The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Association Between Insulin-Like Growth Factor I and Bone Mineral Density in Older Women and Men: The Framingham Heart Study1
Abstract
Few studies of the GH axis and bone have focused specifically on elderly people. The objective of this study was to determine the association between insulin-like growth factor I (IGF-I) and bone mineral density (BMD) in 425 women and 257 men aged 72–94 who participated in the Framingham Osteoporosis Study component of the Framingham Heart Study in 1992–1993. Serum IGF-I level was determined by RIA. BMD at three femoral sites and the lumbar spine was determined by dual x-ray absorptiometry, and at the radius by single-photon absorptiometry. IGF-I level was positively associated with BMD at all five sites (Ward’s area, femoral neck, trochanter, radius, and lumbar spine) in women after adjustment for weight loss and other factors (P ≤ 0.01) and protein intake in a subset of participants (0.006 < P < 0.07). A threshold effect of higher BMD was evident at each of the 3 femoral sites and the spine (P < 0.03) but not at the radius for women in the highest quintile of IGF-I (≥179 g/liter) vs. those in the lowest four quintiles. IGF-I was not significantly associated with BMD in men. These results indicate that higher IGF-I levels are associated with greater BMD in very old women, and suggest that future clinical trials employing GH may have a role in the development of treatments for older women with osteoporosis.
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1 retracted
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EPIDEMIOLOGY OF OSTEOPOROSIS AND OSTEOPOROTIC FRACTURES
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Cited by
Feng, X., & McDonald, J. M. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130203 · Cited by 1,272
Growth Hormone, Insulin-Like Growth Factors, and the Skeleton
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Circulating levels of IGF-1 directly regulate bone growth and density
Yakar, S., Rosen, C. J., Beamer, W. G., Ackert-Bicknell, C. L., Wu, Y., Liu, J.-L., Ooi, G. T., Setser, J., Frystyk, J., Boisclair, Y. R., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215463 · Cited by 739
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Tissue Engineering and Cell-Based Therapies for Fractures and Bone Defects
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Metadata
- Authors
- Langlois, J. A., Rosen, C. J., Visser, M., Hannan, M. T., Harris, T., Wilson, P. W. F., & Kiel, D. P.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1998-12-01
- Volume
- 83
- Issue
- 12
- Pages
- 4257-4262
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2066154604
- Cited by
- 255
- References
- 52
- FWCI
- 6.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Association Between Insulin-Like Growth Factor I and Bone Mineral Density in Older Women and Men: The Framingham Heart Study1. https://app.cochat.ai/papers/10.1210/jcem.83.12.5308
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- Langlois, J. A., Rosen, C. J., Visser, M., Hannan, M. T., Harris, T., Wilson, P. W. F., & Kiel, D. P. (1998). Association Between Insulin-Like Growth Factor I and Bone Mineral Density in Older Women and Men: The Framingham Heart Study1. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem.83.12.5308
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
