the adrenocortical response to psychological stress. Cortisol changes after bicycle ergometry revealed no impact of genetic factors on the secretion of cortisol in response to strenuous physical exercise.
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“HPA-axis responses to physical exercise appear not to differ between men and women (Friedmann and Kindermann, 1989;Kirschbaum et al., 1992;Kraemer et al., 1989).”
From The effects of physical activity on cortisol and sleep: A systematic review and meta-analysis. (2022) · cites this paper as Kirschbaum et al., 1992
Citations
Cites
Physiological functions of glucocorticoids in stress and their relation to pharmacological actions
MUNCK, A., GUYRE, P. M., & HOLBROOK, N. J. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-1-25 · Cited by 3,083
Salivary Cortisol in Psychobiological Research: An Overview
Kirschbaum, C., & Hellhammer, D. H. (2008) · Neuropsychobiology · doi:10.1159/000118611 · Cited by 1,532
Self-citationA review of psychoendocrine research on the pituitary–adrenal cortical system
MASON, J. W. (1968) · Psychosomatic Medicine · doi:10.1097/00006842-196809000-00020 · Cited by 874
Sternberg, E. M., Hill, J. M., Chrousos, G. P., Kamilaris, T., Listwak, S. J., Gold, P. W., & Wilder, R. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2374 · Cited by 723
The Immune-Hypothalamic-Pituitary-Adrenal Axis*
Bateman, A., Singh, A. V., Kral, T., & Solomon, S. (1989) · Endocrine Reviews · doi:10.1210/edrv-10-1-92 · Cited by 675
Hormones in saliva: mode of entry and consequent implications for clinical interpretation
Vining, R. F., McGinley, R. A., & Symons, R. G. (1983) · Clinical Chemistry · doi:10.1093/clinchem/29.10.1752 · Cited by 341
Jones, M. T., Hillhouse, E. W., & Burden, J. (1976) · Journal of Endocrinology · doi:10.1677/joe.0.0690001 · Cited by 257
Adrenal status assessed by direct radioimmunoassay of cortisol in whole saliva or parotid saliva.
Walker, R. F., Riad-Fahmy, D., & Read, G. F. (1978) · Clinical Chemistry · doi:10.1093/clinchem/24.9.1460 · Cited by 186
Salivary cortisol: A practical method for evaluation of adrenal function
Kahn, J., Rubinow, D. R., Davis, C. L., Kling, M. A., & Post, R. M. (1988) · Biological Psychiatry · doi:10.1016/0006-3223(88)90284-3 · Cited by 181
Ab, D., & Dunnick, N. R. (1991) · PubMed · Cited by 163
Buckingham, J. C. (2008) · Neuroendocrinology · doi:10.1159/000123364 · Cited by 160
Heritability of variation of plasma cortisol levels
Meikle, A. W., Stringham, J. D., Woodward, M. G., & Bishop, D. T. (1988) · Metabolism · doi:10.1016/0026-0495(88)90164-3 · Cited by 132
Saliva testosterone and criminal violence among women
Dabbs, J. M., Ruback, R. B., Frady, R. L., Hopper, C. H., & Sgoutas, D. S. (1988) · Personality and Individual Differences · doi:10.1016/0191-8869(88)90088-8 · Cited by 131
The effect of nutritional factors on sex hormone levels in male twins
Bishop, D. T., Meikle, A. W., Slattery, M. L., Stringham, J. D., Ford, M. H., West, D. W., Borecki, I. B., & Rao, D. C. (1988) · Genetic Epidemiology · doi:10.1002/gepi.1370050105 · Cited by 115
Plasma Cortisol and Norepinephrine Responses in Anticipation of Muscular Exercise
Mason, J. W., Hartley, H. L., Kotchen, T. A., Mougey, E. H., Ricketts, P. T., & Jones, L. G. (1973) · Psychosomatic Medicine · doi:10.1097/00006842-197309000-00004 · Cited by 105
Nürnberger, J. I., Gershon, E. S., Simmons, S., Ebert, M. H., Kessler, L. R., Dibble, E. D., Jimerson, S. S., Brown, G. M., Gold, P. W., Jimerson, D. C., et al. (1982) · Psychoneuroendocrinology · doi:10.1016/0306-4530(82)90009-9 · Cited by 93
Berger, T., Bossert, S., Krieg, J.-C., Dirlich, G., Ettmeier, W., Schreiber, W., & Zerssen, D. V. (1987) · Biological Psychiatry · doi:10.1016/0006-3223(87)90067-9 · Cited by 71
Heredity and changes in hormones and metabolic rates with short-term training
Poehlman, É. T., Tremblay, A., Nadeau, A., Dussault, J. H., Thériault, G., & Bouchard, C. (1986) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1986.250.6.e711 · Cited by 67
Influences of Cortisol on Auditory Evoked Potentials (AEPs) and Mood in Humans
Jan Born, A., Hitzler, V., Pietrowsky, R., Pauschinger, P., & Fehm, H. L. (2008) · Neuropsychobiology · doi:10.1159/000118489 · Cited by 61
Hereditary and Environmental Influences on the Variation of Thyroid Hormones in Normal Male Twins*
Meikle, A. W., Stringham, J. D., Woodward, M. G., & Nelson, J. C. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-3-588 · Cited by 53
Plasma Cortisol and Growth Hormone Responses to Intravenous Catheterization
Rose, R. M., & Hurst, M. W. (1975) · Journal of Human Stress · doi:10.1080/0097840x.1975.9940401 · Cited by 49
Rose, R. M., Jenkins, C. D., Hurst, M. W., Livingston, L., & Hall, R. P. (1982) · Psychoneuroendocrinology · doi:10.1016/0306-4530(82)90002-6 · Cited by 37
Isolation of the DNA minisatellite probe MZ 1.3 and its application to DNA ‘fingerprinting’ analysis
Schacker, U., Schneider, P. M., Holtkamp, B., Bohnke, E., Fimmers, R., Sonneborn, H. ‐., & Rittner, C. K. (1990) · Forensic Science International · doi:10.1016/0379-0738(90)90252-t · Cited by 36
Taste thresholds in man are differentially influenced by hydrocortisone and dexamethasone
Fehm‐Wolfsdorf, G., Scheible, E., Zenz, H., Jan Born, A., & Fehm, H. L. (1989) · Psychoneuroendocrinology · doi:10.1016/0306-4530(89)90042-5 · Cited by 35
White, M. C., Adams, E. F., LOIZOU, M., & MASHITER, K. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-55-5-967 · Cited by 35
Meikle, A. W., Bishop, D. T., Stringham, J. D., Ford, M. H., West, D. W., & Rao, D. C. (1989) · Genetic Epidemiology · doi:10.1002/gepi.1370060303 · Cited by 27
Plasma corticosteroids in healthy twin pairs.
Maxwell, J. D., Boyle, J. A., Greig, W. R., & Buchanan, W. W. (1969) · Journal of Medical Genetics · doi:10.1136/jmg.6.3.294 · Cited by 22
Comparisons of the intra-and inter-individual variability in sex hormone levels of men
Couwenbergs, C., Knußmann, R., & Christiansen, K. (1986) · Annals of Human Biology · doi:10.1080/03014468600008201 · Cited by 21
Characteristics of cerebrospinal fluid neuropeptides relevant to clinical research
Berrettini, W. H., Oxenstierna, G., Sedvall, G., Nürnberger, J. I., Gold, P. W., Rubinow, D. R., & Goldin, L. R. (1988) · Psychiatry Research · doi:10.1016/0165-1781(88)90104-7 · Cited by 21
Glucocorticoid influences on the auditory brain-stem responses in man
Jan Born, A., Schwab, R., Pietrowsky, R., Pauschinger, P., & Fehm, H. L. (1989) · Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section · doi:10.1016/0013-4694(89)90007-2 · Cited by 15
Routine applications of DNA fingerprinting with the oligonucleotide probe (CAC)5/(GTG)5
Neitzel, H., Digweed, M., Nürnberg, P., Pöpperl, A., Schmidt, C., Tinschert, S., & Sperling, K. (1991) · Clinical Genetics · doi:10.1111/j.1399-0004.1991.tb02994.x · Cited by 8
[Diagnosis of monozygosity in multiple births by DNA fingerprinting].
Scheurlen, W. G., Hb, V. S., & Kreth, H. W. (1991) · PubMed · Cited by 3
Norman, R. J., Maharaj, C., Adhikari, M., & Sm, J. (1984) · PubMed · Cited by 3
Plasma Human Growth Hormone Levels 4 Hours after Breakfast in Adolescent Twins and Adults
Irie, M., Tsushima, T., Sakuma, M., Matsuzaki, F., Mikami, R., SHISUME, K., & Nakao, K. (1969) · Endocrinologia Japonica · doi:10.1507/endocrj1954.16.283 · Cited by 1
Stabenau, J. R., & Mirsky, H. A. (1970) · Acta geneticae medicae et gemellologiae · doi:10.1017/s1120962300025233 · Cited by 1
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Kirschbaum, C., & Hellhammer, D. H. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90013-2 · Cited by 2,107
Self-citationThe potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders
Heim, C., Ehlert, U., & Hellhammer, D. H. (2000) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00035-9 · Cited by 1,688
Self-citationSex differences in HPA axis responses to stress: a review
Kudielka, B. M., & Kirschbaum, C. (2005) · Biological Psychology · doi:10.1016/j.biopsycho.2004.11.009 · Cited by 1,624
Self-citationKudielka, B. M., Hellhammer, D. H., & Wüst, S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.10.004 · Cited by 963
Self-citationConsistent sex differences in cortisol responses to psychological stress.
Kirschbaum, C., Wüst, S., & Hellhammer, D. (1992) · Psychosomatic Medicine · doi:10.1097/00006842-199211000-00004 · Cited by 730
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Metadata
- Authors
- Kirschbaum, C., Wüst, S., Faig, H. G., & Hellhammer, D. H.
- Affiliations
- Universität Trier (DE)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1992-12
- Volume
- 75
- Issue
- 6
- Pages
- 1526-1530
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1978954988
- Cited by
- 195
- References
- 35
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 8 · 2017: 2 · 2016: 8 · 2015: 6 · 2014: 11 · 2013: 7 · 2012: 6
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- cortisol, heritability, genetic factors, ergometry, psychological stress, public speaking, mental arithmetic, adrenocortical response, monozygotic twins, dizygotic twins, sex differences, intra-individual stability, exercise stress response
- MeSH terms
- Adolescent, Adult, Corticotropin-Releasing Hormone, Physical Exertion, Female, Humans, Hydrocortisone, Male, Statistics as Topic, Stress, Psychological, Twins, Dizygotic, Twins, Monozygotic, Ergometry
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