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Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse
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Although members of the fibroblast growth factor (FGF) family and their receptors have well-established roles in embryogenesis, their contributions to adult physiology remain relatively unexplored. Here, we use real-time quantitative PCR to determine the mRNA expression patterns of all 22 FGFs, the seven principal FGF receptors (FGFRs), and the three members of the Klotho family of coreceptors in 39 different mouse tissues. Unsupervised hierarchical cluster analysis of the mRNA expression data reveals that most FGFs and FGFRs fall into two groups the expression of which is enriched in either the central nervous system or reproductive and gastrointestinal tissues. Interestingly, the FGFs that can act as endocrine hormones, including FGF15/19, FGF21, and FGF23, cluster in a third group that does not include any FGFRs, underscoring their roles in signaling between tissues. We further show that the most recently identified Klotho family member, Lactase-like, is highly and selectively expressed in brown adipose tissue and eye and can function as an additional coreceptor for FGF19. This FGF atlas provides an important resource for guiding future studies to elucidate the physiological functions of FGFs in adult animals.
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“KLB expression is primarily restricted to specific metabolic tissues (for example, the liver, pancreas and adipose tissue)5, and lower expression is observed in the brain22,48–50. Despite some reports to the contrary51,52, KLB is not expressed in muscle5,41.”
From Metabolic messengers: FGF21 (2021) · cites this paper as [5]
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“FGF21, unlike traditional FGFs, is an endocrine hormone produced and secreted predominantly by the liver [129,130].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [130]
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Hotta, Y., Sasaki, S., Konishi, M., Kinoshita, H., Kuwahara, K., Nakao, K., & Itoh, N. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21726 · Cited by 72
Fgf19 is required for zebrafish lens and retina development
Nakayama, Y., Miyake, A., Nakagawa, Y., Mido, T., Yoshikawa, M., Konishi, M., & Itoh, N. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.11.013 · Cited by 69
Aberrant fibroblast growth factor receptor signaling in bladder and other cancers
Chaffer, C. L., Dopheide, B., Savagner, P., Thompson, E. W., & Williams, E. D. (2007) · Differentiation · doi:10.1111/j.1432-0436.2007.00210.x · Cited by 68
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Fgf15 is required for proper morphogenesis of the mouse cardiac outflow tract
Vincentz, J. W., Mcwhirter, J., Murre, C., Baldini, A., & Furuta, Y. (2005) · Genesis · doi:10.1002/gene.20114 · Cited by 66
Fibroblast growth factor 22 and its potential role during skin development and repair.
Beyer, T. A., Werner, S., Dickson, C., & Grose, R. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00139-3 · Cited by 62
Expression of fibroblast growth factors in thyroid cancer
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Study of Fgf15 gene expression in developing mouse brain
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Neuronal localization of fibroblast growth factor-9 immunoreactivity in human and rat brain
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Calbindin 1, fibroblast growth factor 20, and α-synuclein in sporadic Parkinson’s disease
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Detection of spatial localization of Hst-1/Fgf-4 gene expression in brain and testis from adult mice
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Self-citationFGF19‐FGFR4 signaling elaborates lens induction with the FGF8‐L‐Maf cascade in the chick embryo
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Characterization of INT-2: A member of the fibroblast growth factor family
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1 of the 116 references couldn’t be matched to a known paper.
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The Fibroblast Growth Factor signaling pathway
Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050
Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529
Bispecific antibodies: a mechanistic review of the pipeline
Labrijn, A. F., Janmaat, M. L., Reichert, J. M., & Parren, P. W. H. I. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0028-1 · Cited by 1,303
FGF/FGFR signaling in health and disease
Xie, Y., Su, N., Yang, J., Tan, Q., Huang, S., Jin, M., Ni, Z., Zhang, B., Zhang, D., Luo, F., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00222-7 · Cited by 904
Gut-liver axis: Pathophysiological concepts and clinical implications
Tilg, H., Adolph, T. E., & Trauner, M. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.09.017 · Cited by 843
Metadata
- Authors
- Fon Tacer, K., Bookout, A. L., Ding, X., Kurosu, H., John, G. B., Wang, L., Goetz, R., Mohammadi, M., Kuro-o, M., Mangelsdorf, D. J., & Kliewer, S. A.
- Affiliations
- Department of Molecular Biology (K.F.T., X.D., S.A.K.), Dallas, Texas 75390
- Howard Hughes Medical Institute (US)
- Department of Pathology (H.K., G.B.J., L.W., M.K.), Dallas, Texas 75390
- New York University (US)
- Corresponding author
- Mangelsdorf, David J.
- Kliewer, Steven A.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2010-10-01
- Volume
- 24
- Issue
- 10
- Pages
- 2050-2064
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- PMC
- PMC2954642
- OpenAlex
- W1968091833
- Cited by
- 700
- References
- 116
- Citations by year
- 2026: 22 · 2025: 38 · 2024: 46 · 2023: 48 · 2022: 53 · 2021: 68 · 2020: 52 · 2019: 64 · 2018: 55 · 2017: 41 · 2016: 45 · 2015: 53 · 2014: 28 · 2013: 32 · 2012: 35
- FWCI
- 11.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Endocrinology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute (I-1558, I-1275)
- Welch Foundation (I-1275, I-1558, GM007062)
- National Institutes of Health (I-1275, I-1558, DK067158, U19DK62434, AG19712)
- National Institute on Aging (AG-19712, R01AG019712)
- National Institute of General Medical Sciences (T32GM007062, GM007062, RL1GM084436)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-067158, U19 DK-62434, U19DK062434, R01DK067158)
- National Institute of Dental and Craniofacial Research (DE13686, R01DE013686)
- National Center for Research Resources (P20RR20691, P20RR020691)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Keywords
- fibroblast growth factor, fibroblast growth factor receptor, FGF19, FGF21, fibroblast growth factor 23, FGF15/19, tissue-specific gene expression, adult mice, brown adipose tissue, hormone signaling, central nervous system
- MeSH terms
- Fibroblast Growth Factor-23, Animals, Atlases as Topic, Fibroblast Growth Factors, Humans, Mice, Inbred C57BL, RNA, Messenger, Tissue Distribution, Cluster Analysis, Receptors, Fibroblast Growth Factor, Gene Expression Profiling, Microarray Analysis, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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