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Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: effects of androgens.
Abstract
Studies on regional differences of adipose tissue metabolism have mainly been performed in vitro. To allow measurements of lipid uptake in vivo in man, radioactive label from [9,10-3H]oleic acid in 80 g orally administered milk fat was measured after 4 h in abdominal and femoral sc adipose tissues in 28 middle-aged, abdominally obese men. Radioactivity was measured in adipose tissue triglycerides extracted from needle biopsies. Lipoprotein lipase (LPL) activity was also measured. Uptake of label in triglycerides and LPL activity were higher (20% and 15%, respectively; P < 0.05) in the abdominal compared to the femoral adipose tissue region. The men were then randomly assigned to three groups, receiving testosterone (T), dihydrotestosterone, or placebo, for 9 months. After 2 months of treatment, the procedure of administration of label was repeated, this time using [U-14C]oleic acid as a marker. Measurements of radioactive label was then performed after 4 h and monthly up to 7 months. Supplementation with T was followed by an inhibited uptake of label in triglycerides (34%; P < 0.05), lower LPL activity (48%; P < 0.05), and a shorter t1/2 (30%; P < 0.05) in the abdominal adipose tissue region compared with the dihydrotestosterone and placebo groups. No significant effect of T on triglyceride uptake, LPL activity, or t1/2 was found in sc femoral adipose tissue. It was concluded that the turnover rate of depot triglycerides is more rapid in abdominal compared to femoral sc adipose tissue in men. Furthermore, T supplementation inhibits triglyceride uptake and LPL activity and causes a more rapid turnover of triglycerides only in the sc abdominal adipose tissue region. These results demonstrate the marked effects of T on adipose tissue metabolism in vivo and suggest that T is an important regulator of the proportion of depot fat mass in central and peripheral adipose tissue in men.
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“Comprising 40-50% of lean body mass in normal weight adults, skeletal muscle is the most abundant organ in the body (148).”
From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [148]
In the citing paper
“Physiologically, skeletal muscle not only plays a significant role in maintaining posture, movement, and vital actions, skeletal muscle is also an integral regulator of whole-body metabolism as a central determinant of total daily energy expenditure and glucose homeostasis (148, 149).”
From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [148]
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BackgroundMechanisms underlying the metabolic actions of testosterone in humans: A narrative review
Dandona, P., Dhindsa, S., Ghanim, H., & Saad, F. (2020) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14206 · Cited by 90
“the amount of label found in omental and retroperitoneal fat was significantly diminished while that in subcutaneous fat was increased following testosterone therapy.(43) Thus, testosterone clearly has an”
BackgroundBhasin, S. (2003) · Clinical Infectious Diseases · doi:10.1086/375878 · Cited by 78
“[52] studied the uptake and turnover of triglycerides from the peripheral and abdominal subcutaneous fat depots after the administration of labeled oleic acid.”
BackgroundMetabolic syndrome, testosterone deficiency and erectile dysfunction never come alone
Yassin, A. A., Saad, F., & Gooren, L. J. (2008) · Andrologia · doi:10.1111/j.1439-0272.2008.00851.x · Cited by 77
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BackgroundImpact of obesity on hypogonadism in the andropause
TAN, R. S.-H., & Pu, S. J. (2002) · International Journal of Andrology · doi:10.1046/j.1365-2605.2002.00356.x · Cited by 76
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“that regulates the conversion of free fatty acids into triglyceride [56].”
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Lee, M.-J., & Fried, S. K. (2017) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes.2017.26.3.172 · Cited by 72
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Testosterone and Erectile Dysfunction
Yassin, A. A., & Saad, F. (2008) · Journal of Andrology · doi:10.2164/jandrol.107.004630 · Cited by 73
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Sex-specific differences in leg fat uptake are revealed with a high-fat meal
Votruba, S. B., & Jensen, M. D. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00196.2006 · Cited by 71
“We (20, 32, 41) and others (24, 25) have found that the upper body subcutaneous fat (UBSQ) depot takes up meal fat more efficiently than lower body subcutaneous fat (LBSQ) and that this is the case in both women and men (20, 25, 32, 41).”
BackgroundDiabetes, obesity, and erectile dysfunction
Tamler, R. (2009) · Gender Medicine · doi:10.1016/j.genm.2008.12.003 · Cited by 73
Diagnosis of Male Infertility and Hypogonadism
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The Sexual Dimorphism of Lipid Kinetics in Humans
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“Concordant with group differences in omental adipose tissue AKR1C enzyme mRNA abundance, significant positive correlations were found between omental adipose tissue 20 -HSD and 3 -HSD-3 mRNA abundance and total body fat mass, visceral adipose tissue area, omental adipocyte diameter, and omental LPL activity (Fig.”
BackgroundInfluentialReliability of Maximal Voluntary Muscle Strength and Power Testing in Older Men
Schroeder, E. T., Wang, Y., Castaneda‐Sceppa, C., Cloutier, G. J., Vallejo, A. F., Kawakubo, M., Jensky, N. E., Coomber, S., Azen, S. P., & Sattler, F. R. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.5.543 · Cited by 67
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Schroeder, E. T., Singh, A. B., Bhasin, S., Storer, T. W., Azen, C. G., Davidson, T., Martinez, C., Sinha‐Hikim, I., Jaque, S. V., Terk, M. R., et al. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00363.2002 · Cited by 67
O’Sullivan, A. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2008.00539.x · Cited by 67
“The mechanism by which testosterone may influence fat mass distribution is not known (40); however, it is possibly through effects on lipoprotein lipase activity (42) or other regulatory factors (31).”
BackgroundAdipose tissue and fatty acid metabolism in humans.
Jensen, M. D. (2002) · PubMed Central · Cited by 63
Santosa, S., Hensrud, D. D., Votruba, S. B., & Jensen, M. D. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.4.1134 · Cited by 62
“This is done by measuring meal FA uptake with the use of the meal FA tracer/adipose biopsy technique pioneered by Mårin et al (9, 17).”
Regulation of body composition by androgens
Bhasin, S. (2003) · Journal of Endocrinological Investigation · doi:10.1007/bf03345230 · Cited by 63
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Bianchi, V. E., & Locatelli, V. (2018) · Obesity Reviews · doi:10.1111/obr.12633 · Cited by 65
“Furthermore, testosterone increases lipolysis and the number of β-adrenergic receptors on the membranes of adipocytes (137) and inhibit triglyceride uptake and lipoprotein lipase activity (138).”
BackgroundThe complex association between metabolic syndrome and male hypogonadism
Dimopoulou, C., Goulis, D. G., Corona, G., & Maggi, M. (2018) · Metabolism · doi:10.1016/j.metabol.2018.03.024 · Cited by 66
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Local Androgen Inactivation in Abdominal Visceral Adipose Tissue
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“An increased fatty acid turnover has also been observed in human males treated with testosterone (34, 35), and these studies demonstrated that testosterone treatment inhibited the activity of adipose tissue lipoprotein lipase, an important regulator of lipid uptake by the adipocyte (34, 35).”
Late-Life Onset Hypogonadism: A Review
Bassil, N., & Morley, J. E. (2010) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2010.02.003 · Cited by 59
“The mechanism of the decrease in lipids might be related to the decrease in the visceral abdominal fat mass(155) under the influence of androgens, which inhibit lipoprotein lipase activity and increase lipolysis(156) with improvement of insulin sensitivity and mobilization of triglycerides from abdominal fat tissue.(1…”
Kapoor, D., Channer, K. S., & Jones, T. H. (2008) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2008.022 · Cited by 58
“The rising level of testosterone then inhibits lipoprotein lipase enzyme activity in visceral fat, reducing fatty acid uptake and decreasing visceral adipose tissue mass.(14) This in turn results in further increases in testosterone concentrations.”
BackgroundHigher Free Fatty Acid Uptake in Visceral Than in Abdominal Subcutaneous Fat Tissue in Men
Hannukainen, J. C., Kalliokoski, K. K., Borra, R., Viljanen, A. P. M., Janatuinen, T., Kujala, U. M., Kaprio, J. A., Heinonen, O. J., Viljanen, T., Haaparanta‐Solin, M., et al. (2009) · Obesity · doi:10.1038/oby.2009.267 · Cited by 57
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Gene expression regional differences in human subcutaneous adipose tissue
Passaro, A., Miselli, M. A., Sanz, J. M., Nora, E. D., Morieri, M. L., Colonna, R., Pišot, R., & Zuliani, G. (2017) · BMC Genomics · doi:10.1186/s12864-017-3564-2 · Cited by 56
“The heterogeneity between different subcutaneous depots has also been investigated: abdominal subcutaneous adypocytes differ from femoral ones in term of proliferation [17], differentiation [18] and fatty acid release and accumulation capacity [19, 20].”
BackgroundMisra, M., Miller, K. K., Almazan, C., Worley, M., Herzog, D. B., & Klibanski, A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2041 · Cited by 55
“E2 causes a gynecoid distribution of body fat (25, 26).”
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Kopelman, P., & Albon, L. (1997) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a011616 · Cited by 55
Sources of blood glycerol during fasting
Jensen, M. D., Chandramouli, V., Schumann, W. C., Ekberg, K., Previs, S. F., Gupta, S., & Landau, B. R. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.5.e998 · Cited by 54
Agledahl, I., Hansen, J., & Svartberg, J. B. (2008) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510801999068 · Cited by 51
“In a study by Mårin and co-workers, testosterone supplementation inhibited LPL activity and uptake of fatty acids in subcutaneous abdominal adipocytes, thereby inhibiting abdominal obesity [36].”
BackgroundThe Role of Androgen in the Adipose Tissue of Males
Lee, H.-K., Lee, J. K., & Cho, B. (2013) · The World Journal of Men s Health · doi:10.5534/wjmh.2013.31.2.136 · Cited by 51
“It is recognized that androgen reduces the LPL activity in adipose tissue, adjusting the central fat accumulation;(46) in fact, an experiment that examined the effect of androgen on abdominal adipose tissue suggested that the LPL activity in the tissue had decreased and the triglyceride uptake was inhibited in the gro…”
BackgroundSex hormones, body composition and aging
Vermeulen, A., Goemaere, S., & Kaufman, J. (1999) · The Aging Male · doi:10.3109/13685539909003178 · Cited by 55
El-Twab, S. M. A., Mohamed, H. M., & Mahmoud, A. M. (2016) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2015-0503 · Cited by 54
Androgen Deficiency as a Predictor of Metabolic Syndrome in Aging Men
Kapoor, D., & Jones, T. H. (2008) · Drugs & Aging · doi:10.2165/00002512-200825050-00001 · Cited by 52
Divers, S. L., McQuillan, H. J., Matsubara, H., Todo, T., & Lokman, P. M. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m009027 · Cited by 52
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“These effects can be attributed to a stimulating effect of testosterone on fat mobilization and an inhibition of lipoprotein lipase activity, which both reduce net fat storage (Ma ̊rin et al., 1996; Mårin et al., 1995).”
BackgroundMechanisms of obesity-induced male infertility
Phillips, K. P., & Tanphaichitr, N. (2010) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.09.65 · Cited by 51
Regional fat placement in physically fit males and changes with weight loss
Nindl, B. C., Friedl, K. E., Marchitelli, L. J., Shippee, R. L., Thomas, C., & Patton, J. F. (1996) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199607000-00003 · Cited by 48
The aging male: testosterone deficiency and testosterone replacement. An up-date
Alexandersen, P., & Christiansen, C. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00242-9 · Cited by 45
Testosterone for secondary prevention in men with ischaemic heart disease?
Malkin, C. J., Pugh, P. J., Jones, T. H., & Channer, K. S. (2003) · QJM · doi:10.1093/qjmed/hcg086 · Cited by 45
Androgens, cardiovascular risk factors and atherosclerosis
von Eckardstein, A. (1998) · Springer eBooks · doi:10.1007/978-3-642-72185-4_8 · Cited by 44
Androgens, Obesity, and Sleep-Disordered Breathing in Men
Liu, P. Y., Caterson, I. D., Grunstein, R. R., & Handelsman, D. J. (2007) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2007.03.002 · Cited by 43
“Increasing obesity predicts lower future serum testosterone [113,114], possibly due to decreased lipolysis of abdominal fat [53].”
BackgroundEffects of dihydrotestosterone on adipose tissue measured by serial analysis of gene expression
Bolduc, C., Larose, M., Yoshioka, M., Ye, P., Belleau, P., Labrie, C., Morissette, J., Raymond, V., Labrie, F., & St‐Amand, J. (2004) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01503 · Cited by 43
“Moreover, testosterone inhibited triacylglycerol uptake in abdominal adipose tissue of obese men (Marin et al. 1995).”
BackgroundBody Habitus Changes Related to Lipodystrophy
Sattler, F. R. (2003) · Clinical Infectious Diseases · doi:10.1086/367563 · Cited by 43
Adrenal and gonadal function in obesity
Pasquali, R., Vicennati, V., & Gambineri, A. (2002) · Journal of Endocrinological Investigation · doi:10.1007/bf03344053 · Cited by 42
Meal fatty acid uptake in human adipose tissue: technical and experimental design issues
Romanski, S. A., Nelson, R. M., & Jensen, M. D. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.2.e447 · Cited by 41
“It has been taken for granted that (3)H and (14)C fatty acid tracers could be used interchangeably to quantitatively measure meal fatty acid uptake by adipose tissue (19).”
BackgroundMethodEffects of Male Hypogonadism on Regional Adipose Tissue Fatty Acid Storage and Lipogenic Proteins
Santosa, S., & Jensen, M. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031473 · Cited by 41
“Dietary FA in chylomicrons require lipoprotein lipase (LPL) in order to be taken up by adipocytes and testosterone treatment of hypogonadal men decreases LPL activity [5–7].”
BackgroundResultTreatment with oxandrolone and the durability of effects in older men
Schroeder, E. T., Zheng, L., Yarasheski, K. E., Qian, D., Stewart, Y., Flores, C., Martinez, C., Terk, M. R., & Sattler, F. R. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00808.2003 · Cited by 40
“These effects are consistent with the known effects of androgens to decrease lipoprotein lipase and upregulate -adrenergic receptors on adipocytes, which would inhibit the accumulation of lipid and enhance the efflux of lipid from these cells in response to catecholamines (26, 38, 55).”
BackgroundPredictive value of serum testosterone for type 2 diabetes risk assessment in men
Atlantis, E. E., Fahey, P. P., Martin, S., O’Loughlin, P. D., Taylor, A. W., Adams, R., Shi, Z., & Wittert, G. (2016) · BMC Endocrine Disorders · doi:10.1186/s12902-016-0109-7 · Cited by 42
“Research on mechanisms suggest that low serum testosterone decreases insulin resistance indirectly by promoting metabolically favourable changes in body composition [36]; and directly by enhancing catecholamine-induced lipolysis in vitro [37] and reducing lipoprotein lipase activity and triglyceride uptake in human ab…”
BackgroundFink, J. E., Matsumoto, M., & Tamura, Y. (2018) · Steroids · doi:10.1016/j.steroids.2018.08.002 · Cited by 42
“Testosterone seems to affect especially abdominal rather than subcutaneous fat [23].”
Visceral and Subcutaneous Adipose Tissue Diacylglycerol Acyltransferase Activity in Humans
Hou, X., Moser, S., Sarr, M. G., Thompson, G. B., Que, F. G., & Jensen, M. D. (2009) · Obesity · doi:10.1038/oby.2008.659 · Cited by 39
“Likewise, tracers can be used to measure meal-derived fatty acid or FFA storage per gram of tissue (7,11,24,25).”
BackgroundAssociations between Aortic Calcification and Components of Body Composition in Elderly Men
Alexandersen, P., Tankó, L. B., Bagger, Y. Z., Jespersen, J., Skouby, S. O., & Christiansen, C. (2006) · Obesity · doi:10.1038/oby.2006.181 · Cited by 39
Acute Testosterone Deficiency Alters Adipose Tissue Fatty Acid Storage
Santosa, S., Bush, N. C., & Jensen, M. D. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00757 · Cited by 37
“Although testosterone treatment is reported to decrease LPL activity (7, 8) we found that chronic testosterone suppression did not have major effects on LPL activity (4).”
BackgroundHypogonadotrophic hypogonadism in type 2 diabetes
Dandona, P., Dhindsa, S., Chaudhuri, A., Bhatia, V., & Topiwala, S. (2008) · The Aging Male · doi:10.1080/13685530802317934 · Cited by 38
“Inhibition of lipoprotein lipase activity in intra-abdominal adipose tissue and the differentiation of pluripotent mesenchymal precursor cells preferentially into myogenic lineage instead of adipocytic lineage may play a role [50,51].”
BackgroundDumesic, D. A., Abbott, D. H., Eisner, J. R., Herrmann, R. R., Reed, J. E., Welch, T. J., & Jensen, M. D. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00098-3 · Cited by 38
Androstane-3α,17β-Diol Glucuronide as a Steroid Correlate of Visceral Obesity in Men*
Tchernof, A., Labrie, F., Bélanger, A., Prud’homme, D., Bouchard, C., Tremblay, A., Nadeau, A., & Després, J. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3924 · Cited by 38
Independent Effects of Testosterone on Lipid Oxidation and VLDL-TG Production
Høst, C., Gormsen, L. C., Christensen, B., Jessen, N., Hougaard, D. M., Christiansen, J. S., Pedersen, S. B., Jensen, M. D., Nielsen, S., & Gravholt, C. H. (2013) · Diabetes · doi:10.2337/db12-0440 · Cited by 37
“Conversely, T increases lipolysis and reduces adipose tissue lipoprotein lipase (LPL) activity, decreasing TG uptake in abdominal fat (22,23).”
BackgroundWittert, G., Atlantis, E. E., Allan, C. A., Bracken, K., Conway, A. J., Daniel, M., Gebski, V., Grossmann, M., Hague, W. E., Handelsman, D. J., et al. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13601 · Cited by 36
“Direct effects of T are enhanced catecholamine-induced lipolysis(14) and reduced lipoprotein lipase activity and triglyceride uptake in human abdominal adipose tissue.(15) Moreover, T levels correlate positively with mitochondrial indices of insulin sensitivity in human skeletal muscle(16) and modulate pathways regula…”
BackgroundKoutsari, C., Ali, A. H., Nair, K. S., Rizza, R. A., O'Brien, P., Khosla, S., & Jensen, M. D. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0165 · Cited by 35
Kim, W. T., Yun, S. J., Choi, Y. D., Kim, G., Moon, S., Choi, Y. H., Kim, I. Y., & Kim, W. (2011) · Journal of Korean Medical Science · doi:10.3346/jkms.2011.26.9.1214 · Cited by 36
“Testosterone inhibits lipoprotein lipase activity in abdominal adipose tissue, which leads to decreased triglyceride uptake in central fat depots (29).”
BackgroundHypoandrogen-metabolic syndrome: a potentially common and underdiagnosed condition in men
Gould, D. C., Kirby, R. S., & Amoroso, P. (2007) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2006.01239.x · Cited by 35
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Sex and Gender Differences in Body Composition, Lipid Metabolism, and Glucose Regulation
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Lapauw, B., T'Sjoen, G. G., Mahmoud, A., Kaufman, J., & Ruige, J. B. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0881 · Cited by 33
Androgen Inhibits Abdominal Fat Accumulation and Negatively Regulates the PCK1 Gene in Male Chickens
Duan, J., Shao, F., Yonggang, S., Li, J., Ling, Y., Teng, K., Li, H., & Wu, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059636 · Cited by 31
“Additionally, our microarray data found no differences in the expression levels of LPL and HSL genes between capons and intact male chickens, implying that avian species and mammals possess different mechanisms through which androgen status affects adipogenesis.”
BackgroundMonier, P. L., & Wilcox, R. D. (2004) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200407000-00007 · Cited by 31
Waist Circumference Threshold Values for Type 2 Diabetes Risk
Friedl, K. E. (2009) · Journal of Diabetes Science and Technology · doi:10.1177/193229680900300424 · Cited by 31
Leg Fat Percentage Correlates Negatively With Coronary Atherosclerosis
Hara, M., Saikawa, T., Kurokawa, M., Sakata, T., & Yoshimatsu, H. (2004) · Circulation Journal · doi:10.1253/circj.68.1173 · Cited by 29
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Costa, D. N., Santosa, S., & Jensen, M. D. (2025) · Physiological Reviews · doi:10.1152/physrev.00008.2024 · Cited by 34
Tanabe, M., Akehi, Y., Nomiyama, T., Murakami, J., & Yanase, T. (2014) · Endocrine Journal · doi:10.1507/endocrj.ej14-0313 · Cited by 28
Moon, H., Choi, I., Kim, S., Ko, H., Shin, J., Lee, K., Sung, J., & Song, Y. (2017) · Clinical Endocrinology · doi:10.1111/cen.13390 · Cited by 28
Impairment in insulin sensitivity after early androgenization in the post-pubertal female rat
Perelló, M., Castrogiovanni, D. C., Giovambattista, A., Gaillard, R. C., & Spinedi, E. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.02.013 · Cited by 28
Bhasin, S., & Javanbakht, M. (1999) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719902300605 · Cited by 28
Longitudinal associations of the endocrine environment on fat partitioning in postmenopausal women
Goss, A. M., Darnell, B. E., Brown, M. A., Oster, R. A., & Gower, B. A. (2012) · Obesity · doi:10.1038/oby.2011.362 · Cited by 26
“has been suggested that exogenous testosterone plays a role in regulating IAAT accrual by inhibiting lipoprotein lipase activity to a greater degree in visceral adipose tissue than in femoral adipose tissue (22,23).”
Kolovou, G. D., Bilianou, H. I., Marvaki, A., & Mikhailidis, D. P. (2010) · American Journal of Men s Health · doi:10.1177/1557988310370360 · Cited by 25
Miller, C., Madden-Doyle, L., Jayasena, C. N., McIlroy, M., Sherlock, M., & O’Reilly, M. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae128 · Cited by 27
Acylation stimulating protein: a female lipogenic factor?
Saleh, J., Al-Wardy, N., Farhan, H., Al-Khanbashi, M., & Cianflone, K. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00832.x · Cited by 25
“It was suggested that fat assimilation may be directed by testosterone to subcutaneous depots in men (61,62), and as testosterone levels decrease with age (63), abdominal fat accumulates.”
BackgroundHolland, A. M., Roberts, M. D., Mumford, P. W., Mobley, C. B., Kephart, W. C., Conover, C. F., Beggs, L. A., Balaez, A., Otzel, D. M., Yarrow, J. F., et al. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00238.2016 · Cited by 24
“Hypogonadism increases LPL activity in men (24), and testosterone treatment reduces LPL activity and triglyceride uptake in subcutaneous abdominal adipose tissue in hypogonadal men (33).”
BackgroundAssociation between Serum Testosterone Levels and Body Composition among Men 20–59 Years of Age
Ye, J., Zhai, X., Yang, J., & Zhu, Z. (2021) · International Journal of Endocrinology · doi:10.1155/2021/7523996 · Cited by 24
“On the other hand, testosterone has been shown to exert an inhibitory effect on the incorporation of dietary fat into adipose tissue [27].”
BackgroundSex and sex steroids: impact on the kinetics of fatty acids underlying body shape
Santosa, S., & Jensen, M. D. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0029 · Cited by 24
“[70] showed baseline differences in meal FA storage where more meal FA was stored in the abdominal vs.”
Metadata
- Authors
- Mårin, P., Odén, B., & Björntorp, P.
- Affiliations
- Sahlgrenska University Hospital (SE)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1995-01
- Volume
- 80
- Issue
- 1
- Pages
- 239-243
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2129627391
- Cited by
- 332
- References
- 0
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 10 · 2017: 9 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 10 · 2012: 11
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- triglyceride uptake, adipose tissue metabolism, abdominal fat, subcutaneous adipose tissue, androgens, testosterone, dihydrotestosterone, lipoprotein lipase, triglyceride turnover, abdominal obesity
- MeSH terms
- Abdomen, Adipose Tissue, Adult, Femur, Humans, Lipoprotein Lipase, Male, Middle Aged, Skin, Dihydrotestosterone, Testosterone, Triglycerides
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