A Model of Lifetime Osteoporosis Impact
Abstract
The study goal was to use population-based data to model aspects of lifetime osteoporosis impact not previously studied, specifically: (1) to estimate person-years of fracture-related functional impairment against the trajectory of functional status in the general population; (2) jointly to consider hip, vertebral, and Colles' fractures in estimating the percent of women who will ever fracture; and (3) to estimate the lifetime number of fractures expected in a cohort of 10,000 50-year-old white postmenopausal women. The model estimates that 54% of 50-year-old women will sustain osteoporosis-related fractures during their remaining lifetimes. Beyond the functional impairment expected in similarly aged, unfractured women, osteoporosis-related fractures are estimated to cause 6.7% of women to become dependent in basic activities of daily living; 7.8% are expected to require nursing home care for an average of 7.6 years.
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Hip fractures carry the greatest morbidity and mortality for older adults.
“Levothyroxine was also associated with an increase in hip fractures specifically, which carry the greatest morbidity and mortality for older adults.55”
From Levothyroxine dose and risk of fractures in older adults: nested case-control study (2011) · cites this paper as [55]
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- Authors
- Chrischilles, E. A.
- Affiliations
- University of Iowa (US)
- Corresponding author
- Chrischilles, Elizabeth A.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1991-10-01
- Volume
- 151
- Issue
- 10
- Pages
- 2026
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2094251460
- Cited by
- 467
- References
- 36
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 12 · 2022: 2 · 2021: 6 · 2020: 9 · 2019: 11 · 2018: 12 · 2017: 11 · 2016: 11 · 2015: 10 · 2014: 13 · 2013: 15 · 2012: 15
- FWCI
- 8.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Surgery › Hip and Femur Fractures
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- osteoporosis, hip fracture, vertebral fractures, Colles' fracture, functional disability, activities of daily living, nursing home care, postmenopausal women, fracture risk prediction model
- MeSH terms
- Colles' Fracture, Female, Fractures, Spontaneous, Health Status, Hip Fractures, Humans, Markov Chains, Mathematical Computing, Middle Aged, Prognosis, Recurrence, Models, Statistical, Cohort Studies, Osteoporosis, Postmenopausal, Spinal Fractures
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