The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Leptin Concentrations in Relation to Body Mass Index and the Tumor Necrosis Factor-α System in Humans1
Abstract
The expression of leptin, an adipocyte-derived protein whose circulating levels reflect energy stores, can be induced by tumor necrosis factor (TNF)alpha in rodents, but an association between the TNF alpha system and leptin levels has not been reported in humans. To evaluate the potential association between serum leptin and the TNF alpha system, we measured the levels of soluble TNF alpha-receptor (sTNF alpha-R55), which has been validated as a sensitive indicator of activation of the TNF alpha system. We studied two groups: 1) 82 young healthy normal controls and 2) 48 patients with noninsulin dependent diabetes mellitus (NIDDM) and 24 appropriately matched controls. By simple regression analysis in controls, there was a strong positive association between leptin and 3 parameters: body mass index, sTNF alpha-R55, and insulin levels. In a multiple regression analysis model, leptin remained significantly and strongly associated with body mass index, and the association of leptin with both insulin and sTNF alpha-R55, although weakened, remained significant. Patients with NIDDM had leptin concentrations similar to controls of similar weight. Importantly, serum levels of sTNF alpha-R55 were also positively and independently associated with leptin in this group of diabetic subjects and matched controls. These data are consistent with the hypothesis that the TNF alpha system plays a role in regulating leptin levels in humans. Further elucidation of a possible role of the TNF alpha system in leptin expression and circulating levels may have important implications for our understanding of obesity and cachexia in humans.
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Cites
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Cited by
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
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Insulin Resistance and Chronic Cardiovascular Inflammatory Syndrome
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Metadata
- Authors
- Mantzoros, C. S., Moschos, S., Avramopoulos, I., Kaklamani, V., Liolios, A., Doulgerakis, D. E., Griveas, I., Katsilambros, N., & Flier, J. S.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1997-10
- Volume
- 82
- Issue
- 10
- Pages
- 3408-3413
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2058586322
- Cited by
- 274
- References
- 56
- FWCI
- 17.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mantzoros, C. S., Moschos, S., Avramopoulos, I., Kaklamani, V., Liolios, A., Doulgerakis, D. E., Griveas, I., Katsilambros, N., & Flier, J. S. (1997). Leptin Concentrations in Relation to Body Mass Index and the Tumor Necrosis Factor-α System in Humans1. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem.82.10.4323
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