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Cited by 332Lipid metabolism and biosynthesisLipid metabolism and disordersAdipose Tissue and Metabolism

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Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: effects of androgens.

Mårin, P, Odén, B, Björntorp, P·1995·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.80.1.7829619
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Abstract

Studies on regional differences of adipose tissue metabolism have mainly been performed in vitro. To allow measurements of lipid uptake in vivo in man, radioactive label from [9,10-3H]oleic acid in 80 g orally administered milk fat was measured after 4 h in abdominal and femoral sc adipose tissues in 28 middle-aged, abdominally obese men. Radioactivity was measured in adipose tissue triglycerides extracted from needle biopsies. Lipoprotein lipase (LPL) activity was also measured. Uptake of label in triglycerides and LPL activity were higher (20% and 15%, respectively; P < 0.05) in the abdominal compared to the femoral adipose tissue region. The men were then randomly assigned to three groups, receiving testosterone (T), dihydrotestosterone, or placebo, for 9 months. After 2 months of treatment, the procedure of administration of label was repeated, this time using [U-14C]oleic acid as a marker. Measurements of radioactive label was then performed after 4 h and monthly up to 7 months. Supplementation with T was followed by an inhibited uptake of label in triglycerides (34%; P < 0.05), lower LPL activity (48%; P < 0.05), and a shorter t1/2 (30%; P < 0.05) in the abdominal adipose tissue region compared with the dihydrotestosterone and placebo groups. No significant effect of T on triglyceride uptake, LPL activity, or t1/2 was found in sc femoral adipose tissue. It was concluded that the turnover rate of depot triglycerides is more rapid in abdominal compared to femoral sc adipose tissue in men. Furthermore, T supplementation inhibits triglyceride uptake and LPL activity and causes a more rapid turnover of triglycerides only in the sc abdominal adipose tissue region. These results demonstrate the marked effects of T on adipose tissue metabolism in vivo and suggest that T is an important regulator of the proportion of depot fat mass in central and peripheral adipose tissue in men.

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Metadata

Authors
Mårin, P., Odén, B., & Björntorp, P.
Affiliations
Sahlgrenska University Hospital (SE)
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1995-01
Volume
80
Issue
1
Pages
239-243
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.80.1.7829619
OpenAlex
W2129627391
Cited by
332
References
0
Citations by year
2026: 3 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 10 · 2017: 9 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 10 · 2012: 11
FWCI
5.32
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords
triglyceride uptake, adipose tissue metabolism, abdominal fat, subcutaneous adipose tissue, androgens, testosterone, dihydrotestosterone, lipoprotein lipase, triglyceride turnover, abdominal obesity
MeSH terms
Abdomen, Adipose Tissue, Adult, Femur, Humans, Lipoprotein Lipase, Male, Middle Aged, Skin, Dihydrotestosterone, Testosterone, Triglycerides

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