Cited by 568Estrogen and related hormone effectsProstate Cancer Treatment and ResearchHormonal and reproductive studies

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The Roles of Androgen Receptors and Androgen-Binding Proteins in Nongenomic Androgen Actions

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Heinlein, Cynthia A., Chang, Chawnshang·2002·Molecular Endocrinology

DOI 10.1210/me.2002-0070

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Abstract

The biological activity of testosterone and dihydrotestosterone is thought to occur predominantly through binding to the androgen receptor (AR), a member of the nuclear receptor superfamily that functions as a ligand-activated transcription factor. However, androgens have also been reported to induce the rapid activation of kinase-signaling cascades and modulate intracellular calcium levels. These effects are considered to be nongenomic because they occur in cell types that lack a functional AR, in the presence of inhibitors of transcription and translation, or are observed to occur too rapidly to involve changes in gene transcription. Such nongenomic effects of androgens may occur through AR functioning in the cytoplasm to induce the MAPK signal cascade. In addition, androgens may function through the sex hormone binding globulin receptor and possibly a distinct G protein-coupled receptor to activate second messenger signaling mechanisms. The physiological effect of nongenomic androgen action has yet to be determined. However, it may ultimately contribute to regulation of transcription factor activity, including mediation of the transcriptional activity of AR.

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CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES
Thomas, S. Μ., & Brugge, J. S. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.513 · Cited by 2,537
Calcium - a life and death signal
Berridge, M. J., Bootman, M. D., & Lipp, P. (1998) · Nature · doi:10.1038/27094 · Cited by 2,081
Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors
Kousteni, S., Bellido, T., Plotkin, L. I., O’Brien, C. A., Bodenner, D., Li, H., Han, K., Gregorio, G. B. D., Katzenellenbogen, J. A., Katzenellenbogen, B. S., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00268-9 · Cited by 1,163
Biological Actions of Androgens
MOORADIAN, A. D., MORLEY, J. E., & KORENMAN, S. G. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-1-1 · Cited by 1,080
The Endocrinology and Developmental Biology of the Prostate*
Cunha, G. R., Donjacour, A. A., Cooke, P. S., MEE, H., Bigsby, R. M., HIGGINS, S. J., & Sugimura, Y. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-3-338 · Cited by 1,036
Multiple Actions of Steroid Hormones—A Focus on Rapid, Nongenomic Effects
Falkenstein, E., Tillmann, H.-C., Christ, M., Feuring, M., & Wehling, M. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01468-6 · Cited by 1,002
The Free Hormone Hypothesis: A Physiologically Based Mathematical Model*
MENDEL, C. M. (1989) · Endocrine Reviews · doi:10.1210/edrv-10-3-232 · Cited by 961
Androgen Receptor (AR) Coregulators: An Overview
Heinlein, C. A., & Chang, C. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.2.0460 · Cited by 943
Self-citation
The serum transport of steroid hormones
SIITERI, P. K., MURAI, J. T., RAYMOURE, W. J., KUHN, R. W., HAMMOND, G. L., & NISKER, J. A. (1982) · Proceedings of the 1981 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571138-8.50016-0 · Cited by 770
c-Fos and Related Immediate Early Gene Products as Markers of Activity in Neuroendocrine Systems
Hoffman, G. E., Smith, M. S., & Verbalis, J. G. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1006 · Cited by 715

Flagged first, then by citations

Show all 76 references

Research works printed but not linked: 1

Gerdes, 1998, Cloning and tissue expression of two putative steroid membrane receptors., Biol Chem, 379, 907

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Takahara, K., Azuma, H., Sakamoto, T., Kiyama, S., Inamoto, T., Ibuki, N., Nishida, T., Nomi, H., Ubai, T., Segawa, N., et al. (2009) · PubMed · Cited by 38
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Søiland, H., Søreide, K., Janssen, E. A. M., Kørner, H., Baak, J. P. A., & Søreide, J. A. (2007) · Analytical Cellular Pathology · doi:10.1155/2007/487235 · Cited by 38
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Bordallo, J., de Boto, M. J. G., Meana, C., Velasco, L., Bordallo, C., Suárez, L., Cantabrana, B., & Sánchez, M. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.10.039 · Cited by 36
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Roy, V. K., & Krishna, A. (2009) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2009.06.012 · Cited by 36
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Richards, S. M., Liu, M., Jensen, R. V., Schirra, F., Yamagami, H., Lombardi, M. J., Rowley, P., Treister, N. S., Suzuki, T., Sullivan, B. D., et al. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2005.04.037 · Cited by 36
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Musicki, B., Karakus, S., Akakpo, W., Silva, F. H., Liu, J., Chen, H.-W., Zirkin, B. R., & Burnett, A. L. “. (2017) · Andrology · doi:10.1111/andr.12442 · Cited by 36
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Authors: Heinlein, C. A., & Chang, C.
Affiliations: George Whipple Laboratory for Cancer Research, Departments of Pathology (C.A.H., C.C.), Rochester, New York 14642
University of Rochester Medicine (US)
Corresponding author: Chang, Chawnshang
ORCID: Chang, Chawnshang
Venue: Molecular Endocrinology
Publisher: The Endocrine Society
Published: 2002-10-01
Volume: 16
Issue: 10
Pages: 2181-2187
ISSN: 0888-8809 (ISSN-L)
1944-9917
DOI: 10.1210/me.2002-0070
OpenAlex: W2146352944
Cited by: 568
References: 76
Citations by year: 2026: 6 · 2025: 7 · 2024: 9 · 2023: 14 · 2022: 15 · 2021: 26 · 2020: 20 · 2019: 28 · 2018: 20 · 2017: 24 · 2016: 32 · 2015: 18 · 2014: 20 · 2013: 43 · 2012: 31
FWCI: 2.59
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Molecular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: University of Rochester
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: androgen receptor, androgen-binding protein, sex hormone-binding globulin, dihydrotestosterone, testosterone, MAPK signaling, intracellular calcium signaling, G protein-coupled receptors, nuclear receptor superfamily, transcriptional regulation
MeSH terms: Androgen-Binding Protein, Androgens, Animals, Cell Membrane, Humans, Receptors, Androgen, Sex Hormone-Binding Globulin, Transcription, Genetic, Protein Biosynthesis, Genome, MAP Kinase Signaling System

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The Roles of Androgen Receptors and Androgen-Binding Proteins in Nongenomic Androgen Actions

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