Cited by 568Estrogen and related hormone effectsProstate Cancer Treatment and ResearchHormonal and reproductive studies

The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.

The Roles of Androgen Receptors and Androgen-Binding Proteins in Nongenomic Androgen Actions

Open access

Heinlein, Cynthia A., Chang, Chawnshang·2002·Molecular Endocrinology

DOI 10.1210/me.2002-0070

Open this paper in CoChat — free account Open PDF

Abstract

The biological activity of testosterone and dihydrotestosterone is thought to occur predominantly through binding to the androgen receptor (AR), a member of the nuclear receptor superfamily that functions as a ligand-activated transcription factor. However, androgens have also been reported to induce the rapid activation of kinase-signaling cascades and modulate intracellular calcium levels. These effects are considered to be nongenomic because they occur in cell types that lack a functional AR, in the presence of inhibitors of transcription and translation, or are observed to occur too rapidly to involve changes in gene transcription. Such nongenomic effects of androgens may occur through AR functioning in the cytoplasm to induce the MAPK signal cascade. In addition, androgens may function through the sex hormone binding globulin receptor and possibly a distinct G protein-coupled receptor to activate second messenger signaling mechanisms. The physiological effect of nongenomic androgen action has yet to be determined. However, it may ultimately contribute to regulation of transcription factor activity, including mediation of the transcriptional activity of AR.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1210/me.2002-0070

Cites

77 of 77 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES
Thomas, S. Μ., & Brugge, J. S. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.513 · Cited by 2,537
Calcium - a life and death signal
Berridge, M. J., Bootman, M. D., & Lipp, P. (1998) · Nature · doi:10.1038/27094 · Cited by 2,081
Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors
Kousteni, S., Bellido, T., Plotkin, L. I., O’Brien, C. A., Bodenner, D., Li, H., Han, K., Gregorio, G. B. D., Katzenellenbogen, J. A., Katzenellenbogen, B. S., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00268-9 · Cited by 1,163
Biological Actions of Androgens
MOORADIAN, A. D., MORLEY, J. E., & KORENMAN, S. G. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-1-1 · Cited by 1,080
The Endocrinology and Developmental Biology of the Prostate*
Cunha, G. R., Donjacour, A. A., Cooke, P. S., MEE, H., Bigsby, R. M., HIGGINS, S. J., & Sugimura, Y. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-3-338 · Cited by 1,036
Multiple Actions of Steroid Hormones—A Focus on Rapid, Nongenomic Effects
Falkenstein, E., Tillmann, H.-C., Christ, M., Feuring, M., & Wehling, M. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01468-6 · Cited by 1,002
The Free Hormone Hypothesis: A Physiologically Based Mathematical Model*
MENDEL, C. M. (1989) · Endocrine Reviews · doi:10.1210/edrv-10-3-232 · Cited by 961
Androgen Receptor (AR) Coregulators: An Overview
Heinlein, C. A., & Chang, C. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.2.0460 · Cited by 943
Self-citation
The serum transport of steroid hormones
SIITERI, P. K., MURAI, J. T., RAYMOURE, W. J., KUHN, R. W., HAMMOND, G. L., & NISKER, J. A. (1982) · Proceedings of the 1981 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571138-8.50016-0 · Cited by 770
c-Fos and Related Immediate Early Gene Products as Markers of Activity in Neuroendocrine Systems
Hoffman, G. E., Smith, M. S., & Verbalis, J. G. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1006 · Cited by 715

Show all 76 references

Research works printed but not linked: 1

Gerdes, 1998, Cloning and tissue expression of two putative steroid membrane receptors., Biol Chem, 379, 907

Sorted by citations

Androgen Receptor in Prostate Cancer
Heinlein, C. A., & Chang, C. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0032 · Cited by 1,780
Self-citation
Testosterone and Sex Hormone–Binding Globulin Predict the Metabolic Syndrome and Diabetes in Middle-Aged Men
Laaksonen, D. E., Niskanen, L., Punnonen, K., Nyyssönen, K., Tuomainen, T.-P., Valkonen, V.-P., Salonen, R., & Salonen, J. T. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1036 · Cited by 920
Androgens and Cardiovascular Disease
Liu, P. Y., Death, A. K., & Handelsman, D. J. (2003) · Endocrine Reviews · doi:10.1210/er.2003-0005 · Cited by 695
Androgen Receptor Structure, Function and Biology: From Bench to Bedside.
(2016) · Europe PMC (PubMed Central) · Cited by 623
Pharmacology of anabolic steroids
Kicman, A. T. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.165 · Cited by 578
Androgen insensitivity syndrome
Hughes, I. A., Davies, J. D., Bunch, T., Pasterski, V., Mastroyannopoulou, K., & MacDougall, J. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60071-3 · Cited by 579
FSH and testosterone signaling in Sertoli cells
Walker, W. H., & Cheng, J. (2005) · Reproduction · doi:10.1530/rep.1.00358 · Cited by 467
A Conserved Mechanism for Steroid Receptor Translocation to the Plasma Membrane
Pedram, A., Razandi, M., Sainson, R. C. A., Kim, J. K., Hughes, C. C. W., & Levin, E. R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611877200 · Cited by 449
Acute effects of steroid hormones and neuropeptides on human social-emotional behavior: A review of single administration studies
Bos, P. A., Panksepp, J., Bluthé, R.-M., & Honk, J. V. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.01.002 · Cited by 429
Androgen receptors in hormone-dependent and castration-resistant prostate cancer
Shafi, A. A., Yen, A. E., & Weigel, N. L. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.07.003 · Cited by 435
Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan
Stanhewicz, A. E., Wenner, M. M., & Stachenfeld, N. S. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00396.2018 · Cited by 426
Non-genomic actions of sex steroid hormones
Simoncini, T., & Genazzani, A. R. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1480281 · Cited by 369
Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review
Hlisníková, H., Petrovičová, I., Kolena, B., Šidlovská, M., & Sirotkin, A. V. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17186811 · Cited by 355
Testosterone: a vascular hormone in health and disease
Kelly, D. M., & Jones, T. H. (2013) · Journal of Endocrinology · doi:10.1530/joe-12-0582 · Cited by 301
Androgen receptor and growth factor signaling cross-talk in prostate cancer cells.
Zhu, M.-L., & Kyprianou, N. (2008) · Endocrine Related Cancer · doi:10.1677/erc-08-0084 · Cited by 286
Androgen Actions and the Ovary
Walters, K. A., Allan, C. M., & Handelsman, D. J. (2007) · Biology of Reproduction · doi:10.1095/biolreprod.107.064089 · Cited by 262
Cooperative Interactions between Androgen Receptor (AR) and Heat-Shock Protein 27 Facilitate AR Transcriptional Activity
Zoubeidi, A., Zardan, A., Beraldi, E., Fazli, L., Sowery, R. D., Rennie, P. S., Nelson, C. C., & Gleave, M. E. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2057 · Cited by 256
Androgen receptor coregulators and their involvement in the development and progression of prostate cancer
Chmelar, R. S., Buchanan, G., Need, E. F., Tilley, W. D., & Greenberg, N. M. (2006) · International Journal of Cancer · doi:10.1002/ijc.22365 · Cited by 260
Testosterone and dihydrotestosterone, but not estradiol, enhance survival of new hippocampal neurons in adult male rats
Spritzer, M. D., & Galea, L. A. M. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20457 · Cited by 277
Androgen receptors in prostate cancer.
Čulig, Z., Klocker, H., Bartsch, G., & Hobisch, A. (2002) · Endocrine Related Cancer · doi:10.1677/erc.0.0090155 · Cited by 247
Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease
Boese, A. C., Kim, S. C., Yin, K., Lee, J., & Hamblin, M. H. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00217.2016 · Cited by 241
Follicular assembly: mechanisms of action
Pepling, M. E. (2011) · Reproduction · doi:10.1530/rep-11-0299 · Cited by 243
Androgen Receptor Variants Occur Frequently in Castration Resistant Prostate Cancer Metastases
Zhang, X., Morrissey, C. M., Sun, S., Ketchandji, M., Nelson, P. S., True, L. D., Vakar‐Lopez, F., Vessella, R. L., & Plymate, S. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027970 · Cited by 244
Caspase control: protagonists of cancer cell apoptosis.
Fiandalo, M. V., & Kyprianou, N. (2012) · PubMed · Cited by 237
The Metabolic Syndrome and Smoking in Relation to Hypogonadism in Middle-Aged Men: A Prospective Cohort Study
Laaksonen, D. E., Niskanen, L., Punnonen, K., Nyyssönen, K., Tuomainen, T.-P., Valkonen, V.-P., & Salonen, J. T. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0970 · Cited by 230
FoxA1 Specifies Unique Androgen and Glucocorticoid Receptor Binding Events in Prostate Cancer Cells
Sahu, B., Laakso, M., Pihlajamaa, P., Ovaska, K., Sinielnikov, I., Hautaniemi, S., & Jänne, O. A. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-2350 · Cited by 230
Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and up‐regulated after in vitro stimulation and in patients with rheumatoid arthritis
Bartholome, B., Spies, C. M., Gaber, T., Schuchmann, S., Berki, T., Kunkel, D., Bienert, M., Radbruch, A., Burmester, G. R., Lauster, R., et al. (2004) · The FASEB Journal · doi:10.1096/fj.03-0328com · Cited by 229
Role of androgens and the androgen receptor in epithelial‐mesenchymal transition and invasion of prostate cancer cells
Zhu, M., & Kyprianou, N. (2009) · The FASEB Journal · doi:10.1096/fj.09-136994 · Cited by 228
Gender differences in kidney function
Sabolić, I., Asif, A. R., Budach, W. E., Wanke, C., Bahn, A., & Burckhardt, G. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0308-1 · Cited by 220
Androgen receptor (AR) differential roles in hormone-related tumors including prostate, bladder, kidney, lung, breast and liver
Chang, C., Lee, S. O., Yeh, S., & Chang, T. M. (2013) · Oncogene · doi:10.1038/onc.2013.274 · Cited by 214
Self-citation
Oxytocin and social motivation
Gordon, I., Martin, C., Feldman, R., & Leckman, J. F. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.07.007 · Cited by 211
Role of PI3K-AKT-mTOR Pathway as a Pro-Survival Signaling and Resistance-Mediating Mechanism to Therapy of Prostate Cancer
Pungsrinont, T., Kallenbach, J., & Baniahmad, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011088 · Cited by 218
Androgen insensitivity syndrome
Mongan, N. P., Tadokoro‐Cuccaro, R., Bunch, T., & Hughes, I. A. (2015) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2015.04.005 · Cited by 205
Sex hormones and adult hippocampal neurogenesis: Regulation, implications, and potential mechanisms
Mahmoud, R., Wainwright, S. R., & Galea, L. A. M. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.03.002 · Cited by 208
Two Emerging Concepts for Elite Athletes
Crewther, B. T., Cook, C. J., Cardinale, M., Weatherby, R. P., & Lowe, T. E. (2011) · Sports Medicine · doi:10.2165/11539170-000000000-00000 · Cited by 221
Rapid actions of androgens
Michels, G., & Hoppe, U. C. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.08.004 · Cited by 198
Drug Insight: role of the androgen receptor in the development and progression of prostate cancer
Taplin, M. (2007) · Nature Clinical Practice Oncology · doi:10.1038/ncponc0765 · Cited by 199
Testosterone activates mitogen-activated protein kinase and the cAMP response element binding protein transcription factor in Sertoli cells
Fix, C., Jordan, C. L., Cano‐Sánchez, P., & Walker, W. H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404278101 · Cited by 203
Molecular mechanisms of testosterone action in spermatogenesis☆
Walker, W. H. (2008) · Steroids · doi:10.1016/j.steroids.2008.11.017 · Cited by 196
Non-classical actions of testosterone: an update
Rahman, F., & Christian, H. (2007) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2007.09.004 · Cited by 207
GPRC6A Mediates the Non-genomic Effects of Steroids
Pi, M., Parrill, A. L., & Quarles, L. D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.158063 · Cited by 186
The origin of domestication genes in goats
Zheng, Z., Wang, X., Li, M., Li, Y., Yang, Z., Wang, X., Pan, X., Gong, M., Zhang, Y., Guo, Y., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaz5216 · Cited by 184
Recovery responses of testosterone, growth hormone, and IGF-1 after resistance exercise
Kraemer, W. J., Ratamess, N. A., & Nindl, B. C. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00599.2016 · Cited by 181
Mechanism of androgen receptor action
Li, J., & Al‐Azzawi, F. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.03.008 · Cited by 182
Different steroids co-regulate long-term expansion versus terminal differentiation in primary human erythroid progenitors
Leberbauer, C., Boulmé, F., Unfried, G., Huber, J. C., Beug, H., & Müllner, E. W. (2004) · Blood · doi:10.1182/blood-2004-03-1002 · Cited by 180
Activation of Phosphatidylinositol 3-Kinase/Akt Pathway by Androgen through Interaction of p85α, Androgen Receptor, and Src
Sun, M., Yang, L., Feldman, R. I., Sun, X.-M., Bhalla, K. N., Jove, R., Nicosia, S. V., & Cheng, J. Q. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306295200 · Cited by 175
Retracted
Androgen regulation of micro‐RNAs in prostate cancer
Waltering, K. K., Porkka, K. P., Jalava, S. E., Urbanucci, A., Kohonen, P. J., Latonen, L., Kallioniemi, O., Jenster, G. W., & Visakorpi, T. (2010) · The Prostate · doi:10.1002/pros.21276 · Cited by 166
Sex Steroids, Cardiovascular Disease, and Hypertension
Reckelhoff, J. F. (2004) · Hypertension · doi:10.1161/01.hyp.0000151825.36598.36 · Cited by 165
Involvement of androgens in ovarian health and disease
Lebbe, M., & Woodruff, T. K. (2013) · Molecular Human Reproduction · doi:10.1093/molehr/gat065 · Cited by 165
Androgen Receptor (AR) Physiological Roles in Male and Female Reproductive Systems: Lessons Learned from AR-Knockout Mice Lacking AR in Selective Cells1
Chang, C., Lee, S. O., Wang, R.-S., Yeh, S., & Chang, T. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.113.109132 · Cited by 170
Self-citation
Molecular mechanisms associated with diabetic endothelial–erectile dysfunction
Castela, Â., & Costa, C. (2016) · Nature Reviews Urology · doi:10.1038/nrurol.2016.23 · Cited by 161
Androgen Action in the Epididymis
Robaire, B., & Hamzeh, M. (2011) · Journal of Andrology · doi:10.2164/jandrol.111.014266 · Cited by 160
Molecular mechanisms of androgen receptor-mediated gene regulation: structure-function analysis of the AF-1 domain
McEwan, I. J. (2004) · Endocrine-related cancer · doi:10.1677/erc.0.0110281 · Cited by 156
Trauma and immune response—Effect of gender differences
Choudhry, M. A., Bland, K. I., & Chaudry, I. H. (2007) · Injury · doi:10.1016/j.injury.2007.09.027 · Cited by 150
Alterations of androgen receptor in prostate cancer
Linja, M. J., & Visakorpi, T. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.10.012 · Cited by 154
PCA3 noncoding RNA is involved in the control of prostate-cancer cell survival and modulates androgen receptor signaling
Ferreira, L. B., Palumbo, A., de Mello, K. D., Sternberg, C., Caetano, M. S., de Oliveira, F. L., Neves, A. F., Nasciutti, L. E., Goulart, L. R., & Gimba, E. R. P. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-507 · Cited by 151
Steroid hormone biotransformation and xenobiotic induction of hepatic steroid metabolizing enzymes
You, L. (2004) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2004.01.006 · Cited by 145
Genomic actions of the androgen receptor are required for normal male sexual differentiation in a mouse model
Notini, A. J., Davey, R. A., McManus, J. F., Bate, K. L., & Zajac, J. D. (2005) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01884 · Cited by 145
Structural characteristics of anabolic androgenic steroids contributing to binding to the androgen receptor and to their anabolic and androgenic activities
Fragkaki, A. G., Angelis, Y. S., Koupparis, M. Α., Tsantili‐Kakoulidou, A., Kokotos, G., & Georgakopoulos, C. G. (2008) · Steroids · doi:10.1016/j.steroids.2008.10.016 · Cited by 143
The Role of Androgen Hormones in Early Follicular Development
Gervásio, C. G., Bernuci, M. P., de Sá, M. F. S., & Silva, A. C. J. D. S. R. E. (2014) · ISRN Obstetrics and Gynecology · doi:10.1155/2014/818010 · Cited by 144
Membrane Androgen Receptor Activation Induces Apoptotic Regression of Human Prostate Cancer Cellsin Vitroandin Vivo
Hatzoglou, A., Kampa, M., Kogia, C., Charalampopoulos, I., Theodoropoulos, P. A., Anezinis, P., Dambaki, C., Papakonstanti, E. A., Stathopoulos, E. N., Stournaras, C., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0801 · Cited by 140
Osteoblast Deletion of Exon 3 of the Androgen Receptor Gene Results in Trabecular Bone Loss in Adult Male Mice
Notini, A. J., McManus, J. F., Moore, A., Bouxsein, M., Jimenez, M., Chiu, W. M., Glatt, V., Kream, B. E., Handelsman, D. J., Morris, H. A., et al. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.061117 · Cited by 141
Tamoxifen Resistance: Emerging Molecular Targets
Rondón‐Lagos, M., Villegas, V. E., Rangel, N., Sánchez, M. C., & Zaphiropoulos, P. G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081357 · Cited by 138
Estrogen and Androgen Protection of Human Neurons against Intracellular Amyloid 1-42 Toxicity through Heat Shock Protein 70
Zhang, Y. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0913-04.2004 · Cited by 142
The Roles of Androgens in Humans: Biology, Metabolic Regulation and Health
Alemany, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911952 · Cited by 150
Induction of Androgen Receptor Expression by Phosphatidylinositol 3-Kinase/Akt Downstream Substrate, FOXO3a, and Their Roles in Apoptosis of LNCaP Prostate Cancer Cells
Yang, L., Xie, S., Jamaluddin, M. S., Altuwaijri, S., Ni, J., Kim, E., Chen, Y.-T., Hu, Y.-C., Wang, L., Chuang, K.-H., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504461200 · Cited by 131
Self-citation
hZimp10 is an androgen receptor co‐activator and forms a complex with SUMO‐1 at replication foci
Sharma, M., Li, X., Wang, Y., Zarnegar, M. A., Huang, C., Palvimo, J. J., Lim, B., & Sun, Z. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg585 · Cited by 129
Pharmacological and X-Ray Structural Characterization of a Novel Selective Androgen Receptor Modulator: Potent Hyperanabolic Stimulation of Skeletal Muscle with Hypostimulation of Prostate in Rats
Ostrowski, J., Kuhns, J. E., Lupisella, J. A., Manfredi, M. C., Beehler, B. C., Krystek, S. R., Bi, Y., Sun, C., Seethala, R., Golla, R., et al. (2006) · Endocrinology · doi:10.1210/en.2006-0843 · Cited by 131
Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications
Lucas-Herald, A. K., Alves-Lopes, R., Montezano, A. C. I., Ahmed, S. F., & Touyz, R. M. (2017) · Clinical Science · doi:10.1042/cs20170090 · Cited by 138
The Influence of Sex Hormones in Liver Function and Disease
Kasarinaite, A., Sinton, M. C., Saunders, P. T. K., & Hay, D. C. (2023) · Cells · doi:10.3390/cells12121604 · Cited by 139
Regulation of Androgen Receptor Signaling by PTEN (Phosphatase and Tensin Homolog Deleted on Chromosome 10) Tumor Suppressor through Distinct Mechanisms in Prostate Cancer Cells
Lin, H., Hu, Y., Lee, D., & Chang, C. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0117 · Cited by 128
Self-citation
Contributions of sex to cerebrovascular function and pathology
Robison, L. S., Gannon, O. J., Salinero, A. E., & Zuloaga, K. L. (2018) · Brain Research · doi:10.1016/j.brainres.2018.12.030 · Cited by 129
Pathogenesis and therapy of spinal and bulbar muscular atrophy (SBMA)
Katsuno, M., Tanaka, F., Adachi, H., Banno, H., Suzuki, K., Watanabe, H., & Sobue, G. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.05.007 · Cited by 121
Regulation of androgen receptor levels: Implications for prostate cancer progression and therapy
Burnstein, K. L. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20460 · Cited by 117
Salivary testosterone and a trinucleotide (CAG) length polymorphism in the androgen receptor gene predict amygdala reactivity in men
Manuck, S. B., Marsland, A. L., Flory, J. D., Gorka, A. X., Ferrell, R. E., & Hariri, A. R. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.04.013 · Cited by 119
Nongenomic Androgen Activation of Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in MC3T3-E1 Osteoblasts
Kang, H., Cho, C.-L., Huang, K.-L., Wang, J.-C., Hu, Y., Lin, H., Chang, C., & Huang, K. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040306 · Cited by 114
Self-citation
The influence of testosterone upon vascular reactivity
Jones, R., Jones, T. H., & Channer, K. S. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1510029 · Cited by 115
Androgen receptor corepressors: An overview
Wang, L., Hsu, C., & Chang, C. (2004) · The Prostate · doi:10.1002/pros.20170 · Cited by 115
Self-citation
Gene Regulation in Spermatogenesis
MacLean, J. A., & Wilkinson, M. (2005) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(05)71005-x · Cited by 112
Dihydrotestosterone Differentially Modulates the Mitogen-Activated Protein Kinase and the Phosphoinositide 3-Kinase/Akt Pathways through the Nuclear and Novel Membrane Androgen Receptor in C6 Cells
Gatson, J. W., Kaur, P., & Singh, M. (2006) · Endocrinology · doi:10.1210/en.2005-1395 · Cited by 109
The Long-Term Outcome of Boys With Partial Androgen Insensitivity Syndrome and a Mutation in the Androgen Receptor Gene
Lucas-Herald, A. K., Bertelloni, S., Juul, A., Bryce, J., Jiang, J., Rodie, M., Sinnott, R., Boroujerdi, M. A., Johansen, M. L., Hiort, O., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1372 · Cited by 108
ARe we there yet? Understanding androgen receptor signaling in breast cancer
Michmerhuizen, A. R., Spratt, D. E., Pierce, L. J., & Speers, C. W. (2020) · npj Breast Cancer · doi:10.1038/s41523-020-00190-9 · Cited by 111
Metabolic modulation induced by oestradiol and DHT in immature rat Sertoli cells culturedin vitro
Rato, L., Alves, M. G., Socorro, S., Carvalho, R. A., Cavaco, J. E. B., & Oliveira, P. F. (2011) · Bioscience Reports · doi:10.1042/bsr20110030 · Cited by 107
Combining Testosterone and PDE5 Inhibitors in Erectile Dysfunction: Basic Rationale and Clinical Evidences
Greco, E. A., Spera, G., & Aversa, A. (2006) · European Urology · doi:10.1016/j.eururo.2006.06.049 · Cited by 106
Redox Features of the Cell: A Gender Perspective
Malorni, W., Campesi, I., Straface, E., Vella, S., & Franconi, F. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1596 · Cited by 105
Association Between Hormones and Metabolic Syndrome in Older Italian Men
Maggio, M. G., Lauretani, F., Ceda, G. P., Bandinelli, S., Basaria, S. S., Blè, A., Egan, J. M., Paolisso, G., Najjar, S. S., Metter, E. J., et al. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00963.x · Cited by 102
Beneficial and Adverse Effects of Testosterone on the Cardiovascular System in Men
Ruige, J. B., Ouwens, D. M., & Kaufman, J. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1970 · Cited by 100
Sex Hormone-Binding Globulin as an Independent Predictor of Incident Type 2 Diabetes Mellitus in Men
Lakshman, K. M., Bhasin, S., & Araujo, A. B. (2010) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glq002 · Cited by 100
Androgen receptor signaling pathways as a target for breast cancer treatment
Pietri, E., Conteduca, V., Andreis, D., Massa, I., Melegari, E., Sarti, S., Cecconetto, L., Schirone, A., Bravaccini, S., Serra, P., et al. (2016) · Endocrine Related Cancer · doi:10.1530/erc-16-0190 · Cited by 101
Androgen receptor-mediated non-genomic regulation of prostate cancer cell proliferation.
Liao, R. S., Ma, S., Lu, M., Li, R., Yin, Y., & Raj, G. V. (2013) · PubMed Central · doi:10.3978/j.issn.2223-4683.2013.09.07 · Cited by 103
Neurotoxicity by Synthetic Androgen Steroids: Oxidative Stress, Apoptosis, and Neuropathology: A Review
Pomara, C., Neri, M., Bello, S., Fiore, C., Riezzo, I., & Turillazzi, E. (2014) · Current Neuropharmacology · doi:10.2174/1570159x13666141210221434 · Cited by 100
Androgen Receptors in Prostate Cancer
Čulig, Z., Klocker, H., Bartsch, G. H., Steiner, H., & Hobisch, A. (2003) · The Journal of Urology · doi:10.1097/01.ju.0000075099.20662.7f · Cited by 97
Androgen Receptor (AR) Pathophysiological Roles in Androgen Related Diseases in Skin, Metabolism Syndrome, Bone/Muscle and Neuron/Immune Systems: Lessons Learned from Mice Lacking AR in Specific Cells
Chang, C., Yeh, S., Lee, S. O., & Chang, T. (2013) · Nuclear Receptor Signaling · doi:10.1621/nrs.11001 · Cited by 92
Self-citation
ELK1 is up-regulated by androgen in bladder cancer cells and promotes tumor progression
Kawahara, T., Shareef, H. K., Aljarah, A. K., Ide, H., Li, Y., Kashiwagi, E., Netto, G. J., Zheng, Y., & Miyamoto, H. (2015) · Oncotarget · doi:10.18632/oncotarget.5007 · Cited by 89
The immunomodulatory role of the hypothalamus-pituitary-gonad axis: Proximate mechanism for reproduction-immune trade offs?
Segner, H., Verburg-van Kemenade, B. M. L., & Chadzinska, M. (2017) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2016.07.004 · Cited by 86
Functional AR Signaling Is Evident in an In Vitro Mouse Follicle Culture Bioassay That Encompasses Most Stages of Folliculogenesis1
Lenie, S., & Smitz, J. E. J. (2008) · Biology of Reproduction · doi:10.1095/biolreprod.107.067280 · Cited by 87
Beyond the X Factor: Relevance of Sex Hormones in NAFLD Pathophysiology
Torre, S. D. (2021) · Cells · doi:10.3390/cells10092502 · Cited by 91
Testosterone-induced coronary vasodilatation occurs via a non-genomic mechanism: evidence of a direct calcium antagonism action
JONES, R. D., ENGLISH, K. M., Jones, T. H., & CHANNER, K. S. (2004) · Clinical Science · doi:10.1042/cs20030386 · Cited by 85
Prostate Cancer and the Met Hepatocyte Growth Factor Receptor
Knudsen, B. S., & Edlund, M. (2004) · Advances in cancer research · doi:10.1016/s0065-230x(04)91002-0 · Cited by 82
Androgen Induction of Prostate Cancer Cell Invasion Is Mediated by Ezrin
Chuan, Y.-C., Pang, S., Cedazo-Mı́nguez, Á., Norstedt, G., Pousette, Å., & Flores‐Morales, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602237200 · Cited by 82

Authors: Heinlein, C. A., & Chang, C.
Affiliations: George Whipple Laboratory for Cancer Research, Departments of Pathology (C.A.H., C.C.), Rochester, New York 14642
University of Rochester Medicine (US)
Corresponding author: Chang, Chawnshang
ORCID: Chang, Chawnshang
Venue: Molecular Endocrinology
Publisher: The Endocrine Society
Published: 2002-10-01
Volume: 16
Issue: 10
Pages: 2181-2187
ISSN: 0888-8809 (ISSN-L)
1944-9917
DOI: 10.1210/me.2002-0070
OpenAlex: W2146352944
Cited by: 568
References: 76
Citations by year: 2026: 6 · 2025: 7 · 2024: 9 · 2023: 14 · 2022: 15 · 2021: 26 · 2020: 20 · 2019: 28 · 2018: 20 · 2017: 24 · 2016: 32 · 2015: 18 · 2014: 20 · 2013: 43 · 2012: 31
FWCI: 2.59
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Molecular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: University of Rochester
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: androgen receptor, androgen-binding protein, sex hormone-binding globulin, dihydrotestosterone, testosterone, MAPK signaling, intracellular calcium signaling, G protein-coupled receptors, nuclear receptor superfamily, transcriptional regulation
MeSH terms: Androgen-Binding Protein, Androgens, Animals, Cell Membrane, Humans, Receptors, Androgen, Sex Hormone-Binding Globulin, Transcription, Genetic, Protein Biosynthesis, Genome, MAP Kinase Signaling System

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Roles of Androgen Receptors and Androgen-Binding Proteins in Nongenomic Androgen Actions

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks