The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Heterozygous Men1 Mutant Mice Develop a Range of Endocrine Tumors Mimicking Multiple Endocrine Neoplasia Type 1
Open accessAbstract
Multiple endocrine neoplasia type 1 (MEN1) is a hereditary syndrome characterized by the occurrence of multiple endocrine tumors of the parathyroid, pancreas, and anterior pituitary in patients. To study tumorigenesis related to the MEN1 syndrome, we have generated Men1 knockout mice using the gene targeting approach. Heterozygous Men1 mutant mice developed the same range of major endocrine tumors as is seen in MEN1 patients, affecting the parathyroid, pancreatic islets, pituitary and adrenal glands, as well as the thyroid, and exhibiting multistage tumor progression with metastatic potential. In particular, extrapancreatic gastrinoma, pancreatic glucagonoma, and mixed hormone-producing tumors in islets were observed. In addition, there was a high incidence of gonadal tumors of endocrine origin, i.e. Leydig cell tumors, and ovary sex-cord stromal cell tumors in heterozygous Men1 mutant mice. Hormonal disturbance, such as abnormal PTH and insulin levels, was also observed in these mice. These tumors were associated with loss of heterozygosity of the wild-type Men1 allele, suggesting that menin is involved in suppressing the development of these endocrine tumors. All of these features are reminiscent of MEN1 symptoms in humans and establish heterozygous Men1 mutant mice as a suitable model for this disease.
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Cites
Positional Cloning of the Gene for Multiple Endocrine Neoplasia-Type 1
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Menin Interacts with the AP1 Transcription Factor JunD and Represses JunD-Activated Transcription
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Cited by
Yokoyama, A., Somervaille, T. C. P., Smith, K. S., Rozenblatt-Rosen, O., Meyerson, M., & Cleary, M. L. (2005) · Cell · doi:10.1016/j.cell.2005.09.025 · Cited by 688
Lemos, M. C., & Thakker, R. V. (2008) · Human Mutation · doi:10.1002/humu.20605 · Cited by 675
Menin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes
Yokoyama, A., & Cleary, M. L. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.05.003 · Cited by 555
Jensen, R. T., Berna, M. J., Bingham, D. B., & Norton, J. A. (2008) · Cancer · doi:10.1002/cncr.23648 · Cited by 488
Karnik, S. K., Hughes, C. M., Gu, X., Rozenblatt-Rosen, O., McLean, G. W., Xiong, Y., Meyerson, M., & Kim, S. K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503484102 · Cited by 403
Metadata
- Authors
- Bertolino, P., Tong, W.-M., Galendo, D., Wang, Z.-Q., & Zhang, C.-X.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2003-09
- Volume
- 17
- Issue
- 9
- Pages
- 1880-1892
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W2150212366
- Cited by
- 255
- References
- 26
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bertolino, P., Tong, W.-M., Galendo, D., Wang, Z.-Q., & Zhang, C.-X. (2003). Heterozygous Men1 Mutant Mice Develop a Range of Endocrine Tumors Mimicking Multiple Endocrine Neoplasia Type 1. Molecular Endocrinology. https://doi.org/10.1210/me.2003-0154
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