Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837

FGF-21 as a novel metabolic regulator

Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125

Suppression of Aging in Mice by the Hormone Klotho

Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865

Klotho converts canonical FGF receptor into a specific receptor for FGF23

Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006) · Nature · doi:10.1038/nature05315 · Cited by 1,865

Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism.

Shimada, T., Kakitani, M., Yamazaki, Y., Hasegawa, H., Takeuchi, Y., Fujita, T., Fukumoto, S., Tomizuka, K., & Yamashita, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19081 · Cited by 1,503

Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495

Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia

Shimada, T., Mizutani, S., Muto, T., Yoneya, T., Hino, R., Takeda, S., Takeuchi, Y., Fujita, T., Fukumoto, S., & Yamashita, T. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.101545198 · Cited by 1,391

Regulation of Fibroblast Growth Factor-23 Signaling by Klotho

Kurosu, H., Ogawa, Y., Miyoshi, M., Yamamoto, M., Nandi, A., Rosenblatt, K. P., Baum, M. G., Schiavi, S. C., Hu, M. C., Moe, O. W., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c500457200 · Cited by 1,381

Current understanding and controversies on the clinical implications of fibroblast growth factor 21

Badakhshi, Y., & Jin, T. (2020) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2020.1864278 · Cited by 20

Fibroblast Growth Factor Homologous Factors in the Heart: A Potential Locus for Cardiac Arrhythmias

Wei, Q., Barnett, A. S., Pitt, G. S., & Hennessey, J. A. (2011) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2012.05.010 · Cited by 20

Exercise against nonalcoholic fatty liver disease: Possible role and mechanism of lipophagy

Su, P., Chen, J., & Tang, D. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121837 · Cited by 20

Hyperglycemia activates FGFR1 via TLR4/c-Src pathway to induce inflammatory cardiomyopathy in diabetes

Chen, X., Qian, J., Liang, S., Qian, J., Luo, W., Shi, Y., Zhu, H., Hu, X., Wu, G., Li, X., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.01.013 · Cited by 19

Increased fibroblast growth factor-21 in chronic kidney disease is a trade-off between survival benefit and blood pressure dysregulation

Nakano, T., Shiizaki, K., Miura, Y., Matsui, M., Kosaki, K., Mori, S., Yamagata, K., Maeda, S., Kishi, T., Usui, N., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-55643-4 · Cited by 20

The Complexity and Significance of Fibroblast Growth Factor (FGF) Signaling for FGF-Targeted Cancer Therapies

Nguyen, A. L., Facey, C. O. B., & Boman, B. M. (2024) · Cancers · doi:10.3390/cancers17010082 · Cited by 23

Fibroblast Growth Factor 8b Causes Progressive Stromal and Epithelial Changes in the Epididymis and Degeneration of the Seminiferous Epithelium in the Testis of Transgenic Mice1

Elo, T., Sipilä, P., Valve, E. M., Kujala, P. M., Toppari, J., POUTANEN, M. H., & Härkönen, P. L. (2012) · Biology of Reproduction · doi:10.1095/biolreprod.111.097352 · Cited by 19

Fibroblast Growth Factor 21 Promotes C2C12 Cells Myogenic Differentiation by Enhancing Cell Cycle Exit

Liu, X., Wang, Y., Zhao, S., & Li, X. (2017) · BioMed Research International · doi:10.1155/2017/1648715 · Cited by 19

The interrelation between FGF23 and glucose metabolism in humans

Ursem, S. R., Vervloet, M. G., Büttler, R. M., Ackermans, M. T., Oosterwerff, M. M., Eekhoff, E. M. W., Lips, P. T. A. M., Serlie, M. J. M., la Fleur, S. E., & Heijboer, A. C. (2018) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2018.06.013 · Cited by 20

Liver-secreted FGF21 induces sarcopenia by inhibiting satellite cell myogenesis via klotho beta in decompensated cirrhosis

Zhou, D., Shi, Y., Zhang, D., Zuo, J., Zeng, C., Mamtawla, G., Huang, L., Gao, X., Zhang, L., & Wang, X. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103333 · Cited by 18

Fibroblast growth factor 21: update on genetics and molecular biology

Barros, D. R., & Hegele, R. A. (2024) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000960 · Cited by 18

Effects of fasting on the expression pattern of FGFs in different skeletal muscle fibre types and sexes in mice

Jia, W., Wang, N., Yin, L., Chen, X., Hou, B., Wang, J., Qiang, G., Chan, C. B., Yang, X., & Du, G. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00287-7 · Cited by 18

Expanding horizons of achondroplasia treatment: current options and future developments

Fafílek, B., Bosakova, M. K., & Krejčı́, P. (2021) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2021.11.017 · Cited by 23

Eccentric exercise increases circulating fibroblast activation protein α but not bioactive fibroblast growth factor 21 in healthy humans

Parmar, B., Lewis, J. E., Samms, R. J., Ebling, F. J. P., Cheng, C., Adams, A. C., Mallinson, J. E., Cooper, S., Taylor, T., Ghasemi, R., et al. (2018) · Experimental Physiology · doi:10.1113/ep086669 · Cited by 19

Fibroblast growth factors 19 and 21 in acute liver damage

Shan, Z., Álvarez‐Sola, G., Uriarte, I., Arechederra, M., Fernández‐Barrena, M. G., Berasain, C., Ju, C., & Avila, M. A. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.05.26 · Cited by 19

KLB, encoding β-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism

Xu, C., Messina, A., Somm, E., Miraoui, H., Kinnunen, T. K., Acierno, J. S., Niederländer, N. J., Bouilly, J., Dwyer, A. A., Sidis, Y., et al. (2018) · Yearbook of pediatric endocrinology · doi:10.1530/ey.15.7.11 · Cited by 18

Fibroblast growth factor 21 deficiency aggravates obesity-induced hypothalamic inflammation and impairs thermogenic response

Mutsnaini, L., Kim, C.-S., Kim, J., Joe, Y., Chung, H., Choi, H., Roh, E., Kim, M., & Yu, R. (2019) · Inflammation Research · doi:10.1007/s00011-019-01222-2 · Cited by 18

Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21

Pol, C. J., Pollak, N. M., Jurczak, M. J., Zacharia, E. M., Karagiannides, I., Kyriazis, I. D., Ntziachristos, P., Scerbo, D. A., Brown, B. R., Aifantis, I., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.04.010 · Cited by 18

Fibroblast growth factor-21 (FGF21) administration to early-lactating dairy cows. I. Effects on signaling and indices of insulin action

Krumm, C. S., Giesy, S. L., Caixeta, L. S., Perfield, J. W., Sauerwein, H., Moore, B. L., & Boisclair, Y. R. (2019) · Journal of Dairy Science · doi:10.3168/jds.2019-16695 · Cited by 18

Spatial distribution of beta‐klotho mRNA in the mouse hypothalamus, hippocampal region, subiculum, and amygdala

Bono, B. S. M., Ly, N. K. K., Miller, P. A., Williams-Ikhenoba, J. G., Dumiaty, Y., & Chee, M. J. S. (2022) · The Journal of Comparative Neurology · doi:10.1002/cne.25306 · Cited by 19

Serum Fibroblast Growth Factor 21 Is Markedly Decreased following Exercise Training in Patients with Biopsy-Proven Nonalcoholic Steatohepatitis

Stine, J. G., Welles, J. E., Keating, S. E., Hussaini, Z., Soriano, C. T., Heinle, J. W., Geyer, N. R., Chinchilli, V. M., Loomba, R. S., & Kimball, S. R. (2023) · Nutrients · doi:10.3390/nu15061481 · Cited by 17

Fibroblast Growth Factor 21 Is Not Required for the Reductions in Circulating Insulin-Like Growth Factor-1 or Global Cell Proliferation Rates in Response to Moderate Calorie Restriction in Adult Mice

Thompson, A. C. S., Bruss, M. D., Nag, N., Kharitonenkov, A., Adams, A. C., & Hellerstein, M. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111418 · Cited by 17

Roles for fibroblast growth factor-23 and α-Klotho in acute kidney injury

Hu, P., Bao, J., & Li, A. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154435 · Cited by 17

Characterization of clostridium botulinum neurotoxin serotype A (BoNT/A) and fibroblast growth factor receptor interactions using novel receptor dimerization assay

James, N. G., Malik, S. Z., Sanstrum, B. J., Rhéaume, C., Broide, R. S., Jameson, D. M., Brideau-Andersen, A. D., & Jacky, B. (2021) · Scientific Reports · doi:10.1038/s41598-021-87331-7 · Cited by 17

Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats

Moro, J., Chaumontet, C., Even, P. C., Blais, A., Piedcoq, J., Gaudichon, C., Tomé, D., & Azzout‐Marniche, D. (2021) · Scientific Reports · doi:10.1038/s41598-021-91274-4 · Cited by 17

Fibroblast growth factor 21 in dairy cows: current knowledge and potential relevance

Eder, K., Geßner, D. K., & Ringseis, R. (2021) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-021-00621-y · Cited by 18

Expression profile and overexpression outcome indicate a role for βKlotho in skeletal muscle fibro/adipogenesis

Phelps, M., Stuelsatz, P., & Yablonka‐Reuveni, Z. (2016) · FEBS Journal · doi:10.1111/febs.13682 · Cited by 17

Ishige okamurae Extract Ameliorates the Hyperglycemia and Body Weight Gain of db/db Mice through Regulation of the PI3K/Akt Pathway and Thermogenic Factors by FGF21

Seo, Y., Lee, K., Chei, S., Jeon, Y., & Lee, B.-Y. (2019) · Marine Drugs · doi:10.3390/md17070407 · Cited by 17

The Impact of Klotho in Cancer: From Development and Progression to Therapeutic Potential

Ortega, M. A., Boaru, D. L., León-Oliva, D. D., Castro-Martinez, P. D., Minaya‐Bravo, A., Casanova-Martín, C., Barrena-Blázquez, S., Montero, C. G., Fraile‐Μartinez, O., López-González, L., et al. (2025) · Genes · doi:10.3390/genes16020128 · Cited by 18

Localization of fibroblast growth factor 23 protein in the rat hypothalamus

Ursem, S. R., Diepenbroek, C., Bacic, V., Unmehopa, U. A., Eggels, L., Maya‐Monteiro, C. M., Heijboer, A. C., & la Fleur, S. E. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15375 · Cited by 16

Reduction of Plasma BCAAs following Roux-en-Y Gastric Bypass Surgery Is Primarily Mediated by FGF21

Shah, H., Kramer, A., Mullins, C. A., Mattern, M., Gannaban, R. B., Townsend, R. L., Campagna, S. R., Morrison, C. D., Berthoud, H., & Shin, A. C. (2023) · Nutrients · doi:10.3390/nu15071713 · Cited by 17

Clinical Trial: A Phase 2b Study to Evaluate the Efficacy and Safety of MK‐3655 in Individuals With Pre‐Cirrhotic MASH

Raji, A., Gantz, I., Crutchlow, M. F., Flynn, H., Xu, L., Rodgers, A. J., Krishnan, R., Rizk, M. L., Hu, S., Kaufman, K. D., et al. (2025) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70038 · Cited by 17

Retinitis Pigmentosa: over‐expression of anti‐ageing protein Klotho in degenerating photoreceptors

Farinelli, P., Arango‐González, B., Voelkl, J. G. J., Alesutan, I., Lang, F. J. W., Zrenner, E., Paquet‐Durand, F., & Ekström, P. A. R. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12353 · Cited by 16

FGF-1 modulates pancreatic β-cell functions/metabolism: An in vitro study

Kolodziejski, P. A., Sassek, M., Bień, J., Leciejewska, N., Szczepankiewicz, D., Szczepaniak, B., Wojciechowska, M., Nogowski, L., Nowak, K. W., Strowski, M. Z., et al. (2020) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2020.113498 · Cited by 16

Qing'E formula alleviates the aging process in D-galactose-induced aging mice

Zhong, L., Huang, F., Shi, H., Wu, H., Zhang, B., Wu, X., Wei, X., & Wang, Z. (2016) · Biomedical Reports · doi:10.3892/br.2016.667 · Cited by 16

Impact of Bmal1 Rescue and Time-Restricted Feeding on Liver and Muscle Proteomes During the Active Phase in Mice

Smith, J. G., Molendijk, J., Blazev, R., Chen, W. H., Zhang, Q., Litwin, C., Zinna, V. M., Welz, P.-S., Benitah, S. A., Greco, C. M., et al. (2023) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2023.100655 · Cited by 16

Discovery of an artificial peptide agonist to the fibroblast growth factor receptor 1c/βKlotho complex from random peptide T7 phage display

Sakamoto, K., Kawata, Y., Masuda, Y., Umemoto, T., Ito, T., Asami, T., Takekawa, S., Ohtaki, T., & Inooka, H. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.10.009 · Cited by 15

Fibroblast growth factor 21 improves glucose homeostasis partially via down-regulation of Na+-d-glucose cotransporter SGLT1 in the small intestine

Wang, N., Li, S., Guo, X., Li, J., Ren, G., & Li, D. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.10.198 · Cited by 15

Soluble αKlotho downregulates Orai1-mediated store-operated Ca2+ entry via PI3K-dependent signaling

Kim, J., Park, E. Y., Hwang, K., Park, K., Choi, S. J., & Cha, S. (2021) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02510-1 · Cited by 15

Short-term dietary phosphate restriction up-regulates ileal fibroblast growth factor 15 gene expression in mice

Nakahashi, O., Yamamoto, H., Tanaka, S., Kozai, M., Takei, Y., Masuda, M., Kaneko, I., Taketani, Y., Iwano, M., Miyamoto, K., et al. (2014) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.13-109 · Cited by 15

γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers

Trošt, N., Peña‐Llopis, S., Koirala, S., Stojan, J., Potts, P. R., Tacer, K. F., & Martínez, E. D. (2015) · Oncotarget · doi:10.18632/oncotarget.6006 · Cited by 16

mGluR5 Tunes NGF/TrkA Signaling to Orient Spiny Stellate Neuron Dendrites Toward Thalamocortical Axons During Whisker-Barrel Map Formation

Huang, J.-Y., & Lu, H. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx105 · Cited by 16

Exploring endocrine FGFs - structures, functions and biomedical applications

Phan, P. (2024) · International Journal of Biochemistry and Molecular Biology · doi:10.62347/palk2137 · Cited by 16

FGF21 Depletion Attenuates Colitis through Intestinal Epithelial IL-22-STAT3 Activation in Mice

Liu, L., Li, F., Shao, T., Zhang, L., Lee, J., Dryden, G. W., McClain, C. J., Zhao, C., & Feng, W. (2023) · Nutrients · doi:10.3390/nu15092086 · Cited by 14

Diversity of Microglia-Derived Molecules with Neurotrophic Properties That Support Neurons in the Central Nervous System and Other Tissues

Wiens, K. R., Wasti, N., Ulloa, O. O., & Klegeris, A. (2024) · Molecules · doi:10.3390/molecules29235525 · Cited by 16

FAP finds FGF21 easy to digest

Gillum, M. P., & Potthoff, M. J. (2016) · Biochemical Journal · doi:10.1042/bcj20160004 · Cited by 14

Deficiency of fibroblast growth factor 2 (FGF‐2) leads to abnormal spermatogenesis and altered sperm physiology

Saucedo, L., Rumpel, R., Sobarzo, C., Schreiner, D., Brandes, G., Lustig, L., Vazquez-Levin, M. H., Grothe, C., & Marín-Briggiler, C. I. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26876 · Cited by 14

The Level of FGF 21 as a New Risk Factor for the Occurrence of Cardiometabolic Disorders amongst the Psoriatic Patients

Kiluk, P., Baran, A. M., Kaminski, T. W., Maciaszek, M., & Flisiak, I. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122206 · Cited by 15

γ‑Klotho is correlated with resistance to docetaxel in castration‑resistant prostate cancer

Onishi, K., Miyake, M., Hori, S., Onishi, S., Iida, K., Morizawa, Y., Tatsumi, Y., Nakai, Y., Tanaka, N., & Fujimoto, K. (2020) · Oncology Letters · doi:10.3892/ol.2020.11308 · Cited by 14

Fibroblast Growth Factor–21 ameliorates hepatic encephalopathy by activating the STAT3-SOCS3 pathway to inhibit activated hepatic stellate cells

Opoku, Y. K., Liu, Z., Afrifa, J., Kumi, A. K., Liu, H., Ghartey‐Kwansah, G., Koranteng, H., Jiang, X., Ren, G., & Li, D. (2020) · EXCLI journal · doi:10.17179/excli2020-1287 · Cited by 14

What Can We Learn from FGF-2 Isoform-Specific Mouse Mutants? Differential Insights into FGF-2 Physiology In Vivo

von Hövel, F. F., Kefalakes, E., & Grothe, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010390 · Cited by 14

Pancreatic Tumorigenesis: Oncogenic KRAS and the Vulnerability of the Pancreas to Obesity

Luo, Y., Li, X., Ma, J., Abbruzzese, J. L., & Lu, W. (2021) · Cancers · doi:10.3390/cancers13040778 · Cited by 14

Association between amorphous calcium-phosphate ratios in circulating calciprotein particles and prognostic biomarkers in hemodialysis patients

Nakamura, K., Isoyama, N., Nakayama, Y., Hiroyoshi, T., Fujikawa, K., Miura, Y., Kurosu, H., Matsuyama, H., & Kuro‐o, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-17405-7 · Cited by 14

Metabolic Regulation by Nuclear Receptors

Liu, S., Downes, M., & Evans, R. M. (2015) · Springer eBooks · doi:10.1007/978-4-431-55651-0_2 · Cited by 14

FGF10 and the Mystery of Duodenal Atresia in Humans

Teague, W. J., Jones, M. L. M., Hawkey, L., Smyth, I., Catubig, A., King, S. K., Sarila, G., Li, R., & Hutson, J. M. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00530 · Cited by 14

Mitochondrial Unfolded Protein Responses in White Adipose Tissue: Lipoatrophy, Whole-Body Metabolism and Lifespan

Kobayashi, M., Nezu, Y., Tagawa, R., & Higami, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062854 · Cited by 14

Genesis of the Master Circadian Pacemaker in Mice

Cheng, A. H., & Cheng, H. M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.659974 · Cited by 14

Proglumide Reverses Nonalcoholic Steatohepatitis by Interaction with the Farnesoid X Receptor and Altering the Microbiome

Gay, M. D., Cao, H., Shivapurkar, N., Dakshanamurthy, S., Kallakury, B., Tucker, R. D., Kwagyan, J., & Smith, J. P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031899 · Cited by 14

Hepatic PTP4A1 ameliorates high-fat diet-induced hepatosteatosis and hyperglycemia by the activation of the CREBH/FGF21 axis

Hwang, B., Kwon, M., Cho, M. J., Lee, N.-K., Lee, J., Lee, J.-W., Oh, K., Bae, K., Hwang, J. H., Min, J., et al. (2023) · Theranostics · doi:10.7150/thno.79434 · Cited by 13

Primer on fibroblast growth factor 7 (FGF 7)

Zheng, Y., Liu, W.-H., Yang, B., & Krentsis, I. M. (2024) · Differentiation · doi:10.1016/j.diff.2024.100801 · Cited by 13

Oncogenic FGFR Fusions Produce Centrosome and Cilia Defects by Ectopic Signaling

Niţă, A., Abraham, S. P., Krejčı́, P., & Bosakova, M. K. (2021) · Cells · doi:10.3390/cells10061445 · Cited by 14

Characterization of FGF21 Sites of Production and Signaling in Mice

Sullivan, A. I., Jensen-Cody, S. O., Claflin, K. E., Vorhies, K., Flippo, K. H., & Potthoff, M. J. (2024) · Endocrinology · doi:10.1210/endocr/bqae120 · Cited by 11

β-Klotho as novel therapeutic target in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A narrative review

Meroni, M., Dongiovanni, P., Tiano, F., Piciotti, R., Alisi, A., & Panera, N. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117608 · Cited by 13

Novel therapeutic targets and predictive markers for hepatocellular carcinoma

Chan, S. L., Chan, A. W. H., & Yeo, W. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1031109 · Cited by 12

Association of fibroblast growth factor 21 with metabolic syndrome and endothelial function in children: a prospective cross-sectional study on novel biomarkers

Domouzoglou, E. M., Vlahos, A. P., Cholevas, V., Papafaklis, M. I., Chaliasos, N., Siomou, E. C., Michalis, L. K., Tsatsoulis, A. A., & Naka, K. Κ. (2021) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2040258.129 · Cited by 12

Advances in FGFs for diabetes care applications

Liu, Y., Chen, Q., Li, Y., Bi, L., He, Z., Shao, C., Jin, L., Peng, R., & Zhang, X. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121015 · Cited by 12

From Beats to Metabolism: the Heart at the Core of Interorgan Metabolic Cross Talk

Romero-Becerra, R., Santamans, A. M., Arcones, A. C., & Sabio, G. (2023) · Physiology · doi:10.1152/physiol.00018.2023 · Cited by 12

Interrupting the FGF19-FGFR4 Axis to Therapeutically Disrupt Cancer Progression

Lang, L., Shull, A. Y., & Teng, Y. (2018) · Current Cancer Drug Targets · doi:10.2174/1568009618666180319091731 · Cited by 12

The potential role of plasma fibroblast growth factor 21 as a diagnostic biomarker for abdominal aortic aneurysm presence and development

Xie, T., Yin, L., Guo, D., Zhang, Z., Chen, Y., Liu, B., Wang, W., & Zheng, Y. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119346 · Cited by 12

The Role of Fibroblast Growth Factor 21 in Diabetic Cardiovascular Complications and Related Epigenetic Mechanisms

Xiao, M., Tang, Y., Wang, S., Wang, J., Wang, J., Guo, Y., Zhang, J., & Gu, J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.598008 · Cited by 12

Hepato-cardiac interorgan communication controls cardiac hypertrophy via combined endocrine-autocrine FGF21 signaling

Mia, S., Siokatas, G., Sidiropoulou, R., Hoffman, M., Fragkiadakis, K., Markopoulou, E., Elesawy, M., Roy, R., Blair, S., Kuwabara, Y., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102125 · Cited by 11

Effect of high-intensity circuit training on obesity indices, physical fitness, and browning factors in inactive female college students

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